Compound in Profiling

Compound Information

Test on : Millipore

Compound Name : -

Inchikey : HBDSHCUSXQATPO-BGBJRWHRSA-N

ChemSpider : 21105558

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
Abl	2	2
Ack	2	1
ALK	2	1
Axl	3	3
Src	11	10
Tec	5	4
PDGFR	5	5
Csk	2	1
DDR	2	1
EGFR	4	2
Eph	14	11
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	2
Met	2	2
Musk	1	1
Ret	1	1
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	2

TK - Abl

Bioactivity
Kinase	Millipore
ABL1	active (49%)
ABL2	active (30%)

TK - Ack

Bioactivity
Kinase	Millipore
ACK	active (34%)

TK - ALK

Bioactivity
Kinase	Millipore
ALK	inactive (52%)

TK - Axl

Bioactivity
Kinase	Millipore
AXL	active (17%)
MER	active (-2%)
TYRO3	inactive (62%)

TK - Src

Bioactivity
Kinase	Millipore
BLK	active (11%)
BRK	inactive (91%)
SRC	active (35%)
FGR	active (8%)
FYN	active (5%)
HCK	active (15%)
LCK	active (13%)
LYN	active (8%)
FRK	active (13%)
YES	active (17%)

TK - Tec

Bioactivity
Kinase	Millipore
BMX	active (21%)
BTK	active (31%)
ITK	active (19%)
TXK	active (45%)

TK - PDGFR

Bioactivity
Kinase	Millipore
KIT	active (20%)
FLT3	active (1%)
FMS	active (15%)
PDGFRa	inactive (87%)
PDGFRb	inactive (84%)

TK - Csk

Bioactivity
Kinase	Millipore
CSK	inactive (101%)

TK - DDR

Bioactivity
Kinase	Millipore
DDR2	inactive (94%)

TK - EGFR

Bioactivity
Kinase	Millipore
EGFR	active (15%)
ErbB4	inactive (107%)

TK - Eph

Bioactivity
Kinase	Millipore
EphA1	inactive (55%)
EphA2	inactive (61%)
EphA3	inactive (58%)
EphA4	inactive (96%)
EphA5	inactive (59%)
EphA7	inactive (70%)
EphA8	inactive (84%)
EphB1	inactive (59%)
EphB2	inactive (91%)
EphB3	inactive (105%)
EphB4	inactive (67%)

TK - FAK

Bioactivity
Kinase	Millipore
FAK	active (39%)
PYK2	active (14%)

TK - Fer

Bioactivity
Kinase	Millipore
FER	inactive (70%)
FES	inactive (72%)

TK - FGFR

Bioactivity
Kinase	Millipore
FGFR1	active (3%)
FGFR2	active (22%)
FGFR3	active (20%)
FGFR4	inactive (100%)

TK - VEGFR

Bioactivity
Kinase	Millipore
FLT1	active (1%)
FLT4	active (-1%)
KDR	active (4%)

TK - InsR

Bioactivity
Kinase	Millipore
IGF1R	active (37%)
INSR	active (17%)
IRR	active (2%)

TK - JakA

Bioactivity
Kinase	Millipore
JAK2	inactive (92%)
JAK3	active (21%)

TK - Met

Bioactivity
Kinase	Millipore
MET	inactive (86%)
RON	inactive (86%)

TK - Musk

Bioactivity
Kinase	Millipore
MUSK	inactive (58%)

TK - Ret

Bioactivity
Kinase	Millipore
RET	active (1%)

TK - Sev

Bioactivity
Kinase	Millipore
ROS	inactive (105%)

TK - Syk

Bioactivity
Kinase	Millipore
SYK	active (49%)
ZAP70	inactive (79%)

TK - Tie

Bioactivity
Kinase	Millipore
TIE2	inactive (103%)

TK - Trk

Bioactivity
Kinase	Millipore
TRKA	active (0%)
TRKB	active (0%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
STKR	12	2
RAF	5	1
IRAK	4	2
LISK	4	1
MLK	10	2
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	Millipore
ALK4	inactive (104%)
TGFbR1	inactive (104%)

TKL - RAF

Bioactivity
Kinase	Millipore
RAF1	inactive (89%)

TKL - IRAK

Bioactivity
Kinase	Millipore
IRAK1	inactive (60%)
IRAK4	active (41%)

TKL - LISK

Bioactivity
Kinase	Millipore
LIMK1	inactive (61%)

TKL - MLK

Bioactivity
Kinase	Millipore
MLK1	active (6%)
TAK1	inactive (64%)

TKL - RIPK

Bioactivity
Kinase	Millipore
RIPK2	inactive (60%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
CAMKL	20	12
CAMK1	5	3
CAMK2	4	3
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	4
MLCK	5	1
PHK	2	1
PIM	3	3
PKD	3	2
STK33	1	-
TSSK	5	2

CAMK - CAMKL

Bioactivity
Kinase	Millipore
AMPKa1	active (2%)
AMPKa2	active (1%)
NuaK1	active (4%)
BRSK1	active (13%)
BRSK2	active (10%)
CHK1	inactive (65%)
LKB1	inactive (83%)
MARK1	active (37%)
MELK	active (15%)
MARK2	active (48%)
PASK	inactive (112%)
SIK	active (43%)

CAMK - CAMK1

Bioactivity
Kinase	Millipore
CaMK1a	inactive (72%)
CaMK4	inactive (66%)
CaMK1d	inactive (71%)

CAMK - CAMK2

Bioactivity
Kinase	Millipore
CaMK2b	active (33%)
CaMK2g	active (12%)
CaMK2d	active (10%)

CAMK - RAD53

Bioactivity
Kinase	Millipore
CHK2	active (13%)

CAMK - DAPK

Bioactivity
Kinase	Millipore
DAPK1	inactive (91%)
DAPK2	inactive (73%)
DRAK1	active (6%)
DAPK3	inactive (81%)

CAMK - DCAMKL

Bioactivity
Kinase	Millipore
DCLK2	inactive (119%)

CAMK - MAPKAPK

Bioactivity
Kinase	Millipore
MAPKAPK2	inactive (101%)
MAPKAPK3	inactive (117%)
MNK2	inactive (62%)
MAPKAPK5	inactive (78%)

CAMK - MLCK

Bioactivity
Kinase	Millipore
smMLCK	active (46%)

CAMK - PHK

Bioactivity
Kinase	Millipore
PHKg2	active (25%)

CAMK - PIM

Bioactivity
Kinase	Millipore
PIM1	inactive (76%)
PIM2	inactive (68%)
PIM3	inactive (94%)

CAMK - PKD

Bioactivity
Kinase	Millipore
PKD1	inactive (113%)
PKD2	inactive (109%)

CAMK - STK33

Bioactivity
Kinase	Millipore
STK33	active (43%)

CAMK - TSSK

Bioactivity
Kinase	Millipore
TSSK1	inactive (78%)
TSSK2	inactive (95%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
STE11	8	1
STE20	31	14
STE7	7	3

STE - STE11

Bioactivity
Kinase	Millipore
MAP3K5	inactive (52%)

STE - STE20

Bioactivity
Kinase	Millipore
GCK	active (13%)
LOK	inactive (66%)
MINK	inactive (54%)
MST1	active (8%)
MST2	active (6%)
MST3	active (42%)
PAK2	inactive (103%)
PAK3	inactive (88%)
PAK4	inactive (55%)
PAK5	inactive (64%)
PAK6	inactive (63%)
TAO1	inactive (83%)
TAO2	inactive (75%)
TAO3	inactive (85%)

STE - STE7

Bioactivity
Kinase	Millipore
MAP2K1	inactive (64%)
MAP2K6	inactive (63%)
MAP2K7	inactive (52%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
Aur	3	3
Haspin	1	1
IKK	4	3
NEK	11	5
PLK	4	3
TLK	2	1
ULK	5	2
WNK	4	2

Other - Aur

Bioactivity
Kinase	Millipore
AurA	active (7%)
AurB	active (1%)
AurC	inactive (61%)

Other - Haspin

Bioactivity
Kinase	Millipore
Haspin	active (26%)

Other - IKK

Bioactivity
Kinase	Millipore
IKKa	inactive (76%)
IKKb	inactive (87%)
TBK1	active (9%)

Other - NEK

Bioactivity
Kinase	Millipore
NEK11	inactive (70%)
NEK2	inactive (93%)
NEK3	inactive (86%)
NEK6	inactive (91%)
NEK7	inactive (106%)

Other - PLK

Bioactivity
Kinase	Millipore
PLK1	inactive (83%)
PLK3	inactive (96%)
PLK2	inactive (97%)

Other - TLK

Bioactivity
Kinase	Millipore
TLK2	inactive (60%)

Other - ULK

Bioactivity
Kinase	Millipore
ULK2	inactive (93%)
ULK3	inactive (55%)

Other - WNK

Bioactivity
Kinase	Millipore
Wnk2	inactive (90%)
Wnk3	inactive (89%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
CK1	7	4
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	Millipore
CK1g1	inactive (57%)
CK1g2	inactive (64%)
CK1g3	inactive (63%)
CK1d	active (14%)

CK1 - VRK

Bioactivity
Kinase	Millipore
VRK2	inactive (71%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
CK2	3	2
CLK	4	2
DYRK	10	4
GSK	2	2
MAPK	14	10
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	Millipore
CK2a1	inactive (112%)
CK2a2	inactive (102%)

CMGC - CLK

Bioactivity
Kinase	Millipore
CLK2	active (14%)
CLK3	inactive (79%)

CMGC - DYRK

Bioactivity
Kinase	Millipore
DYRK2	inactive (79%)
HIPK1	inactive (90%)
HIPK2	active (48%)
HIPK3	inactive (88%)

CMGC - GSK

Bioactivity
Kinase	Millipore
GSK3A	active (5%)
GSK3B	active (10%)

CMGC - MAPK

Bioactivity
Kinase	Millipore
JNK1	inactive (63%)
JNK2	inactive (55%)
JNK3	active (7%)
Erk1	inactive (114%)
Erk2	inactive (104%)
NLK	inactive (82%)
p38a	inactive (94%)
p38b	inactive (101%)
p38g	inactive (95%)
p38d	inactive (90%)

CMGC - SRPK

Bioactivity
Kinase	Millipore
MSSK1	inactive (85%)
SRPK1	inactive (90%)
SRPK2	inactive (96%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
DMPK	7	5
GRK	7	3
RSK	8	7
PDK1	1	1
PKA	5	2
Akt	3	3
PKC	9	8
PKN	3	1
SGK	3	3

AGC - DMPK

Bioactivity
Kinase	Millipore
DMPK1	inactive (109%)
MRCKa	inactive (142%)
MRCKb	inactive (106%)
ROCK1	inactive (108%)
ROCK2	inactive (85%)

AGC - GRK

Bioactivity
Kinase	Millipore
GPRK5	inactive (92%)
GPRK6	inactive (81%)
GPRK7	inactive (73%)

AGC - RSK

Bioactivity
Kinase	Millipore
MSK1	inactive (61%)
MSK2	active (32%)
p70S6K	active (37%)
RSK3	active (40%)
RSK2	active (50%)
RSK1	active (19%)
RSK4	active (20%)

AGC - PDK1

Bioactivity
Kinase	Millipore
PDK1	inactive (53%)

AGC - PKA

Bioactivity
Kinase	Millipore
PKACa	inactive (90%)
PRKX	active (48%)

AGC - Akt

Bioactivity
Kinase	Millipore
AKT1	inactive (107%)
AKT2	inactive (98%)
AKT3	inactive (95%)

AGC - PKC

Bioactivity
Kinase	Millipore
PKCa	inactive (93%)
PKCg	inactive (92%)
PKCd	inactive (85%)
PKCe	inactive (106%)
PKCz	inactive (101%)
PKCh	inactive (91%)
PKCt	inactive (81%)
PKCi	inactive (96%)

AGC - PKN

Bioactivity
Kinase	Millipore
PKN2	inactive (91%)

AGC - SGK

Bioactivity
Kinase	Millipore
SGK1	inactive (59%)
SGK2	inactive (61%)
SGK3	inactive (89%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	Millipore
Alpha	6	1
PIKK	6	1

Atypical - Alpha

Bioactivity
Kinase	Millipore
eEF2K	inactive (109%)

Atypical - PIKK

Bioactivity
Kinase	Millipore
FRAP	inactive (100%)