Showing entry for Replicase polyprotein 1a


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026080
Protein NameReplicase polyprotein 1a
Uniport IdP0DTC1
Gene
Gene Id43740578
Domain-
Pfam PF16348   PF12379   PF01661   PF16251   PF11501   PF09401   PF12124   PF08716   PF08717   PF08710   PF05409   PF11633   PF08715  
OrganismSevere acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0039595 induction by virus of catabolism of host mRNA
Biological Process GO:0039520 induction by virus of host autophagy
Biological Process GO:0039519 modulation by virus of host autophagy
Biological Process GO:0039648 modulation by virus of host protein ubiquitination
Biological Process GO:0039690 positive stranded viral RNA replication
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0039548 suppression by virus of host IRF3 activity
Biological Process GO:0039579 suppression by virus of host ISG15 activity
Biological Process GO:0039644 suppression by virus of host NF-kappaB transcription factor activity
Biological Process GO:0039722 suppression by virus of host toll-like receptor signaling pathway
Biological Process GO:0039547 suppression by virus of host TRAF activity
Biological Process GO:0039604 suppression by virus of host translation
Biological Process GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway
Biological Process GO:0039501 suppression by virus of host type I interferon production
Biological Process GO:0019079 viral genome replication
Biological Process GO:0019082 viral protein processing
Biological Process GO:0039694 viral RNA genome replication
molecular function GO:0004197 cysteine-type endopeptidase activity
molecular function GO:0008234 cysteine-type peptidase activity
molecular function GO:0004519 endonuclease activity
molecular function GO:0019785 ISG15-specific protease activity
molecular function GO:0046983 protein dimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003727 single-stranded RNA binding
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
molecular function GO:0016740 transferase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0039714 cytoplasmic viral factory
cellular component GO:0030430 host cell cytoplasm
cellular component GO:0033644 host cell membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694271 Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
R-HSA-9694271 Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
R-HSA-9694301 Maturation of replicase proteins
R-HSA-9694301 Maturation of replicase proteins
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694682 SARS-CoV-2 Genome Replication and Transcription
R-HSA-9694686 Replication of the SARS-CoV-2 genome
R-HSA-9694686 Replication of the SARS-CoV-2 genome
R-HSA-9694786 Transcription of SARS-CoV-2 sgRNAs
R-HSA-9694786 Transcription of SARS-CoV-2 sgRNAs
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein