Showing entry for Sarcoplasmic/endoplasmic reticulum calcium ATPase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT026177
Protein NameSarcoplasmic/endoplasmic reticulum calcium ATPase 1
Uniport IdQ64578
GeneAtp2a1
Gene Id116601
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase
Pfam PF00689   PF00690  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008637 apoptotic mitochondrial changes
Biological Process GO:0070509 calcium ion import
Biological Process GO:1990036 calcium ion import into sarcoplasmic reticulum
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process GO:0051659 maintenance of mitochondrion location
Biological Process GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
Biological Process GO:0045988 negative regulation of striated muscle contraction
Biological Process GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
Biological Process GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
Biological Process GO:0106134 positive regulation of cardiac muscle cell contraction
Biological Process GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration
Biological Process GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
Biological Process GO:0051561 positive regulation of mitochondrial calcium ion concentration
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0006942 regulation of striated muscle contraction
Biological Process GO:0090076 relaxation of skeletal muscle
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0070296 sarcoplasmic reticulum calcium ion transport
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0030899 calcium-dependent ATPase activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005388 calcium transmembrane transporter activity, phosphorylative mechanism
molecular function GO:0005338 nucleotide-sugar transmembrane transporter activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0031673 H zone
cellular component GO:0031674 I band
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0033017 sarcoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0023873 Ivermectin 874.51
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein