Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : -

Inchikey : CBXVHMLTAMBOAT-UHFFFAOYSA-N

ChemSpider : 4703829

Pubchem CID : 5793317

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (-1.74%)
TYK2	inactive (1.67%)
JAK2	inactive (-0.24%)
JAK3	inactive (4.38%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (0.29%)
FES	inactive (0.85%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (8.09%)
ABL2	inactive (12.05%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (-6.97%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (-0.8%)
BTK	inactive (3.78%)
TXK	inactive (3.92%)
TEC	inactive (4.33%)
ITK	inactive (1.38%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (-3.16%)
SRM	inactive (-2.68%)
FRK	inactive (0.7%)
BLK	inactive (11.19%)
LCK	inactive (3.66%)
HCK	inactive (6.19%)
FGR	inactive (9.99%)
FYN	inactive (0.85%)
SRC	inactive (6.44%)
YES	inactive (5.49%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (-11.35%)
EphA4	inactive (-5.42%)
EphA3	inactive (2.43%)
EphB4	inactive (0.71%)
EphB3	inactive (-0.26%)
EphB2	inactive (-1.87%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (0.28%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (-2.83%)
ZAP70	inactive (1.47%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (1%)
ALK	inactive (2.77%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (4.27%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (1.98%)
IGF1R	inactive (-2.24%)
IRR	inactive (-0.18%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (-0.71%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (16.19%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (11.83%)
TRKB	inactive (31.21%)
TRKC	inactive (39.24%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (-1.57%)
MET	inactive (4.08%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (2.86%)
MER	inactive (1.27%)
TYRO3	inactive (0.35%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	inactive (18.75%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (4.71%)
FGFR2	inactive (27.21%)
FGFR3	inactive (26.51%)
FGFR4	inactive (-0.45%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (7.86%)
KDR	inactive (22.57%)
FLT4	inactive (14.56%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	inactive (16.71%)
KIT	active (80.09%)
FLT3	active (61.66%)
PDGFRa	inactive (37.72%)
PDGFRb	inactive (31.67%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (2.63%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (-0.62%)
TNK1	inactive (3.63%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (0.75%)
ErbB2	inactive (-4.77%)
ErbB4	inactive (7.37%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (-0.03%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (3.31%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (4.98%)
MST1	active (65.86%)
MST2	active (55.01%)
MST4	inactive (17.09%)
HGK	active (72.26%)
MINK	active (61.83%)
LOK	inactive (3.53%)
PAK1	inactive (5.13%)
PAK3	inactive (-1.09%)
PAK2	inactive (-0.31%)
PAK5	inactive (-10.99%)
PAK6	inactive (-8.53%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (1.05%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (-0.4%)
CK1g2	inactive (0.86%)
CK1g1	inactive (1.26%)
CK1g3	inactive (-0.55%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (1.12%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (7.36%)
AurC	inactive (23.59%)
AurA	inactive (27.76%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (1.65%)
NEK2	inactive (0.07%)
NEK9	inactive (4.02%)
NEK7	inactive (2.3%)
NEK6	inactive (-1.82%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	inactive (6.6%)
IKKe	inactive (-2.89%)
IKKb	inactive (1.12%)
IKKa	inactive (4.99%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	inactive (33.16%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (4.95%)
GPRK6	inactive (-1.05%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	inactive (8.93%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (1.23%)
MSK2	inactive (2.32%)
RSK1	inactive (0.22%)
RSK2	inactive (2.42%)
RSK4	inactive (2.46%)
RSK3	inactive (3.92%)
p70S6K	inactive (2.59%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (-0.04%)
AKT1	inactive (-0.7%)
AKT3	inactive (0.38%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (1.07%)
SGK3	inactive (-1.14%)
SGK2	inactive (0.76%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (-1.47%)
PKCg	inactive (-1.54%)
PKCa	inactive (-0.36%)
PKCt	inactive (-1.65%)
PKCi	inactive (0.19%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (3.82%)
PKG1	inactive (0.41%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (-2.35%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (2.75%)
ROCK2	inactive (2.52%)
MRCKb	inactive (1.36%)
MRCKa	inactive (1.3%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (0.67%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (-0.15%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (2.05%)
CaMK1d	inactive (2.43%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (10.99%)
PHKg2	inactive (0.07%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (3.28%)
CaMK2a	inactive (2.25%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (-2.03%)
MAPKAPK2	inactive (-0.37%)
MAPKAPK3	inactive (1.35%)
MNK2	-
MNK1	inactive (0.54%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (1.79%)
PKD1	inactive (1.76%)
PKD2	inactive (1.97%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (7.46%)
MARK3	inactive (3.82%)
MARK1	inactive (3.86%)
QIK	inactive (10.43%)
SIK	inactive (1.4%)
NuaK1	active (62.19%)
BRSK1	inactive (9.92%)
BRSK2	inactive (12.82%)
MELK	inactive (6.27%)
CHK1	inactive (3.5%)
PASK	inactive (0.32%)
AMPKa1	inactive (6.53%)
AMPKa2	inactive (12.28%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (-1.16%)
TSSK1	inactive (0.43%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (1.29%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (1.85%)
PIM3	inactive (-0.92%)
PIM1	inactive (0.99%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (1.49%)
p38a	inactive (5.27%)
p38b	inactive (6.52%)
p38d	inactive (0.5%)
Erk2	inactive (2.7%)
Erk1	inactive (1.36%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	inactive (31.34%)
GSK3B	inactive (23.68%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (-5.98%)
MSSK1	inactive (-2.57%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (-0.91%)
CLK2	inactive (3.06%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	-
HIPK4	inactive (-0.65%)
DYRK1B	inactive (1.94%)
DYRK1A	inactive (2.94%)
DYRK2	inactive (-0.62%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (-4.47%)