Showing entry for Mothers against decapentaplegic homolog 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026119
Protein NameMothers against decapentaplegic homolog 3
Uniport IdQ8BUN5
GeneSmad3
Gene Id17127
DomainMH1; MH2
Pfam PF03165   PF03166  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0030325 adrenal gland development
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0048589 developmental growth
Biological Process GO:0048701 embryonic cranial skeleton morphogenesis
Biological Process GO:0048617 embryonic foregut morphogenesis
Biological Process GO:0009880 embryonic pattern specification
Biological Process GO:0007492 endoderm development
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0007369 gastrulation
Biological Process GO:0001947 heart looping
Biological Process GO:0006955 immune response
Biological Process GO:0002520 immune system development
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0070306 lens fiber cell differentiation
Biological Process GO:0001889 liver development
Biological Process GO:0001707 mesoderm formation
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0061767 negative regulation of lung blood pressure
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0045668 negative regulation of osteoblast differentiation
Biological Process GO:0033689 negative regulation of osteoblast proliferation
Biological Process GO:0042177 negative regulation of protein catabolic process
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0038092 nodal signaling pathway
Biological Process GO:0002076 osteoblast development
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0048340 paraxial mesoderm morphogenesis
Biological Process GO:0060039 pericardium development
Biological Process GO:0010694 positive regulation of alkaline phosphatase activity
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0032332 positive regulation of chondrocyte differentiation
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:1901203 positive regulation of extracellular matrix assembly
Biological Process GO:0051894 positive regulation of focal adhesion assembly
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0050927 positive regulation of positive chemotaxis
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032916 positive regulation of transforming growth factor beta3 production
Biological Process GO:0050821 protein stabilization
Biological Process GO:0051098 regulation of binding
Biological Process GO:0050678 regulation of epithelial cell proliferation
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0016202 regulation of striated muscle tissue development
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032909 regulation of transforming growth factor beta2 production
Biological Process GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0023019 signal transduction involved in regulation of gene expression
Biological Process GO:0001501 skeletal system development
Biological Process GO:0007183 SMAD protein complex assembly
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0001756 somitogenesis
Biological Process GO:0042110 T cell activation
Biological Process GO:0030878 thyroid gland development
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0060290 transdifferentiation
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:0001657 ureteric bud development
molecular function GO:0008013 beta-catenin binding
molecular function GO:0043425 bHLH transcription factor binding
molecular function GO:0003682 chromatin binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0000987 cis-regulatory region sequence-specific DNA binding
molecular function GO:0005518 collagen binding
molecular function GO:0070410 co-SMAD binding
molecular function GO:0017151 DEAD/H-box RNA helicase binding
molecular function GO:0003677 DNA binding
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0019899 enzyme binding
molecular function GO:0035259 glucocorticoid receptor binding
molecular function GO:0042802 identical protein binding
molecular function GO:0031962 mineralocorticoid receptor binding
molecular function GO:0019902 phosphatase binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0001102 RNA polymerase II activating transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0070412 R-SMAD binding
molecular function GO:0043565 sequence-specific DNA binding
molecular function GO:0046332 SMAD binding
molecular function GO:0001223 transcription coactivator binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
molecular function GO:0005160 transforming growth factor beta receptor binding
molecular function GO:0043130 ubiquitin binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0071144 heteromeric SMAD protein complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005637 nuclear inner membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0043235 receptor complex
cellular component GO:0071141 SMAD protein complex
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0023236 Helenine 232.15
BXGC0030148 Isoalantolactone 232.15
BXGC0047707 5Alpha-Epoxyalantolactone 248.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein