Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : 154447-35-5

Inchikey
Same : KKTZALUTXUZPSN-N
RBC, Millipore : KKTZALUTXUZPSN-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 8036228

Pubchem CID
RBC, Millipore : 9860529

ChEMBL
RBC, Millipore : CHEMBL104468

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (108.93%)	inactive (114%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (101.08%)	inactive (103%)
AKT2	inactive (98.95%)	inactive (133%)
AKT3	inactive (98.28%)	inactive (111%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (104.95%)	inactive (117%)
MRCKa	inactive (87.6%)	inactive (105%)
MRCKb	inactive (98.34%)	inactive (95%)
ROCK1	inactive (94.19%)	inactive (121%)
ROCK2	inactive (95.85%)	inactive (99%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (98.88%)	-
BARK2	inactive (102.46%)	-
GPRK4	inactive (104.46%)	-
GPRK5	inactive (105.78%)	inactive (103%)
GPRK6	inactive (93.81%)	inactive (96%)
GPRK7	inactive (107.36%)	inactive (98%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (102.7%)	inactive (125%)
MSK2	inactive (99.43%)	inactive (106%)
p70S6K	inactive (99.3%)	inactive (74%)
p70S6Kb	inactive (99.61%)	-
RSK2	inactive (103.5%)	inactive (57%)
RSK4	inactive (95.41%)	inactive (110%)
RSK1	inactive (92%)	inactive (109%)
RSK3	inactive (98.81%)	inactive (108%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (96.59%)	inactive (97%)
PKACa	inactive (101.67%)	inactive (101%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (89.21%)	inactive (102%)
PKCd	inactive (95.12%)	inactive (100%)
PKCe	inactive (89.59%)	inactive (87%)
PKCh	inactive (94.7%)	inactive (94%)
PKCg	inactive (101.35%)	inactive (106%)
PKCi	inactive (95.49%)	inactive (85%)
PKCt	inactive (90.62%)	inactive (94%)
PKCz	inactive (105.57%)	inactive (109%)
PKCb	inactive (99.95%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (102.46%)	-
PKG1	inactive (94.59%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (105.59%)	-
PKN2	inactive (93.24%)	inactive (101%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (98.05%)	inactive (105%)
SGK2	inactive (101.78%)	inactive (92%)
SGK3	inactive (105.97%)	inactive (97%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (103.8%)	inactive (99%)
ABL2	inactive (101.15%)	inactive (116%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (100.37%)	inactive (90%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (104.25%)	inactive (81%)
LTK	inactive (101.09%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (98.11%)	inactive (82%)
MER	inactive (96.36%)	inactive (105%)
TYRO3	inactive (97.26%)	inactive (87%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (104.36%)	inactive (113%)
BRK	inactive (101.1%)	inactive (110%)
SRC	inactive (99.35%)	inactive (92%)
FGR	inactive (94.57%)	inactive (107%)
FRK	inactive (98.83%)	inactive (115%)
FYN	inactive (113%)	inactive (83%)
HCK	inactive (114.03%)	inactive (85%)
LCK	inactive (99.2%)	inactive (118%)
SRM	inactive (97.08%)	-
YES	inactive (98.66%)	inactive (103%)
LYN	inactive (102.23%)	inactive (103%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (92.67%)	inactive (88%)
BTK	inactive (111.75%)	inactive (94%)
ITK	inactive (100.09%)	inactive (96%)
TEC	inactive (149.85%)	-
TXK	inactive (98.86%)	inactive (90%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (104.52%)	inactive (117%)
FLT3	inactive (103.52%)	inactive (101%)
FMS	inactive (102.63%)	inactive (111%)
PDGFRb	inactive (110.61%)	inactive (98%)
PDGFRa	inactive (83.94%)	inactive (112%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (101.36%)	inactive (103%)
CTK	inactive (90.66%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (105.06%)	inactive (106%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (96.15%)	inactive (110%)
ErbB2	inactive (105.34%)	-
ErbB4	inactive (101.04%)	inactive (106%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (94.19%)	inactive (91%)
EphA2	inactive (110.32%)	inactive (114%)
EphA3	inactive (112.16%)	inactive (92%)
EphA4	inactive (94.44%)	inactive (114%)
EphA5	inactive (110.19%)	inactive (124%)
EphA6	-	-
EphA7	inactive (98.64%)	inactive (103%)
EphA8	inactive (100.96%)	inactive (100%)
EphB1	inactive (104.13%)	inactive (95%)
EphB2	inactive (84.99%)	inactive (113%)
EphB3	inactive (89.96%)	inactive (110%)
EphB4	inactive (96.34%)	inactive (101%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (107.56%)	inactive (132%)
PYK2	inactive (94.29%)	inactive (130%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (91.21%)	inactive (112%)
FES	inactive (100.46%)	inactive (116%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (92.09%)	inactive (109%)
FGFR2	inactive (107.45%)	inactive (111%)
FGFR3	inactive (98.16%)	inactive (123%)
FGFR4	inactive (107.61%)	inactive (122%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (95.51%)	inactive (98%)
FLT4	inactive (111.84%)	inactive (94%)
KDR	inactive (86.81%)	inactive (103%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (107.47%)	inactive (124%)
IRR	inactive (97.37%)	inactive (116%)
INSR	inactive (92.35%)	inactive (108%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (103.68%)	-
JAK2	inactive (94.9%)	inactive (112%)
JAK3	inactive (103.41%)	inactive (100%)
TYK2	inactive (110.86%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (75.6%)	inactive (100%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (99.83%)	inactive (99%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (103.24%)	inactive (98%)
MET	inactive (161.15%)	inactive (121%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (97.04%)	inactive (100%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (93.02%)	inactive (126%)
ZAP70	inactive (103.04%)	inactive (119%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (94.4%)	inactive (81%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (96.44%)	inactive (106%)
TRKB	inactive (94.01%)	inactive (114%)
TRKC	inactive (103.17%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (100.05%)	-
ALK2	inactive (107.29%)	-
ALK4	inactive (103.23%)	inactive (120%)
TGFbR1	inactive (98.49%)	inactive (89%)
TGFbR2	inactive (121.83%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (92.02%)	-
BRAF	inactive (95.69%)	-
RAF1	inactive (97.89%)	inactive (83%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (111.55%)	inactive (83%)
IRAK4	inactive (122.07%)	inactive (96%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (98.04%)	inactive (108%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (96.93%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (110.66%)	inactive (96%)
MLK2	inactive (101.93%)	-
MLK3	inactive (99.21%)	-
TAK1	inactive (98.28%)	inactive (93%)
ZAK	inactive (97.99%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (104.21%)	inactive (86%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (90.09%)	inactive (101%)
BRSK1	inactive (100.38%)	inactive (91%)
BRSK2	inactive (92.62%)	inactive (102%)
CHK1	inactive (104.29%)	inactive (90%)
LKB1	inactive (103.7%)	inactive (102%)
MARK1	inactive (99.51%)	inactive (93%)
MARK3	inactive (109.9%)	-
MARK4	inactive (102.38%)	-
MELK	inactive (103.36%)	inactive (92%)
PASK	inactive (94.93%)	inactive (141%)
QIK	inactive (126.45%)	-
NuaK2	inactive (119.71%)	-
MARK2	inactive (100.53%)	inactive (106%)
AMPKa1	-	inactive (110%)
AMPKa2	-	inactive (105%)
SIK	-	inactive (95%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (110.74%)	inactive (104%)
CaMK1b	inactive (97.37%)	-
CaMK1d	inactive (91.06%)	inactive (101%)
CaMK1g	inactive (101.57%)	-
CaMK4	inactive (93.98%)	inactive (115%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (99.43%)	-
CaMK2b	inactive (98.12%)	inactive (103%)
CaMK2d	inactive (99.93%)	inactive (99%)
CaMK2g	inactive (95.52%)	inactive (104%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (103.6%)	inactive (111%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (90.87%)	inactive (90%)
DAPK2	inactive (114.79%)	inactive (92%)
DRAK1	inactive (94.59%)	inactive (92%)
DAPK3	inactive (94.57%)	inactive (105%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (100.24%)	inactive (83%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (98.34%)	inactive (100%)
MAPKAPK3	inactive (105.26%)	inactive (127%)
MAPKAPK5	inactive (98.4%)	active (28%)
MNK1	inactive (95.03%)	-
MNK2	inactive (88.5%)	inactive (100%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (92.3%)	inactive (92%)
skMLCK	inactive (97.74%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (98.2%)	-
PHKg2	inactive (99.82%)	inactive (90%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (54.77%)	inactive (55%)
PIM2	inactive (78.77%)	inactive (87%)
PIM3	inactive (95.41%)	inactive (92%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (101.71%)	inactive (77%)
PKD3	inactive (98.81%)	-
PKD2	inactive (100.54%)	inactive (100%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (100.86%)	inactive (101%)
TSSK2	inactive (100.2%)	inactive (95%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (97.54%)	inactive (93%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (98.24%)	inactive (88%)
MAP3K2	inactive (108.8%)	-
MAP3K3	inactive (101.84%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (98.31%)	-
NIK	inactive (81.19%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (117.87%)	inactive (91%)
HGK	inactive (89.35%)	-
KHS1	inactive (102.98%)	-
LOK	inactive (96.88%)	inactive (98%)
MINK	inactive (95.97%)	inactive (102%)
MST1	inactive (99.47%)	inactive (91%)
MST2	inactive (99.07%)	inactive (113%)
MST3	inactive (102.66%)	inactive (70%)
MST4	inactive (93.17%)	-
OSR1	inactive (108.16%)	-
PAK1	inactive (93.54%)	-
PAK2	inactive (102.79%)	inactive (97%)
PAK3	inactive (102.12%)	inactive (67%)
PAK4	inactive (108.47%)	inactive (94%)
PAK5	inactive (108.12%)	inactive (94%)
PAK6	inactive (91.98%)	inactive (120%)
SLK	inactive (101.83%)	-
YSK1	inactive (94.77%)	-
STLK3	inactive (95.73%)	-
TAO1	inactive (97.48%)	inactive (102%)
TAO2	inactive (108.38%)	inactive (98%)
TAO3	inactive (98.72%)	inactive (98%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (99.27%)	inactive (114%)
MAP2K2	inactive (99.99%)	-
MAP2K6	inactive (94.13%)	inactive (92%)
MAP2K7	-	inactive (102%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (97.98%)	inactive (125%)
AurB	inactive (97.55%)	inactive (110%)
AurC	inactive (107.26%)	inactive (102%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (111.56%)	-
CaMKK2	inactive (104.13%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (85.59%)	inactive (74%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (93.37%)	inactive (124%)
IKKb	inactive (105.21%)	inactive (96%)
IKKe	inactive (100.63%)	-
TBK1	inactive (101.98%)	inactive (77%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (106.3%)	-
NEK11	inactive (99.11%)	inactive (98%)
NEK2	inactive (94.77%)	inactive (79%)
NEK4	inactive (97.39%)	-
NEK6	inactive (92.47%)	inactive (100%)
NEK7	inactive (96.62%)	inactive (103%)
NEK9	inactive (101.85%)	-
NEK3	inactive (111.09%)	inactive (120%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (103.07%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (68.4%)	inactive (56%)
PLK2	inactive (105.93%)	inactive (98%)
PLK3	inactive (63.95%)	inactive (99%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (109.75%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (99.05%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (102.65%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (96.14%)	-
ULK2	inactive (94.91%)	inactive (102%)
ULK3	active (0%)	inactive (106%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (100.71%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (102.72%)	inactive (110%)
Wnk3	inactive (97.47%)	inactive (103%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (101%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (97.9%)	inactive (98%)
CK1g1	inactive (100.66%)	inactive (100%)
CK1g2	inactive (102.42%)	inactive (102%)
CK1g3	inactive (98.15%)	inactive (102%)
CK1a	inactive (115.14%)	-
CK1e	inactive (92.53%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (93.29%)	-
VRK2	-	inactive (105%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (70.87%)	active (18%)
CK2a2	inactive (78.57%)	inactive (56%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (98.3%)	-
CLK2	inactive (100.9%)	inactive (98%)
CLK3	inactive (81.08%)	inactive (91%)
CLK4	inactive (101.31%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (79.04%)	-
DYRK1B	inactive (90.51%)	-
DYRK2	inactive (88.88%)	inactive (97%)
DYRK3	inactive (96.03%)	-
DYRK4	inactive (91.87%)	-
HIPK1	inactive (102.42%)	inactive (90%)
HIPK2	inactive (105.24%)	inactive (70%)
HIPK3	inactive (107.11%)	inactive (71%)
HIPK4	inactive (101.32%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (105.53%)	inactive (101%)
Erk2	inactive (103.53%)	inactive (103%)
JNK3	inactive (73.85%)	inactive (98%)
NLK	inactive (102.57%)	inactive (108%)
p38a	inactive (96.69%)	inactive (100%)
p38b	inactive (97.95%)	inactive (93%)
p38d	inactive (99.83%)	inactive (100%)
p38g	inactive (97.45%)	inactive (104%)
JNK1	inactive (97.17%)	inactive (103%)
JNK2	inactive (100.96%)	inactive (110%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (97.08%)	inactive (119%)
GSK3B	inactive (123.59%)	inactive (101%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (105.44%)	inactive (112%)
SRPK1	inactive (90.89%)	inactive (99%)
SRPK2	inactive (100.2%)	inactive (97%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (108.93%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (99%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (95%)