Compound Information


Test on : Metz, GPCR

Compound Name
Metz, GPCR : GW843682X

Inchikey
Same : JSKUWFIZUALZLX-N
Metz, GPCR : JSKUWFIZUALZLX-UHFFFAOYSA-N

ChemSpider
Metz, GPCR : 8002051

Pubchem CID
Metz, GPCR : 9826308

ChEMBL
Metz, GPCR : CHEMBL514499




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
333
734
712
111
521
955
222
31-
847
313
AGC - Akt

Bioactivity
KinaseMetzGPCR
AKT1inactive (>7943.28nM)inactive (-2.44%)
AKT2inactive (>7943.28nM)inactive (-2.54%)
AKT3inactive (>10000nM)inactive (-1.66%)
AGC - DMPK

Bioactivity
KinaseMetzGPCR
MRCKainactive (>10000nM)inactive (-3.27%)
ROCK1inactive (>10000nM)inactive (4.31%)
ROCK2inactive (>7943.28nM)inactive (8.03%)
MRCKb-inactive (-0.14%)
AGC - GRK

Bioactivity
KinaseMetzGPCR
GPRK5--
GPRK7-inactive (6.72%)
GPRK6-inactive (0.91%)
AGC - PDK1

Bioactivity
KinaseMetzGPCR
PDK1inactive (>3981.07nM)inactive (7.65%)
AGC - PKA

Bioactivity
KinaseMetzGPCR
PKACainactive (>7943.28nM)-
PRKXactive (1000nM)inactive (2.8%)
AGC - PKC

Bioactivity
KinaseMetzGPCR
PKCd--
PKCginactive (>7943.28nM)inactive (0.51%)
PKCzinactive (>7943.28nM)-
PKCi-inactive (3.32%)
PKCt-inactive (3.1%)
PKCh-inactive (5.95%)
PKCa-inactive (-2.48%)
AGC - PKG

Bioactivity
KinaseMetzGPCR
PKG1active (316.23nM)inactive (0.86%)
PKG2inactive (>1584.89nM)inactive (1.12%)
AGC - PKN

Bioactivity
KinaseMetzGPCR
PKN2inactive (>7943.28nM)-
AGC - RSK

Bioactivity
KinaseMetzGPCR
RSK2inactive (7943.28nM)inactive (11.05%)
p70S6Kinactive (>6309.57nM)inactive (3.22%)
MSK1active (251.19nM)inactive (1.02%)
MSK2-inactive (5.14%)
RSK1-inactive (9.54%)
RSK4-inactive (23.62%)
RSK3-inactive (8.42%)
AGC - SGK

Bioactivity
KinaseMetzGPCR
SGK1inactive (>10000nM)inactive (1.49%)
SGK3-inactive (1.64%)
SGK2-inactive (0.81%)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
61-
Atypical - Alpha

Bioactivity
KinaseMetzGPCR
eEF2Kinactive (>3981.07nM)-

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
522
442
20913
521
311
545
212
333
323
111
11-
522
CAMK - CAMK1

Bioactivity
KinaseMetzGPCR
CaMK1ainactive (>7943.28nM)-
CaMK1d-inactive (-1.9%)
CaMK4-inactive (-1.47%)
CAMK - CAMK2

Bioactivity
KinaseMetzGPCR
CaMK2binactive (>7943.28nM)-
CaMK2dinactive (>6309.57nM)inactive (7.03%)
CaMK2ginactive (>6309.57nM)-
CaMK2a-inactive (-0.1%)
CAMK - CAMKL

Bioactivity
KinaseMetzGPCR
CHK1-inactive (3.46%)
BRSK1active (251.19nM)inactive (41.06%)
MARK2inactive (>7943.28nM)-
MARK3inactive (>6309.57nM)inactive (21.53%)
MELKactive (158.49nM)inactive (10.35%)
AMPKa1inactive (>5011.87nM)inactive (19.15%)
PASKinactive (>1584.89nM)inactive (0.3%)
MARK4-inactive (18.37%)
QIK-inactive (35.44%)
MARK1-inactive (22.1%)
SIK-active (56.61%)
NuaK1-active (65.53%)
BRSK2-active (52.38%)
AMPKa2-inactive (6.24%)
CAMK - DAPK

Bioactivity
KinaseMetzGPCR
DAPK3inactive (>1258.93nM)-
DRAK1--
DAPK1-inactive (-4.22%)
CAMK - DCAMKL

Bioactivity
KinaseMetzGPCR
DCLK1inactive (>10000nM)-
DCLK2-inactive (-0.6%)
CAMK - MAPKAPK

Bioactivity
KinaseMetzGPCR
MAPKAPK2inactive (>7943.28nM)inactive (1.47%)
MAPKAPK3inactive (>10000nM)inactive (4.41%)
MNK2inactive (>10000nM)inactive (7.89%)
MAPKAPK5active (63.1nM)inactive (2.23%)
MNK1-inactive (7.06%)
CAMK - PHK

Bioactivity
KinaseMetzGPCR
PHKg2inactive (>5011.87nM)inactive (6.56%)
PHKg1-inactive (8.75%)
CAMK - PIM

Bioactivity
KinaseMetzGPCR
PIM1inactive (>10000nM)inactive (2.8%)
PIM2inactive (>1584.89nM)inactive (-2.85%)
PIM3-inactive (5.54%)
CAMK - PKD

Bioactivity
KinaseMetzGPCR
PKD3inactive (>10000nM)inactive (-0.49%)
PKD2inactive (>10000nM)inactive (-1.87%)
PKD1-inactive (0.99%)
CAMK - RAD53

Bioactivity
KinaseMetzGPCR
CHK2inactive (>5011.87nM)inactive (5.56%)
CAMK - STK33

Bioactivity
KinaseMetzGPCR
STK33--
CAMK - TSSK

Bioactivity
KinaseMetzGPCR
TSSK1active (199.53nM)inactive (6.32%)
TSSK2active (63.1nM)inactive (2.55%)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
754
CK1 - CK1

Bioactivity
KinaseMetzGPCR
CK1ainactive (>6309.57nM)inactive (3.61%)
CK1dinactive (>7943.28nM)-
CK1g1inactive (>6309.57nM)inactive (2.06%)
CK1g2inactive (>7943.28nM)inactive (1.15%)
CK1g3-inactive (1.63%)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
207-
311
422
1065
222
1486
312
CMGC - CDK

Bioactivity
KinaseMetzGPCR
CDC2inactive (>7943.28nM)-
CDK2inactive (>7943.28nM)-
CDK5inactive (>10000nM)-
CDK8--
CDK7--
CDK9--
CDK11inactive (>100000nM)-
CMGC - CK2

Bioactivity
KinaseMetzGPCR
CK2a1-inactive (8.83%)
CMGC - CLK

Bioactivity
KinaseMetzGPCR
CLK2inactive (>7943.28nM)inactive (6.82%)
CLK4active (398.11nM)-
CLK3-inactive (-2.17%)
CMGC - DYRK

Bioactivity
KinaseMetzGPCR
DYRK1Ainactive (5011.87nM)inactive (2.2%)
DYRK3inactive (>6309.57nM)-
DYRK4--
HIPK2inactive (>3162.28nM)-
HIPK4inactive (>7943.28nM)inactive (40.65%)
DYRK1B-inactive (-2.84%)
HIPK1-inactive (4.22%)
DYRK2-inactive (3.25%)
CMGC - GSK

Bioactivity
KinaseMetzGPCR
GSK3Ainactive (>7943.28nM)inactive (4.9%)
GSK3Binactive (1995.26nM)inactive (7.21%)
CMGC - MAPK

Bioactivity
KinaseMetzGPCR
Erk2inactive (>7943.28nM)inactive (6.38%)
p38ginactive (>6309.57nM)-
p38dinactive (>7943.28nM)inactive (5.14%)
JNK1inactive (>3162.28nM)-
JNK2inactive (>3981.07nM)inactive (2.16%)
p38a-inactive (9.56%)
JNK3--
NLK--
p38b-inactive (7.82%)
Erk1-inactive (3.77%)
CMGC - SRPK

Bioactivity
KinaseMetzGPCR
SRPK1inactive (>7943.28nM)inactive (0.47%)
MSSK1-inactive (5.51%)

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
323
21-
11-
444
1125
431
11-
31-
1-1
Other - Aur

Bioactivity
KinaseMetzGPCR
AurBinactive (>6309.57nM)inactive (26.55%)
AurAinactive (>3981.07nM)inactive (13.73%)
AurC-inactive (35.93%)
Other - CAMKK

Bioactivity
KinaseMetzGPCR
CaMKK2--
Other - CDC7

Bioactivity
KinaseMetzGPCR
CDC7inactive (>1258.93nM)-
Other - IKK

Bioactivity
KinaseMetzGPCR
IKKe-inactive (5.84%)
TBK1-inactive (13.58%)
IKKainactive (>3981.07nM)inactive (3.6%)
IKKbinactive (>3162.28nM)inactive (5.75%)
Other - NEK

Bioactivity
KinaseMetzGPCR
NEK2active (501.19nM)inactive (17.09%)
NEK4inactive (>6309.57nM)-
NEK1-inactive (19.05%)
NEK9-active (58.69%)
NEK7-inactive (5.2%)
NEK6-inactive (2.1%)
Other - PLK

Bioactivity
KinaseMetzGPCR
PLK1active (12.59nM)active (96.27%)
PLK3active (7.94nM)-
PLK4active (199.53nM)-
Other - TOPK

Bioactivity
KinaseMetzGPCR
PBKinactive (>10000nM)-
Other - WEE

Bioactivity
KinaseMetzGPCR
Wee1--
Other - TTK

Bioactivity
KinaseMetzGPCR
TTK-inactive (10.1%)

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
31912
721
STE - STE20

Bioactivity
KinaseMetzGPCR
GCKinactive (>6309.57nM)inactive (18.1%)
HGKactive (251.19nM)inactive (30.15%)
KHS1active (199.53nM)-
MINKinactive (>7943.28nM)inactive (25.5%)
PAK1inactive (>10000nM)inactive (7.26%)
PAK4inactive (>5011.87nM)-
SLKactive (12.59nM)-
MST2active (199.53nM)active (52.76%)
TAO1inactive (>10000nM)-
MST1-active (55.54%)
MST4-inactive (-13.33%)
LOK-active (88.3%)
PAK3-inactive (5.02%)
PAK2-inactive (1.77%)
PAK5-inactive (2.59%)
PAK6-inactive (-0.46%)
STE - STE7

Bioactivity
KinaseMetzGPCR
MAP2K1-inactive (2.9%)
MAP2K2--

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
212
212
222
323
211
433
1416
221
222
424
323
434
222
555
111
111
11910
212
535
333
333
2-1
1-1
2-1
TK - Abl

Bioactivity
KinaseMetzGPCR
ABL1inactive (>630.96nM)inactive (17.87%)
ABL2-inactive (13.24%)
TK - Ack

Bioactivity
KinaseMetzGPCR
ACK-inactive (6.53%)
TNK1-active (59.13%)
TK - ALK

Bioactivity
KinaseMetzGPCR
ALK-inactive (5.04%)
LTK-inactive (4.35%)
TK - Axl

Bioactivity
KinaseMetzGPCR
TYRO3-inactive (10.34%)
AXLactive (251.19nM)inactive (-1.95%)
MER-inactive (9.28%)
TK - Csk

Bioactivity
KinaseMetzGPCR
CTK--
CSK-inactive (9.28%)
TK - EGFR

Bioactivity
KinaseMetzGPCR
EGFRactive (251.19nM)inactive (3.5%)
ErbB2active (1000nM)inactive (4.42%)
ErbB4inactive (>3981.07nM)inactive (11.76%)
TK - Eph

Bioactivity
KinaseMetzGPCR
EphA2inactive (>3162.28nM)inactive (3.23%)
EphA4-inactive (23.34%)
EphA3-inactive (7.13%)
EphB4-inactive (1.61%)
EphB3-inactive (0.77%)
EphB2-inactive (17.27%)
TK - FAK

Bioactivity
KinaseMetzGPCR
FAKactive (501.19nM)-
PYK2active (158.49nM)inactive (19.35%)
TK - Fer

Bioactivity
KinaseMetzGPCR
FER-inactive (10.53%)
FES-inactive (1.4%)
TK - FGFR

Bioactivity
KinaseMetzGPCR
FGFR1inactive (3981.07nM)inactive (13%)
FGFR3inactive (>1995.26nM)inactive (18.25%)
FGFR2-inactive (20.87%)
FGFR4-inactive (-1.16%)
TK - InsR

Bioactivity
KinaseMetzGPCR
IGF1Rinactive (>1000nM)inactive (-2.72%)
INSRinactive (>5011.87nM)inactive (2.13%)
IRR-inactive (3.34%)
TK - JakA

Bioactivity
KinaseMetzGPCR
JAK2inactive (1258.93nM)inactive (1.84%)
JAK3active (199.53nM)inactive (-2.61%)
TYK2inactive (>1995.26nM)inactive (-6.76%)
JAK1-inactive (2.62%)
TK - Met

Bioactivity
KinaseMetzGPCR
METinactive (>3162.28nM)inactive (19.5%)
RON-inactive (8.36%)
TK - PDGFR

Bioactivity
KinaseMetzGPCR
FMSactive (501.19nM)inactive (29.05%)
FLT3active (50.12nM)inactive (9.95%)
KITactive (125.89nM)inactive (20.46%)
PDGFRa-active (83.53%)
PDGFRb-active (83.5%)
TK - Ret

Bioactivity
KinaseMetzGPCR
RET-inactive (41.65%)
TK - Sev

Bioactivity
KinaseMetzGPCR
ROS-inactive (20.55%)
TK - Src

Bioactivity
KinaseMetzGPCR
BLKinactive (>1584.89nM)inactive (17.77%)
LCKinactive (1995.26nM)inactive (12.6%)
LYNinactive (>1584.89nM)-
SRCinactive (5011.87nM)inactive (21.16%)
FRK-inactive (3.46%)
SRM-inactive (-0.81%)
FYNinactive (>794.33nM)inactive (9.2%)
BRK-inactive (5.16%)
HCK-inactive (29.25%)
FGR-inactive (14.59%)
YES-inactive (7.91%)
TK - Syk

Bioactivity
KinaseMetzGPCR
SYK-inactive (-7.75%)
ZAP70-inactive (-1.32%)
TK - Tec

Bioactivity
KinaseMetzGPCR
BTK-inactive (-1.82%)
ITKactive (1000nM)inactive (-0.36%)
BMX-inactive (8.1%)
TXK-inactive (2.84%)
TEC-inactive (7.03%)
TK - Trk

Bioactivity
KinaseMetzGPCR
TRKAactive (398.11nM)inactive (5.01%)
TRKBinactive (>5011.87nM)inactive (10.17%)
TRKC-inactive (10.36%)
TK - VEGFR

Bioactivity
KinaseMetzGPCR
FLT4active (100nM)active (53.11%)
KDRactive (251.19nM)active (68.9%)
FLT1active (125.89nM)inactive (9.39%)
TK - DDR

Bioactivity
KinaseMetzGPCR
DDR2-inactive (7.43%)
TK - Musk

Bioactivity
KinaseMetzGPCR
MUSK-inactive (32.67%)
TK - Tie

Bioactivity
KinaseMetzGPCR
TIE2-inactive (20.9%)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
421
41-
21-
102-
511
121-
TKL - IRAK

Bioactivity
KinaseMetzGPCR
IRAK1inactive (>7943.28nM)-
IRAK4inactive (>10000nM)inactive (1.85%)
TKL - LISK

Bioactivity
KinaseMetzGPCR
LIMK1inactive (7943.28nM)-
TKL - LRRK

Bioactivity
KinaseMetzGPCR
LRRK2--
TKL - MLK

Bioactivity
KinaseMetzGPCR
ZAKinactive (>7943.28nM)-
MLK2--
TKL - RAF

Bioactivity
KinaseMetzGPCR
BRAF-inactive (4.85%)
TKL - STKR

Bioactivity
KinaseMetzGPCR
ALK2--