Showing entry for Origin recognition complex subunit 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026086
Protein NameOrigin recognition complex subunit 2
Uniport IdQ13416
GeneORC2
Gene Id4999
DomainORC2
Pfam PF04084  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006260 DNA replication
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
molecular function GO:0003688 DNA replication origin binding
cellular component GO:0005813 centrosome
cellular component GO:0000939 condensed chromosome inner kinetochore
cellular component GO:0000792 heterochromatin
cellular component GO:0016020 membrane
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005664 nuclear origin of replication recognition complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000808 origin recognition complex
Reactome
Pathway Id Pathway Name
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-113510 E2F mediated regulation of DNA replication
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-68616 Assembly of the ORC complex at the origin of replication
R-HSA-68689 CDC6 association with the ORC:origin complex
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69206 G1/S Transition
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein