Compound in Profiling

Compound Information

Test on : GPCR

Compound Name : -

Inchikey : KCVNXJLUFNZAMY-LCYFTJDESA-N

ChemSpider : 8077098

Pubchem CID : 9901444

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

TK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
JakA	4	4
Fer	2	2
Abl	2	2
Csk	2	1
Tec	5	5
Src	11	10
Eph	14	6
FAK	2	1
Syk	2	2
ALK	2	2
Sev	1	1
InsR	3	3
DDR	2	1
Musk	1	1
Trk	3	3
Met	2	2
Axl	3	3
Ret	1	1
FGFR	4	4
VEGFR	3	3
PDGFR	5	5
Tie	2	1
Ack	2	2
EGFR	4	3

TK - JakA

Bioactivity
Kinase	GPCR
JAK1	inactive (6.08%)
TYK2	inactive (-1.95%)
JAK2	inactive (2.13%)
JAK3	inactive (0.9%)

TK - Fer

Bioactivity
Kinase	GPCR
FER	inactive (6.18%)
FES	inactive (3.46%)

TK - Abl

Bioactivity
Kinase	GPCR
ABL1	inactive (10.86%)
ABL2	inactive (13.3%)

TK - Csk

Bioactivity
Kinase	GPCR
CSK	inactive (-0.23%)

TK - Tec

Bioactivity
Kinase	GPCR
BMX	inactive (5.84%)
BTK	inactive (-0.4%)
TXK	inactive (6.83%)
TEC	inactive (7.41%)
ITK	inactive (3.54%)

TK - Src

Bioactivity
Kinase	GPCR
BRK	inactive (5.69%)
SRM	inactive (-1.56%)
FRK	inactive (5.58%)
BLK	inactive (8.59%)
LCK	inactive (6.78%)
HCK	inactive (17.57%)
FGR	inactive (13.75%)
FYN	inactive (4.25%)
SRC	inactive (12.91%)
YES	inactive (9.49%)

TK - Eph

Bioactivity
Kinase	GPCR
EphA2	inactive (1.68%)
EphA4	inactive (3.9%)
EphA3	inactive (3.78%)
EphB4	inactive (3.73%)
EphB3	inactive (2.58%)
EphB2	inactive (10.77%)

TK - FAK

Bioactivity
Kinase	GPCR
PYK2	inactive (27.35%)

TK - Syk

Bioactivity
Kinase	GPCR
SYK	inactive (-1.66%)
ZAP70	inactive (4.58%)

TK - ALK

Bioactivity
Kinase	GPCR
LTK	inactive (10.56%)
ALK	inactive (12.71%)

TK - Sev

Bioactivity
Kinase	GPCR
ROS	inactive (9.87%)

TK - InsR

Bioactivity
Kinase	GPCR
INSR	inactive (11.93%)
IGF1R	inactive (5.81%)
IRR	inactive (2.55%)

TK - DDR

Bioactivity
Kinase	GPCR
DDR2	inactive (6%)

TK - Musk

Bioactivity
Kinase	GPCR
MUSK	inactive (12.12%)

TK - Trk

Bioactivity
Kinase	GPCR
TRKA	inactive (16.17%)
TRKB	inactive (32.9%)
TRKC	inactive (32.26%)

TK - Met

Bioactivity
Kinase	GPCR
RON	inactive (7.57%)
MET	inactive (6.92%)

TK - Axl

Bioactivity
Kinase	GPCR
AXL	inactive (-2.91%)
MER	inactive (8.24%)
TYRO3	inactive (8.3%)

TK - Ret

Bioactivity
Kinase	GPCR
RET	inactive (30.56%)

TK - FGFR

Bioactivity
Kinase	GPCR
FGFR1	inactive (8.92%)
FGFR2	inactive (26.92%)
FGFR3	inactive (21.02%)
FGFR4	inactive (3.92%)

TK - VEGFR

Bioactivity
Kinase	GPCR
FLT1	inactive (15.24%)
KDR	inactive (35.34%)
FLT4	inactive (14.78%)

TK - PDGFR

Bioactivity
Kinase	GPCR
FMS	inactive (25.14%)
KIT	active (63.93%)
FLT3	inactive (36.39%)
PDGFRa	inactive (26.16%)
PDGFRb	inactive (22.26%)

TK - Tie

Bioactivity
Kinase	GPCR
TIE2	inactive (8.33%)

TK - Ack

Bioactivity
Kinase	GPCR
ACK	inactive (1.26%)
TNK1	inactive (5.85%)

TK - EGFR

Bioactivity
Kinase	GPCR
EGFR	inactive (9.72%)
ErbB2	inactive (-0.02%)
ErbB4	inactive (14.64%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
IRAK	4	1
RAF	5	1

TKL - IRAK

Bioactivity
Kinase	GPCR
IRAK4	inactive (2.37%)

TKL - RAF

Bioactivity
Kinase	GPCR
BRAF	inactive (7.76%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
STE20	31	12
STE7	7	1

STE - STE20

Bioactivity
Kinase	GPCR
GCK	inactive (28.9%)
MST1	inactive (26.12%)
MST2	inactive (21.22%)
MST4	inactive (-1.86%)
HGK	active (78.15%)
MINK	active (70.16%)
LOK	inactive (9.72%)
PAK1	inactive (8.78%)
PAK3	inactive (4.94%)
PAK2	inactive (2.04%)
PAK5	inactive (-8.7%)
PAK6	inactive (1.64%)

STE - STE7

Bioactivity
Kinase	GPCR
MAP2K1	inactive (5.35%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
CK1	7	4

CK1 - CK1

Bioactivity
Kinase	GPCR
CK1a	inactive (21.6%)
CK1g2	inactive (12.72%)
CK1g1	inactive (10.6%)
CK1g3	inactive (14.03%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
PLK	4	1
Aur	3	3
NEK	11	5
IKK	4	4
TTK	1	1

Other - PLK

Bioactivity
Kinase	GPCR
PLK1	inactive (4.79%)

Other - Aur

Bioactivity
Kinase	GPCR
AurB	inactive (40.46%)
AurC	active (76.66%)
AurA	inactive (47.6%)

Other - NEK

Bioactivity
Kinase	GPCR
NEK1	inactive (4.56%)
NEK2	inactive (4.55%)
NEK9	inactive (4.34%)
NEK7	inactive (4.33%)
NEK6	inactive (1.95%)

Other - IKK

Bioactivity
Kinase	GPCR
TBK1	inactive (14.44%)
IKKe	inactive (14.54%)
IKKb	inactive (4.39%)
IKKa	inactive (3.57%)

Other - TTK

Bioactivity
Kinase	GPCR
TTK	inactive (21.32%)

AGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
GRK	7	2
PDK1	1	1
RSK	8	7
Akt	3	3
SGK	3	3
PKC	9	5
PKG	2	2
PKA	5	1
DMPK	7	4

AGC - GRK

Bioactivity
Kinase	GPCR
GPRK7	inactive (9.13%)
GPRK6	inactive (11.51%)

AGC - PDK1

Bioactivity
Kinase	GPCR
PDK1	inactive (23.73%)

AGC - RSK

Bioactivity
Kinase	GPCR
MSK1	inactive (14.82%)
MSK2	inactive (18.55%)
RSK1	inactive (17.63%)
RSK2	inactive (15.16%)
RSK4	inactive (22.41%)
RSK3	inactive (26.18%)
p70S6K	inactive (8%)

AGC - Akt

Bioactivity
Kinase	GPCR
AKT2	inactive (1.98%)
AKT1	inactive (0.97%)
AKT3	inactive (0.33%)

AGC - SGK

Bioactivity
Kinase	GPCR
SGK1	inactive (26.88%)
SGK3	inactive (5.21%)
SGK2	inactive (11.46%)

AGC - PKC

Bioactivity
Kinase	GPCR
PKCh	inactive (3.72%)
PKCg	inactive (3.27%)
PKCa	inactive (2.84%)
PKCt	inactive (1.6%)
PKCi	inactive (2.43%)

AGC - PKG

Bioactivity
Kinase	GPCR
PKG2	inactive (7.34%)
PKG1	inactive (4.68%)

AGC - PKA

Bioactivity
Kinase	GPCR
PRKX	inactive (2.25%)

AGC - DMPK

Bioactivity
Kinase	GPCR
ROCK1	inactive (3.96%)
ROCK2	inactive (5.46%)
MRCKb	inactive (2.14%)
MRCKa	inactive (0.03%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
RAD53	1	1
DCAMKL	3	1
CAMK1	5	2
PHK	2	2
CAMK2	4	2
MAPKAPK	5	5
PKD	3	3
CAMKL	20	13
TSSK	5	2
DAPK	5	1
PIM	3	3

CAMK - RAD53

Bioactivity
Kinase	GPCR
CHK2	inactive (32.79%)

CAMK - DCAMKL

Bioactivity
Kinase	GPCR
DCLK2	inactive (2.32%)

CAMK - CAMK1

Bioactivity
Kinase	GPCR
CaMK4	inactive (2.86%)
CaMK1d	inactive (3.7%)

CAMK - PHK

Bioactivity
Kinase	GPCR
PHKg1	inactive (33.28%)
PHKg2	inactive (13.42%)

CAMK - CAMK2

Bioactivity
Kinase	GPCR
CaMK2d	inactive (16.34%)
CaMK2a	inactive (8.27%)

CAMK - MAPKAPK

Bioactivity
Kinase	GPCR
MAPKAPK5	inactive (1.53%)
MAPKAPK2	inactive (4.45%)
MAPKAPK3	inactive (12.14%)
MNK2	inactive (2.05%)
MNK1	inactive (4.02%)

CAMK - PKD

Bioactivity
Kinase	GPCR
PKD3	inactive (9.04%)
PKD1	inactive (10.99%)
PKD2	inactive (10.99%)

CAMK - CAMKL

Bioactivity
Kinase	GPCR
MARK4	inactive (15.51%)
MARK3	inactive (17%)
MARK1	inactive (24.38%)
QIK	inactive (11.35%)
SIK	inactive (10.8%)
NuaK1	inactive (35.83%)
BRSK1	inactive (17.89%)
BRSK2	inactive (25.98%)
MELK	inactive (19.03%)
CHK1	inactive (14.29%)
PASK	inactive (-1.04%)
AMPKa1	inactive (11.98%)
AMPKa2	inactive (11.2%)

CAMK - TSSK

Bioactivity
Kinase	GPCR
TSSK2	inactive (1.39%)
TSSK1	inactive (4.78%)

CAMK - DAPK

Bioactivity
Kinase	GPCR
DAPK1	inactive (12.49%)

CAMK - PIM

Bioactivity
Kinase	GPCR
PIM2	inactive (0.69%)
PIM3	inactive (-2.38%)
PIM1	inactive (0.73%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	GPCR
MAPK	14	6
GSK	2	2
SRPK	3	2
CLK	4	2
DYRK	10	5
CK2	3	1

CMGC - MAPK

Bioactivity
Kinase	GPCR
JNK2	inactive (10.89%)
p38a	inactive (13.48%)
p38b	inactive (9.54%)
p38d	inactive (5.02%)
Erk2	inactive (4.54%)
Erk1	inactive (1.27%)

CMGC - GSK

Bioactivity
Kinase	GPCR
GSK3A	inactive (19.98%)
GSK3B	inactive (19.71%)

CMGC - SRPK

Bioactivity
Kinase	GPCR
SRPK1	inactive (-4.31%)
MSSK1	inactive (0.27%)

CMGC - CLK

Bioactivity
Kinase	GPCR
CLK3	inactive (3.43%)
CLK2	inactive (13.72%)

CMGC - DYRK

Bioactivity
Kinase	GPCR
HIPK1	inactive (2.88%)
HIPK4	inactive (4.51%)
DYRK1B	inactive (4.25%)
DYRK1A	inactive (7.61%)
DYRK2	inactive (9.5%)

CMGC - CK2

Bioactivity
Kinase	GPCR
CK2a1	inactive (3.93%)