Showing entry for F-box/WD repeat-containing protein 11


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025928
Protein NameF-box/WD repeat-containing protein 11
Uniport IdQ9UKB1
GeneFBXW11
Gene Id23291
DomainBeta-TrCP_D; F-box-like; WD40
Pfam PF12125   PF12937   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04340 Hedgehog signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04710 Circadian rhythm
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048854 brain morphogenesis
Biological Process GO:0000132 establishment of mitotic spindle orientation
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0007281 germ cell development
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0031023 microtubule organizing center organization
Biological Process GO:1901223 negative regulation of NIK/NF-kappaB signaling
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0038061 NIK/NF-kappaB signaling
Biological Process GO:0007097 nuclear migration
Biological Process GO:0042753 positive regulation of circadian rhythm
Biological Process GO:0045862 positive regulation of proteolysis
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0031648 protein destabilization
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:2000574 regulation of microtubule motor activity
Biological Process GO:0008090 retrograde axonal transport
Biological Process GO:0048511 rhythmic process
Biological Process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0051403 stress-activated MAPK cascade
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0047496 vesicle transport along microtubule
Biological Process GO:0016032 viral process
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0070840 dynein complex binding
molecular function GO:0051010 microtubule plus-end binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:1904115 axon cytoplasm
cellular component GO:0005813 centrosome
cellular component GO:0005881 cytoplasmic microtubule
cellular component GO:0005829 cytosol
cellular component GO:0000776 kinetochore
cellular component GO:0005875 microtubule associated complex
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005635 nuclear envelope
cellular component GO:0005634 nucleus
cellular component GO:0019005 SCF ubiquitin ligase complex
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1640170 Cell Cycle
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-392499 Metabolism of proteins
R-HSA-446652 Interleukin-1 family signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450294 MAP kinase activation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-597592 Post-translational protein modification
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8951664 Neddylation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079541 BXGD003081 Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151846 BXGD003485 Periosteal Disorder Musculoskeletal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0152427 BXGD003590 Polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278512 BXGD006528 Metastatic osteosarcoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345354 BXGD007728 Radial polydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0489786 BXGD009018 Height
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1266184 BXGD011991 Atypical Teratoid Rhabdoid Tumor Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1368683 BXGD012900 Epithelioma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347613 BXGD017039 Childhood Atypical Teratoid/Rhabdoid Tumor
C2677504 BXGD017376 AUTISM, SUSCEPTIBILITY TO, 15
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539781 BXGD019086 Progressive cGVHD
C3550704 BXGD019137 Abnormality of digit
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021812 BXGD020798 Abnormality of the head
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4050064 BXGD021958 ROSE Cluster 5
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316870 BXGD022707 Abnormality of the eye
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein