Compound Information


Test on : RBC, Metz

Compound Name
RBC, Metz : VX-702

Inchikey
Same : FYSRKRZDBHOFAY-N
RBC, Metz : FYSRKRZDBHOFAY-UHFFFAOYSA-N

ChemSpider
RBC, Metz : 8516613

Pubchem CID
RBC, Metz : 10341154

ChEMBL
RBC, Metz : CHEMBL1090090




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
111
333
753
761
884
532
995
232
321
331
41-
AGC - PDK1

Bioactivity
KinaseRBCMetz
PDK1inactive (87.4%)-
AGC - Akt

Bioactivity
KinaseRBCMetz
AKT1inactive (84.72%)-
AKT2inactive (118.28%)-
AKT3inactive (86.24%)-
AGC - DMPK

Bioactivity
KinaseRBCMetz
DMPK1inactive (103.72%)-
MRCKainactive (93.8%)-
MRCKbinactive (96.52%)-
ROCK1inactive (107.81%)inactive (2511.89nM)
ROCK2inactive (97.66%)-
AGC - GRK

Bioactivity
KinaseRBCMetz
BARK1inactive (99.03%)-
BARK2inactive (98.14%)-
GPRK4inactive (90.74%)-
GPRK5inactive (103.21%)-
GPRK6inactive (97.05%)-
GPRK7inactive (108.5%)-
AGC - RSK

Bioactivity
KinaseRBCMetz
MSK1inactive (92.85%)-
MSK2inactive (99.01%)-
p70S6Kinactive (100.13%)-
p70S6Kbinactive (100.08%)-
RSK2inactive (99.84%)-
RSK4inactive (101.25%)-
RSK1inactive (108.84%)-
RSK3inactive (97.53%)-
AGC - PKA

Bioactivity
KinaseRBCMetz
PKACginactive (109.18%)-
PRKXinactive (123.07%)-
PKACainactive (100.84%)-
AGC - PKC

Bioactivity
KinaseRBCMetz
PKCainactive (85.96%)-
PKCdinactive (103.55%)-
PKCeinactive (100.78%)-
PKChinactive (112.44%)-
PKCginactive (91.25%)-
PKCiinactive (99.14%)-
PKCtinactive (85.11%)-
PKCzinactive (89.94%)-
PKCbinactive (94.64%)-
AGC - PKG

Bioactivity
KinaseRBCMetz
PKG2inactive (98.09%)-
PKG1inactive (88.06%)-
AGC - PKN

Bioactivity
KinaseRBCMetz
PKN1inactive (101.2%)-
PKN2inactive (99.71%)-
AGC - SGK

Bioactivity
KinaseRBCMetz
SGK1inactive (121.07%)-
SGK2inactive (106.76%)-
SGK3inactive (99.92%)-
AGC - NDR

Bioactivity
KinaseRBCMetz
NDR1inactive (101.19%)-

TK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
221
211
222
332
11119
553
555
221
21-
433
14121
222
222
442
333
332
443
11-
111
222
111
221
21-
333
TK - Abl

Bioactivity
KinaseRBCMetz
ABL1inactive (99.67%)-
ABL2inactive (100%)-
TK - Ack

Bioactivity
KinaseRBCMetz
ACKinactive (96.1%)-
TK - ALK

Bioactivity
KinaseRBCMetz
ALKinactive (99.57%)-
LTKinactive (95.02%)-
TK - Axl

Bioactivity
KinaseRBCMetz
AXLinactive (100.77%)-
MERinactive (113.77%)-
TYRO3inactive (100.71%)-
TK - Src

Bioactivity
KinaseRBCMetz
BLKinactive (100.05%)-
BRKinactive (98.72%)-
SRCinactive (108.84%)-
FGRinactive (94.73%)-
FRKinactive (105.78%)-
FYNinactive (110.36%)-
HCKinactive (89.54%)-
LCKinactive (86.3%)-
SRMinactive (92.93%)-
YESinactive (97.77%)-
LYNinactive (98.14%)-
TK - Tec

Bioactivity
KinaseRBCMetz
BMXinactive (107.75%)-
BTKinactive (98.23%)-
ITKinactive (104.65%)-
TECinactive (114.21%)-
TXKinactive (103.69%)-
TK - PDGFR

Bioactivity
KinaseRBCMetz
KITinactive (97.69%)-
FLT3inactive (97.21%)-
FMSinactive (109.14%)-
PDGFRbinactive (62.76%)-
PDGFRainactive (101.99%)-
TK - Csk

Bioactivity
KinaseRBCMetz
CSKinactive (89.97%)-
CTKinactive (77.59%)-
TK - DDR

Bioactivity
KinaseRBCMetz
DDR2inactive (100.26%)-
TK - EGFR

Bioactivity
KinaseRBCMetz
EGFRinactive (92.73%)-
ErbB2inactive (105.56%)-
ErbB4inactive (98.1%)-
TK - Eph

Bioactivity
KinaseRBCMetz
EphA1inactive (99.07%)-
EphA2inactive (88.97%)-
EphA3inactive (96.97%)-
EphA4inactive (104.93%)-
EphA5inactive (104.56%)-
EphA6inactive (95%)-
EphA7inactive (79.9%)-
EphA8inactive (98.66%)-
EphB1inactive (100.14%)-
EphB2inactive (106.73%)-
EphB3inactive (65.77%)-
EphB4inactive (83.88%)-
TK - FAK

Bioactivity
KinaseRBCMetz
FAKinactive (98.9%)-
PYK2inactive (101.68%)-
TK - Fer

Bioactivity
KinaseRBCMetz
FERinactive (95.56%)-
FESinactive (99.03%)-
TK - FGFR

Bioactivity
KinaseRBCMetz
FGFR1inactive (99.02%)-
FGFR2inactive (99.51%)-
FGFR3inactive (90.17%)-
FGFR4inactive (96.18%)-
TK - VEGFR

Bioactivity
KinaseRBCMetz
FLT1inactive (101.87%)-
FLT4inactive (97.5%)-
KDRinactive (96.55%)-
TK - InsR

Bioactivity
KinaseRBCMetz
IGF1Rinactive (92.33%)-
IRRinactive (102.41%)-
INSRinactive (104.4%)-
TK - JakA

Bioactivity
KinaseRBCMetz
JAK1inactive (98.82%)-
JAK2inactive (106.83%)-
JAK3inactive (95.72%)-
TYK2inactive (93.46%)-
TK - Musk

Bioactivity
KinaseRBCMetz
MUSKinactive (101.9%)-
TK - Ret

Bioactivity
KinaseRBCMetz
RETinactive (93.12%)-
TK - Met

Bioactivity
KinaseRBCMetz
RONinactive (90.13%)-
METinactive (89.43%)-
TK - Sev

Bioactivity
KinaseRBCMetz
ROSinactive (95.02%)-
TK - Syk

Bioactivity
KinaseRBCMetz
SYKinactive (109.95%)-
ZAP70inactive (100.12%)-
TK - Tie

Bioactivity
KinaseRBCMetz
TIE2inactive (96.73%)-
TK - Trk

Bioactivity
KinaseRBCMetz
TRKAinactive (96.26%)-
TRKBinactive (101.7%)-
TRKCinactive (95.87%)-

TKL


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
1251
531
422
411
211
1052
51-
TKL - STKR

Bioactivity
KinaseRBCMetz
ALK1inactive (99.29%)-
ALK2inactive (105.05%)-
ALK4inactive (113.39%)-
TGFbR1inactive (96.69%)-
TGFbR2inactive (102.17%)-
TKL - RAF

Bioactivity
KinaseRBCMetz
ARAFinactive (99.36%)-
BRAFinactive (94.06%)-
RAF1inactive (97.53%)-
TKL - IRAK

Bioactivity
KinaseRBCMetz
IRAK1inactive (94.2%)-
IRAK4inactive (87.52%)-
TKL - LISK

Bioactivity
KinaseRBCMetz
LIMK1inactive (98.51%)-
TKL - LRRK

Bioactivity
KinaseRBCMetz
LRRK2inactive (82.03%)-
TKL - MLK

Bioactivity
KinaseRBCMetz
MLK1inactive (112.25%)-
MLK2inactive (104.16%)-
MLK3inactive (104.89%)-
TAK1inactive (104.72%)-
ZAKinactive (97.93%)-
TKL - RIPK

Bioactivity
KinaseRBCMetz
RIPK2inactive (101.09%)-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
20139
552
444
111
542
311
554
52-
221
333
332
522
1-1
CAMK - CAMKL

Bioactivity
KinaseRBCMetz
NuaK1inactive (108.41%)-
BRSK1inactive (94.15%)-
BRSK2inactive (96.55%)-
CHK1inactive (89.17%)-
LKB1inactive (99.46%)-
MARK1inactive (131.85%)-
MARK3inactive (98.14%)-
MARK4inactive (102.26%)-
MELKinactive (87.15%)-
PASKinactive (103.04%)-
QIKinactive (95.11%)-
NuaK2inactive (98.72%)-
MARK2inactive (130.96%)-
AMPKa1--
CAMK - CAMK1

Bioactivity
KinaseRBCMetz
CaMK1ainactive (98.11%)-
CaMK1binactive (108.06%)-
CaMK1dinactive (113.75%)-
CaMK1ginactive (108.33%)-
CaMK4inactive (91.87%)-
CAMK - CAMK2

Bioactivity
KinaseRBCMetz
CaMK2ainactive (90.95%)-
CaMK2binactive (104.27%)-
CaMK2dinactive (87.25%)-
CaMK2ginactive (105.43%)-
CAMK - RAD53

Bioactivity
KinaseRBCMetz
CHK2inactive (97.64%)-
CAMK - DAPK

Bioactivity
KinaseRBCMetz
DAPK1inactive (98.16%)-
DAPK2inactive (86.77%)-
DRAK1inactive (100.17%)-
DAPK3inactive (107.03%)-
CAMK - DCAMKL

Bioactivity
KinaseRBCMetz
DCLK2inactive (97.48%)-
DCLK1--
CAMK - MAPKAPK

Bioactivity
KinaseRBCMetz
MAPKAPK2inactive (98.9%)-
MAPKAPK3inactive (99.05%)-
MAPKAPK5inactive (93.38%)-
MNK1inactive (91.43%)-
MNK2inactive (100.81%)-
CAMK - MLCK

Bioactivity
KinaseRBCMetz
smMLCKinactive (101.08%)-
skMLCKinactive (100.8%)-
CAMK - PHK

Bioactivity
KinaseRBCMetz
PHKg1inactive (92.04%)-
PHKg2inactive (93.14%)-
CAMK - PIM

Bioactivity
KinaseRBCMetz
PIM1inactive (98.77%)-
PIM2inactive (98.3%)-
PIM3inactive (97.66%)-
CAMK - PKD

Bioactivity
KinaseRBCMetz
PKD1inactive (97.75%)-
PKD3inactive (85.1%)inactive (2511.89nM)
PKD2inactive (81.84%)inactive (5011.87nM)
CAMK - TSSK

Bioactivity
KinaseRBCMetz
TSSK1inactive (83.02%)-
TSSK2inactive (88.59%)-
CAMK - STK33

Bioactivity
KinaseRBCMetz
STK33inactive (93.97%)-

STE


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
83-
22-
31239
732
STE - STE11

Bioactivity
KinaseRBCMetz
MAP3K5inactive (101.84%)-
MAP3K2inactive (121.52%)-
MAP3K3inactive (118.17%)-
STE - STE-Unique

Bioactivity
KinaseRBCMetz
COTinactive (94.3%)-
NIKinactive (113.96%)-
STE - STE20

Bioactivity
KinaseRBCMetz
GCKinactive (107.96%)-
HGKinactive (108.19%)-
KHS1inactive (98.26%)-
LOKinactive (93.79%)-
MINKinactive (100.39%)-
MST1inactive (100.52%)-
MST2inactive (94.08%)-
MST3inactive (105.33%)-
MST4inactive (117.24%)-
OSR1inactive (96.88%)-
PAK1inactive (110.38%)-
PAK2inactive (100.87%)-
PAK3inactive (98.29%)-
PAK4inactive (92.62%)-
PAK5inactive (96.35%)-
PAK6inactive (103.29%)-
SLKinactive (90.75%)-
YSK1inactive (97.08%)-
STLK3inactive (93.66%)-
TAO1inactive (96.24%)-
TAO2inactive (98.74%)-
TAO3inactive (95.74%)-
MYO3Binactive (99.25%)-
STE - STE7

Bioactivity
KinaseRBCMetz
MAP2K1inactive (88.98%)-
MAP2K2inactive (92.35%)-
MAP2K6inactive (96.54%)-

Other


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
332
221
11-
444
1182
111
433
11-
41-
11-
53-
311
42-
21-
1-1
Other - Aur

Bioactivity
KinaseRBCMetz
AurAinactive (86.43%)-
AurBinactive (91.27%)-
AurCinactive (83.76%)-
Other - CAMKK

Bioactivity
KinaseRBCMetz
CaMKK1inactive (98.9%)-
CaMKK2inactive (101.19%)-
Other - Haspin

Bioactivity
KinaseRBCMetz
Haspininactive (81.27%)-
Other - IKK

Bioactivity
KinaseRBCMetz
IKKainactive (100.37%)-
IKKbinactive (94.85%)-
IKKeinactive (87.96%)-
TBK1inactive (106.41%)-
Other - NEK

Bioactivity
KinaseRBCMetz
NEK1inactive (69.61%)-
NEK11inactive (92.86%)-
NEK2inactive (108.75%)-
NEK4inactive (103.56%)-
NEK6inactive (90.48%)-
NEK7inactive (90.11%)-
NEK9inactive (104.44%)-
NEK3inactive (96%)-
Other - TOPK

Bioactivity
KinaseRBCMetz
PBKinactive (110.3%)-
Other - PLK

Bioactivity
KinaseRBCMetz
PLK1inactive (95.11%)-
PLK2inactive (101.68%)-
PLK3inactive (94.67%)-
PLK4--
Other - SgK496

Bioactivity
KinaseRBCMetz
SgK496inactive (100.68%)-
Other - NAK

Bioactivity
KinaseRBCMetz
MPSK1inactive (100.23%)-
Other - TTK

Bioactivity
KinaseRBCMetz
TTKinactive (98.77%)-
Other - ULK

Bioactivity
KinaseRBCMetz
ULK1inactive (103.57%)-
ULK2inactive (100.83%)-
ULK3inactive (101.14%)-
Other - WEE

Bioactivity
KinaseRBCMetz
Wee1inactive (100.97%)-
Other - WNK

Bioactivity
KinaseRBCMetz
Wnk2inactive (96.42%)-
Wnk3inactive (96.63%)-
Other - TLK

Bioactivity
KinaseRBCMetz
TLK2inactive (95.75%)-
Other - CDC7

Bioactivity
KinaseRBCMetz
CDC7--

CK1


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
765
31-
CK1 - CK1

Bioactivity
KinaseRBCMetz
CK1dinactive (89.8%)-
CK1g1inactive (102.38%)-
CK1g2inactive (99.64%)-
CK1g3inactive (103.46%)-
CK1aactive (0%)-
CK1einactive (98.19%)-
CK1 - VRK

Bioactivity
KinaseRBCMetz
VRK1inactive (104.3%)-

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
321
442
1096
14108
222
331
20-7
CMGC - CK2

Bioactivity
KinaseRBCMetz
CK2a1inactive (110.95%)-
CK2a2inactive (108.53%)-
CMGC - CLK

Bioactivity
KinaseRBCMetz
CLK1inactive (107.64%)-
CLK2inactive (86.92%)-
CLK3inactive (112.37%)-
CLK4inactive (113.91%)-
CMGC - DYRK

Bioactivity
KinaseRBCMetz
DYRK1Ainactive (98.74%)-
DYRK1Binactive (97.05%)-
DYRK2inactive (101.75%)-
DYRK3inactive (104.54%)-
DYRK4inactive (96.26%)-
HIPK1inactive (100.14%)-
HIPK2inactive (100.41%)-
HIPK3inactive (98.4%)-
HIPK4inactive (90.47%)-
CMGC - MAPK

Bioactivity
KinaseRBCMetz
Erk1inactive (95.22%)-
Erk2inactive (85.72%)-
JNK3inactive (98.43%)-
NLKactive (15.78%)-
p38aactive (5.23%)-
p38bactive (22.32%)-
p38dinactive (93.95%)-
p38ginactive (92.09%)-
JNK1inactive (100.35%)-
JNK2inactive (93.53%)-
CMGC - GSK

Bioactivity
KinaseRBCMetz
GSK3Ainactive (98.56%)-
GSK3Binactive (101.43%)-
CMGC - SRPK

Bioactivity
KinaseRBCMetz
MSSK1inactive (105.01%)-
SRPK1inactive (98.96%)-
SRPK2--
CMGC - CDK

Bioactivity
KinaseRBCMetz
CDC2--
CDK2--
CDK5--
CDK8--
CDK7--
CDK9--
CDK11--

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetz
51-
6-1
Atypical - PDHK

Bioactivity
KinaseRBCMetz
PDHK1inactive (87.4%)-
Atypical - Alpha

Bioactivity
KinaseRBCMetz
eEF2K--