Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : WHI-P154

Inchikey
Same : CBIAKDAYHRWZCU-N
RBC, Millipore : CBIAKDAYHRWZCU-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 3663

Pubchem CID
RBC, Millipore : 3795

ChEMBL
RBC, Millipore : CHEMBL473773

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (96.64%)	inactive (97%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (93.99%)	inactive (107%)
AKT2	inactive (98.66%)	inactive (100%)
AKT3	inactive (101.31%)	inactive (101%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (101.45%)	inactive (105%)
MRCKa	inactive (96.93%)	inactive (82%)
MRCKb	inactive (98.02%)	inactive (91%)
ROCK1	inactive (96.07%)	inactive (116%)
ROCK2	inactive (89.93%)	active (39%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (99.04%)	-
BARK2	inactive (102.58%)	-
GPRK4	inactive (105.3%)	-
GPRK5	inactive (101.36%)	inactive (89%)
GPRK6	inactive (104.49%)	inactive (85%)
GPRK7	inactive (96.41%)	inactive (75%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (93.4%)	inactive (117%)
MSK2	inactive (93.84%)	inactive (83%)
p70S6K	inactive (82.09%)	inactive (60%)
p70S6Kb	inactive (102.32%)	-
RSK2	inactive (69.37%)	active (39%)
RSK4	inactive (57.81%)	inactive (69%)
RSK1	inactive (78.24%)	active (44%)
RSK3	inactive (63.64%)	inactive (92%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (89.22%)	inactive (90%)
PKACa	inactive (97.67%)	inactive (88%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (108.57%)	inactive (107%)
PKCd	inactive (97.31%)	inactive (100%)
PKCe	inactive (93.16%)	inactive (89%)
PKCh	inactive (86.25%)	inactive (94%)
PKCg	inactive (94.07%)	inactive (102%)
PKCi	inactive (93.95%)	inactive (88%)
PKCt	inactive (92.85%)	inactive (83%)
PKCz	inactive (93.05%)	inactive (96%)
PKCb	inactive (98.69%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (84.13%)	-
PKG1	inactive (87.12%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (95.56%)	-
PKN2	inactive (97.21%)	inactive (87%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (95.69%)	inactive (71%)
SGK2	inactive (95.13%)	inactive (62%)
SGK3	inactive (94.5%)	inactive (99%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (79.42%)	inactive (64%)
ABL2	inactive (58.37%)	inactive (76%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	active (10.54%)	active (14%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	active (12.45%)	active (19%)
LTK	active (5.44%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (89.37%)	active (36%)
MER	inactive (87.72%)	inactive (69%)
TYRO3	inactive (78.6%)	active (38%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (83.78%)	active (21%)
BRK	active (20.07%)	active (18%)
SRC	inactive (77.51%)	inactive (54%)
FGR	inactive (57.76%)	active (39%)
FRK	inactive (74.73%)	active (35%)
FYN	inactive (80.36%)	active (49%)
HCK	inactive (52.16%)	active (32%)
LCK	active (48.95%)	active (27%)
SRM	inactive (90.37%)	-
YES	active (34.62%)	active (25%)
LYN	active (40.28%)	active (7%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (95.26%)	inactive (65%)
BTK	inactive (85.52%)	inactive (80%)
ITK	inactive (92.78%)	inactive (89%)
TEC	inactive (107.6%)	-
TXK	inactive (83.32%)	inactive (81%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (97.32%)	inactive (102%)
FLT3	active (6.34%)	active (49%)
FMS	inactive (95.25%)	inactive (63%)
PDGFRb	inactive (93.74%)	inactive (105%)
PDGFRa	inactive (88.86%)	inactive (103%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (91.63%)	inactive (90%)
CTK	inactive (98.04%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (118.86%)	inactive (90%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	active (2.22%)	active (-4%)
ErbB2	active (33.09%)	-
ErbB4	active (29.08%)	active (16%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (80.37%)	active (35%)
EphA2	inactive (80.59%)	inactive (90%)
EphA3	inactive (95.44%)	inactive (79%)
EphA4	inactive (83.69%)	inactive (89%)
EphA5	inactive (72.33%)	inactive (74%)
EphA6	-	-
EphA7	active (46.08%)	active (34%)
EphA8	inactive (88.32%)	inactive (70%)
EphB1	inactive (81.44%)	inactive (62%)
EphB2	inactive (66.07%)	inactive (65%)
EphB3	inactive (88.06%)	inactive (99%)
EphB4	inactive (52.19%)	active (19%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (99.46%)	inactive (106%)
PYK2	inactive (86.92%)	inactive (85%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (85.22%)	inactive (105%)
FES	inactive (94.86%)	inactive (95%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (93.37%)	inactive (58%)
FGFR2	inactive (95.86%)	inactive (94%)
FGFR3	inactive (98.8%)	inactive (109%)
FGFR4	inactive (102.62%)	inactive (126%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (83.36%)	active (29%)
FLT4	active (48.53%)	active (14%)
KDR	inactive (69.61%)	active (30%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (103.94%)	inactive (71%)
IRR	inactive (96.81%)	inactive (102%)
INSR	inactive (92.36%)	inactive (114%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (81.49%)	-
JAK2	inactive (94.96%)	inactive (102%)
JAK3	inactive (100.27%)	inactive (93%)
TYK2	inactive (96.52%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (78.22%)	inactive (77%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (21.4%)	active (23%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (100.92%)	inactive (90%)
MET	inactive (96.39%)	inactive (86%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (65.7%)	inactive (88%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (86.72%)	inactive (99%)
ZAP70	inactive (99.69%)	inactive (144%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (93.77%)	inactive (61%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (96.38%)	inactive (82%)
TRKB	inactive (94.79%)	inactive (110%)
TRKC	inactive (83.37%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (102.43%)	-
ALK2	inactive (128.08%)	-
ALK4	inactive (105.14%)	inactive (111%)
TGFbR1	inactive (97.39%)	inactive (79%)
TGFbR2	inactive (104.79%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (89.93%)	-
BRAF	inactive (98.36%)	-
RAF1	inactive (92.07%)	inactive (64%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (75.46%)	active (40%)
IRAK4	inactive (91.14%)	active (44%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (85.14%)	inactive (78%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (82.68%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (80.11%)	active (45%)
MLK2	inactive (98.21%)	-
MLK3	inactive (83.67%)	-
TAK1	inactive (100.37%)	inactive (81%)
ZAK	inactive (88.97%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	active (36.74%)	active (20%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (68.16%)	inactive (78%)
BRSK1	inactive (81.59%)	active (17%)
BRSK2	inactive (80.09%)	inactive (91%)
CHK1	inactive (92.77%)	inactive (80%)
LKB1	inactive (103.49%)	inactive (106%)
MARK1	inactive (94.78%)	inactive (70%)
MARK3	inactive (98.75%)	-
MARK4	inactive (92.41%)	-
MELK	inactive (83.4%)	inactive (73%)
PASK	inactive (57.9%)	inactive (73%)
QIK	inactive (92.25%)	-
NuaK2	inactive (88.28%)	-
MARK2	inactive (94.47%)	inactive (101%)
AMPKa1	-	inactive (82%)
AMPKa2	-	inactive (93%)
SIK	-	inactive (90%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (102.82%)	inactive (104%)
CaMK1b	inactive (102.99%)	-
CaMK1d	inactive (98.64%)	inactive (98%)
CaMK1g	inactive (103.05%)	-
CaMK4	inactive (95.63%)	inactive (122%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (98.02%)	-
CaMK2b	inactive (99.32%)	inactive (73%)
CaMK2d	inactive (95.66%)	inactive (79%)
CaMK2g	inactive (95.23%)	inactive (68%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (50.98%)	active (46%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (92.04%)	inactive (88%)
DAPK2	inactive (99.99%)	inactive (96%)
DRAK1	inactive (72.25%)	inactive (77%)
DAPK3	inactive (99.07%)	inactive (83%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (100.98%)	inactive (73%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (97.71%)	inactive (106%)
MAPKAPK3	inactive (96.18%)	inactive (124%)
MAPKAPK5	inactive (98.69%)	inactive (77%)
MNK1	active (32.68%)	-
MNK2	active (18.05%)	active (10%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (84.62%)	inactive (71%)
skMLCK	inactive (87.31%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (71.95%)	-
PHKg2	inactive (97.96%)	inactive (97%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (75.53%)	inactive (66%)
PIM2	inactive (94.07%)	inactive (78%)
PIM3	inactive (73.32%)	inactive (87%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (70.13%)	active (47%)
PKD3	inactive (72.82%)	-
PKD2	inactive (69.67%)	inactive (93%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (84.73%)	inactive (87%)
TSSK2	inactive (98.69%)	inactive (93%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (80.71%)	inactive (76%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (98.62%)	inactive (77%)
MAP3K2	inactive (92.44%)	-
MAP3K3	inactive (81.96%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (97.59%)	-
NIK	inactive (82.62%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (100.99%)	inactive (52%)
HGK	inactive (59.34%)	-
KHS1	active (28.91%)	-
LOK	active (14.49%)	active (17%)
MINK	inactive (64.36%)	inactive (83%)
MST1	inactive (90.02%)	inactive (81%)
MST2	inactive (89.63%)	inactive (97%)
MST3	inactive (91.69%)	inactive (54%)
MST4	inactive (90.2%)	-
OSR1	inactive (98.81%)	-
PAK1	inactive (94.06%)	-
PAK2	inactive (90.59%)	inactive (104%)
PAK3	inactive (94.17%)	inactive (57%)
PAK4	inactive (95.73%)	inactive (89%)
PAK5	inactive (97.66%)	inactive (98%)
PAK6	inactive (92.82%)	inactive (123%)
SLK	inactive (50.28%)	-
YSK1	inactive (99.62%)	-
STLK3	inactive (87.4%)	-
TAO1	inactive (93.3%)	inactive (86%)
TAO2	inactive (95.77%)	inactive (98%)
TAO3	inactive (98.84%)	inactive (82%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (98.2%)	inactive (119%)
MAP2K2	inactive (86.21%)	-
MAP2K6	inactive (84.87%)	inactive (88%)
MAP2K7	-	inactive (119%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (83.11%)	active (49%)
AurB	inactive (63.51%)	active (43%)
AurC	inactive (83.7%)	active (45%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (95.81%)	-
CaMKK2	inactive (92.43%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (84.77%)	inactive (65%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (106.95%)	inactive (97%)
IKKb	inactive (88.05%)	inactive (97%)
IKKe	inactive (94.6%)	-
TBK1	inactive (84.67%)	active (41%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (90.52%)	-
NEK11	inactive (103.42%)	active (50%)
NEK2	inactive (105.27%)	inactive (73%)
NEK4	inactive (93.11%)	-
NEK6	inactive (100.1%)	inactive (86%)
NEK7	inactive (100.94%)	inactive (99%)
NEK9	inactive (103.81%)	-
NEK3	inactive (88.45%)	inactive (106%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (101.1%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (98.76%)	inactive (64%)
PLK2	inactive (104.06%)	inactive (93%)
PLK3	inactive (95.24%)	inactive (92%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (105.94%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (104.01%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (104.71%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (87.18%)	-
ULK2	inactive (104.1%)	inactive (89%)
ULK3	active (0%)	inactive (91%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (92.54%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (102.01%)	inactive (96%)
Wnk3	inactive (95.74%)	inactive (87%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (86%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (89.74%)	inactive (81%)
CK1g1	inactive (92.38%)	inactive (90%)
CK1g2	inactive (96.43%)	inactive (71%)
CK1g3	inactive (101.37%)	inactive (97%)
CK1a	inactive (89.59%)	-
CK1e	inactive (85.12%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (86.43%)	-
VRK2	-	inactive (83%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (93.7%)	inactive (58%)
CK2a2	inactive (89.22%)	inactive (97%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (77.2%)	-
CLK2	inactive (96.73%)	inactive (80%)
CLK3	inactive (54.07%)	inactive (82%)
CLK4	inactive (100.59%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (97.76%)	-
DYRK1B	inactive (91.34%)	-
DYRK2	inactive (59.98%)	active (48%)
DYRK3	inactive (95.31%)	-
DYRK4	inactive (101.21%)	-
HIPK1	inactive (104.24%)	inactive (97%)
HIPK2	inactive (102.13%)	inactive (87%)
HIPK3	inactive (67.67%)	inactive (95%)
HIPK4	inactive (107.43%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (97.01%)	inactive (68%)
Erk2	inactive (101.72%)	inactive (98%)
JNK3	inactive (88.99%)	inactive (51%)
NLK	inactive (76.2%)	inactive (69%)
p38a	inactive (87.29%)	inactive (51%)
p38b	inactive (90.08%)	inactive (93%)
p38d	inactive (101.56%)	inactive (111%)
p38g	inactive (92.84%)	inactive (98%)
JNK1	inactive (101.04%)	inactive (96%)
JNK2	inactive (88.45%)	inactive (99%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (131.07%)	inactive (116%)
GSK3B	inactive (91.97%)	inactive (89%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (92.4%)	inactive (95%)
SRPK1	inactive (91.76%)	inactive (103%)
SRPK2	inactive (62.98%)	inactive (93%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (96.64%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (96%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (106%)