Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : 3-(4-Pyridyl)indole

Inchikey
Same : LLJRXVHJOJRCSM-N
RBC, Millipore : LLJRXVHJOJRCSM-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 559358

Pubchem CID
RBC, Millipore : 644354

ChEMBL
RBC, Millipore : CHEMBL380071

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (96.57%)	inactive (111%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (100.35%)	inactive (103%)
AKT2	inactive (96.36%)	inactive (121%)
AKT3	inactive (101.18%)	inactive (89%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (108.53%)	inactive (147%)
MRCKa	inactive (99.88%)	inactive (113%)
MRCKb	inactive (103.84%)	inactive (94%)
ROCK1	inactive (84.16%)	inactive (114%)
ROCK2	inactive (71.86%)	active (37%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (97.73%)	-
BARK2	inactive (95.37%)	-
GPRK4	inactive (94.9%)	-
GPRK5	inactive (99.24%)	inactive (98%)
GPRK6	inactive (103.35%)	inactive (87%)
GPRK7	inactive (98.37%)	inactive (96%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (96.73%)	inactive (115%)
MSK2	inactive (90.99%)	inactive (80%)
p70S6K	inactive (79.94%)	inactive (53%)
p70S6Kb	inactive (97.81%)	-
RSK2	inactive (97.35%)	inactive (72%)
RSK4	inactive (111.79%)	inactive (89%)
RSK1	inactive (93.82%)	inactive (98%)
RSK3	inactive (88.96%)	inactive (117%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (107.09%)	-
PRKX	inactive (54.25%)	active (48%)
PKACa	inactive (91.61%)	inactive (93%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (97.4%)	inactive (98%)
PKCd	inactive (83.22%)	inactive (63%)
PKCe	inactive (81.5%)	inactive (73%)
PKCh	inactive (84.89%)	inactive (64%)
PKCg	inactive (99.37%)	inactive (106%)
PKCi	inactive (82.38%)	inactive (89%)
PKCt	inactive (125.25%)	inactive (88%)
PKCz	inactive (98.26%)	inactive (94%)
PKCb	inactive (89.49%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	active (38.27%)	-
PKG1	inactive (64.81%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (66.4%)	-
PKN2	inactive (80.81%)	active (30%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (93.77%)	inactive (102%)
SGK2	inactive (91.02%)	inactive (92%)
SGK3	inactive (92.82%)	inactive (101%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (109.32%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (98.8%)	inactive (98%)
ABL2	inactive (91.86%)	inactive (110%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (96.15%)	inactive (80%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (105.9%)	inactive (76%)
LTK	inactive (102.77%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (99.81%)	inactive (81%)
MER	inactive (92.99%)	inactive (100%)
TYRO3	inactive (98.14%)	inactive (91%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (99.59%)	inactive (125%)
BRK	inactive (85.51%)	inactive (95%)
SRC	inactive (99.97%)	inactive (80%)
FGR	inactive (94.53%)	inactive (117%)
FRK	inactive (105.56%)	inactive (88%)
FYN	inactive (98.69%)	inactive (89%)
HCK	inactive (99.53%)	inactive (68%)
LCK	inactive (101.94%)	inactive (102%)
SRM	inactive (106.97%)	-
YES	inactive (97.06%)	inactive (117%)
LYN	inactive (101.55%)	inactive (105%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (95.79%)	inactive (86%)
BTK	inactive (103.68%)	inactive (99%)
ITK	inactive (94.78%)	inactive (101%)
TEC	inactive (122.8%)	-
TXK	inactive (104.19%)	inactive (109%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (93.23%)	inactive (110%)
FLT3	inactive (91.51%)	inactive (107%)
FMS	inactive (100.64%)	inactive (110%)
PDGFRb	inactive (104.57%)	inactive (113%)
PDGFRa	inactive (94.96%)	inactive (120%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (106.57%)	inactive (114%)
CTK	inactive (93.92%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (92.57%)	inactive (129%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (97.34%)	inactive (125%)
ErbB2	inactive (95.64%)	-
ErbB4	inactive (83.68%)	inactive (88%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (104.65%)	inactive (87%)
EphA2	inactive (105.74%)	inactive (104%)
EphA3	inactive (106.8%)	inactive (106%)
EphA4	inactive (107.56%)	inactive (109%)
EphA5	inactive (99.4%)	inactive (102%)
EphA6	inactive (103.94%)	-
EphA7	inactive (98.21%)	inactive (99%)
EphA8	inactive (100.67%)	inactive (96%)
EphB1	inactive (107.69%)	inactive (108%)
EphB2	inactive (114.42%)	inactive (108%)
EphB3	inactive (99.98%)	inactive (106%)
EphB4	inactive (89.72%)	inactive (111%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (97.66%)	inactive (116%)
PYK2	inactive (95.35%)	inactive (127%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (91.59%)	inactive (109%)
FES	inactive (104.57%)	inactive (111%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (92.72%)	inactive (121%)
FGFR2	inactive (104.71%)	inactive (111%)
FGFR3	inactive (98.91%)	inactive (123%)
FGFR4	inactive (84.58%)	inactive (112%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (97.89%)	inactive (85%)
FLT4	inactive (118.69%)	inactive (91%)
KDR	inactive (94.17%)	inactive (100%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (104.59%)	inactive (121%)
IRR	inactive (100.86%)	inactive (125%)
INSR	inactive (90.5%)	inactive (110%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (109.24%)	-
JAK2	inactive (93.84%)	inactive (97%)
JAK3	inactive (95.27%)	inactive (103%)
TYK2	inactive (101.03%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (78.91%)	inactive (88%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (97.28%)	inactive (103%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (98.95%)	inactive (96%)
MET	inactive (91.39%)	inactive (117%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (81.55%)	inactive (88%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (98.6%)	inactive (118%)
ZAP70	inactive (105.27%)	inactive (94%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (100.83%)	inactive (77%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (96.95%)	inactive (91%)
TRKB	inactive (107.23%)	inactive (134%)
TRKC	inactive (100.04%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (100.45%)	-
ALK2	inactive (94.67%)	-
ALK4	inactive (98.8%)	inactive (127%)
TGFbR1	inactive (102.54%)	inactive (87%)
TGFbR2	inactive (118.62%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (97.72%)	-
BRAF	inactive (94.03%)	-
RAF1	inactive (93.18%)	inactive (73%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (127.47%)	inactive (76%)
IRAK4	inactive (108.74%)	inactive (94%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (92.04%)	inactive (98%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (92.77%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (83.31%)	inactive (74%)
MLK2	inactive (101.47%)	-
MLK3	inactive (95.2%)	-
TAK1	inactive (95.45%)	inactive (85%)
ZAK	inactive (102.26%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (89.91%)	inactive (87%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (94.81%)	inactive (97%)
BRSK1	inactive (90.26%)	inactive (52%)
BRSK2	inactive (98.55%)	inactive (106%)
CHK1	inactive (103.94%)	inactive (89%)
LKB1	inactive (90.71%)	inactive (100%)
MARK1	inactive (94.52%)	inactive (81%)
MARK3	inactive (98.01%)	-
MARK4	inactive (94.72%)	-
MELK	inactive (101.99%)	inactive (91%)
PASK	inactive (101.02%)	inactive (99%)
QIK	inactive (90.45%)	-
NuaK2	inactive (135.75%)	-
MARK2	inactive (101.83%)	inactive (112%)
AMPKa1	-	inactive (93%)
AMPKa2	-	inactive (122%)
SIK	-	inactive (79%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (108.47%)	inactive (106%)
CaMK1b	inactive (98.45%)	-
CaMK1d	inactive (106.54%)	inactive (101%)
CaMK1g	inactive (98.96%)	-
CaMK4	inactive (101.41%)	inactive (118%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (104.05%)	-
CaMK2b	inactive (90.49%)	active (47%)
CaMK2d	inactive (102.53%)	inactive (87%)
CaMK2g	inactive (92.64%)	inactive (79%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (99.27%)	inactive (86%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (97.69%)	inactive (85%)
DAPK2	inactive (107.99%)	inactive (100%)
DRAK1	inactive (93.01%)	inactive (102%)
DAPK3	inactive (100.54%)	inactive (110%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (98.08%)	inactive (75%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (101.09%)	inactive (90%)
MAPKAPK3	inactive (97.76%)	inactive (103%)
MAPKAPK5	inactive (96.14%)	inactive (87%)
MNK1	inactive (75.5%)	-
MNK2	active (39.18%)	active (35%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (96.75%)	inactive (72%)
skMLCK	inactive (96.2%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (90.31%)	-
PHKg2	inactive (101.47%)	inactive (103%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (93.51%)	inactive (97%)
PIM2	inactive (105.21%)	inactive (97%)
PIM3	inactive (103.16%)	inactive (91%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (95.5%)	inactive (87%)
PKD3	inactive (90.68%)	-
PKD2	inactive (95.75%)	inactive (104%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (103.46%)	inactive (94%)
TSSK2	inactive (96.9%)	inactive (100%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (97.28%)	inactive (98%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (108.72%)	inactive (93%)
MAP3K2	inactive (94.86%)	-
MAP3K3	inactive (103.27%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (99%)	-
NIK	inactive (112.07%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (101.24%)	inactive (86%)
HGK	inactive (54.35%)	-
KHS1	inactive (105.99%)	-
LOK	inactive (93.71%)	inactive (86%)
MINK	inactive (84.56%)	inactive (85%)
MST1	inactive (103.4%)	inactive (89%)
MST2	inactive (111.73%)	inactive (103%)
MST3	inactive (93.54%)	inactive (61%)
MST4	inactive (103.86%)	-
OSR1	inactive (97.2%)	-
PAK1	inactive (99.12%)	-
PAK2	inactive (83.99%)	inactive (98%)
PAK3	inactive (101.99%)	inactive (61%)
PAK4	inactive (96.71%)	inactive (93%)
PAK5	inactive (93.8%)	inactive (97%)
PAK6	inactive (104.2%)	inactive (106%)
SLK	inactive (102.61%)	-
YSK1	inactive (117.25%)	-
STLK3	inactive (99.83%)	-
TAO1	inactive (88.42%)	inactive (100%)
TAO2	inactive (92.07%)	inactive (110%)
TAO3	inactive (102.73%)	inactive (98%)
MYO3B	inactive (96.43%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (96.46%)	inactive (87%)
MAP2K2	inactive (103.14%)	-
MAP2K6	inactive (106.28%)	inactive (77%)
MAP2K7	-	inactive (101%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (78.03%)	inactive (99%)
AurB	inactive (95.94%)	inactive (92%)
AurC	inactive (93.08%)	inactive (66%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (122.14%)	-
CaMKK2	inactive (112.65%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (62.34%)	active (48%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (107.26%)	inactive (97%)
IKKb	inactive (101.79%)	inactive (105%)
IKKe	inactive (96.45%)	-
TBK1	inactive (93.42%)	inactive (65%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (101.39%)	-
NEK11	inactive (76.91%)	inactive (89%)
NEK2	inactive (105.61%)	inactive (78%)
NEK4	inactive (95.41%)	-
NEK6	inactive (93.41%)	inactive (95%)
NEK7	inactive (103.77%)	inactive (95%)
NEK9	inactive (101.07%)	-
NEK3	inactive (91.61%)	inactive (114%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (97.13%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (101.64%)	inactive (86%)
PLK2	inactive (99.9%)	inactive (107%)
PLK3	inactive (95.29%)	inactive (91%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (95.95%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (110%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (112.35%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (83.76%)	-
ULK2	inactive (105.57%)	inactive (104%)
ULK3	inactive (82.98%)	inactive (104%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (89.31%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (96.88%)	inactive (107%)
Wnk3	inactive (100.38%)	inactive (98%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (95.84%)	inactive (103%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (105.34%)	inactive (85%)
CK1g1	inactive (79.19%)	inactive (96%)
CK1g2	inactive (95.04%)	inactive (107%)
CK1g3	inactive (107.96%)	inactive (110%)
CK1a	inactive (100.32%)	-
CK1e	inactive (100.02%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (101.45%)	-
VRK2	-	inactive (101%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (95.01%)	inactive (78%)
CK2a2	inactive (94.95%)	inactive (126%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (104.66%)	-
CLK2	inactive (100.85%)	inactive (112%)
CLK3	inactive (92.56%)	inactive (87%)
CLK4	inactive (101.2%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (77.62%)	-
DYRK1B	inactive (90.49%)	-
DYRK2	inactive (77.45%)	inactive (77%)
DYRK3	inactive (100.65%)	-
DYRK4	inactive (98.7%)	-
HIPK1	inactive (97.37%)	inactive (95%)
HIPK2	inactive (94.06%)	inactive (100%)
HIPK3	inactive (107.11%)	inactive (95%)
HIPK4	inactive (93.8%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (98.94%)	inactive (77%)
Erk2	inactive (100.2%)	inactive (101%)
JNK3	inactive (101.88%)	inactive (85%)
NLK	inactive (95.08%)	inactive (96%)
p38a	inactive (104.21%)	inactive (77%)
p38b	inactive (111.71%)	inactive (96%)
p38d	inactive (122.67%)	inactive (103%)
p38g	inactive (103.92%)	inactive (100%)
JNK1	inactive (100.28%)	inactive (97%)
JNK2	inactive (103.25%)	inactive (107%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (102.74%)	inactive (123%)
GSK3B	inactive (103.59%)	inactive (94%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (96.03%)	inactive (102%)
SRPK1	inactive (108.03%)	inactive (108%)
SRPK2	inactive (102.82%)	inactive (89%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (96.57%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (86%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (109%)