Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : DGCXNBUJPWPMJJ-UHFFFAOYSA-N

CANNOT FIND

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (79.01%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (79.72%)
AKT2	inactive (55.76%)
AKT3	inactive (81.23%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (84.81%)
MRCKa	inactive (91.6%)
MRCKb	inactive (82.64%)
ROCK1	inactive (94.52%)
ROCK2	inactive (81.7%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (106.01%)
BARK2	inactive (106.45%)
GPRK4	inactive (68.41%)
GPRK5	inactive (74.28%)
GPRK6	inactive (57.97%)
GPRK7	inactive (78.09%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (68.68%)
MSK2	inactive (72.22%)
p70S6K	inactive (85.77%)
p70S6Kb	inactive (86.31%)
RSK2	inactive (75.05%)
RSK4	inactive (62.34%)
RSK1	inactive (53.07%)
RSK3	inactive (89.1%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (88.55%)
PRKX	inactive (94.3%)
PKACa	inactive (76.62%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (91.4%)
PKCd	inactive (102.3%)
PKCe	inactive (99.04%)
PKCh	active (49.23%)
PKCg	inactive (59.32%)
PKCi	inactive (85.7%)
PKCt	inactive (83.03%)
PKCz	inactive (99.13%)
PKCb	active (29.29%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (140.02%)
PKG1	inactive (108.7%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (97.53%)
PKN2	inactive (77.06%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (67.19%)
SGK2	inactive (75.08%)
SGK3	inactive (90.42%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (46.64%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (89.75%)
ABL2	inactive (89.72%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	active (44.94%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (83.46%)
LTK	inactive (176.61%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	active (10.31%)
MER	inactive (93.13%)
TYRO3	active (33.29%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (108.61%)
BRK	inactive (110.8%)
SRC	inactive (80.4%)
FGR	inactive (79.76%)
FRK	active (33.88%)
FYN	inactive (76.23%)
HCK	inactive (83.96%)
LCK	inactive (70.48%)
SRM	active (6.34%)
YES	inactive (89.15%)
LYN	inactive (85.17%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (79.03%)
BTK	inactive (90.55%)
ITK	inactive (71.48%)
TEC	active (2.44%)
TXK	inactive (90.82%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	active (22.16%)
FLT3	inactive (100.02%)
FMS	active (11.63%)
PDGFRb	active (11.35%)
PDGFRa	active (44.11%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (84.76%)
CTK	inactive (99.68%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (58.71%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	active (36.99%)
ErbB2	active (22.24%)
ErbB4	inactive (50.2%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (73.05%)
EphA2	inactive (100.02%)
EphA3	inactive (81.64%)
EphA4	inactive (61.06%)
EphA5	inactive (81.54%)
EphA6	inactive (105.72%)
EphA7	inactive (81.95%)
EphA8	inactive (92.57%)
EphB1	inactive (89.47%)
EphB2	inactive (86.1%)
EphB3	inactive (90.17%)
EphB4	inactive (97.09%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (87.03%)
PYK2	inactive (52.06%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (89.09%)
FES	inactive (87.55%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	active (24.22%)
FGFR2	inactive (59.36%)
FGFR3	active (26.7%)
FGFR4	inactive (57.97%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	active (3.06%)
FLT4	active (5.79%)
KDR	active (1.95%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (91.14%)
IRR	inactive (86.7%)
INSR	active (32.26%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (101.04%)
JAK2	inactive (82.55%)
JAK3	inactive (90.38%)
TYK2	inactive (77.21%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (107.07%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (100.61%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (93.63%)
MET	inactive (83.28%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (91.12%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (94.76%)
ZAP70	inactive (68.23%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	active (4.27%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (76.65%)
TRKB	active (29.41%)
TRKC	inactive (87.2%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (104.78%)
ALK2	inactive (93.07%)
ALK4	inactive (112.88%)
TGFbR1	inactive (106.54%)
TGFbR2	inactive (93.37%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (104.07%)
BRAF	inactive (84.9%)
RAF1	inactive (76.07%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (77.56%)
IRAK4	inactive (96.9%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (64.99%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (85.55%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (63.33%)
MLK2	inactive (94.65%)
MLK3	inactive (68.99%)
TAK1	inactive (89.85%)
ZAK	inactive (69.78%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (100.59%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (89.81%)
BRSK1	inactive (84.77%)
BRSK2	inactive (66.74%)
CHK1	inactive (111.86%)
LKB1	inactive (99.09%)
MARK1	inactive (98.16%)
MARK3	inactive (78.06%)
MARK4	inactive (88.09%)
MELK	inactive (55.73%)
PASK	inactive (73.39%)
QIK	inactive (106.16%)
NuaK2	inactive (92.54%)
MARK2	inactive (94.22%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (68.72%)
CaMK1b	inactive (83.38%)
CaMK1d	inactive (93.94%)
CaMK1g	active (28.49%)
CaMK4	inactive (85.38%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (84.71%)
CaMK2b	inactive (85.15%)
CaMK2d	inactive (93%)
CaMK2g	inactive (91.13%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (54.72%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (92.17%)
DAPK2	inactive (83.39%)
DRAK1	inactive (83.76%)
DAPK3	inactive (96.2%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (86.48%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (103.99%)
MAPKAPK3	inactive (76.03%)
MAPKAPK5	inactive (66.86%)
MNK1	inactive (79.34%)
MNK2	inactive (78.25%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (94.12%)
skMLCK	inactive (88.14%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (92.46%)
PHKg2	inactive (96.12%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (94.08%)
PIM2	inactive (92.78%)
PIM3	inactive (93.34%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (86.5%)
PKD3	inactive (83.44%)
PKD2	inactive (91.69%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (88.74%)
TSSK2	inactive (74.99%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (107.01%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (105.96%)
MAP3K2	inactive (82.96%)
MAP3K3	inactive (133.52%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (75.89%)
NIK	inactive (123.52%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (79.4%)
HGK	inactive (89.01%)
KHS1	inactive (78.69%)
LOK	inactive (84.33%)
MINK	inactive (91.22%)
MST1	inactive (87.83%)
MST2	inactive (97.45%)
MST3	inactive (101.44%)
MST4	inactive (91.75%)
OSR1	inactive (83.01%)
PAK1	inactive (96.13%)
PAK2	inactive (96.25%)
PAK3	inactive (97.12%)
PAK4	inactive (91.38%)
PAK5	inactive (93.4%)
PAK6	inactive (108.04%)
SLK	inactive (92.42%)
YSK1	inactive (100.73%)
STLK3	inactive (89.2%)
TAO1	inactive (90.22%)
TAO2	inactive (91.93%)
TAO3	inactive (90.85%)
MYO3B	inactive (88.38%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (88.68%)
MAP2K2	inactive (94.69%)
MAP2K6	inactive (85.66%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (71.37%)
AurB	inactive (84.73%)
AurC	inactive (95.42%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (74.94%)
CaMKK2	inactive (76.86%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (79.2%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (71.99%)
IKKb	inactive (73.35%)
IKKe	inactive (89.18%)
TBK1	inactive (87%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	active (46.3%)
NEK11	inactive (87.97%)
NEK2	inactive (77.71%)
NEK4	inactive (96.08%)
NEK6	inactive (96.28%)
NEK7	inactive (83.56%)
NEK9	inactive (118.9%)
NEK3	inactive (110.66%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (64.47%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	active (28.6%)
PLK2	active (37.27%)
PLK3	active (28.53%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (81.53%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (80.54%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (124.72%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (107.47%)
ULK2	inactive (104.74%)
ULK3	inactive (103.29%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (70.86%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (142.58%)
Wnk3	inactive (116.13%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (100.15%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (86.84%)
CK1g1	inactive (85.15%)
CK1g2	inactive (82.19%)
CK1g3	inactive (80.34%)
CK1a	inactive (85.8%)
CK1e	inactive (80.56%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (90.53%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (101.45%)
CK2a2	inactive (76.2%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (79.43%)
CLK2	inactive (92.11%)
CLK3	inactive (81.21%)
CLK4	inactive (78.26%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (95.05%)
DYRK1B	inactive (81.04%)
DYRK2	inactive (113.32%)
DYRK3	inactive (88.62%)
DYRK4	inactive (88.52%)
HIPK1	inactive (99.29%)
HIPK2	inactive (106.78%)
HIPK3	inactive (100.97%)
HIPK4	inactive (97.9%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (86.96%)
Erk2	inactive (87.51%)
JNK3	inactive (55%)
NLK	inactive (98.16%)
p38a	inactive (88.61%)
p38b	inactive (101.11%)
p38d	inactive (95.57%)
p38g	inactive (92.53%)
JNK1	inactive (78.33%)
JNK2	inactive (51.94%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (88.72%)
GSK3B	inactive (83.49%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (89.39%)
SRPK1	inactive (109.24%)
SRPK2	inactive (95.77%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (79.01%)