Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : p38 MAP Kinase Inhibitor

Inchikey
Same : DZFBYHUKZSRPHU-N
RBC, Millipore : DZFBYHUKZSRPHU-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 4503

Pubchem CID
RBC, Millipore : 4665

ChEMBL
RBC, Millipore : CHEMBL91730

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (103.59%)	inactive (114%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (96.44%)	inactive (108%)
AKT2	inactive (97.79%)	inactive (114%)
AKT3	inactive (94.29%)	inactive (106%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (87.59%)	inactive (113%)
MRCKa	inactive (97.95%)	inactive (119%)
MRCKb	inactive (102.64%)	inactive (99%)
ROCK1	inactive (109.31%)	inactive (122%)
ROCK2	inactive (89.54%)	inactive (98%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (106.06%)	-
BARK2	inactive (95.04%)	-
GPRK4	inactive (97.91%)	-
GPRK5	inactive (90.26%)	inactive (101%)
GPRK6	inactive (90.09%)	inactive (99%)
GPRK7	inactive (102.99%)	inactive (99%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (93.47%)	inactive (104%)
MSK2	inactive (103.02%)	inactive (97%)
p70S6K	inactive (89.94%)	inactive (129%)
p70S6Kb	inactive (95.52%)	-
RSK2	inactive (94.32%)	inactive (122%)
RSK4	inactive (90.29%)	inactive (103%)
RSK1	inactive (103.29%)	inactive (93%)
RSK3	inactive (91.82%)	inactive (115%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (91.85%)	-
PRKX	inactive (97.02%)	inactive (78%)
PKACa	inactive (90.74%)	inactive (92%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (100.49%)	inactive (108%)
PKCd	inactive (92.64%)	inactive (106%)
PKCe	inactive (96.68%)	inactive (114%)
PKCh	inactive (88.96%)	inactive (92%)
PKCg	inactive (100.99%)	inactive (109%)
PKCi	inactive (96.16%)	inactive (113%)
PKCt	inactive (119.49%)	inactive (93%)
PKCz	inactive (99.01%)	inactive (114%)
PKCb	inactive (92.44%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (109.83%)	-
PKG1	inactive (95.58%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (92.42%)	-
PKN2	inactive (96.4%)	inactive (99%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (97.34%)	inactive (93%)
SGK2	inactive (94.33%)	inactive (103%)
SGK3	inactive (100.05%)	inactive (115%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (93.72%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (98.14%)	inactive (108%)
ABL2	inactive (82.8%)	inactive (105%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (91.21%)	inactive (83%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (83.77%)	inactive (91%)
LTK	inactive (75.5%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (112.84%)	inactive (118%)
MER	inactive (82.72%)	inactive (108%)
TYRO3	inactive (105.39%)	inactive (108%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (91.6%)	inactive (101%)
BRK	inactive (57.45%)	inactive (59%)
SRC	inactive (91.63%)	inactive (113%)
FGR	inactive (87.39%)	inactive (86%)
FRK	inactive (78.53%)	inactive (90%)
FYN	inactive (94.76%)	inactive (86%)
HCK	inactive (91.14%)	inactive (94%)
LCK	inactive (100.81%)	inactive (90%)
SRM	inactive (103.51%)	-
YES	inactive (85.1%)	inactive (115%)
LYN	inactive (97.45%)	inactive (75%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (95.75%)	inactive (91%)
BTK	inactive (83.59%)	inactive (97%)
ITK	inactive (79.68%)	inactive (104%)
TEC	inactive (111.91%)	-
TXK	inactive (94.44%)	inactive (84%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (94.89%)	inactive (117%)
FLT3	inactive (92.8%)	inactive (87%)
FMS	inactive (101.9%)	inactive (103%)
PDGFRb	inactive (100.86%)	inactive (100%)
PDGFRa	inactive (102.89%)	inactive (101%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (86.11%)	inactive (111%)
CTK	inactive (86.02%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (90.57%)	inactive (86%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (57.71%)	inactive (54%)
ErbB2	inactive (102.57%)	-
ErbB4	inactive (73.19%)	inactive (104%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (93.07%)	inactive (93%)
EphA2	inactive (100.64%)	inactive (95%)
EphA3	inactive (84.39%)	inactive (98%)
EphA4	inactive (93.55%)	inactive (102%)
EphA5	inactive (106.34%)	inactive (119%)
EphA6	inactive (57.01%)	-
EphA7	inactive (98.53%)	inactive (100%)
EphA8	inactive (94.39%)	inactive (97%)
EphB1	inactive (90.47%)	inactive (128%)
EphB2	inactive (101.31%)	inactive (121%)
EphB3	inactive (92.23%)	inactive (83%)
EphB4	inactive (97.16%)	inactive (105%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (95.08%)	inactive (87%)
PYK2	inactive (91.74%)	inactive (90%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (94.26%)	inactive (103%)
FES	inactive (92.28%)	inactive (90%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (93.72%)	inactive (127%)
FGFR2	inactive (94.04%)	inactive (103%)
FGFR3	inactive (88.06%)	inactive (123%)
FGFR4	inactive (92.39%)	inactive (120%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (81.32%)	inactive (100%)
FLT4	inactive (91.51%)	inactive (93%)
KDR	inactive (90.6%)	inactive (102%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (92.82%)	inactive (103%)
IRR	inactive (95.39%)	inactive (112%)
INSR	inactive (109.92%)	inactive (111%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (103.26%)	-
JAK2	inactive (95.09%)	inactive (98%)
JAK3	inactive (106.44%)	inactive (116%)
TYK2	inactive (90.86%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (102.18%)	inactive (95%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (99.57%)	inactive (93%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (95.05%)	inactive (78%)
MET	inactive (100.79%)	inactive (67%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (97.57%)	inactive (111%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (98.86%)	active (41%)
ZAP70	inactive (107.96%)	inactive (127%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (94.41%)	inactive (103%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (95.53%)	inactive (107%)
TRKB	inactive (88.45%)	inactive (97%)
TRKC	inactive (99.25%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (88.11%)	-
ALK2	inactive (91.65%)	-
ALK4	inactive (123.06%)	inactive (86%)
TGFbR1	inactive (100.6%)	inactive (91%)
TGFbR2	inactive (97.74%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	active (49.79%)	-
BRAF	inactive (82.87%)	-
RAF1	inactive (61.41%)	active (33%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (102.56%)	inactive (111%)
IRAK4	inactive (81.92%)	inactive (103%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (91.53%)	inactive (95%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (102.24%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (102.72%)	inactive (108%)
MLK2	inactive (88.07%)	-
MLK3	inactive (98.02%)	-
TAK1	inactive (100.46%)	inactive (106%)
ZAK	inactive (91.21%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (50.18%)	active (47%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (89.11%)	inactive (110%)
BRSK1	inactive (88.67%)	inactive (100%)
BRSK2	inactive (90.76%)	inactive (103%)
CHK1	inactive (100.74%)	inactive (110%)
LKB1	inactive (98.83%)	inactive (102%)
MARK1	inactive (94.53%)	inactive (100%)
MARK3	inactive (87.17%)	-
MARK4	inactive (79.99%)	-
MELK	inactive (86.54%)	inactive (104%)
PASK	inactive (93.57%)	inactive (135%)
QIK	inactive (100.97%)	-
NuaK2	inactive (88.66%)	-
MARK2	inactive (88.82%)	inactive (101%)
AMPKa1	-	inactive (97%)
AMPKa2	-	inactive (104%)
SIK	-	inactive (141%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (94.44%)	inactive (86%)
CaMK1b	inactive (92.05%)	-
CaMK1d	inactive (72.23%)	inactive (101%)
CaMK1g	inactive (104%)	-
CaMK4	inactive (104.15%)	inactive (101%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (86.9%)	-
CaMK2b	inactive (93.69%)	inactive (105%)
CaMK2d	inactive (95.64%)	inactive (114%)
CaMK2g	inactive (109.47%)	inactive (107%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (91.42%)	active (43%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (84.47%)	inactive (94%)
DAPK2	inactive (103.67%)	inactive (105%)
DRAK1	inactive (104.77%)	inactive (107%)
DAPK3	inactive (94.68%)	inactive (101%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (99.85%)	inactive (122%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (98.55%)	inactive (90%)
MAPKAPK3	inactive (100.82%)	inactive (122%)
MAPKAPK5	inactive (99.71%)	inactive (92%)
MNK1	inactive (93.87%)	-
MNK2	inactive (97.21%)	inactive (111%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (101.44%)	inactive (116%)
skMLCK	inactive (100.6%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (94.06%)	-
PHKg2	inactive (121.37%)	inactive (112%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (101.25%)	inactive (104%)
PIM2	inactive (114.11%)	inactive (128%)
PIM3	inactive (89.92%)	inactive (94%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (84.66%)	inactive (99%)
PKD3	inactive (74.46%)	-
PKD2	inactive (73.38%)	inactive (106%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (76.2%)	inactive (107%)
TSSK2	inactive (80.05%)	inactive (97%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (100.75%)	inactive (103%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (115.28%)	inactive (100%)
MAP3K2	inactive (98.85%)	-
MAP3K3	inactive (96.17%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (87.13%)	-
NIK	inactive (102.38%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (87.7%)	inactive (106%)
HGK	inactive (93.52%)	-
KHS1	inactive (83.1%)	-
LOK	inactive (81.9%)	inactive (110%)
MINK	inactive (97.28%)	inactive (104%)
MST1	inactive (89.98%)	inactive (88%)
MST2	inactive (88.34%)	inactive (97%)
MST3	inactive (110.64%)	inactive (87%)
MST4	inactive (94.13%)	-
OSR1	inactive (83.29%)	-
PAK1	inactive (92.35%)	-
PAK2	inactive (101.6%)	inactive (103%)
PAK3	inactive (98.26%)	inactive (78%)
PAK4	inactive (81.95%)	inactive (99%)
PAK5	inactive (86.33%)	inactive (108%)
PAK6	inactive (73.54%)	inactive (89%)
SLK	inactive (98.15%)	-
YSK1	inactive (110.85%)	-
STLK3	inactive (128.39%)	-
TAO1	inactive (101.64%)	inactive (109%)
TAO2	inactive (100.9%)	inactive (103%)
TAO3	inactive (89.52%)	inactive (99%)
MYO3B	inactive (90.73%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (70.08%)	inactive (111%)
MAP2K2	inactive (82.47%)	-
MAP2K6	inactive (79.41%)	inactive (74%)
MAP2K7	-	inactive (77%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (94.04%)	inactive (112%)
AurB	inactive (95.08%)	inactive (112%)
AurC	inactive (100.21%)	inactive (105%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (98.53%)	-
CaMKK2	inactive (82.98%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (96.49%)	inactive (91%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (100.98%)	inactive (131%)
IKKb	inactive (102.45%)	inactive (126%)
IKKe	inactive (98.32%)	-
TBK1	inactive (111.66%)	inactive (106%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (78.67%)	-
NEK11	inactive (103.86%)	inactive (81%)
NEK2	inactive (85.44%)	inactive (107%)
NEK4	inactive (93.92%)	-
NEK6	inactive (105.66%)	inactive (101%)
NEK7	inactive (90.06%)	inactive (102%)
NEK9	inactive (106.66%)	-
NEK3	inactive (100.43%)	inactive (95%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (87.72%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (98.32%)	inactive (77%)
PLK2	inactive (92.53%)	inactive (107%)
PLK3	inactive (96.29%)	inactive (96%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (92.9%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (99.99%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (110.34%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (102.64%)	-
ULK2	inactive (110.65%)	inactive (111%)
ULK3	inactive (94.25%)	inactive (98%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (81.56%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (112.07%)	inactive (106%)
Wnk3	inactive (93.6%)	inactive (89%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (108.82%)	inactive (101%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	active (26.67%)	active (44%)
CK1g1	inactive (83.36%)	inactive (95%)
CK1g2	inactive (93.78%)	inactive (112%)
CK1g3	inactive (101.59%)	inactive (101%)
CK1a	inactive (63.74%)	-
CK1e	active (34.95%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (92.95%)	-
VRK2	-	inactive (100%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (95.33%)	inactive (103%)
CK2a2	-	inactive (114%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (97%)	-
CLK2	inactive (98.97%)	inactive (122%)
CLK3	inactive (88.68%)	inactive (91%)
CLK4	inactive (78.86%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (89.76%)	-
DYRK1B	inactive (92.19%)	-
DYRK2	inactive (86.9%)	inactive (106%)
DYRK3	inactive (82.72%)	-
DYRK4	inactive (81.5%)	-
HIPK1	inactive (110.15%)	inactive (110%)
HIPK2	inactive (89.04%)	inactive (108%)
HIPK3	inactive (100.95%)	inactive (99%)
HIPK4	inactive (94.56%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (102.72%)	inactive (110%)
Erk2	inactive (77.32%)	inactive (122%)
JNK3	inactive (97.12%)	active (-2%)
NLK	active (16.03%)	active (42%)
p38a	active (11.17%)	active (3%)
p38b	inactive (55.86%)	active (23%)
p38d	inactive (102.37%)	inactive (103%)
p38g	inactive (85.16%)	inactive (96%)
JNK1	inactive (90.18%)	inactive (84%)
JNK2	active (6.07%)	active (7%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (93.35%)	inactive (89%)
GSK3B	inactive (91.63%)	inactive (102%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (92.22%)	inactive (106%)
SRPK1	inactive (97.92%)	inactive (113%)
SRPK2	inactive (94.41%)	inactive (104%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (103.59%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (109%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (89%)