Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz

Compound Name
DRx, RBC, Metz : Tozasertib

Inchikey
Same : GCIKSSRWRFVXBI-N
DRx, RBC, Metz : GCIKSSRWRFVXBI-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz : 4591897

Pubchem CID
DRx, RBC, Metz : 5494449

ChEMBL
DRx, RBC, Metz : CHEMBL572878

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
NAK	4	4	1	-
Aur	3	3	3	2
CAMKK	2	2	2	1
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	4
NEK	11	9	8	2
WEE	3	3	1	1
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	-
TLK	2	2	1	-
TTK	1	1	1	-
Haspin	1	-	1	-
TOPK	1	-	1	1
WNK	4	-	2	-
CDC7	1	-	-	1

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz
AAK1	active (290nM)	-	-
BIKE	active (65nM)	-	-
GAK	inactive (3200nM)	-	-
MPSK1	active (610nM)	inactive (52.81%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz
AurA	active (3.9nM)	active (5.19%)	active (3.16nM)
AurB	active (7.4nM)	active (4.89%)	active (5.01nM)
AurC	active (6.3nM)	active (40.42%)	-

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz
CaMKK1	inactive (4600nM)	inactive (85.96%)	-
CaMKK2	inactive (10001nM)	inactive (106.44%)	inactive (>2511.89nM)

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz
HRI	inactive (10001nM)	-	-
PKR	inactive (10001nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz
IRE1	inactive (5600nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz
IKKa	inactive (10001nM)	inactive (99.4%)	inactive (>3981.07nM)
IKKb	inactive (10001nM)	inactive (84.93%)	inactive (>3162.28nM)
IKKe	active (2600nM)	inactive (84.8%)	inactive (>3162.28nM)
TBK1	active (490nM)	inactive (90.53%)	inactive (>1995.26nM)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz
NEK1	inactive (10001nM)	inactive (67.64%)	-
NEK11	inactive (10001nM)	inactive (82.76%)	-
NEK2	inactive (10001nM)	inactive (104.59%)	inactive (>3981.07nM)
NEK3	inactive (10001nM)	inactive (95.05%)	-
NEK4	inactive (10001nM)	inactive (102.79%)	inactive (>6309.57nM)
NEK5	inactive (4200nM)	-	-
NEK6	inactive (10001nM)	inactive (94.17%)	-
NEK7	inactive (8700nM)	inactive (92.83%)	-
NEK9	inactive (10001nM)	inactive (101.75%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz
MYT1	inactive (10001nM)	-	-
Wee1	inactive (3200nM)	inactive (100.44%)	-
Wee1B	inactive (4200nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz
PLK1	inactive (10001nM)	inactive (95.25%)	inactive (>7943.28nM)
PLK2	inactive (10001nM)	inactive (103.79%)	-
PLK3	inactive (10001nM)	inactive (98.77%)	inactive (>7943.28nM)
PLK4	active (9.2nM)	-	active (25.12nM)

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz
SgK496	inactive (10001nM)	inactive (97.17%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz
SBK	inactive (10001nM)	-	-
SgK110	active (530nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz
CLIK1	inactive (10001nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz
Fused	inactive (10001nM)	-	-
ULK1	inactive (10001nM)	inactive (99.23%)	-
ULK2	inactive (10001nM)	inactive (100.73%)	-
ULK3	active (310nM)	inactive (87.33%)	-

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz
TLK1	inactive (4000nM)	-	-
TLK2	inactive (10001nM)	inactive (86.62%)	-

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz
TTK	inactive (8100nM)	inactive (103.95%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz
Haspin	-	inactive (67.95%)	-

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz
PBK	-	inactive (106.56%)	inactive (>10000nM)

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz
Wnk2	-	inactive (96.01%)	-
Wnk3	-	inactive (93.33%)	-

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz
CDC7	-	-	inactive (>1258.93nM)

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Abl	2	2	2	1
ALK	2	2	2	2
Axl	3	3	3	2
Src	11	11	11	9
Tec	5	5	5	3
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	-
EGFR	4	4	3	3
Eph	14	13	12	1
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	2
VEGFR	3	3	3	3
InsR	3	3	3	2
JakA	4	4	4	3
Met	2	2	2	2
Musk	1	1	1	-
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	1
Tie	2	2	1	-
Ack	2	2	1	1
Trk	3	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz
ABL1	active (13nM)	active (13.76%)	active (15.85nM)
ABL2	active (4nM)	active (5.75%)	-

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz
ALK	inactive (3100nM)	inactive (91.46%)	inactive (2511.89nM)
LTK	inactive (7500nM)	inactive (84.19%)	active (501.19nM)

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz
AXL	active (210nM)	active (44.28%)	active (199.53nM)
MER	active (1700nM)	inactive (106.16%)	-
TYRO3	inactive (10001nM)	inactive (84.99%)	inactive (1258.93nM)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz
BLK	active (2200nM)	inactive (81.35%)	active (31.62nM)
BRK	inactive (10001nM)	inactive (94.64%)	-
FGR	active (790nM)	inactive (58.16%)	-
FRK	inactive (3800nM)	inactive (101.33%)	-
FYN	active (530nM)	inactive (72.15%)	inactive (3162.28nM)
HCK	inactive (6200nM)	inactive (82.66%)	inactive (>3162.28nM)
LCK	active (61nM)	active (12.26%)	active (125.89nM)
LYN	active (650nM)	inactive (52.59%)	active (251.19nM)
SRC	active (170nM)	active (26.73%)	active (158.49nM)
SRM	inactive (10001nM)	inactive (95.94%)	-
YES	active (470nM)	active (33.94%)	-

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz
BMX	active (2600nM)	active (40.02%)	-
BTK	inactive (4400nM)	inactive (63.59%)	inactive (1584.89nM)
ITK	active (350nM)	inactive (98.73%)	active (63.1nM)
TEC	inactive (8700nM)	inactive (112.07%)	-
TXK	active (2700nM)	inactive (78.84%)	-

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz
FMS	active (1800nM)	inactive (106.39%)	inactive (>2511.89nM)
FLT3	active (6.5nM)	active (6.67%)	active (398.11nM)
KIT	active (240nM)	inactive (89.2%)	inactive (>5011.87nM)
PDGFRa	active (1600nM)	inactive (71.36%)	inactive (>501.19nM)
PDGFRb	active (310nM)	inactive (71.52%)	active (398.11nM)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz
CSK	inactive (4800nM)	inactive (78.13%)	-
CTK	inactive (10001nM)	inactive (78.65%)	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz
DDR1	active (28nM)	-	-
DDR2	active (230nM)	inactive (61.87%)	-

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz
EGFR	inactive (10001nM)	inactive (93.75%)	inactive (1584.89nM)
ErbB2	inactive (10001nM)	inactive (101.89%)	inactive (>1584.89nM)
ErbB3	inactive (7100nM)	-	-
ErbB4	inactive (10001nM)	inactive (93.12%)	inactive (>3981.07nM)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz
EphA1	active (1000nM)	inactive (78.08%)	-
EphA2	active (840nM)	active (34.43%)	active (630.96nM)
EphA3	active (1500nM)	active (44.21%)	-
EphA4	inactive (4300nM)	inactive (72.07%)	-
EphA5	inactive (10001nM)	inactive (88.01%)	-
EphA6	inactive (4700nM)	active (48.38%)	-
EphA7	inactive (10001nM)	inactive (74.74%)	-
EphA8	active (500nM)	inactive (77.08%)	-
EphB1	active (1900nM)	inactive (69.66%)	-
EphB2	inactive (5600nM)	inactive (78.3%)	-
EphB3	inactive (10001nM)	inactive (62.17%)	-
EphB4	active (1700nM)	active (46.11%)	-
EphB6	active (28nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz
FAK	inactive (10001nM)	inactive (100.26%)	inactive (>6309.57nM)
PYK2	active (2600nM)	inactive (95.49%)	inactive (>1584.89nM)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz
FER	inactive (4200nM)	inactive (92.16%)	-
FES	inactive (7400nM)	inactive (97.21%)	-

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz
FGFR1	active (550nM)	inactive (73.95%)	active (794.33nM)
FGFR2	active (570nM)	inactive (66.37%)	-
FGFR3	active (860nM)	inactive (70.62%)	active (630.96nM)
FGFR4	inactive (7200nM)	inactive (87.76%)	-

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz
FLT1	active (100nM)	inactive (76.96%)	inactive (1258.93nM)
FLT4	active (1900nM)	inactive (55.43%)	inactive (1584.89nM)
KDR	active (2000nM)	inactive (85.27%)	active (316.23nM)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz
IGF1R	active (740nM)	inactive (96.28%)	inactive (>1584.89nM)
INSR	active (630nM)	active (43.5%)	active (1000nM)
IRR	active (290nM)	inactive (52.37%)	-

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz
JAK1	inactive (5900nM)	inactive (91.86%)	-
JAK2	active (190nM)	inactive (75.53%)	active (251.19nM)
JAK3	active (630nM)	inactive (91.8%)	inactive (>5011.87nM)
TYK2	active (510nM)	inactive (67.67%)	active (199.53nM)

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz
MET	active (670nM)	inactive (70.91%)	inactive (>794.33nM)
RON	active (1300nM)	inactive (83.59%)	active (794.33nM)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz
MUSK	active (300nM)	inactive (102.8%)	-

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz
RET	active (28nM)	active (3.91%)	active (12.59nM)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz
ROS	active (610nM)	active (30.22%)	active (158.49nM)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz
SYK	active (1800nM)	inactive (99.19%)	-
ZAP70	inactive (10001nM)	inactive (105.66%)	-

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz
TIE1	active (270nM)	-	-
TIE2	active (450nM)	active (27.77%)	-

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz
TNK1	active (83nM)	-	-
ACK	inactive (4400nM)	inactive (66.43%)	inactive (>3981.07nM)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz
TRKA	active (38nM)	active (6.52%)	active (316.23nM)
TRKB	active (240nM)	active (26.93%)	active (316.23nM)
TRKC	active (200nM)	active (6.04%)	active (630.96nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STKR	12	10	5	1
RIPK	5	4	1	-
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz
ALK2	active (1900nM)	inactive (162.3%)	inactive (1258.93nM)
ALK4	inactive (10001nM)	inactive (114.12%)	-
ACTR2	inactive (10001nM)	-	-
ACTR2B	inactive (10001nM)	-	-
ALK1	inactive (9500nM)	inactive (99.46%)	-
BMPR1A	inactive (10001nM)	-	-
BMPR1B	active (1100nM)	-	-
BMPR2	inactive (7100nM)	-	-
TGFbR1	inactive (8400nM)	inactive (94.74%)	-
TGFbR2	inactive (10001nM)	inactive (101.73%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz
SgK288	inactive (5600nM)	-	-
RIPK1	active (20nM)	-	-
RIPK2	inactive (10001nM)	inactive (103.97%)	-
ANKRD3	active (300nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz
BRAF	inactive (10001nM)	inactive (103.8%)	-
RAF1	inactive (10001nM)	inactive (117.18%)	-
ARAF	-	inactive (122.73%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz
DLK	active (190nM)	-	-
LZK	active (180nM)	-	-
MLK1	active (390nM)	active (38.71%)	-
MLK2	active (1800nM)	inactive (61.05%)	active (398.11nM)
MLK3	active (680nM)	inactive (52.72%)	-
TAK1	active (2300nM)	inactive (90.73%)	-
HH498	inactive (10001nM)	-	-
ZAK	active (2800nM)	inactive (91.04%)	inactive (7943.28nM)

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz
IRAK1	inactive (10001nM)	inactive (91.53%)	inactive (>7943.28nM)
IRAK3	inactive (10001nM)	-	-
IRAK4	inactive (3700nM)	inactive (78%)	inactive (2511.89nM)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz
LIMK1	active (2600nM)	active (33.11%)	active (794.33nM)
LIMK2	active (2600nM)	-	-
TESK1	inactive (5600nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz
LRRK2	inactive (10001nM)	inactive (56.37%)	active (630.96nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
ABC1	5	2	-	-
PIKK	6	1	-	-
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz
ADCK3	inactive (10001nM)	-	-
ADCK4	inactive (10001nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz
FRAP	inactive (10001nM)	-	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz
RIOK1	active (360nM)	-	-
RIOK2	active (250nM)	-	-
RIOK3	active (600nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	inactive (>3981.07nM)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz
PDHK1	-	inactive (82.71%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Akt	3	3	3	3
DMPK	7	7	5	3
GRK	7	3	6	1
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	5
PKG	2	2	3	2
RSK	8	1	8	4
SGK	3	1	3	1
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz
AKT1	inactive (10001nM)	inactive (99.19%)	inactive (>7943.28nM)
AKT2	inactive (10001nM)	inactive (103.23%)	inactive (>7943.28nM)
AKT3	inactive (10001nM)	inactive (85%)	inactive (>10000nM)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz
CRIK	inactive (10001nM)	-	-
DMPK1	inactive (10001nM)	inactive (98.51%)	-
DMPK2	inactive (10001nM)	-	-
MRCKa	inactive (10001nM)	inactive (75.25%)	inactive (>10000nM)
MRCKb	inactive (10001nM)	inactive (101.05%)	-
ROCK1	inactive (10001nM)	inactive (109.68%)	inactive (>3981.07nM)
ROCK2	inactive (10001nM)	inactive (91.99%)	inactive (>3981.07nM)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz
RHOK	inactive (10001nM)	-	-
GPRK4	active (400nM)	inactive (90.32%)	-
GPRK7	inactive (10001nM)	inactive (95.45%)	-
BARK1	-	inactive (107.32%)	-
BARK2	-	inactive (96.06%)	-
GPRK5	-	inactive (103.88%)	inactive (>3981.07nM)
GPRK6	-	inactive (103.97%)	-

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz
LATS1	inactive (5500nM)	-	-
LATS2	inactive (6500nM)	-	-
NDR1	inactive (10001nM)	inactive (97.76%)	-
NDR2	inactive (6900nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz
MAST1	inactive (10001nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz
PDK1	inactive (10001nM)	inactive (82.71%)	inactive (2511.89nM)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz
PKACa	inactive (10001nM)	inactive (98.11%)	inactive (>3981.07nM)
PKACb	inactive (10001nM)	-	-
PRKX	inactive (10001nM)	inactive (136.86%)	inactive (>3162.28nM)
PKACg	-	inactive (112%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz
PKN1	active (1500nM)	inactive (82.56%)	-
PKN2	inactive (5000nM)	inactive (99.8%)	inactive (5011.87nM)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz
PKCd	inactive (10001nM)	inactive (97.51%)	inactive (>7943.28nM)
PKCe	inactive (10001nM)	inactive (97.8%)	-
PKCh	inactive (10001nM)	inactive (111.23%)	-
PKCi	inactive (10001nM)	inactive (98.92%)	-
PKCt	inactive (5300nM)	inactive (86.03%)	inactive (>1995.26nM)
PKCa	-	inactive (81.97%)	-
PKCg	-	inactive (94.16%)	inactive (>7943.28nM)
PKCz	-	inactive (76.35%)	inactive (7943.28nM)
PKCb	-	inactive (89.72%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz
PKG1	inactive (10001nM)	inactive (90.8%)	inactive (>1995.26nM)
PKG2	inactive (10001nM)	inactive (105.45%)	inactive (>1584.89nM)

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz
p70S6K	inactive (10001nM)	inactive (95.96%)	inactive (3162.28nM)
MSK1	-	inactive (85.7%)	inactive (>1995.26nM)
MSK2	-	inactive (100.03%)	-
p70S6Kb	-	inactive (94.43%)	-
RSK2	-	inactive (82.13%)	inactive (>3981.07nM)
RSK4	-	inactive (90.73%)	-
RSK1	-	inactive (103.02%)	-
RSK3	-	inactive (76.05%)	-

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz
SGK3	inactive (10001nM)	inactive (101.32%)	-
SGK1	-	inactive (115.85%)	inactive (>6309.57nM)
SGK2	-	inactive (95.47%)	-

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz
YANK1	inactive (10001nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CAMKL	20	19	13	9
CAMK1	5	4	5	2
CAMK2	4	4	4	4
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	2
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	-
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	1
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz
AMPKa1	active (1100nM)	-	inactive (2511.89nM)
AMPKa2	active (350nM)	-	-
NuaK1	active (200nM)	active (18.54%)	-
BRSK1	inactive (8400nM)	inactive (112.11%)	inactive (6309.57nM)
BRSK2	inactive (10001nM)	inactive (89.6%)	-
CHK1	inactive (8700nM)	inactive (77.09%)	inactive (>3162.28nM)
HUNK	inactive (9800nM)	-	-
LKB1	active (1300nM)	inactive (101.84%)	-
MARK1	inactive (4900nM)	inactive (114.08%)	-
MARK2	active (1400nM)	inactive (117.58%)	active (1000nM)
MARK3	active (2500nM)	inactive (96.91%)	inactive (3981.07nM)
MARK4	inactive (4900nM)	inactive (87.42%)	active (1000nM)
MELK	active (240nM)	inactive (53.45%)	active (39.81nM)
NIM1	inactive (10001nM)	-	-
QSK	inactive (10001nM)	-	-
SIK	active (2500nM)	-	-
QIK	active (1700nM)	inactive (79.95%)	active (1000nM)
NuaK2	active (530nM)	inactive (77.54%)	-
SNRK	inactive (10001nM)	-	-
PASK	-	inactive (99.17%)	inactive (>1584.89nM)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz
CaMK1a	inactive (7000nM)	inactive (102.98%)	inactive (>7943.28nM)
CaMK1d	inactive (4900nM)	inactive (110.07%)	inactive (>2511.89nM)
CaMK1g	inactive (6500nM)	inactive (110.87%)	-
CaMK4	inactive (10001nM)	inactive (93.9%)	-
CaMK1b	-	inactive (99.01%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz
CaMK2a	inactive (10001nM)	inactive (84.06%)	inactive (>3981.07nM)
CaMK2b	inactive (10001nM)	inactive (118.49%)	inactive (>7943.28nM)
CaMK2d	inactive (10001nM)	inactive (87.11%)	inactive (>6309.57nM)
CaMK2g	inactive (10001nM)	inactive (108.93%)	inactive (>6309.57nM)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz
CHK2	inactive (10001nM)	inactive (100.31%)	inactive (>2511.89nM)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz
DAPK1	inactive (10001nM)	inactive (102.24%)	-
DAPK2	inactive (10001nM)	inactive (98.15%)	-
DAPK3	inactive (9900nM)	inactive (109.32%)	inactive (>5011.87nM)
DRAK1	inactive (9000nM)	inactive (104.23%)	-
DRAK2	inactive (10001nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz
DCLK1	inactive (10001nM)	-	inactive (>10000nM)
DCLK2	inactive (10001nM)	inactive (99.15%)	-
DCLK3	inactive (3600nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz
MAPKAPK2	inactive (3800nM)	inactive (100.53%)	inactive (>7943.28nM)
MAPKAPK5	inactive (10001nM)	inactive (95.8%)	inactive (>1584.89nM)
MNK1	inactive (10001nM)	inactive (92.83%)	-
MNK2	inactive (5200nM)	inactive (97.61%)	inactive (>10000nM)
MAPKAPK3	-	inactive (97.71%)	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz
caMLCK	active (15nM)	-	-
smMLCK	inactive (10001nM)	inactive (96.96%)	-
skMLCK	active (43nM)	active (18.9%)	-
SgK085	active (2200nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz
PHKg1	active (2200nM)	inactive (69.92%)	-
PHKg2	inactive (4400nM)	inactive (90.55%)	inactive (>5011.87nM)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz
PIM1	inactive (10001nM)	inactive (98.61%)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (97.31%)	inactive (>1584.89nM)
PIM3	inactive (10001nM)	inactive (101.1%)	-

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz
PKD1	inactive (10001nM)	inactive (101.68%)	-
PKD2	inactive (10001nM)	inactive (77.31%)	inactive (5011.87nM)
PKD3	inactive (10001nM)	inactive (86.63%)	inactive (>3981.07nM)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz
STK33	inactive (10001nM)	inactive (90.11%)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz
TSSK1	inactive (10001nM)	inactive (90.51%)	inactive (>1584.89nM)
TSSK2	-	inactive (83.85%)	inactive (>1584.89nM)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STE11	8	8	3	-
STE20	31	27	23	9
STE7	7	7	3	2
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz
MAP3K5	inactive (10001nM)	inactive (102.08%)	-
MAP3K6	inactive (10001nM)	-	-
MAP3K1	inactive (10001nM)	-	-
MAP3K7	inactive (10001nM)	-	-
MAP3K2	active (1100nM)	inactive (116.44%)	-
MAP3K3	active (1900nM)	inactive (113.49%)	-
MAP3K4	active (2500nM)	-	-
MAP3K8	active (51nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz
HPK1	active (72nM)	-	-
LOK	active (120nM)	active (40.6%)	-
GCK	active (2600nM)	inactive (102.33%)	inactive (>3162.28nM)
KHS2	active (290nM)	-	-
HGK	active (2400nM)	inactive (92.78%)	inactive (>5011.87nM)
KHS1	active (83nM)	active (18.29%)	active (158.49nM)
MINK	active (1100nM)	inactive (83.04%)	inactive (6309.57nM)
MST1	active (200nM)	active (48.86%)	-
MST2	active (510nM)	inactive (80.23%)	inactive (>2511.89nM)
MST3	inactive (3600nM)	inactive (96.73%)	-
MST4	inactive (3500nM)	inactive (130.05%)	-
MYO3A	inactive (10001nM)	-	-
MYO3B	inactive (10001nM)	inactive (92.78%)	-
OSR1	inactive (10001nM)	inactive (99.47%)	-
PAK1	inactive (4400nM)	inactive (100.47%)	inactive (7943.28nM)
PAK2	inactive (5700nM)	inactive (93.08%)	-
PAK3	inactive (3300nM)	inactive (87.68%)	-
PAK4	inactive (4300nM)	inactive (85.44%)	inactive (3981.07nM)
PAK6	inactive (9700nM)	inactive (103.93%)	-
PAK5	inactive (3300nM)	inactive (91.71%)	-
SLK	active (82nM)	inactive (59.59%)	active (501.19nM)
STLK3	inactive (10001nM)	inactive (94.85%)	-
TAO1	active (290nM)	active (44.65%)	active (79.43nM)
TAO2	active (430nM)	active (18.65%)	-
TAO3	active (81nM)	inactive (76.3%)	-
TNIK	active (1800nM)	-	-
YSK1	inactive (4800nM)	inactive (94.76%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz
MAP2K1	active (1800nM)	inactive (89.67%)	inactive (1258.93nM)
MAP2K2	active (2000nM)	inactive (91.34%)	inactive (1995.26nM)
MAP2K3	inactive (10001nM)	-	-
MAP2K4	inactive (10001nM)	-	-
MAP2K5	active (260nM)	-	-
MAP2K6	active (2600nM)	inactive (98.64%)	-
MAP2K7	inactive (10001nM)	-	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz
COT	-	inactive (114.59%)	-
NIK	-	inactive (110.51%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CDK	20	8	-	7
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	1
DYRK	10	8	9	6
MAPK	14	14	10	8
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz
PITSLRE	active (290nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (10001nM)	-	active (199.53nM)
PCTAIRE1	active (230nM)	-	-
PCTAIRE2	inactive (5600nM)	-	-
PCTAIRE3	inactive (10001nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	inactive (10001nM)	-	-
CDC2	-	-	inactive (>7943.28nM)
CDK2	-	-	inactive (>7943.28nM)
CDK5	-	-	inactive (>3162.28nM)
CDK8	-	-	inactive (>3981.07nM)
CDK7	-	-	inactive (>3981.07nM)
CDK9	-	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz
CDKL1	inactive (10001nM)	-	-
CDKL2	active (49nM)	-	-
CDKL3	active (350nM)	-	-
CDKL5	active (2800nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz
CLK1	inactive (10001nM)	inactive (106.46%)	-
CLK2	inactive (10001nM)	inactive (88%)	inactive (>3981.07nM)
CLK3	inactive (10001nM)	inactive (109.96%)	-
CLK4	inactive (10001nM)	inactive (90.04%)	inactive (>3162.28nM)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz
CK2a1	inactive (10001nM)	inactive (114.11%)	inactive (>6309.57nM)
CK2a2	inactive (10001nM)	inactive (120.5%)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz
DYRK1A	inactive (10001nM)	inactive (98.44%)	inactive (>1995.26nM)
DYRK1B	inactive (10001nM)	inactive (98.82%)	inactive (>2511.89nM)
DYRK2	inactive (10001nM)	inactive (101.31%)	-
HIPK1	inactive (10001nM)	inactive (98.59%)	-
HIPK2	inactive (10001nM)	inactive (101.95%)	inactive (>3162.28nM)
HIPK3	inactive (10001nM)	inactive (99.11%)	-
HIPK4	inactive (10001nM)	inactive (95.26%)	inactive (>7943.28nM)
PRP4	active (2500nM)	-	-
DYRK3	-	inactive (105.47%)	inactive (>6309.57nM)
DYRK4	-	inactive (97.44%)	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz
Erk1	inactive (10001nM)	inactive (96.05%)	-
Erk2	inactive (10001nM)	inactive (91.22%)	inactive (>7943.28nM)
Erk3	inactive (10001nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (6800nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	inactive (10001nM)	inactive (95.39%)	inactive (>5011.87nM)
JNK2	inactive (10001nM)	inactive (108.41%)	inactive (>3981.07nM)
JNK3	active (2800nM)	inactive (106.54%)	inactive (1995.26nM)
NLK	inactive (10001nM)	inactive (102.52%)	-
p38a	inactive (10001nM)	inactive (97.15%)	inactive (>3981.07nM)
p38b	inactive (10001nM)	inactive (93.48%)	-
p38d	inactive (10001nM)	inactive (89.5%)	inactive (>7943.28nM)
p38g	inactive (10001nM)	inactive (96.22%)	inactive (>6309.57nM)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz
GSK3A	inactive (10001nM)	inactive (101.05%)	inactive (>3981.07nM)
GSK3B	inactive (10001nM)	inactive (104.07%)	inactive (>3981.07nM)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz
ICK	inactive (10001nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz
SRPK1	active (82nM)	inactive (96.44%)	inactive (>7943.28nM)
SRPK2	active (680nM)	inactive (94.65%)	-
MSSK1	active (240nM)	inactive (105.34%)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CK1	7	7	6	5
VRK	3	1	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz
CK1a	inactive (10001nM)	inactive (96.67%)	inactive (>3981.07nM)
CK1a2	inactive (10001nM)	-	-
CK1d	inactive (10001nM)	inactive (92.6%)	inactive (>7943.28nM)
CK1e	inactive (10001nM)	inactive (98.78%)	-
CK1g1	inactive (10001nM)	inactive (99.08%)	inactive (>6309.57nM)
CK1g2	inactive (10001nM)	inactive (96.15%)	inactive (>7943.28nM)
CK1g3	inactive (10001nM)	inactive (100.26%)	-

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz
VRK2	inactive (10001nM)	-	-
VRK1	-	inactive (107.36%)	-