Showing entry for Transforming growth factor beta-1 proprotein



                       
General Target Information
BXGT IdBXGT026120
Protein NameTransforming growth factor beta-1 proprotein
Uniport IdP04202
GeneTgfb1
Gene Id21803
DomainTGFb_propeptide; TGF_beta
Pfam PF00019   PF00688  
OrganismMus musculus (Mouse)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Biological Process GO:0007568 aging
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0003180 aortic valve morphogenesis
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0060751 branch elongation involved in mammary gland duct branching
Biological Process GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
Biological Process GO:0001775 cell activation
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0016477 cell migration
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071549 cellular response to dexamethasone stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:1990314 cellular response to insulin-like growth factor stimulus
Biological Process GO:0071479 cellular response to ionizing radiation
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071407 cellular response to organic cyclic compound
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0002062 chondrocyte differentiation
Biological Process GO:0007182 common-partner SMAD protein phosphorylation
Biological Process GO:0061448 connective tissue development
Biological Process GO:0006952 defense response
Biological Process GO:0009817 defense response to fungus, incompatible interaction
Biological Process GO:0048565 digestive tract development
Biological Process GO:1990402 embryonic liver development
Biological Process GO:0007492 endoderm development
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:0085029 extracellular matrix assembly
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0007565 female pregnancy
Biological Process GO:0060364 frontal suture morphogenesis
Biological Process GO:0008354 germ cell migration
Biological Process GO:0007507 heart development
Biological Process GO:0003179 heart valve morphogenesis
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0030214 hyaluronan catabolic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0048839 inner ear development
Biological Process GO:0070306 lens fiber cell differentiation
Biological Process GO:0031663 lipopolysaccharide-mediated signaling pathway
Biological Process GO:0097421 liver regeneration
Biological Process GO:0048535 lymph node development
Biological Process GO:0060744 mammary gland branching involved in thelarche
Biological Process GO:0030879 mammary gland development
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0031293 membrane protein intracellular domain proteolysis
Biological Process GO:0007093 mitotic cell cycle checkpoint
Biological Process GO:0032943 mononuclear cell proliferation
Biological Process GO:0001763 morphogenesis of a branching structure
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0042552 myelination
Biological Process GO:0043011 myeloid dendritic cell differentiation
Biological Process GO:0070168 negative regulation of biomineral tissue development
Biological Process GO:0043537 negative regulation of blood vessel endothelial cell migration
Biological Process GO:0022408 negative regulation of cell-cell adhesion
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045918 negative regulation of cytolysis
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0060965 negative regulation of gene silencing by miRNA
Biological Process GO:1900126 negative regulation of hyaluronan biosynthetic process
Biological Process GO:0050777 negative regulation of immune response
Biological Process GO:0032700 negative regulation of interleukin-17 production
Biological Process GO:0010936 negative regulation of macrophage cytokine production
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0045662 negative regulation of myoblast differentiation
Biological Process GO:0007406 negative regulation of neuroblast proliferation
Biological Process GO:0030279 negative regulation of ossification
Biological Process GO:0050765 negative regulation of phagocytosis
Biological Process GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:1903077 negative regulation of protein localization to plasma membrane
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
Biological Process GO:0048642 negative regulation of skeletal muscle tissue development
Biological Process GO:0050868 negative regulation of T cell activation
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0001843 neural tube closure
Biological Process GO:0021915 neural tube development
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0014003 oligodendrocyte development
Biological Process GO:0043932 ossification involved in bone remodeling
Biological Process GO:0030316 osteoclast differentiation
Biological Process GO:0060389 pathway-restricted SMAD protein phosphorylation
Biological Process GO:0006796 phosphate-containing compound metabolic process
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:2000727 positive regulation of cardiac muscle cell differentiation
Biological Process GO:0071158 positive regulation of cell cycle arrest
Biological Process GO:0051781 positive regulation of cell division
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032270 positive regulation of cellular protein metabolic process
Biological Process GO:0050921 positive regulation of chemotaxis
Biological Process GO:0032967 positive regulation of collagen biosynthetic process
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0031536 positive regulation of exit from mitosis
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0035066 positive regulation of histone acetylation
Biological Process GO:0031065 positive regulation of histone deacetylation
Biological Process GO:0032740 positive regulation of interleukin-17 production
Biological Process GO:0048298 positive regulation of isotype switching to IgA isotypes
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0014008 positive regulation of microglia differentiation
Biological Process GO:0071677 positive regulation of mononuclear cell migration
Biological Process GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0042482 positive regulation of odontogenesis
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
Biological Process GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:0035307 positive regulation of protein dephosphorylation
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:1900182 positive regulation of protein localization to nucleus
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:1903911 positive regulation of receptor clustering
Biological Process GO:0045591 positive regulation of regulatory T cell differentiation
Biological Process GO:0060391 positive regulation of SMAD protein signal transduction
Biological Process GO:0051152 positive regulation of smooth muscle cell differentiation
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:2000679 positive regulation of transcription regulatory region DNA binding
Biological Process GO:0043117 positive regulation of vascular permeability
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0043491 protein kinase B signaling
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0032801 receptor catabolic process
Biological Process GO:2000249 regulation of actin cytoskeleton reorganization
Biological Process GO:0051098 regulation of binding
Biological Process GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
Biological Process GO:0061035 regulation of cartilage development
Biological Process GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0051101 regulation of DNA binding
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0032667 regulation of interleukin-23 production
Biological Process GO:0042306 regulation of protein import into nucleus
Biological Process GO:0045589 regulation of regulatory T cell differentiation
Biological Process GO:0060390 regulation of SMAD protein signal transduction
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0016202 regulation of striated muscle tissue development
Biological Process GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0045066 regulatory T cell differentiation
Biological Process GO:0070723 response to cholesterol
Biological Process GO:0042493 response to drug
Biological Process GO:0032355 response to estradiol
Biological Process GO:0009749 response to glucose
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0035902 response to immobilization stress
Biological Process GO:0034616 response to laminar fluid shear stress
Biological Process GO:0010033 response to organic substance
Biological Process GO:0032570 response to progesterone
Biological Process GO:1902074 response to salt
Biological Process GO:0033280 response to vitamin D
Biological Process GO:0009611 response to wounding
Biological Process GO:0007435 salivary gland morphogenesis
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0001501 skeletal system development
Biological Process GO:0007183 SMAD protein complex assembly
Biological Process GO:0060395 SMAD protein signal transduction
Biological Process GO:0042110 T cell activation
Biological Process GO:0030217 T cell differentiation
Biological Process GO:0043029 T cell homeostasis
Biological Process GO:0072540 T-helper 17 cell lineage commitment
Biological Process GO:0002513 tolerance induction to self antigen
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
Biological Process GO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development
Biological Process GO:0001657 ureteric bud development
Biological Process GO:0001570 vasculogenesis
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
Biological Process GO:0042060 wound healing
molecular function GO:0003823 antigen binding
molecular function GO:0005125 cytokine activity
molecular function GO:0019899 enzyme binding
molecular function GO:0008083 growth factor activity
molecular function GO:0042802 identical protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0043539 protein serine/threonine kinase activator activity
molecular function GO:0005160 transforming growth factor beta receptor binding
molecular function GO:0034714 type III transforming growth factor beta receptor binding
molecular function GO:0005114 type II transforming growth factor beta receptor binding
molecular function GO:0034713 type I transforming growth factor beta receptor binding
cellular component GO:0030424 axon
cellular component GO:0072562 blood microparticle
cellular component GO:0009986 cell surface
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0005737 cytoplasm
cellular component GO:0031012 extracellular matrix
cellular component GO:0005615 extracellular space
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0030141 secretory granule
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0023236 Helenine 232.15
BXGC0030148 Isoalantolactone 232.15
BXGC0047707 5Alpha-Epoxyalantolactone 248.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein