Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz, Millipore

Compound Name
DRx : UNII-WS78QR6DSV
RBC : UNII-2Z5A7553WW
Metz, Millipore : 152121-47-6

Inchikey
Same : CDMGBJANTYXAIV-N
DRx : CDMGBJANTYXAIV-HHHXNRCGSA-N
RBC : CDMGBJANTYXAIV-MHZLTWQESA-N
Metz, Millipore : CDMGBJANTYXAIV-UHFFFAOYSA-N

ChemSpider
DRx : -
RBC : 7822386
Metz, Millipore : 153453

Pubchem CID
DRx : 40467016
RBC : 9543416
Metz, Millipore : 176155

ChEMBL
DRx : -
RBC : -
Metz, Millipore : CHEMBL10

DRx	RBC	Metz, Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
NAK	4	4	1	-	-
Aur	3	3	3	2	3
CAMKK	2	2	2	1	-
PEK	4	2	-	-	-
IRE	2	1	-	-	-
IKK	4	4	4	4	3
NEK	11	9	8	2	5
WEE	3	3	1	1	-
PLK	4	4	3	3	3
SgK496	1	1	1	-	-
NKF1	3	2	-	-	-
NKF4	2	1	-	-	-
ULK	5	4	3	-	2
TLK	2	2	1	-	1
TTK	1	1	1	-	-
Haspin	1	-	1	-	1
TOPK	1	-	1	1	-
WNK	4	-	2	-	2
CDC7	1	-	-	1	-

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AAK1	inactive (10001nM)	-	-	-
BIKE	inactive (10001nM)	-	-	-
GAK	active (19nM)	-	-	-
MPSK1	inactive (10001nM)	inactive (111.28%)	-	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AurA	inactive (10001nM)	inactive (99.54%)	inactive (>3981.07nM)	inactive (117%)
AurB	inactive (10001nM)	inactive (87.68%)	inactive (>5011.87nM)	inactive (102%)
AurC	inactive (10001nM)	inactive (98.48%)	-	inactive (115%)

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMKK1	inactive (10001nM)	inactive (125.29%)	-	-
CaMKK2	inactive (10001nM)	inactive (110.44%)	inactive (>2511.89nM)	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HRI	inactive (10001nM)	-	-	-
PKR	inactive (10001nM)	-	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRE1	inactive (10001nM)	-	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IKKa	inactive (10001nM)	inactive (100.2%)	inactive (>3981.07nM)	inactive (113%)
IKKb	inactive (10001nM)	inactive (106.32%)	inactive (>3162.28nM)	inactive (104%)
IKKe	inactive (10001nM)	inactive (98.04%)	inactive (>3162.28nM)	-
TBK1	inactive (10001nM)	inactive (99.67%)	inactive (>3162.28nM)	inactive (124%)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
NEK1	inactive (10001nM)	inactive (94.69%)	-	-
NEK11	inactive (10001nM)	inactive (81.28%)	-	inactive (90%)
NEK2	inactive (10001nM)	inactive (104.97%)	inactive (>6309.57nM)	inactive (114%)
NEK3	inactive (10001nM)	inactive (92.23%)	-	inactive (104%)
NEK4	inactive (10001nM)	inactive (98.23%)	inactive (>6309.57nM)	-
NEK5	inactive (10001nM)	-	-	-
NEK6	inactive (10001nM)	inactive (103.44%)	-	inactive (112%)
NEK7	inactive (10001nM)	inactive (98.85%)	-	inactive (101%)
NEK9	inactive (10001nM)	inactive (99.07%)	-	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MYT1	inactive (10001nM)	-	-	-
Wee1	inactive (10001nM)	inactive (92.08%)	-	-
Wee1B	inactive (10001nM)	-	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PLK1	inactive (10001nM)	inactive (100.46%)	inactive (>7943.28nM)	inactive (117%)
PLK2	inactive (10001nM)	inactive (95.63%)	-	inactive (116%)
PLK3	inactive (10001nM)	inactive (97.26%)	inactive (>7943.28nM)	inactive (90%)
PLK4	inactive (10001nM)	-	inactive (>3981.07nM)	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK496	inactive (10001nM)	inactive (100.47%)	-	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SBK	inactive (10001nM)	-	-	-
SgK110	inactive (10001nM)	-	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLIK1	inactive (10001nM)	-	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Fused	active (1300nM)	-	-	-
ULK1	inactive (10001nM)	inactive (89.28%)	-	-
ULK2	inactive (10001nM)	inactive (83.55%)	-	inactive (120%)
ULK3	inactive (10001nM)	inactive (83.19%)	-	inactive (104%)

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TLK1	inactive (10001nM)	-	-	-
TLK2	inactive (10001nM)	inactive (96.45%)	-	inactive (113%)

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TTK	active (2500nM)	inactive (99.86%)	-	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Haspin	-	inactive (88.25%)	-	inactive (88%)

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PBK	-	inactive (101.95%)	inactive (>10000nM)	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Wnk2	-	inactive (102.51%)	-	inactive (117%)
Wnk3	-	inactive (98.96%)	-	inactive (110%)

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDC7	-	-	inactive (>1258.93nM)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Abl	2	2	2	1	2
ALK	2	2	2	2	1
Axl	3	3	3	2	3
Src	11	11	11	9	10
Tec	5	5	5	3	4
PDGFR	5	5	5	5	5
Csk	2	2	2	1	1
DDR	2	2	1	-	1
EGFR	4	4	3	3	2
Eph	14	13	12	1	11
FAK	2	2	2	2	2
Fer	2	2	2	2	2
FGFR	4	4	4	2	4
VEGFR	3	3	3	3	3
InsR	3	3	3	2	3
JakA	4	4	4	3	2
Met	2	2	2	2	2
Musk	1	1	1	-	1
Ret	1	1	1	1	1
Sev	1	1	1	1	1
Syk	2	2	2	1	2
Tie	2	2	1	-	1
Ack	2	2	1	1	1
Trk	3	3	3	3	2

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ABL1	inactive (10001nM)	inactive (96.97%)	inactive (>3162.28nM)	inactive (89%)
ABL2	inactive (10001nM)	inactive (91.52%)	-	inactive (86%)

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK	inactive (10001nM)	inactive (104.76%)	inactive (>6309.57nM)	inactive (122%)
LTK	inactive (10001nM)	inactive (100.82%)	inactive (>2511.89nM)	-

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AXL	inactive (10001nM)	inactive (100.5%)	inactive (>1995.26nM)	inactive (122%)
MER	inactive (10001nM)	inactive (93.87%)	-	inactive (117%)
TYRO3	inactive (10001nM)	inactive (96.99%)	inactive (>3162.28nM)	inactive (107%)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BLK	inactive (10001nM)	inactive (101.66%)	inactive (>1584.89nM)	inactive (101%)
BRK	inactive (3900nM)	inactive (54.21%)	inactive (>2511.89nM)	inactive (59%)
FGR	inactive (10001nM)	inactive (92.68%)	-	inactive (87%)
FRK	active (1800nM)	inactive (87.25%)	active (251.19nM)	inactive (71%)
FYN	inactive (10001nM)	inactive (89.81%)	inactive (>3981.07nM)	inactive (76%)
HCK	inactive (10001nM)	inactive (96.07%)	inactive (>3162.28nM)	inactive (105%)
LCK	active (2800nM)	inactive (94.98%)	inactive (5011.87nM)	inactive (79%)
LYN	inactive (10001nM)	inactive (91.81%)	inactive (>1584.89nM)	active (47%)
SRC	inactive (5300nM)	inactive (92.59%)	inactive (>1995.26nM)	inactive (112%)
SRM	inactive (10001nM)	inactive (101.85%)	inactive (>1584.89nM)	-
YES	inactive (10001nM)	inactive (92.65%)	-	inactive (110%)

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BMX	inactive (10001nM)	inactive (94.38%)	-	inactive (81%)
BTK	inactive (10001nM)	inactive (97.23%)	inactive (>6309.57nM)	inactive (94%)
ITK	inactive (10001nM)	inactive (97.02%)	inactive (>1584.89nM)	inactive (100%)
TEC	inactive (10001nM)	inactive (113.37%)	-	-
TXK	inactive (4500nM)	inactive (63.94%)	-	inactive (77%)

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FMS	inactive (10001nM)	inactive (95.52%)	inactive (>2511.89nM)	inactive (109%)
FLT3	inactive (10001nM)	inactive (91.51%)	inactive (>2511.89nM)	inactive (91%)
KIT	inactive (10001nM)	inactive (91.32%)	inactive (>3981.07nM)	inactive (119%)
PDGFRa	inactive (10001nM)	inactive (98.82%)	inactive (>3162.28nM)	inactive (110%)
PDGFRb	inactive (10001nM)	inactive (102.78%)	inactive (>1995.26nM)	inactive (120%)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CSK	inactive (10001nM)	inactive (87.66%)	-	inactive (103%)
CTK	inactive (10001nM)	inactive (95.59%)	inactive (>1995.26nM)	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DDR1	active (1000nM)	-	-	-
DDR2	inactive (5000nM)	inactive (103.2%)	-	inactive (94%)

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EGFR	active (1700nM)	inactive (86.51%)	inactive (>1258.93nM)	active (1%)
ErbB2	inactive (10001nM)	inactive (94.56%)	inactive (>1258.93nM)	-
ErbB3	inactive (10001nM)	-	-	-
ErbB4	inactive (4800nM)	inactive (66.83%)	inactive (>3981.07nM)	inactive (115%)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EphA1	inactive (10001nM)	inactive (97.01%)	-	inactive (90%)
EphA2	inactive (10001nM)	inactive (94.76%)	inactive (>6309.57nM)	inactive (95%)
EphA3	inactive (10001nM)	inactive (96.08%)	-	inactive (105%)
EphA4	inactive (10001nM)	inactive (95.55%)	-	inactive (110%)
EphA5	inactive (10001nM)	inactive (89.53%)	-	inactive (96%)
EphA6	active (1200nM)	inactive (57.15%)	-	-
EphA7	inactive (10001nM)	inactive (83.06%)	-	inactive (102%)
EphA8	inactive (10001nM)	inactive (101.16%)	-	inactive (91%)
EphB1	inactive (10001nM)	inactive (93.02%)	-	inactive (106%)
EphB2	inactive (10001nM)	inactive (108.29%)	-	inactive (101%)
EphB3	inactive (10001nM)	inactive (96.65%)	-	inactive (114%)
EphB4	inactive (10001nM)	inactive (91.1%)	-	inactive (107%)
EphB6	inactive (3100nM)	-	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FAK	inactive (10001nM)	inactive (95.52%)	inactive (>6309.57nM)	inactive (125%)
PYK2	inactive (10001nM)	inactive (92.53%)	inactive (>1584.89nM)	inactive (115%)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FER	inactive (10001nM)	inactive (95.05%)	inactive (>1584.89nM)	inactive (107%)
FES	inactive (10001nM)	inactive (97.29%)	inactive (>1995.26nM)	inactive (112%)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FGFR1	inactive (10001nM)	inactive (90.72%)	inactive (>3981.07nM)	inactive (142%)
FGFR2	inactive (10001nM)	inactive (103.46%)	-	inactive (99%)
FGFR3	inactive (10001nM)	inactive (96.97%)	inactive (>1995.26nM)	inactive (115%)
FGFR4	inactive (10001nM)	inactive (73.79%)	-	inactive (110%)

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FLT1	inactive (10001nM)	inactive (95.16%)	inactive (>3981.07nM)	inactive (101%)
FLT4	inactive (10001nM)	inactive (119.2%)	inactive (6309.57nM)	inactive (93%)
KDR	inactive (10001nM)	inactive (99.23%)	inactive (>2511.89nM)	inactive (107%)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IGF1R	inactive (10001nM)	inactive (94.32%)	inactive (>1995.26nM)	inactive (102%)
INSR	inactive (10001nM)	inactive (88.9%)	inactive (>5011.87nM)	inactive (94%)
IRR	inactive (10001nM)	inactive (100.3%)	-	inactive (109%)

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
JAK1	inactive (10001nM)	inactive (105.36%)	-	-
JAK2	inactive (10001nM)	inactive (99.5%)	inactive (>2511.89nM)	inactive (112%)
JAK3	inactive (10001nM)	inactive (93.85%)	inactive (>5011.87nM)	inactive (107%)
TYK2	inactive (10001nM)	inactive (101.56%)	inactive (>1995.26nM)	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MET	inactive (10001nM)	inactive (102.77%)	inactive (>2511.89nM)	inactive (123%)
RON	inactive (10001nM)	inactive (100.98%)	inactive (>3981.07nM)	inactive (105%)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MUSK	inactive (10001nM)	inactive (90.33%)	-	inactive (143%)

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RET	inactive (10001nM)	inactive (85.05%)	inactive (>3162.28nM)	inactive (90%)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ROS	inactive (10001nM)	inactive (94.41%)	inactive (>2511.89nM)	inactive (117%)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SYK	inactive (10001nM)	inactive (98%)	inactive (>1584.89nM)	inactive (112%)
ZAP70	inactive (10001nM)	inactive (94.42%)	-	inactive (124%)

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TIE1	inactive (10001nM)	-	-	-
TIE2	inactive (10001nM)	inactive (94.53%)	-	inactive (102%)

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TNK1	inactive (10001nM)	-	-	-
ACK	inactive (10001nM)	inactive (82.11%)	inactive (>3981.07nM)	inactive (93%)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TRKA	inactive (10001nM)	inactive (100.47%)	inactive (>2511.89nM)	inactive (121%)
TRKB	inactive (10001nM)	inactive (103.95%)	inactive (>3981.07nM)	inactive (94%)
TRKC	inactive (10001nM)	inactive (97.97%)	inactive (>2511.89nM)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STKR	12	10	5	1	2
RIPK	5	4	1	-	1
RAF	5	2	3	1	1
MLK	10	8	5	2	2
IRAK	4	3	2	2	2
LISK	4	3	1	1	1
LRRK	2	1	1	1	-

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK2	inactive (10001nM)	inactive (97.44%)	inactive (>3981.07nM)	-
ALK4	active (3000nM)	inactive (127.24%)	-	inactive (87%)
ACTR2	inactive (10001nM)	-	-	-
ACTR2B	inactive (10001nM)	-	-	-
ALK1	inactive (10001nM)	inactive (97.67%)	-	-
BMPR1A	inactive (10001nM)	-	-	-
BMPR1B	inactive (3300nM)	-	-	-
BMPR2	inactive (10001nM)	-	-	-
TGFbR1	inactive (7100nM)	inactive (100.51%)	-	inactive (130%)
TGFbR2	active (1800nM)	inactive (144.37%)	-	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK288	inactive (10001nM)	-	-	-
RIPK1	inactive (10001nM)	-	-	-
RIPK2	active (24nM)	active (49.08%)	-	active (24%)
ANKRD3	inactive (10001nM)	-	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BRAF	active (710nM)	inactive (78.79%)	-	-
RAF1	active (980nM)	active (41.08%)	-	active (17%)
ARAF	-	active (42.66%)	-	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DLK	inactive (10001nM)	-	-	-
LZK	inactive (10001nM)	-	-	-
MLK1	inactive (10001nM)	inactive (95.04%)	-	inactive (101%)
MLK2	inactive (10001nM)	inactive (103.83%)	inactive (>3162.28nM)	-
MLK3	inactive (10001nM)	inactive (96.4%)	-	-
TAK1	inactive (10001nM)	inactive (94.04%)	-	inactive (106%)
HH498	inactive (3500nM)	-	-	-
ZAK	inactive (4400nM)	inactive (100.35%)	inactive (>7943.28nM)	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRAK1	inactive (10001nM)	inactive (129.36%)	inactive (>7943.28nM)	inactive (108%)
IRAK3	inactive (10001nM)	-	-	-
IRAK4	inactive (10001nM)	inactive (129.61%)	inactive (>10000nM)	inactive (113%)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LIMK1	inactive (10001nM)	inactive (91.32%)	inactive (>6309.57nM)	inactive (110%)
LIMK2	inactive (10001nM)	-	-	-
TESK1	inactive (10001nM)	-	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LRRK2	inactive (10001nM)	inactive (100.3%)	inactive (>2511.89nM)	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
ABC1	5	2	-	-	-
PIKK	6	1	-	-	1
RIO	3	3	-	-	-
Alpha	6	1	-	1	1
PDHK	5	-	1	-	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ADCK3	inactive (10001nM)	-	-	-
ADCK4	inactive (3100nM)	-	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FRAP	inactive (10001nM)	-	-	inactive (106%)

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RIOK1	inactive (10001nM)	-	-	-
RIOK2	inactive (10001nM)	-	-	-
RIOK3	inactive (10001nM)	-	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ChaK2	inactive (10001nM)	-	-	-
eEF2K	-	-	inactive (>3981.07nM)	inactive (111%)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDHK1	-	inactive (96.32%)	-	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Akt	3	3	3	3	3
DMPK	7	7	5	3	5
GRK	7	3	6	1	3
NDR	4	4	1	-	-
MAST	5	1	-	-	-
PDK1	1	1	1	1	1
PKA	5	3	3	2	2
PKN	3	2	2	1	1
PKC	9	5	9	5	8
PKG	2	2	3	2	-
RSK	8	1	8	4	7
SGK	3	1	3	1	3
YANK	3	3	-	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AKT1	inactive (10001nM)	inactive (102.38%)	inactive (>7943.28nM)	inactive (102%)
AKT2	inactive (10001nM)	inactive (96.78%)	inactive (>7943.28nM)	inactive (107%)
AKT3	inactive (10001nM)	inactive (101.55%)	inactive (>10000nM)	inactive (117%)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CRIK	active (420nM)	-	-	-
DMPK1	inactive (10001nM)	inactive (103.44%)	-	inactive (122%)
DMPK2	active (400nM)	-	-	-
MRCKa	inactive (6200nM)	inactive (94.26%)	inactive (>10000nM)	inactive (106%)
MRCKb	active (2700nM)	inactive (104.55%)	-	inactive (113%)
ROCK1	inactive (10001nM)	inactive (101.65%)	inactive (>3981.07nM)	inactive (70%)
ROCK2	inactive (10001nM)	inactive (98.4%)	inactive (>5011.87nM)	inactive (119%)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RHOK	inactive (10001nM)	-	-	-
GPRK4	inactive (10001nM)	inactive (95.46%)	-	-
GPRK7	inactive (10001nM)	inactive (107.14%)	-	inactive (109%)
BARK1	-	inactive (101.31%)	-	-
BARK2	-	inactive (98.22%)	-	-
GPRK5	-	inactive (104.29%)	inactive (>3981.07nM)	inactive (109%)
GPRK6	-	inactive (102.24%)	-	inactive (107%)

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LATS1	inactive (10001nM)	-	-	-
LATS2	inactive (10001nM)	-	-	-
NDR1	inactive (10001nM)	inactive (104.52%)	-	-
NDR2	inactive (10001nM)	-	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAST1	inactive (10001nM)	-	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDK1	inactive (10001nM)	inactive (96.32%)	inactive (>3981.07nM)	inactive (117%)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKACa	inactive (10001nM)	inactive (98.88%)	inactive (>2511.89nM)	inactive (105%)
PKACb	inactive (10001nM)	-	-	-
PRKX	inactive (10001nM)	inactive (99.32%)	inactive (>3162.28nM)	inactive (98%)
PKACg	-	inactive (106.67%)	-	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKN1	inactive (10001nM)	inactive (96.5%)	-	-
PKN2	inactive (10001nM)	inactive (95.81%)	inactive (>7943.28nM)	inactive (103%)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKCd	inactive (10001nM)	inactive (106.86%)	inactive (>7943.28nM)	inactive (105%)
PKCe	inactive (10001nM)	inactive (114.99%)	-	inactive (125%)
PKCh	inactive (10001nM)	inactive (95.75%)	-	inactive (79%)
PKCi	inactive (10001nM)	inactive (95.16%)	inactive (>5011.87nM)	inactive (105%)
PKCt	inactive (10001nM)	inactive (111.33%)	inactive (>2511.89nM)	inactive (105%)
PKCa	-	inactive (92.33%)	-	inactive (107%)
PKCg	-	inactive (89.98%)	inactive (>7943.28nM)	inactive (104%)
PKCz	-	inactive (103.25%)	inactive (>7943.28nM)	inactive (108%)
PKCb	-	inactive (97.89%)	-	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKG1	inactive (10001nM)	inactive (94.32%)	inactive (>1995.26nM)	-
PKG2	inactive (10001nM)	inactive (92.67%)	inactive (>1584.89nM)	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
p70S6K	inactive (10001nM)	inactive (97.39%)	inactive (>6309.57nM)	inactive (103%)
MSK1	-	inactive (103.5%)	inactive (>1995.26nM)	inactive (97%)
MSK2	-	inactive (99.59%)	inactive (>1584.89nM)	inactive (102%)
p70S6Kb	-	inactive (97.16%)	-	-
RSK2	-	inactive (95.69%)	inactive (>3981.07nM)	inactive (108%)
RSK4	-	inactive (110.23%)	-	inactive (114%)
RSK1	-	inactive (99.88%)	-	inactive (107%)
RSK3	-	inactive (101.78%)	-	inactive (86%)

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SGK3	inactive (10001nM)	inactive (101.06%)	-	inactive (120%)
SGK1	-	inactive (97.33%)	inactive (>7943.28nM)	inactive (96%)
SGK2	-	inactive (106.05%)	-	inactive (114%)

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
YANK1	active (1300nM)	-	-	-
YANK2	active (2100nM)	-	-	-
YANK3	inactive (10001nM)	-	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CAMKL	20	19	13	9	12
CAMK1	5	4	5	2	3
CAMK2	4	4	4	4	3
CASK	1	1	-	-	-
RAD53	1	1	1	1	1
DAPK	5	5	4	2	4
DCAMKL	3	3	1	1	1
MAPKAPK	5	4	5	4	4
MLCK	5	4	2	-	1
PHK	2	2	2	1	1
PIM	3	3	3	3	3
PKD	3	3	3	2	2
STK33	1	1	-	1	-
TSSK	5	1	2	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AMPKa1	inactive (10001nM)	-	inactive (>3162.28nM)	inactive (109%)
AMPKa2	inactive (10001nM)	-	-	inactive (104%)
NuaK1	inactive (10001nM)	inactive (94.42%)	-	inactive (97%)
BRSK1	inactive (10001nM)	inactive (97.86%)	inactive (>10000nM)	inactive (104%)
BRSK2	inactive (10001nM)	inactive (101.42%)	-	inactive (102%)
CHK1	inactive (10001nM)	inactive (97.33%)	inactive (>5011.87nM)	inactive (104%)
HUNK	inactive (10001nM)	-	-	-
LKB1	inactive (10001nM)	inactive (81.56%)	-	inactive (109%)
MARK1	inactive (10001nM)	inactive (104.61%)	-	inactive (105%)
MARK2	inactive (10001nM)	inactive (99.08%)	inactive (>7943.28nM)	inactive (108%)
MARK3	inactive (10001nM)	inactive (100.64%)	inactive (>6309.57nM)	-
MARK4	inactive (10001nM)	inactive (98.46%)	inactive (>5011.87nM)	-
MELK	inactive (10001nM)	inactive (101.56%)	inactive (>1995.26nM)	inactive (107%)
NIM1	inactive (10001nM)	-	-	-
QSK	inactive (3900nM)	-	-	-
SIK	inactive (10001nM)	-	-	inactive (132%)
QIK	inactive (10001nM)	inactive (82.14%)	active (1000nM)	-
NuaK2	inactive (10001nM)	inactive (130.93%)	-	-
SNRK	inactive (10001nM)	-	-	-
PASK	-	inactive (99.07%)	-	inactive (113%)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK1a	inactive (10001nM)	inactive (105.96%)	inactive (>6309.57nM)	inactive (115%)
CaMK1d	inactive (10001nM)	inactive (104.66%)	inactive (>2511.89nM)	inactive (138%)
CaMK1g	inactive (10001nM)	inactive (99.25%)	-	-
CaMK4	inactive (10001nM)	inactive (101.38%)	-	inactive (113%)
CaMK1b	-	inactive (102.1%)	-	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK2a	inactive (10001nM)	inactive (100.77%)	inactive (>3981.07nM)	-
CaMK2b	inactive (10001nM)	inactive (97.58%)	inactive (>7943.28nM)	inactive (114%)
CaMK2d	inactive (10001nM)	inactive (102.59%)	inactive (>6309.57nM)	inactive (108%)
CaMK2g	inactive (10001nM)	inactive (82.16%)	inactive (>6309.57nM)	inactive (103%)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CASK	inactive (10001nM)	-	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CHK2	inactive (10001nM)	inactive (99.55%)	inactive (>6309.57nM)	inactive (90%)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DAPK1	inactive (10001nM)	inactive (90.35%)	-	inactive (85%)
DAPK2	inactive (10001nM)	inactive (101.83%)	-	inactive (90%)
DAPK3	inactive (10001nM)	inactive (95.46%)	inactive (>5011.87nM)	inactive (98%)
DRAK1	inactive (10001nM)	inactive (98.95%)	inactive (>3981.07nM)	inactive (123%)
DRAK2	inactive (10001nM)	-	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DCLK1	inactive (10001nM)	-	inactive (>10000nM)	-
DCLK2	inactive (10001nM)	inactive (99.84%)	-	inactive (132%)
DCLK3	inactive (10001nM)	-	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAPKAPK2	inactive (10001nM)	inactive (98.28%)	inactive (>7943.28nM)	inactive (104%)
MAPKAPK5	inactive (10001nM)	inactive (92.54%)	inactive (>1584.89nM)	inactive (145%)
MNK1	inactive (10001nM)	inactive (98.53%)	-	-
MNK2	inactive (10001nM)	inactive (94.42%)	inactive (>10000nM)	inactive (103%)
MAPKAPK3	-	inactive (101.04%)	inactive (>10000nM)	inactive (104%)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
caMLCK	inactive (10001nM)	-	-	-
smMLCK	inactive (10001nM)	inactive (101.39%)	-	inactive (118%)
skMLCK	inactive (10001nM)	inactive (99.89%)	-	-
SgK085	inactive (10001nM)	-	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PHKg1	inactive (10001nM)	inactive (94.09%)	-	-
PHKg2	inactive (10001nM)	inactive (102.45%)	inactive (>5011.87nM)	inactive (109%)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PIM1	inactive (10001nM)	inactive (102.72%)	inactive (>6309.57nM)	inactive (84%)
PIM2	inactive (10001nM)	inactive (104.07%)	inactive (>1584.89nM)	inactive (125%)
PIM3	inactive (10001nM)	inactive (98.09%)	inactive (>7943.28nM)	inactive (107%)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKD1	inactive (10001nM)	inactive (95.77%)	-	inactive (123%)
PKD2	inactive (10001nM)	inactive (95.8%)	inactive (6309.57nM)	inactive (105%)
PKD3	inactive (10001nM)	inactive (84.13%)	inactive (>3981.07nM)	-

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
STK33	inactive (10001nM)	inactive (98.12%)	-	inactive (106%)

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TSSK1	inactive (10001nM)	inactive (108.37%)	inactive (>1584.89nM)	inactive (106%)
TSSK2	-	inactive (95.71%)	inactive (>1584.89nM)	inactive (94%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STE11	8	8	3	-	1
STE20	31	27	23	9	14
STE7	7	7	3	2	3
STE-Unique	2	-	2	-	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP3K5	inactive (10001nM)	inactive (106.75%)	-	inactive (138%)
MAP3K6	inactive (10001nM)	-	-	-
MAP3K1	inactive (10001nM)	-	-	-
MAP3K7	inactive (10001nM)	-	-	-
MAP3K2	inactive (10001nM)	inactive (95.26%)	-	-
MAP3K3	inactive (10001nM)	inactive (101.55%)	-	-
MAP3K4	inactive (10001nM)	-	-	-
MAP3K8	inactive (10001nM)	-	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HPK1	inactive (10001nM)	-	-	-
LOK	inactive (10001nM)	inactive (89.15%)	-	inactive (109%)
GCK	inactive (10001nM)	inactive (105.78%)	inactive (>2511.89nM)	inactive (104%)
KHS2	inactive (10001nM)	-	-	-
HGK	inactive (3700nM)	inactive (95.76%)	active (398.11nM)	-
KHS1	inactive (10001nM)	inactive (99.49%)	inactive (>7943.28nM)	-
MINK	inactive (10001nM)	inactive (107%)	inactive (2511.89nM)	inactive (112%)
MST1	inactive (10001nM)	inactive (101.46%)	-	inactive (111%)
MST2	inactive (10001nM)	inactive (102.19%)	inactive (>5011.87nM)	inactive (104%)
MST3	inactive (10001nM)	inactive (98.95%)	-	inactive (115%)
MST4	inactive (10001nM)	inactive (96.75%)	-	-
MYO3A	inactive (10001nM)	-	-	-
MYO3B	inactive (10001nM)	inactive (104.3%)	-	-
OSR1	inactive (10001nM)	inactive (101.87%)	-	-
PAK1	inactive (10001nM)	inactive (99.17%)	inactive (>10000nM)	-
PAK2	inactive (10001nM)	inactive (77.95%)	-	inactive (110%)
PAK3	inactive (10001nM)	inactive (101.97%)	-	inactive (114%)
PAK4	inactive (10001nM)	inactive (91.99%)	inactive (>5011.87nM)	inactive (106%)
PAK6	inactive (10001nM)	inactive (76.68%)	-	inactive (110%)
PAK5	inactive (10001nM)	inactive (103.94%)	-	inactive (105%)
SLK	inactive (3700nM)	inactive (94.07%)	inactive (1995.26nM)	-
STLK3	inactive (10001nM)	inactive (93.94%)	-	-
TAO1	inactive (10001nM)	inactive (97.91%)	inactive (>5011.87nM)	inactive (100%)
TAO2	inactive (10001nM)	inactive (93.98%)	-	inactive (111%)
TAO3	inactive (10001nM)	inactive (102.73%)	-	inactive (108%)
TNIK	active (820nM)	-	-	-
YSK1	inactive (10001nM)	inactive (111.12%)	-	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP2K1	inactive (10001nM)	inactive (94.76%)	inactive (>3162.28nM)	inactive (113%)
MAP2K2	inactive (9600nM)	inactive (99.87%)	inactive (>3981.07nM)	-
MAP2K3	inactive (10001nM)	-	-	-
MAP2K4	inactive (10001nM)	-	-	-
MAP2K5	active (1400nM)	-	-	-
MAP2K6	inactive (10001nM)	inactive (101.98%)	-	active (43%)
MAP2K7	inactive (10001nM)	-	-	inactive (86%)

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
COT	-	inactive (92.12%)	-	-
NIK	-	inactive (117.93%)	-	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CDK	20	8	-	7	-
CDKL	5	4	-	-	-
CLK	4	4	4	2	2
CK2	3	2	2	1	2
DYRK	10	8	9	6	4
MAPK	14	14	10	8	10
GSK	2	2	2	2	2
RCK	3	2	-	-	-
SRPK	3	3	3	1	3

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PITSLRE	inactive (10001nM)	-	-	-
CHED	inactive (10001nM)	-	-	-
CDK11	inactive (10001nM)	-	-	-
PCTAIRE1	inactive (10001nM)	-	-	-
PCTAIRE2	inactive (10001nM)	-	-	-
PCTAIRE3	inactive (10001nM)	-	-	-
PFTAIRE2	inactive (10001nM)	-	-	-
PFTAIRE1	inactive (10001nM)	-	-	-
CDC2	-	-	inactive (>7943.28nM)	-
CDK2	-	-	inactive (>7943.28nM)	-
CDK5	-	-	inactive (>3162.28nM)	-
CDK8	-	-	inactive (>3981.07nM)	-
CDK7	-	-	inactive (>3981.07nM)	-
CDK9	-	-	inactive (>1584.89nM)	-

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDKL1	inactive (10001nM)	-	-	-
CDKL2	inactive (10001nM)	-	-	-
CDKL3	inactive (10001nM)	-	-	-
CDKL5	inactive (10001nM)	-	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLK1	inactive (10001nM)	inactive (101.4%)	-	-
CLK2	inactive (10001nM)	inactive (107.64%)	inactive (>3981.07nM)	inactive (114%)
CLK3	inactive (10001nM)	inactive (99.14%)	-	inactive (98%)
CLK4	inactive (10001nM)	inactive (98.72%)	inactive (>2511.89nM)	-

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK2a1	inactive (10001nM)	inactive (86.24%)	inactive (>6309.57nM)	inactive (100%)
CK2a2	inactive (10001nM)	inactive (104.29%)	-	inactive (122%)

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DYRK1A	inactive (10001nM)	inactive (95.56%)	inactive (>1995.26nM)	-
DYRK1B	inactive (10001nM)	inactive (104.04%)	inactive (>2511.89nM)	-
DYRK2	inactive (10001nM)	inactive (98.74%)	-	inactive (115%)
HIPK1	inactive (10001nM)	inactive (103.63%)	-	inactive (102%)
HIPK2	inactive (10001nM)	inactive (101.86%)	inactive (>3162.28nM)	inactive (110%)
HIPK3	inactive (10001nM)	inactive (103.04%)	-	inactive (110%)
HIPK4	inactive (10001nM)	inactive (93.49%)	inactive (>7943.28nM)	-
PRP4	inactive (10001nM)	-	-	-
DYRK3	-	inactive (98.98%)	inactive (>6309.57nM)	-
DYRK4	-	inactive (99.2%)	inactive (>7943.28nM)	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Erk1	inactive (10001nM)	inactive (100.57%)	-	inactive (124%)
Erk2	inactive (10001nM)	inactive (94.7%)	inactive (>7943.28nM)	inactive (118%)
Erk3	inactive (10001nM)	-	-	-
Erk4	inactive (10001nM)	-	-	-
Erk5	inactive (10001nM)	-	-	-
Erk7	inactive (10001nM)	-	-	-
JNK1	active (1100nM)	inactive (96.09%)	inactive (1258.93nM)	inactive (111%)
JNK2	active (130nM)	inactive (100.4%)	active (199.53nM)	inactive (74%)
JNK3	active (35nM)	inactive (113.93%)	active (25.12nM)	active (20%)
NLK	active (25nM)	inactive (53.79%)	-	inactive (62%)
p38a	active (12nM)	active (22.82%)	active (19.95nM)	active (5%)
p38b	active (70nM)	inactive (68.92%)	-	active (24%)
p38d	inactive (10001nM)	inactive (105.91%)	inactive (>7943.28nM)	inactive (111%)
p38g	active (1500nM)	inactive (104.61%)	inactive (>6309.57nM)	inactive (114%)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
GSK3A	inactive (10001nM)	inactive (94.13%)	inactive (>3981.07nM)	inactive (86%)
GSK3B	active (1700nM)	inactive (80.24%)	inactive (1584.89nM)	inactive (93%)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ICK	inactive (10001nM)	-	-	-
MAK	inactive (10001nM)	-	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SRPK1	inactive (10001nM)	inactive (99.53%)	inactive (>7943.28nM)	inactive (112%)
SRPK2	inactive (10001nM)	inactive (101.92%)	-	inactive (112%)
MSSK1	inactive (10001nM)	inactive (99.4%)	-	inactive (102%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CK1	7	7	6	5	4
VRK	3	1	1	-	1

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK1a	active (75nM)	inactive (63.9%)	active (316.23nM)	-
CK1a2	active (1700nM)	-	-	-
CK1d	active (37nM)	active (13.93%)	active (39.81nM)	active (11%)
CK1e	active (100nM)	active (30.97%)	-	-
CK1g1	inactive (10001nM)	inactive (95.71%)	inactive (>6309.57nM)	inactive (119%)
CK1g2	inactive (10001nM)	inactive (95.65%)	inactive (>7943.28nM)	inactive (120%)
CK1g3	inactive (10001nM)	inactive (103.23%)	inactive (>6309.57nM)	inactive (125%)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
VRK2	inactive (10001nM)	-	-	inactive (114%)
VRK1	-	inactive (95.83%)	-	-