Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : -

Inchikey : ADGOSWMTFHSWDE-UHFFFAOYSA-N

ChemSpider : 5021554

Pubchem CID : 6539086

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (23.78%)
TYK2	inactive (-1.72%)
JAK2	inactive (4.95%)
JAK3	inactive (18.79%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (-62.56%)
FES	inactive (3.18%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (13.29%)
ABL2	inactive (9.85%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (6.51%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (8.26%)
BTK	inactive (0.06%)
TXK	inactive (4.42%)
TEC	inactive (10.48%)
ITK	inactive (3.12%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (6.65%)
SRM	inactive (1.02%)
FRK	inactive (2.76%)
BLK	inactive (12.16%)
LCK	inactive (7.02%)
HCK	inactive (17.75%)
FGR	inactive (13.41%)
FYN	inactive (19.18%)
SRC	inactive (27.08%)
YES	inactive (24.09%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (2.41%)
EphA4	inactive (18.22%)
EphA3	inactive (4.65%)
EphB4	inactive (5.27%)
EphB3	inactive (4.37%)
EphB2	inactive (13.29%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (20.94%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (-1.66%)
ZAP70	inactive (8.11%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (7.11%)
ALK	inactive (11.1%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (13.21%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (6.66%)
IGF1R	inactive (3.17%)
IRR	inactive (3.71%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (1.93%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (21.55%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (11.98%)
TRKB	inactive (43.16%)
TRKC	inactive (44.21%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (7.24%)
MET	inactive (11.99%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (3.27%)
MER	inactive (6.35%)
TYRO3	inactive (9.93%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	active (51.86%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (4.32%)
FGFR2	inactive (8.85%)
FGFR3	inactive (5.37%)
FGFR4	inactive (2.46%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (5.48%)
KDR	inactive (34.08%)
FLT4	inactive (26.69%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	inactive (6.33%)
KIT	inactive (9.5%)
FLT3	inactive (18.47%)
PDGFRa	active (54.2%)
PDGFRb	active (68.88%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (5.99%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (3.98%)
TNK1	inactive (16.47%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (5.59%)
ErbB2	inactive (5.69%)
ErbB4	inactive (14.57%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (1.67%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (38.38%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (8.35%)
MST1	active (75.51%)
MST2	active (70.04%)
MST4	inactive (6.6%)
HGK	active (52.1%)
MINK	inactive (41.46%)
LOK	inactive (12.21%)
PAK1	inactive (11.47%)
PAK3	inactive (5.04%)
PAK2	inactive (2.78%)
PAK5	inactive (-1.29%)
PAK6	inactive (-14.92%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (38.01%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (6.05%)
CK1g2	inactive (9.42%)
CK1g1	inactive (10.75%)
CK1g3	inactive (12.91%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (4.25%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (17.8%)
AurC	inactive (23.18%)
AurA	inactive (49.88%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (4.83%)
NEK2	inactive (5.08%)
NEK9	inactive (19.02%)
NEK7	inactive (5.01%)
NEK6	inactive (3.62%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	inactive (30.41%)
IKKe	inactive (26.61%)
IKKb	inactive (14.69%)
IKKa	inactive (0.02%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	active (71.3%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (18%)
GPRK6	inactive (16.29%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	inactive (27.26%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (11.05%)
MSK2	inactive (13.65%)
RSK1	inactive (7.85%)
RSK2	inactive (9.61%)
RSK4	inactive (13.04%)
RSK3	inactive (12.8%)
p70S6K	inactive (8.54%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (2.17%)
AKT1	inactive (0.95%)
AKT3	inactive (2.49%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (14.58%)
SGK3	inactive (6.44%)
SGK2	inactive (7.54%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (4.66%)
PKCg	inactive (7.85%)
PKCa	inactive (3.66%)
PKCt	inactive (6.44%)
PKCi	inactive (1.81%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (28.19%)
PKG1	inactive (18.86%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (7.39%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (8.77%)
ROCK2	inactive (25.39%)
MRCKb	inactive (5.24%)
MRCKa	inactive (7.89%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (18.97%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (2.86%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (-4.25%)
CaMK1d	inactive (2.23%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (25.82%)
PHKg2	inactive (10%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (8.04%)
CaMK2a	inactive (4.11%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (4.54%)
MAPKAPK2	inactive (5.55%)
MAPKAPK3	inactive (10.63%)
MNK2	inactive (14.18%)
MNK1	inactive (16.82%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (17.58%)
PKD1	inactive (22.9%)
PKD2	inactive (22.34%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (14.6%)
MARK3	inactive (5.47%)
MARK1	inactive (22.26%)
QIK	inactive (12.67%)
SIK	inactive (13.88%)
NuaK1	active (66.41%)
BRSK1	inactive (31.17%)
BRSK2	inactive (46.02%)
MELK	inactive (46.89%)
CHK1	inactive (19.32%)
PASK	inactive (2.55%)
AMPKa1	active (64.4%)
AMPKa2	inactive (26.31%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (6.71%)
TSSK1	inactive (13.34%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (14.16%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (7.42%)
PIM3	inactive (18.92%)
PIM1	inactive (15.62%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (10.93%)
p38a	inactive (7.84%)
p38b	inactive (9.47%)
p38d	inactive (6.17%)
Erk2	inactive (38.46%)
Erk1	inactive (15.88%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	active (76.05%)
GSK3B	active (77.67%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (2.62%)
MSSK1	inactive (0.48%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (8.02%)
CLK2	active (66.09%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	inactive (34.34%)
HIPK4	inactive (17.59%)
DYRK1B	inactive (15.6%)
DYRK1A	inactive (15.93%)
DYRK2	inactive (16.2%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (21.02%)