Compound in Profiling

Compound Information

Test on : RBC, Metz

Compound Name
RBC, Metz : 129-56-6

Inchikey
Same : ACPOUJIDANTYHO-N
RBC, Metz : ACPOUJIDANTYHO-UHFFFAOYSA-N

ChemSpider
RBC, Metz : 8201

Pubchem CID
RBC, Metz : 8515

ChEMBL
RBC, Metz : CHEMBL7064

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	3
GRK	7	6	1
RSK	8	8	4
PKA	5	3	2
PKC	9	9	5
PKG	2	3	2
PKN	3	2	1
SGK	3	3	1
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz
PDK1	inactive (99.05%)	active (630.96nM)

AGC - Akt

Bioactivity
Kinase	RBC	Metz
AKT1	inactive (102.16%)	inactive (>7943.28nM)
AKT2	inactive (95.95%)	inactive (>7943.28nM)
AKT3	inactive (97%)	inactive (>10000nM)

AGC - DMPK

Bioactivity
Kinase	RBC	Metz
DMPK1	inactive (99.04%)	-
MRCKa	inactive (101.51%)	inactive (>10000nM)
MRCKb	inactive (97.2%)	-
ROCK1	inactive (98.19%)	inactive (1995.26nM)
ROCK2	inactive (89.44%)	inactive (3162.28nM)

AGC - GRK

Bioactivity
Kinase	RBC	Metz
BARK1	inactive (99.44%)	-
BARK2	inactive (100.45%)	-
GPRK4	inactive (96.63%)	-
GPRK5	inactive (98.8%)	-
GPRK6	inactive (90.06%)	-
GPRK7	inactive (91.94%)	-

AGC - RSK

Bioactivity
Kinase	RBC	Metz
MSK1	inactive (79.51%)	-
MSK2	inactive (87.43%)	-
p70S6K	-	active (125.89nM)
p70S6Kb	inactive (107.54%)	-
RSK2	inactive (75.28%)	active (398.11nM)
RSK4	inactive (88.16%)	-
RSK1	inactive (68.4%)	-
RSK3	inactive (80.32%)	-

AGC - PKA

Bioactivity
Kinase	RBC	Metz
PKACg	-	-
PRKX	inactive (89.5%)	inactive (>1584.89nM)
PKACa	inactive (98.57%)	inactive (>7943.28nM)

AGC - PKC

Bioactivity
Kinase	RBC	Metz
PKCa	inactive (76.09%)	-
PKCd	inactive (94.9%)	inactive (>7943.28nM)
PKCe	inactive (98.54%)	-
PKCh	inactive (87.56%)	-
PKCg	inactive (98.29%)	active (316.23nM)
PKCi	inactive (95.02%)	inactive (>5011.87nM)
PKCt	inactive (87.08%)	-
PKCz	inactive (98.28%)	inactive (>7943.28nM)
PKCb	inactive (99.33%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz
PKG2	inactive (93.04%)	inactive (>1584.89nM)
PKG1	inactive (87.83%)	inactive (>1995.26nM)

AGC - PKN

Bioactivity
Kinase	RBC	Metz
PKN1	inactive (90.62%)	-
PKN2	inactive (94.25%)	inactive (>7943.28nM)

AGC - SGK

Bioactivity
Kinase	RBC	Metz
SGK1	inactive (59.47%)	active (251.19nM)
SGK2	inactive (85.11%)	-
SGK3	inactive (94.56%)	-

AGC - NDR

Bioactivity
Kinase	RBC	Metz
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Abl	2	2	1
Ack	2	1	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	-
EGFR	4	3	3
Eph	14	12	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Musk	1	1	-
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	1
Tie	2	1	-
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	RBC	Metz
ABL1	inactive (94.2%)	inactive (>630.96nM)
ABL2	inactive (99.63%)	-

TK - Ack

Bioactivity
Kinase	RBC	Metz
ACK	inactive (66.28%)	-

TK - ALK

Bioactivity
Kinase	RBC	Metz
ALK	inactive (91.67%)	-
LTK	inactive (77.81%)	-

TK - Axl

Bioactivity
Kinase	RBC	Metz
AXL	inactive (85.82%)	-
MER	inactive (83.66%)	-
TYRO3	inactive (88.43%)	active (1000nM)

TK - Src

Bioactivity
Kinase	RBC	Metz
BLK	inactive (101.74%)	active (199.53nM)
BRK	inactive (94.14%)	-
SRC	inactive (97.56%)	inactive (>1995.26nM)
FGR	inactive (88.83%)	-
FRK	inactive (95.08%)	active (63.1nM)
FYN	inactive (93.19%)	inactive (>794.33nM)
HCK	inactive (87.33%)	-
LCK	inactive (97.08%)	inactive (1995.26nM)
SRM	inactive (99.15%)	inactive (>1584.89nM)
YES	inactive (88.19%)	-
LYN	inactive (96.98%)	active (1000nM)

TK - Tec

Bioactivity
Kinase	RBC	Metz
BMX	inactive (90.84%)	-
BTK	inactive (97.77%)	inactive (>1258.93nM)
ITK	inactive (83.19%)	-
TEC	inactive (102.06%)	-
TXK	inactive (73.39%)	-

TK - PDGFR

Bioactivity
Kinase	RBC	Metz
KIT	inactive (81.93%)	inactive (1258.93nM)
FLT3	active (12.46%)	active (50.12nM)
FMS	inactive (86.71%)	active (125.89nM)
PDGFRb	inactive (85.15%)	-
PDGFRa	inactive (101.46%)	-

TK - Csk

Bioactivity
Kinase	RBC	Metz
CSK	inactive (95.57%)	-
CTK	inactive (106.53%)	active (501.19nM)

TK - DDR

Bioactivity
Kinase	RBC	Metz
DDR2	inactive (101.78%)	-

TK - EGFR

Bioactivity
Kinase	RBC	Metz
EGFR	inactive (99.3%)	inactive (>1995.26nM)
ErbB2	inactive (98.05%)	-
ErbB4	inactive (98.25%)	inactive (3981.07nM)

TK - Eph

Bioactivity
Kinase	RBC	Metz
EphA1	inactive (77.77%)	-
EphA2	inactive (89.03%)	inactive (>3162.28nM)
EphA3	inactive (94.21%)	-
EphA4	inactive (106.51%)	-
EphA5	inactive (102.19%)	-
EphA6	-	-
EphA7	inactive (90.94%)	-
EphA8	inactive (92.51%)	-
EphB1	inactive (88.77%)	-
EphB2	inactive (100.26%)	-
EphB3	inactive (92.52%)	-
EphB4	inactive (90.92%)	-

TK - FAK

Bioactivity
Kinase	RBC	Metz
FAK	inactive (64.83%)	-
PYK2	inactive (82.22%)	-

TK - Fer

Bioactivity
Kinase	RBC	Metz
FER	inactive (69.39%)	active (50.12nM)
FES	inactive (64.27%)	active (79.43nM)

TK - FGFR

Bioactivity
Kinase	RBC	Metz
FGFR1	inactive (69.44%)	active (251.19nM)
FGFR2	inactive (92.3%)	-
FGFR3	inactive (85.14%)	active (158.49nM)
FGFR4	inactive (99.63%)	-

TK - VEGFR

Bioactivity
Kinase	RBC	Metz
FLT1	inactive (87.28%)	active (199.53nM)
FLT4	inactive (63.58%)	active (15.85nM)
KDR	inactive (89.88%)	active (630.96nM)

TK - InsR

Bioactivity
Kinase	RBC	Metz
IGF1R	inactive (94.86%)	inactive (>1995.26nM)
IRR	inactive (83.12%)	-
INSR	inactive (86.93%)	active (501.19nM)

TK - JakA

Bioactivity
Kinase	RBC	Metz
JAK1	inactive (87.23%)	-
JAK2	inactive (77.67%)	-
JAK3	inactive (73.98%)	-
TYK2	inactive (66.36%)	inactive (1258.93nM)

TK - Musk

Bioactivity
Kinase	RBC	Metz
MUSK	inactive (62.17%)	-

TK - Ret

Bioactivity
Kinase	RBC	Metz
RET	active (34.15%)	active (63.1nM)

TK - Met

Bioactivity
Kinase	RBC	Metz
RON	inactive (102.99%)	-
MET	inactive (111.56%)	active (501.19nM)

TK - Sev

Bioactivity
Kinase	RBC	Metz
ROS	inactive (75.98%)	-

TK - Syk

Bioactivity
Kinase	RBC	Metz
SYK	inactive (75.04%)	active (63.1nM)
ZAP70	inactive (88.8%)	-

TK - Tie

Bioactivity
Kinase	RBC	Metz
TIE2	inactive (92.19%)	-

TK - Trk

Bioactivity
Kinase	RBC	Metz
TRKA	inactive (97.12%)	inactive (1258.93nM)
TRKB	active (48.16%)	active (794.33nM)
TRKC	active (27.27%)	active (7.94nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STKR	12	5	1
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	1
MLK	10	5	2
RIPK	5	1	-

TKL - STKR

Bioactivity
Kinase	RBC	Metz
ALK1	inactive (111.83%)	-
ALK2	inactive (134.09%)	-
ALK4	inactive (100.69%)	-
TGFbR1	inactive (99.2%)	-
TGFbR2	inactive (104.84%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz
ARAF	inactive (105.33%)	-
BRAF	inactive (109.05%)	-
RAF1	inactive (88.24%)	-

TKL - IRAK

Bioactivity
Kinase	RBC	Metz
IRAK1	inactive (72.43%)	-
IRAK4	inactive (95.73%)	active (158.49nM)

TKL - LISK

Bioactivity
Kinase	RBC	Metz
LIMK1	inactive (78.08%)	-

TKL - LRRK

Bioactivity
Kinase	RBC	Metz
LRRK2	inactive (62.22%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Metz
MLK1	active (33.55%)	-
MLK2	inactive (86.68%)	-
MLK3	inactive (56.95%)	-
TAK1	inactive (59.26%)	-
ZAK	inactive (75.46%)	active (501.19nM)

TKL - RIPK

Bioactivity
Kinase	RBC	Metz
RIPK2	inactive (75.25%)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CAMKL	20	13	9
CAMK1	5	5	2
CAMK2	4	4	4
RAD53	1	1	1
DAPK	5	4	2
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	1

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz
NuaK1	active (23.86%)	-
BRSK1	inactive (56.87%)	active (794.33nM)
BRSK2	inactive (55.83%)	-
CHK1	inactive (72.19%)	inactive (1258.93nM)
LKB1	inactive (53.86%)	-
MARK1	inactive (60.07%)	-
MARK3	inactive (72.25%)	active (3.98nM)
MARK4	inactive (53.96%)	-
MELK	active (21.57%)	active (398.11nM)
PASK	inactive (92.17%)	-
QIK	inactive (83.07%)	-
NuaK2	inactive (80.66%)	-
MARK2	inactive (59.86%)	-
AMPKa1	-	inactive (>1584.89nM)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz
CaMK1a	inactive (96.85%)	inactive (>1584.89nM)
CaMK1b	inactive (101.61%)	-
CaMK1d	inactive (91.89%)	-
CaMK1g	inactive (100.55%)	-
CaMK4	inactive (92.85%)	-

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz
CaMK2a	inactive (82.59%)	-
CaMK2b	inactive (86.31%)	inactive (6309.57nM)
CaMK2d	inactive (83.37%)	active (1000nM)
CaMK2g	inactive (91.1%)	inactive (1584.89nM)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz
CHK2	active (34.13%)	active (501.19nM)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz
DAPK1	inactive (81.49%)	-
DAPK2	inactive (108.73%)	-
DRAK1	active (29.07%)	active (39.81nM)
DAPK3	inactive (88.37%)	active (398.11nM)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz
DCLK2	inactive (88.63%)	-
DCLK1	-	inactive (>10000nM)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz
MAPKAPK2	inactive (98.68%)	inactive (>7943.28nM)
MAPKAPK3	inactive (99.25%)	inactive (>10000nM)
MAPKAPK5	inactive (91.25%)	inactive (>1584.89nM)
MNK1	inactive (97.02%)	-
MNK2	inactive (59.09%)	active (316.23nM)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz
smMLCK	active (47.99%)	-
skMLCK	active (22.2%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz
PHKg1	inactive (65.79%)	-
PHKg2	inactive (76.47%)	active (630.96nM)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz
PIM1	inactive (61.25%)	active (501.19nM)
PIM2	inactive (85.94%)	active (316.23nM)
PIM3	inactive (55.31%)	active (199.53nM)

CAMK - PKD

Bioactivity
Kinase	RBC	Metz
PKD1	active (28.64%)	-
PKD3	active (31.23%)	active (100nM)
PKD2	active (33.58%)	active (158.49nM)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz
TSSK1	inactive (73.37%)	inactive (>1584.89nM)
TSSK2	inactive (98.88%)	inactive (>1584.89nM)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz
STK33	active (47.7%)	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STE11	8	3	-
STE-Unique	2	2	-
STE20	31	23	9
STE7	7	3	2

STE - STE11

Bioactivity
Kinase	RBC	Metz
MAP3K5	active (47.79%)	-
MAP3K2	inactive (100.16%)	-
MAP3K3	inactive (104.92%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz
COT	inactive (108.81%)	-
NIK	inactive (94.2%)	-

STE - STE20

Bioactivity
Kinase	RBC	Metz
GCK	active (42.79%)	active (50.12nM)
HGK	inactive (64.02%)	active (316.23nM)
KHS1	inactive (54.82%)	-
LOK	inactive (74.68%)	-
MINK	inactive (67.7%)	active (199.53nM)
MST1	inactive (62.31%)	-
MST2	inactive (67.2%)	active (316.23nM)
MST3	inactive (77.5%)	-
MST4	inactive (83.42%)	-
OSR1	inactive (97.38%)	-
PAK1	inactive (94.82%)	inactive (>10000nM)
PAK2	inactive (91.1%)	-
PAK3	inactive (90.66%)	-
PAK4	inactive (99.43%)	inactive (>5011.87nM)
PAK5	inactive (89.08%)	-
PAK6	inactive (94.48%)	-
SLK	inactive (91.64%)	inactive (3162.28nM)
YSK1	inactive (91.03%)	-
STLK3	inactive (82.83%)	-
TAO1	inactive (92.49%)	inactive (5011.87nM)
TAO2	inactive (101.06%)	-
TAO3	inactive (84.75%)	-
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Metz
MAP2K1	inactive (96.38%)	-
MAP2K2	inactive (93.97%)	-
MAP2K6	inactive (87.15%)	-

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Aur	3	3	2
CAMKK	2	2	1
Haspin	1	1	-
IKK	4	4	4
NEK	11	8	2
TOPK	1	1	1
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	-
WEE	3	1	1
WNK	4	2	-
TLK	2	1	-
CDC7	1	-	1

Other - Aur

Bioactivity
Kinase	RBC	Metz
AurA	active (32.15%)	-
AurB	active (14.93%)	active (10nM)
AurC	active (41.19%)	-

Other - CAMKK

Bioactivity
Kinase	RBC	Metz
CaMKK1	inactive (84.33%)	-
CaMKK2	inactive (65.46%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Metz
Haspin	active (35.26%)	-

Other - IKK

Bioactivity
Kinase	RBC	Metz
IKKa	inactive (110.57%)	-
IKKb	inactive (75.83%)	-
IKKe	inactive (88.92%)	-
TBK1	inactive (81.38%)	-

Other - NEK

Bioactivity
Kinase	RBC	Metz
NEK1	inactive (70.73%)	-
NEK11	inactive (103.25%)	-
NEK2	inactive (104.47%)	inactive (6309.57nM)
NEK4	inactive (89.8%)	active (1000nM)
NEK6	inactive (97.59%)	-
NEK7	inactive (102.7%)	-
NEK9	inactive (96.99%)	-
NEK3	inactive (84.33%)	-

Other - TOPK

Bioactivity
Kinase	RBC	Metz
PBK	inactive (89.14%)	active (1000nM)

Other - PLK

Bioactivity
Kinase	RBC	Metz
PLK1	inactive (95.12%)	inactive (>7943.28nM)
PLK2	inactive (94.99%)	-
PLK3	inactive (99.6%)	-
PLK4	-	active (199.53nM)

Other - SgK496

Bioactivity
Kinase	RBC	Metz
SgK496	inactive (99.51%)	-

Other - NAK

Bioactivity
Kinase	RBC	Metz
MPSK1	inactive (69.07%)	-

Other - TTK

Bioactivity
Kinase	RBC	Metz
TTK	inactive (68.85%)	-

Other - ULK

Bioactivity
Kinase	RBC	Metz
ULK1	inactive (62.23%)	-
ULK2	inactive (114.25%)	-
ULK3	active (0%)	-

Other - WEE

Bioactivity
Kinase	RBC	Metz
Wee1	inactive (91.25%)	-

Other - WNK

Bioactivity
Kinase	RBC	Metz
Wnk2	inactive (101.76%)	-
Wnk3	inactive (89.89%)	-

Other - TLK

Bioactivity
Kinase	RBC	Metz
TLK2	active (0%)	-

Other - CDC7

Bioactivity
Kinase	RBC	Metz
CDC7	-	active (1000nM)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK1	7	6	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	RBC	Metz
CK1d	active (13.08%)	active (31.62nM)
CK1g1	inactive (85.59%)	inactive (>6309.57nM)
CK1g2	inactive (87.78%)	inactive (1995.26nM)
CK1g3	inactive (117.34%)	active (1000nM)
CK1a	active (47.88%)	active (316.23nM)
CK1e	active (25.19%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz
VRK1	inactive (89.17%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK2	3	2	1
CLK	4	4	2
DYRK	10	9	6
MAPK	14	10	8
GSK	2	2	2
SRPK	3	3	1
CDK	20	-	7

CMGC - CK2

Bioactivity
Kinase	RBC	Metz
CK2a1	inactive (75.03%)	active (501.19nM)
CK2a2	inactive (89.22%)	-

CMGC - CLK

Bioactivity
Kinase	RBC	Metz
CLK1	inactive (82.65%)	-
CLK2	inactive (95.39%)	active (630.96nM)
CLK3	active (38.61%)	-
CLK4	inactive (75.45%)	active (63.1nM)

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz
DYRK1A	inactive (71.59%)	active (125.89nM)
DYRK1B	inactive (65.71%)	-
DYRK2	active (14.2%)	-
DYRK3	inactive (101.73%)	active (316.23nM)
DYRK4	inactive (105.06%)	inactive (>7943.28nM)
HIPK1	inactive (93.86%)	-
HIPK2	inactive (97.65%)	active (199.53nM)
HIPK3	inactive (84.78%)	-
HIPK4	inactive (106.75%)	inactive (1995.26nM)

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz
Erk1	inactive (102.05%)	-
Erk2	inactive (95.84%)	inactive (5011.87nM)
JNK3	inactive (115.29%)	-
NLK	inactive (96.12%)	-
p38a	inactive (97.86%)	-
p38b	inactive (92.82%)	-
p38d	inactive (99.37%)	inactive (>7943.28nM)
p38g	inactive (93.53%)	inactive (>6309.57nM)
JNK1	inactive (79.87%)	active (125.89nM)
JNK2	active (36.4%)	active (50.12nM)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz
GSK3A	inactive (117.53%)	inactive (1258.93nM)
GSK3B	inactive (86.79%)	active (316.23nM)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz
MSSK1	inactive (92.53%)	-
SRPK1	inactive (94.27%)	inactive (>7943.28nM)
SRPK2	inactive (86.13%)	-

CMGC - CDK

Bioactivity
Kinase	RBC	Metz
CDC2	-	active (1000nM)
CDK2	-	active (79.43nM)
CDK5	-	active (1000nM)
CDK8	-	-
CDK7	-	-
CDK9	-	-
CDK11	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDHK	5	1	-
Alpha	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz
PDHK1	inactive (99.05%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz
eEF2K	-	-