Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : AXPBLFXFGVEGKU-UHFFFAOYSA-N

CANNOT FIND

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (89.8%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (94.41%)
AKT2	inactive (104.2%)
AKT3	inactive (90.66%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (98.73%)
MRCKa	inactive (112.35%)
MRCKb	inactive (88.17%)
ROCK1	inactive (104.99%)
ROCK2	inactive (85.02%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (97.31%)
BARK2	inactive (99.17%)
GPRK4	inactive (92.4%)
GPRK5	inactive (108.56%)
GPRK6	inactive (99.5%)
GPRK7	inactive (100.85%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (90.78%)
MSK2	inactive (101.44%)
p70S6K	inactive (87.67%)
p70S6Kb	inactive (107.29%)
RSK2	inactive (80.14%)
RSK4	inactive (62.05%)
RSK1	inactive (80.42%)
RSK3	active (44.2%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (99.22%)
PRKX	inactive (110.05%)
PKACa	inactive (73.81%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	active (49.46%)
PKCd	active (40.27%)
PKCe	inactive (78.02%)
PKCh	inactive (102.43%)
PKCg	inactive (93.64%)
PKCi	inactive (99.38%)
PKCt	inactive (71.53%)
PKCz	inactive (89.75%)
PKCb	inactive (88.37%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (108.94%)
PKG1	inactive (85.45%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (74.18%)
PKN2	inactive (105.37%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (125.57%)
SGK2	inactive (103.19%)
SGK3	inactive (94.38%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	inactive (85.07%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	active (1.8%)
ABL2	active (2.19%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	active (3.54%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (65.99%)
LTK	inactive (57.74%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	active (37.63%)
MER	active (28.92%)
TYRO3	active (47.75%)

TK - Src

Bioactivity
Kinase	RBC
BLK	active (20.73%)
BRK	inactive (93.08%)
SRC	active (6.05%)
FGR	active (11.49%)
FRK	active (29.2%)
FYN	active (29.42%)
HCK	active (11.88%)
LCK	active (1.88%)
SRM	inactive (90.65%)
YES	active (7.29%)
LYN	active (2.13%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	active (14.48%)
BTK	active (5.69%)
ITK	inactive (103.18%)
TEC	inactive (96.11%)
TXK	active (27.53%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (93.64%)
FLT3	active (30.26%)
FMS	active (43.09%)
PDGFRb	inactive (74.83%)
PDGFRa	inactive (86.95%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	active (12.33%)
CTK	inactive (139.74%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (104.75%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	active (3.84%)
ErbB2	active (32.95%)
ErbB4	active (1.53%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (97.72%)
EphA2	active (9.58%)
EphA3	active (31.66%)
EphA4	active (27.01%)
EphA5	active (37.14%)
EphA6	active (4.38%)
EphA7	inactive (77.15%)
EphA8	active (10.52%)
EphB1	active (11.8%)
EphB2	active (17.43%)
EphB3	active (49.42%)
EphB4	active (12.48%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (95.96%)
PYK2	active (32.56%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (54.64%)
FES	active (35.71%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (64.42%)
FGFR2	inactive (58.1%)
FGFR3	inactive (82.57%)
FGFR4	inactive (94.06%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	active (44.54%)
FLT4	active (44.1%)
KDR	inactive (65.28%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (91.55%)
IRR	active (36.9%)
INSR	inactive (69.81%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (98.99%)
JAK2	inactive (97.42%)
JAK3	inactive (88.5%)
TYK2	inactive (98.13%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (81.66%)

TK - Ret

Bioactivity
Kinase	RBC
RET	active (18.94%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (85.41%)
MET	inactive (84.5%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (95.39%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	active (21.1%)
ZAP70	inactive (100.93%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (82.65%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (105.65%)
TRKB	inactive (69.15%)
TRKC	active (15.25%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (67.65%)
ALK2	inactive (93.27%)
ALK4	inactive (104.76%)
TGFbR1	inactive (99.05%)
TGFbR2	inactive (95.73%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (109.13%)
BRAF	inactive (91.75%)
RAF1	inactive (104.98%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (91.27%)
IRAK4	inactive (63.15%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (96.41%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	active (30.12%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	active (16.48%)
MLK2	active (22.88%)
MLK3	active (13.47%)
TAK1	active (28.29%)
ZAK	inactive (67.65%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (111.13%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	active (11.43%)
BRSK1	inactive (97.53%)
BRSK2	inactive (94.2%)
CHK1	active (38.9%)
LKB1	inactive (98.07%)
MARK1	inactive (108.81%)
MARK3	inactive (65.36%)
MARK4	inactive (60.56%)
MELK	active (25.8%)
PASK	inactive (108.82%)
QIK	active (1.93%)
NuaK2	inactive (59.47%)
MARK2	inactive (99.92%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (68.94%)
CaMK1b	inactive (109.23%)
CaMK1d	active (16.57%)
CaMK1g	inactive (82.66%)
CaMK4	inactive (90.66%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (92.7%)
CaMK2b	inactive (86.25%)
CaMK2d	inactive (94.59%)
CaMK2g	inactive (130.84%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	active (21.7%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (105.76%)
DAPK2	inactive (82.86%)
DRAK1	inactive (107.35%)
DAPK3	inactive (106.92%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (98.39%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (94.74%)
MAPKAPK3	inactive (98.22%)
MAPKAPK5	inactive (94.74%)
MNK1	inactive (96.92%)
MNK2	inactive (98.7%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (72.04%)
skMLCK	active (32.05%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (52.08%)
PHKg2	inactive (102.96%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (99.16%)
PIM2	inactive (111.49%)
PIM3	inactive (97.69%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	active (43.71%)
PKD3	active (42.25%)
PKD2	active (35.54%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (79.24%)
TSSK2	inactive (83.89%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (63.55%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (95.7%)
MAP3K2	active (23.47%)
MAP3K3	active (11.8%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (100.88%)
NIK	inactive (129.16%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	active (3.16%)
HGK	active (1.03%)
KHS1	active (1.72%)
LOK	active (12.61%)
MINK	active (1.21%)
MST1	active (7.4%)
MST2	active (13.86%)
MST3	active (11.02%)
MST4	active (5.9%)
OSR1	inactive (100.06%)
PAK1	active (11.68%)
PAK2	inactive (69.37%)
PAK3	active (9.9%)
PAK4	inactive (95.78%)
PAK5	inactive (83.64%)
PAK6	inactive (104.67%)
SLK	active (21.59%)
YSK1	active (10.1%)
STLK3	inactive (93.6%)
TAO1	inactive (52.78%)
TAO2	inactive (65.41%)
TAO3	inactive (71.33%)
MYO3B	active (40.28%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (65.35%)
MAP2K2	active (8.43%)
MAP2K6	inactive (93.44%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (86.04%)
AurB	inactive (83.15%)
AurC	inactive (82.1%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (84.79%)
CaMKK2	inactive (85.13%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (65.6%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (98.1%)
IKKb	inactive (95.36%)
IKKe	inactive (75.45%)
TBK1	inactive (65.68%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	active (15.17%)
NEK11	inactive (93.98%)
NEK2	active (8.56%)
NEK4	active (32.6%)
NEK6	inactive (85.32%)
NEK7	inactive (94.61%)
NEK9	inactive (94.04%)
NEK3	inactive (85.88%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (104.39%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (93.81%)
PLK2	inactive (100.07%)
PLK3	inactive (98.49%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (104.48%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (85.12%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (109.96%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (79.11%)
ULK2	inactive (92.25%)
ULK3	inactive (100.34%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	active (40.47%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (94.23%)
Wnk3	inactive (91.81%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (92.16%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	active (10.86%)
CK1g1	inactive (95.69%)
CK1g2	inactive (98.25%)
CK1g3	inactive (98.29%)
CK1a	active (49.52%)
CK1e	active (11.44%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (100.25%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (115.6%)
CK2a2	inactive (108.03%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (81.01%)
CLK2	inactive (69.3%)
CLK3	inactive (94.93%)
CLK4	inactive (76.63%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (99.39%)
DYRK1B	inactive (97.05%)
DYRK2	inactive (104.26%)
DYRK3	inactive (91.76%)
DYRK4	inactive (97.93%)
HIPK1	inactive (96.28%)
HIPK2	inactive (89.05%)
HIPK3	inactive (93.5%)
HIPK4	inactive (74.57%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (98.9%)
Erk2	inactive (93.66%)
JNK3	inactive (105.52%)
NLK	inactive (101.16%)
p38a	inactive (88.59%)
p38b	inactive (101.09%)
p38d	inactive (91.24%)
p38g	inactive (99.94%)
JNK1	inactive (105.13%)
JNK2	inactive (108.01%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (102.67%)
GSK3B	inactive (99.88%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (105.59%)
SRPK1	inactive (98.45%)
SRPK2	inactive (100.54%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (89.8%)