Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : GSK-3 Inhibitor XIII

Inchikey
Same : JYCUVOXSZBECAY-N
RBC, Millipore : JYCUVOXSZBECAY-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 4925398

Pubchem CID
RBC, Millipore : 6419766

ChEMBL
RBC, Millipore : CHEMBL359482

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (90.35%)	inactive (94%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (107.3%)	inactive (113%)
AKT2	inactive (127.16%)	inactive (103%)
AKT3	inactive (95.47%)	inactive (83%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (100.3%)	inactive (111%)
MRCKa	inactive (108.5%)	inactive (122%)
MRCKb	inactive (87.14%)	inactive (96%)
ROCK1	inactive (98.79%)	inactive (120%)
ROCK2	inactive (87.61%)	inactive (90%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (106.18%)	-
BARK2	inactive (105.78%)	-
GPRK4	inactive (92.11%)	-
GPRK5	inactive (118.98%)	inactive (92%)
GPRK6	inactive (75.77%)	inactive (76%)
GPRK7	inactive (79.17%)	inactive (55%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (70.49%)	inactive (72%)
MSK2	inactive (107.61%)	inactive (59%)
p70S6K	inactive (60.39%)	active (46%)
p70S6Kb	inactive (99.7%)	-
RSK2	inactive (66.14%)	inactive (58%)
RSK4	inactive (56.25%)	active (43%)
RSK1	inactive (58.02%)	active (29%)
RSK3	inactive (50.66%)	inactive (51%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (100.87%)	inactive (81%)
PKACa	inactive (97.21%)	inactive (85%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (92.19%)	inactive (99%)
PKCd	inactive (91.31%)	inactive (105%)
PKCe	inactive (87.14%)	inactive (93%)
PKCh	inactive (89.62%)	inactive (86%)
PKCg	inactive (98.56%)	inactive (83%)
PKCi	inactive (82.6%)	inactive (112%)
PKCt	inactive (82.28%)	inactive (64%)
PKCz	inactive (97.05%)	inactive (110%)
PKCb	inactive (87.33%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (98.17%)	-
PKG1	inactive (97.34%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (89.94%)	-
PKN2	inactive (87.2%)	inactive (84%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (95.46%)	inactive (81%)
SGK2	inactive (99.73%)	inactive (77%)
SGK3	inactive (104.3%)	inactive (107%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (75.37%)	inactive (54%)
ABL2	active (42.48%)	active (33%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	active (10.84%)	active (13%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (75.85%)	inactive (70%)
LTK	inactive (63.62%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (101.36%)	active (33%)
MER	inactive (72.16%)	active (19%)
TYRO3	inactive (94.23%)	inactive (98%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (56.22%)	active (9%)
BRK	inactive (61.57%)	active (40%)
SRC	active (24.42%)	active (14%)
FGR	inactive (54.78%)	active (18%)
FRK	inactive (72.49%)	active (46%)
FYN	active (40.04%)	active (2%)
HCK	inactive (77.28%)	active (23%)
LCK	inactive (75.58%)	active (23%)
SRM	inactive (98.67%)	-
YES	active (20.42%)	active (6%)
LYN	inactive (79.86%)	active (9%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	active (41.13%)	active (5%)
BTK	active (43.39%)	active (19%)
ITK	active (45.4%)	active (5%)
TEC	inactive (105.94%)	-
TXK	active (45.31%)	active (30%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (40.79%)	active (23%)
FLT3	active (10.49%)	active (2%)
FMS	active (33.09%)	active (4%)
PDGFRb	inactive (55.39%)	inactive (79%)
PDGFRa	inactive (81.58%)	inactive (89%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (98.4%)	inactive (102%)
CTK	inactive (96.07%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (93.19%)	inactive (71%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (97.42%)	active (15%)
ErbB2	inactive (108.48%)	-
ErbB4	inactive (92.03%)	inactive (106%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (69.86%)	active (36%)
EphA2	inactive (94.8%)	inactive (75%)
EphA3	inactive (88.95%)	inactive (54%)
EphA4	inactive (70.71%)	inactive (96%)
EphA5	inactive (90.59%)	inactive (84%)
EphA6	-	-
EphA7	inactive (72.55%)	active (50%)
EphA8	inactive (98.23%)	inactive (91%)
EphB1	inactive (93.08%)	inactive (88%)
EphB2	inactive (76.7%)	inactive (100%)
EphB3	inactive (86.54%)	inactive (111%)
EphB4	inactive (91.07%)	inactive (75%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (59.89%)	active (36%)
PYK2	inactive (61.37%)	active (20%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	active (31.65%)	active (43%)
FES	inactive (94.68%)	inactive (58%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	active (48.85%)	active (4%)
FGFR2	inactive (83.75%)	active (24%)
FGFR3	inactive (71.66%)	active (34%)
FGFR4	inactive (81.88%)	inactive (106%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (78.7%)	active (0%)
FLT4	active (44.93%)	active (0%)
KDR	active (36.53%)	active (5%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (70.84%)	active (17%)
IRR	active (20.7%)	active (8%)
INSR	active (31.56%)	active (16%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (83.67%)	-
JAK2	inactive (52.58%)	active (14%)
JAK3	inactive (96.7%)	active (41%)
TYK2	active (34.28%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (51.02%)	active (21%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (8.76%)	active (2%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (96.59%)	inactive (79%)
MET	inactive (130.32%)	inactive (94%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	active (16.68%)	inactive (84%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (61.88%)	active (16%)
ZAP70	inactive (104.56%)	inactive (114%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (104.4%)	inactive (77%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	active (14.63%)	active (-2%)
TRKB	active (4.37%)	active (1%)
TRKC	active (2.01%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (115.07%)	-
ALK2	inactive (149.03%)	-
ALK4	inactive (103.31%)	inactive (96%)
TGFbR1	inactive (97.11%)	inactive (96%)
TGFbR2	inactive (116.22%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (89.68%)	-
BRAF	inactive (99.52%)	-
RAF1	inactive (99.84%)	inactive (84%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (79.32%)	inactive (69%)
IRAK4	inactive (93.18%)	active (45%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (59.58%)	inactive (51%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (88.27%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (14.78%)	active (4%)
MLK2	inactive (75.37%)	-
MLK3	active (18.09%)	-
TAK1	inactive (78.28%)	inactive (67%)
ZAK	inactive (87.08%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (70.37%)	inactive (81%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (3.88%)	active (3%)
BRSK1	-	inactive (57%)
BRSK2	inactive (61.38%)	inactive (59%)
CHK1	inactive (69.1%)	inactive (54%)
LKB1	inactive (69.04%)	inactive (88%)
MARK1	inactive (93.65%)	inactive (66%)
MARK3	inactive (88.97%)	-
MARK4	inactive (83.48%)	-
MELK	inactive (69.14%)	active (46%)
PASK	inactive (96.38%)	inactive (108%)
QIK	inactive (99.56%)	-
NuaK2	inactive (71.09%)	-
MARK2	inactive (89.61%)	inactive (80%)
AMPKa1	-	active (15%)
AMPKa2	-	active (5%)
SIK	-	inactive (60%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (93.08%)	inactive (61%)
CaMK1b	inactive (101.57%)	-
CaMK1d	inactive (85.38%)	inactive (71%)
CaMK1g	inactive (101.32%)	-
CaMK4	inactive (94.15%)	active (47%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (108.41%)	-
CaMK2b	inactive (97.75%)	inactive (88%)
CaMK2d	inactive (97.35%)	inactive (63%)
CaMK2g	inactive (95.92%)	inactive (60%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (31.26%)	active (22%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	active (39.12%)	inactive (59%)
DAPK2	inactive (89.46%)	inactive (56%)
DRAK1	inactive (81.35%)	active (42%)
DAPK3	inactive (57.47%)	active (46%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (87.45%)	inactive (99%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (100%)	inactive (98%)
MAPKAPK3	inactive (81.05%)	inactive (100%)
MAPKAPK5	inactive (93.15%)	inactive (92%)
MNK1	inactive (93.5%)	-
MNK2	inactive (71.78%)	inactive (90%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (60.19%)	inactive (55%)
skMLCK	inactive (62.77%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (71.71%)	-
PHKg2	inactive (86.26%)	inactive (85%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (83.31%)	inactive (104%)
PIM2	inactive (92.68%)	inactive (126%)
PIM3	inactive (130.32%)	inactive (87%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (77.36%)	inactive (88%)
PKD3	inactive (93.9%)	-
PKD2	inactive (75.9%)	inactive (110%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (76.72%)	inactive (72%)
TSSK2	inactive (105.02%)	inactive (96%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	active (44.7%)	inactive (77%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (99.48%)	inactive (94%)
MAP3K2	inactive (78.45%)	-
MAP3K3	inactive (82.91%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (104.91%)	-
NIK	inactive (93.47%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (45.32%)	active (38%)
HGK	active (25.68%)	-
KHS1	active (20.19%)	-
LOK	inactive (56.23%)	active (50%)
MINK	active (35.59%)	inactive (61%)
MST1	inactive (58%)	active (48%)
MST2	inactive (58.54%)	inactive (55%)
MST3	inactive (66.03%)	inactive (59%)
MST4	inactive (91.2%)	-
OSR1	inactive (98.11%)	-
PAK1	inactive (79.46%)	-
PAK2	inactive (91.81%)	inactive (87%)
PAK3	inactive (90.21%)	inactive (78%)
PAK4	inactive (84.24%)	active (9%)
PAK5	inactive (53.1%)	active (21%)
PAK6	inactive (78.93%)	active (47%)
SLK	active (42.2%)	-
YSK1	inactive (86.72%)	-
STLK3	inactive (118.13%)	-
TAO1	inactive (114.83%)	inactive (85%)
TAO2	inactive (90.31%)	inactive (83%)
TAO3	inactive (86.9%)	inactive (82%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (91.64%)	inactive (88%)
MAP2K2	inactive (101.71%)	-
MAP2K6	inactive (93.15%)	inactive (101%)
MAP2K7	-	inactive (72%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (19.77%)	active (1%)
AurB	inactive (52.03%)	active (-2%)
AurC	inactive (51.81%)	active (7%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (90.7%)	-
CaMKK2	inactive (88.56%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (90.51%)	inactive (103%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (96.49%)	inactive (102%)
IKKb	inactive (69.81%)	inactive (78%)
IKKe	inactive (67.14%)	-
TBK1	inactive (53.77%)	active (19%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (93%)	-
NEK11	inactive (104.83%)	inactive (66%)
NEK2	inactive (99.27%)	inactive (88%)
NEK4	inactive (95%)	-
NEK6	inactive (93.94%)	inactive (105%)
NEK7	inactive (97.66%)	inactive (105%)
NEK9	inactive (79.94%)	-
NEK3	inactive (100.89%)	inactive (76%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (95.4%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (97.1%)	inactive (73%)
PLK2	inactive (110.18%)	inactive (89%)
PLK3	inactive (88.34%)	inactive (84%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (86.01%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	active (24.74%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (102.03%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (81.11%)	-
ULK2	inactive (95.1%)	inactive (93%)
ULK3	active (0%)	active (29%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (88%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (82.64%)	inactive (74%)
Wnk3	inactive (74.9%)	inactive (74%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (62%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (96.72%)	inactive (96%)
CK1g1	inactive (75.72%)	inactive (83%)
CK1g2	inactive (69.26%)	inactive (62%)
CK1g3	inactive (75.01%)	inactive (96%)
CK1a	inactive (94.62%)	-
CK1e	inactive (97.43%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (81%)	-
VRK2	-	inactive (86%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	active (26.97%)	active (43%)
CK2a2	active (14.99%)	active (21%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (73.99%)	-
CLK2	inactive (91.72%)	active (10%)
CLK3	active (33.76%)	inactive (53%)
CLK4	active (34.32%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (103.59%)	-
DYRK1B	inactive (90.82%)	-
DYRK2	inactive (83.96%)	inactive (88%)
DYRK3	inactive (81.89%)	-
DYRK4	inactive (102.98%)	-
HIPK1	inactive (96.28%)	inactive (95%)
HIPK2	inactive (101.24%)	inactive (64%)
HIPK3	inactive (88.5%)	inactive (92%)
HIPK4	inactive (101.65%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (80.81%)	inactive (83%)
Erk2	inactive (89.35%)	inactive (106%)
JNK3	inactive (88.73%)	inactive (51%)
NLK	inactive (94.66%)	inactive (92%)
p38a	inactive (103.36%)	inactive (90%)
p38b	inactive (96.78%)	inactive (97%)
p38d	inactive (105.91%)	inactive (97%)
p38g	inactive (86.78%)	inactive (103%)
JNK1	inactive (92.05%)	inactive (94%)
JNK2	inactive (92.45%)	inactive (86%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (11.28%)	active (9%)
GSK3B	active (27.94%)	active (20%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (61.47%)	active (46%)
SRPK1	inactive (90.15%)	inactive (73%)
SRPK2	inactive (68.77%)	inactive (67%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (90.35%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (87%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (109%)