Showing entry for H(+)/Cl(-) exchange transporter 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026083
Protein NameH(+)/Cl(-) exchange transporter 7
Uniport IdP51798
GeneCLCN7
Gene Id1186
DomainCBS; Voltage_CLC
Pfam PF00571   PF00654  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0009268 response to pH
molecular function GO:0015297 antiporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0005254 chloride channel activity
molecular function GO:0015108 chloride transmembrane transporter activity
molecular function GO:0022857 transmembrane transporter activity
molecular function GO:0005247 voltage-gated chloride channel activity
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-2672351 Stimuli-sensing channels
R-HSA-382551 Transport of small molecules
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001126 BXGD000025 Renal tubular acidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003578 BXGD000211 Apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004604 BXGD000278 Back Pain Pathological Conditions, Signs and Symptoms
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008711 BXGD000566 Chronic rhinitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017638 BXGD001132 Glioma Neoplasms
C0018552 BXGD001202 Hamartoma Neoplasms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0020224 BXGD001366 Polyhydramnios Female Urogenital Diseases and Pregnancy Complications
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020598 BXGD001440 Hypocalcemia Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0026618 BXGD001909 Dental Fluorosis, Acquired Stomatognathic Diseases
C0027543 BXGD001997 Avascular necrosis of bone Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029410 BXGD002138 Osteoarthritis of hip Musculoskeletal Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0029454 BXGD002155 Osteopetrosis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029464 BXGD002161 Osteosclerosis Musculoskeletal Diseases
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040427 BXGD002864 Tooth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085660 BXGD003228 Aseptic necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0085682 BXGD003238 Hypophosphatemia Nutritional and Metabolic Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0152009 BXGD003515 White blood cell abnormality Hemic and Lymphatic Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238397 BXGD004923 Pulmonary artery stenosis Cardiovascular Diseases
C0239174 BXGD004969 Late tooth eruption
C0240231 BXGD005026 Fractures of the long bones Wounds and Injuries
C0241144 BXGD005080 Petechiae of skin Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0242567 BXGD005177 Opsoclonus Eye Diseases; Nervous System Diseases
C0266052 BXGD005614 Precocious exfoliation of primary tooth Stomatognathic Diseases
C0271344 BXGD006187 Compression of optic nerve Eye Diseases; Nervous System Diseases
C0349588 BXGD007933 Short stature
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426790 BXGD008577 Narrow thorax
C0432261 BXGD008759 Osteopetrosis - intermediate type Musculoskeletal Diseases
C0456070 BXGD008863 Growth delay
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0522214 BXGD009196 Abnormal visual evoked potential Nervous System Diseases
C0554970 BXGD009428 Pallor of optic disc
C0557874 BXGD009444 Global developmental delay
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0686377 BXGD009834 CNS metastases Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0948201 BXGD011515 Alloimmunisation
C1290708 BXGD012194 Osteomyelitis of mandible Infections; Musculoskeletal Diseases
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1318518 BXGD012396 Infantile malignant osteopetrosis Musculoskeletal Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832160 BXGD013803 Abnormality of temperature regulation
C1837260 BXGD014214 Prominent forehead
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1839829 BXGD014413 Short distal phalanx of finger
C1839866 BXGD014421 Elevated serum acid phosphatase Nutritional and Metabolic Diseases
C1842083 BXGD014494 Abnormality of the ribs
C1843331 BXGD014574 Generalized osteosclerosis Musculoskeletal Diseases
C1850134 BXGD015111 Sandwich appearance of vertebral bodies
C1855340 BXGD015490 Bowing of the long bones
C1855895 BXGD015557 Erlenmeyer flask deformity of the femurs
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C1963077 BXGD016680 Bone Pain, CTCAE 3.0
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1969093 BXGD016757 Osteopetrosis, Autosomal Recessive 6 Musculoskeletal Diseases
C1969106 BXGD016758 Osteopetrosis, Autosomal Recessive 4 Musculoskeletal Diseases
C2132198 BXGD016930 Abnormal blistering of the skin
C2674432 BXGD017246 Reduced bone mineral density
C2919142 BXGD017867 Short Stature, CTCAE
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3164374 BXGD018527 Abnormality of pulmonary valve
C3179239 BXGD018549 Osteopetrosis Autosomal Dominant Type 2 Musculoskeletal Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3645711 BXGD019248 Congenital Osteopetrosis Musculoskeletal Diseases
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3805574 BXGD019481 Increased fracture rate
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3887513 BXGD019887 Avascular necrosis Pathological Conditions, Signs and Symptoms
C4020847 BXGD020486 Abnormality of pelvic girdle bone morphology
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021624 BXGD020701 Osteosclerosis of the base of the skull
C4021785 BXGD020778 Abnormality of the metacarpal bones Musculoskeletal Diseases
C4023681 BXGD021239 Delayed fine motor development
C4023722 BXGD021253 Abnormality of hair texture
C4024763 BXGD021410 Optic atrophy from cranial nerve compression Eye Diseases; Nervous System Diseases
C4025164 BXGD021572 Cortical sclerosis Musculoskeletal Diseases
C4025251 BXGD021606 Abnormality of the vertebral endplates
C4025814 BXGD021806 Abnormality of the metaphysis
C4272578 BXGD022330 Autosomal Recessive Osteopetrosis Musculoskeletal Diseases
C4272579 BXGD022331 Autosomal Dominant Osteopetrosis Musculoskeletal Diseases
C4330904 BXGD022808 Osteoclast-Rich Osteopetrosis Musculoskeletal Diseases
C4551970 BXGD023457 Sclerotic vertebral endplates
C4553018 BXGD023532 Avascular Necrosis, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4554063 BXGD023559 Bone Pain, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein