Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : 6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine

Inchikey : DIJLFIHLUYAZCI-UHFFFAOYSA-N

ChemSpider : 4486953

Pubchem CID : 5329802

ChEMBL : CHEMBL373073

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (7.71%)
TYK2	inactive (3.74%)
JAK2	inactive (3.1%)
JAK3	inactive (0.39%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (1.69%)
FES	inactive (-0.8%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (11.39%)
ABL2	inactive (5.3%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (-0.98%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (2.73%)
BTK	inactive (-0.38%)
TXK	inactive (2.2%)
TEC	inactive (3.07%)
ITK	inactive (0.68%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (2.82%)
SRM	inactive (3.06%)
FRK	inactive (0.16%)
BLK	inactive (4.67%)
LCK	inactive (5.93%)
HCK	inactive (7.05%)
FGR	inactive (7.14%)
FYN	inactive (3.42%)
SRC	inactive (7.59%)
YES	inactive (6.69%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (-2.53%)
EphA4	inactive (1.4%)
EphA3	inactive (-2.59%)
EphB4	inactive (0.16%)
EphB3	inactive (0.05%)
EphB2	inactive (4.07%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (8.21%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (-0.57%)
ZAP70	inactive (-0.14%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (0.01%)
ALK	inactive (1.1%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (4.11%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (2.44%)
IGF1R	inactive (-0.91%)
IRR	inactive (-2.2%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (0.02%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (2.3%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (2.94%)
TRKB	inactive (1.81%)
TRKC	inactive (0.25%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (-1.06%)
MET	inactive (0.32%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (2.96%)
MER	inactive (2.01%)
TYRO3	inactive (2.56%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	inactive (0.94%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (-10.05%)
FGFR2	inactive (-4.78%)
FGFR3	inactive (-2.94%)
FGFR4	inactive (-1.73%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (0.12%)
KDR	inactive (2.97%)
FLT4	inactive (4.44%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	inactive (17.89%)
KIT	inactive (8.52%)
FLT3	inactive (-0.84%)
PDGFRa	inactive (16.47%)
PDGFRb	inactive (11.23%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (2.73%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (1.96%)
TNK1	inactive (6.1%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (2%)
ErbB2	inactive (0.38%)
ErbB4	inactive (1.85%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (0.08%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (-0.19%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (4.72%)
MST1	inactive (-0.96%)
MST2	inactive (-0.72%)
MST4	inactive (0.97%)
HGK	inactive (9.41%)
MINK	inactive (6.5%)
LOK	inactive (0.33%)
PAK1	inactive (-0.27%)
PAK3	inactive (-1.01%)
PAK2	inactive (-0.84%)
PAK5	inactive (-1.65%)
PAK6	inactive (-9.7%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (1.35%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (-1.14%)
CK1g2	inactive (-0.54%)
CK1g1	inactive (-0.49%)
CK1g3	inactive (0.61%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (-1.15%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (11.66%)
AurC	inactive (16.73%)
AurA	inactive (1.33%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (3.78%)
NEK2	inactive (-1.7%)
NEK9	inactive (2.28%)
NEK7	inactive (-0.87%)
NEK6	inactive (-1.06%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	inactive (1.62%)
IKKe	inactive (-1.16%)
IKKb	inactive (6.4%)
IKKa	inactive (-3.79%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	inactive (0.09%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (-1.5%)
GPRK6	inactive (0.98%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	inactive (1.28%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (-3.04%)
MSK2	inactive (-0.35%)
RSK1	inactive (0.11%)
RSK2	inactive (2.31%)
RSK4	inactive (1.58%)
RSK3	inactive (0.29%)
p70S6K	inactive (-0.54%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (-0.64%)
AKT1	inactive (-1.46%)
AKT3	inactive (1.62%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (-0.33%)
SGK3	inactive (-2.55%)
SGK2	inactive (1.43%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (-1.49%)
PKCg	inactive (8.58%)
PKCa	inactive (3%)
PKCt	inactive (-1.64%)
PKCi	inactive (-1.03%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (1.5%)
PKG1	inactive (0.25%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (0.29%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (1.74%)
ROCK2	inactive (1.85%)
MRCKb	inactive (-0.07%)
MRCKa	inactive (-2.67%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (3.25%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (0.37%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (-1.72%)
CaMK1d	inactive (2.96%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (2.53%)
PHKg2	inactive (-2.23%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (-0.85%)
CaMK2a	inactive (-0.48%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (-0.51%)
MAPKAPK2	inactive (-0.76%)
MAPKAPK3	inactive (-1.91%)
MNK2	inactive (4.21%)
MNK1	inactive (2%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (-1.37%)
PKD1	inactive (-1.28%)
PKD2	inactive (-0.42%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (1.62%)
MARK3	inactive (4.01%)
MARK1	inactive (2.81%)
QIK	inactive (7.33%)
SIK	inactive (11.97%)
NuaK1	inactive (2.41%)
BRSK1	inactive (-0.34%)
BRSK2	inactive (1.73%)
MELK	inactive (-1.79%)
CHK1	inactive (2.78%)
PASK	inactive (0.48%)
AMPKa1	inactive (0.8%)
AMPKa2	inactive (-2.04%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (-0.58%)
TSSK1	inactive (1.43%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (-3.05%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (2.23%)
PIM3	inactive (6.86%)
PIM1	inactive (2.3%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (-0.18%)
p38a	inactive (0.41%)
p38b	inactive (-0.96%)
p38d	inactive (-2.56%)
Erk2	inactive (0.69%)
Erk1	inactive (-1.51%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	inactive (7.92%)
GSK3B	inactive (8%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (1.06%)
MSSK1	inactive (-0.8%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (11.42%)
CLK2	inactive (2.78%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	inactive (5.4%)
HIPK4	inactive (16.5%)
DYRK1B	inactive (12.03%)
DYRK1A	inactive (22.73%)
DYRK2	inactive (18.49%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (14.15%)