Showing entry for DNA replication licensing factor MCM6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025969
Protein NameDNA replication licensing factor MCM6
Uniport IdQ14566
GeneMCM6
Gene Id4175
DomainMCM; MCM6_C; MCM_lid; MCM_N; MCM_OB
Pfam PF00493   PF18263   PF17855   PF14551   PF17207  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03030 DNA replication
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006260 DNA replication
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0006268 DNA unwinding involved in DNA replication
Biological Process GO:0000727 double-strand break repair via break-induced replication
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:1902969 mitotic DNA replication
Biological Process GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
molecular function GO:0005524 ATP binding
molecular function GO:0003678 DNA helicase activity
molecular function GO:0003688 DNA replication origin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0003697 single-stranded DNA binding
cellular component GO:0042555 MCM complex
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-176974 Unwinding of DNA
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69190 DNA strand elongation
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69306 DNA Replication
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007129 BXGD000439 Merkel cell carcinoma Neoplasms; Infections
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022951 BXGD001595 Lactose Intolerance Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0268181 BXGD005847 Lactose Intolerance, Adult Type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280790 BXGD006763 Adult Anaplastic Oligodendroglioma Neoplasms
C0334590 BXGD007129 Anaplastic Oligodendroglioma Neoplasms
C0562350 BXGD009476 Hip circumference
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C1305855 BXGD012348 Body mass index
C1332943 BXGD012559 Childhood Anaplastic Oligodendroglioma Neoplasms
C1513302 BXGD013198 Mild Adverse Event
C1857231 BXGD015685 LACTASE PERSISTENCE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3642346 BXGD019245 Luminal B Breast Carcinoma
C3830345 BXGD019750 ECOG Performance Status 1
C3894553 BXGD020038 response to simvastatin
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4476604 BXGD022839 Decreased small intestinal mucosa lactase activity
C4521577 BXGD023063 Neck Pain Score 1
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein