Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : SCHEMBL1737451
Millipore : su6656

Inchikey
Same : LOGJQOUIVKBFGH-N
RBC : LOGJQOUIVKBFGH-UHFFFAOYSA-N
Millipore : LOGJQOUIVKBFGH-YBEGLDIGSA-N

ChemSpider
RBC : 5118
Millipore : 4471568

Pubchem CID
RBC : 5309
Millipore : 5312137

ChEMBL
RBC : -
Millipore : CHEMBL605003

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (102.95%)	inactive (101%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (107.04%)	inactive (101%)
AKT2	inactive (105.48%)	inactive (109%)
AKT3	inactive (96.69%)	inactive (92%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (102.13%)	inactive (113%)
MRCKa	inactive (92.26%)	inactive (111%)
MRCKb	inactive (100.51%)	inactive (97%)
ROCK1	inactive (95.22%)	inactive (132%)
ROCK2	inactive (88.23%)	inactive (99%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (95.04%)	-
BARK2	inactive (97%)	-
GPRK4	inactive (79.85%)	-
GPRK5	inactive (95.3%)	inactive (101%)
GPRK6	inactive (82.59%)	inactive (95%)
GPRK7	inactive (82.26%)	inactive (101%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (105.51%)	inactive (115%)
MSK2	inactive (103.59%)	inactive (107%)
p70S6K	inactive (96.46%)	inactive (108%)
p70S6Kb	inactive (92.57%)	-
RSK2	inactive (70.09%)	inactive (61%)
RSK4	inactive (67.35%)	inactive (84%)
RSK1	inactive (68.07%)	active (36%)
RSK3	inactive (52.77%)	inactive (95%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (114.32%)	-
PRKX	inactive (98.1%)	inactive (95%)
PKACa	inactive (106.2%)	inactive (102%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (94.92%)	inactive (105%)
PKCd	inactive (95.45%)	inactive (107%)
PKCe	inactive (94.65%)	inactive (98%)
PKCh	inactive (78.48%)	inactive (102%)
PKCg	inactive (86.78%)	inactive (102%)
PKCi	inactive (95.88%)	inactive (99%)
PKCt	inactive (112.3%)	inactive (93%)
PKCz	inactive (98.87%)	inactive (108%)
PKCb	inactive (91.99%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (95.95%)	-
PKG1	inactive (82.46%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (91.17%)	-
PKN2	inactive (84.33%)	inactive (95%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (105.14%)	inactive (82%)
SGK2	inactive (101.19%)	inactive (115%)
SGK3	inactive (98.11%)	inactive (105%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (94.56%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (57.27%)	inactive (77%)
ABL2	inactive (56.82%)	inactive (114%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	active (12.62%)	active (13%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	active (43.6%)	active (44%)
LTK	inactive (52.72%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	active (39.73%)	inactive (51%)
MER	active (20.88%)	active (12%)
TYRO3	inactive (57.2%)	inactive (67%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	active (13.88%)	active (10%)
BRK	inactive (56.29%)	inactive (98%)
SRC	active (23.57%)	active (31%)
FGR	active (18.2%)	active (21%)
FRK	inactive (86.05%)	inactive (54%)
FYN	active (33.13%)	active (22%)
HCK	active (31.58%)	active (10%)
LCK	active (34.72%)	active (5%)
SRM	inactive (103.84%)	-
YES	active (13.49%)	active (12%)
LYN	active (16.18%)	active (3%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (102.56%)	inactive (76%)
BTK	inactive (97.44%)	inactive (91%)
ITK	inactive (61.21%)	active (23%)
TEC	inactive (116.18%)	-
TXK	inactive (95.99%)	inactive (92%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (60.66%)	active (29%)
FLT3	active (10.24%)	active (27%)
FMS	active (37.22%)	active (4%)
PDGFRb	inactive (96.53%)	inactive (80%)
PDGFRa	inactive (93.74%)	active (33%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (93.14%)	inactive (101%)
CTK	inactive (103.76%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (100.9%)	inactive (97%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (93.39%)	active (21%)
ErbB2	inactive (100.8%)	-
ErbB4	inactive (105.6%)	inactive (88%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (94.51%)	inactive (96%)
EphA2	inactive (96.47%)	inactive (89%)
EphA3	inactive (98.62%)	inactive (91%)
EphA4	inactive (91.3%)	inactive (102%)
EphA5	inactive (85.1%)	inactive (107%)
EphA6	inactive (61.91%)	-
EphA7	inactive (91.08%)	inactive (94%)
EphA8	inactive (100.03%)	inactive (96%)
EphB1	inactive (82.76%)	inactive (73%)
EphB2	inactive (98.45%)	inactive (101%)
EphB3	inactive (105.45%)	inactive (120%)
EphB4	inactive (85.8%)	inactive (70%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	active (33.08%)	active (21%)
PYK2	inactive (52.56%)	active (13%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (51.81%)	inactive (59%)
FES	inactive (76.86%)	inactive (82%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (71.36%)	active (36%)
FGFR2	active (49.25%)	inactive (51%)
FGFR3	inactive (57.11%)	inactive (104%)
FGFR4	inactive (92.95%)	inactive (84%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (84.92%)	inactive (67%)
FLT4	inactive (78.07%)	active (33%)
KDR	inactive (96.91%)	inactive (51%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (89.54%)	inactive (104%)
IRR	inactive (93.31%)	inactive (85%)
INSR	inactive (91.59%)	inactive (93%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (66.8%)	-
JAK2	active (46.09%)	inactive (67%)
JAK3	inactive (64.84%)	inactive (66%)
TYK2	active (11.35%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (82.81%)	inactive (53%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (6.29%)	active (22%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (100.72%)	inactive (64%)
MET	inactive (92.15%)	inactive (104%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (83.29%)	inactive (104%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (77.74%)	inactive (97%)
ZAP70	inactive (89.97%)	inactive (114%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (95.37%)	active (45%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	active (24.67%)	active (-2%)
TRKB	active (15.63%)	active (4%)
TRKC	active (2.88%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (101.92%)	-
ALK2	inactive (98.65%)	-
ALK4	inactive (104.56%)	inactive (111%)
TGFbR1	inactive (95.86%)	inactive (88%)
TGFbR2	inactive (129.37%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (104.83%)	-
BRAF	inactive (89.16%)	-
RAF1	inactive (97.74%)	inactive (91%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	active (5.59%)	active (9%)
IRAK4	inactive (57.72%)	active (19%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (60.69%)	inactive (90%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (1.78%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (74.56%)	inactive (84%)
MLK2	inactive (99.12%)	-
MLK3	inactive (57.37%)	-
TAK1	inactive (89.03%)	inactive (100%)
ZAK	inactive (99.36%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (88.86%)	inactive (94%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (10.9%)	active (10%)
BRSK1	active (32.35%)	inactive (97%)
BRSK2	active (48.7%)	active (40%)
CHK1	inactive (76.26%)	inactive (77%)
LKB1	inactive (90.43%)	inactive (99%)
MARK1	inactive (54.63%)	active (24%)
MARK3	inactive (68.9%)	-
MARK4	inactive (51.48%)	-
MELK	inactive (89.1%)	inactive (105%)
PASK	inactive (95.59%)	inactive (108%)
QIK	inactive (86.45%)	-
NuaK2	inactive (95.07%)	-
MARK2	inactive (61.72%)	inactive (98%)
AMPKa1	-	active (43%)
AMPKa2	-	active (45%)
SIK	-	inactive (110%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (107.1%)	inactive (104%)
CaMK1b	inactive (95.73%)	-
CaMK1d	inactive (99.77%)	inactive (107%)
CaMK1g	inactive (97.14%)	-
CaMK4	inactive (96.57%)	inactive (89%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (61.43%)	-
CaMK2b	inactive (70.04%)	inactive (71%)
CaMK2d	inactive (73.24%)	active (18%)
CaMK2g	inactive (98.92%)	active (17%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (46.14%)	active (35%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (102.23%)	inactive (90%)
DAPK2	inactive (93.52%)	inactive (102%)
DRAK1	inactive (100.58%)	inactive (70%)
DAPK3	inactive (94.35%)	inactive (94%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (72.03%)	inactive (55%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (101.17%)	inactive (81%)
MAPKAPK3	inactive (100.42%)	inactive (94%)
MAPKAPK5	inactive (99.75%)	inactive (110%)
MNK1	inactive (108.46%)	-
MNK2	inactive (84.11%)	inactive (96%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (97.25%)	inactive (102%)
skMLCK	inactive (97.93%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (72.39%)	-
PHKg2	inactive (78.78%)	active (48%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (100.75%)	inactive (105%)
PIM2	inactive (108.1%)	inactive (123%)
PIM3	inactive (116.74%)	inactive (93%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (101.82%)	inactive (91%)
PKD3	inactive (90.36%)	-
PKD2	inactive (102.25%)	inactive (107%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (74.55%)	inactive (91%)
TSSK2	inactive (91.77%)	inactive (100%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (77.16%)	inactive (85%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (105.54%)	inactive (102%)
MAP3K2	active (36.96%)	-
MAP3K3	active (48.67%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (94.64%)	-
NIK	inactive (94.6%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (20.84%)	active (5%)
HGK	active (46.15%)	-
KHS1	active (3.08%)	-
LOK	active (9.53%)	inactive (63%)
MINK	inactive (83.81%)	inactive (124%)
MST1	active (13.09%)	active (23%)
MST2	active (24.29%)	active (28%)
MST3	active (47.72%)	inactive (60%)
MST4	active (45.61%)	-
OSR1	inactive (89.09%)	-
PAK1	inactive (96.1%)	-
PAK2	inactive (92.51%)	inactive (99%)
PAK3	inactive (97.56%)	inactive (103%)
PAK4	inactive (97.55%)	inactive (74%)
PAK5	inactive (101.5%)	inactive (102%)
PAK6	inactive (98.91%)	inactive (76%)
SLK	active (23.36%)	-
YSK1	inactive (79.65%)	-
STLK3	inactive (99.54%)	-
TAO1	inactive (85.83%)	active (37%)
TAO2	inactive (89.59%)	inactive (93%)
TAO3	inactive (55.35%)	inactive (89%)
MYO3B	inactive (98.91%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (88.71%)	inactive (101%)
MAP2K2	inactive (104.44%)	-
MAP2K6	inactive (94.62%)	inactive (91%)
MAP2K7	-	inactive (82%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (16.11%)	active (36%)
AurB	active (11.03%)	active (-1%)
AurC	active (33.78%)	inactive (75%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (65.36%)	-
CaMKK2	active (27.27%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (115.99%)	inactive (127%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (115.08%)	inactive (111%)
IKKb	inactive (106.9%)	inactive (100%)
IKKe	inactive (87.86%)	-
TBK1	inactive (80.56%)	inactive (74%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (93.08%)	-
NEK11	inactive (82.49%)	active (47%)
NEK2	inactive (97.98%)	inactive (97%)
NEK4	inactive (99.92%)	-
NEK6	inactive (90.73%)	inactive (115%)
NEK7	inactive (103.28%)	inactive (111%)
NEK9	inactive (93.24%)	-
NEK3	inactive (98.16%)	inactive (88%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (99.72%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (100.7%)	inactive (96%)
PLK2	inactive (94.44%)	inactive (101%)
PLK3	inactive (94.54%)	inactive (101%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (96.04%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (104.13%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (89.73%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	active (6.13%)	-
ULK2	active (26.28%)	active (38%)
ULK3	active (26.35%)	active (11%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (94.48%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (101.25%)	inactive (94%)
Wnk3	inactive (96.46%)	inactive (100%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (101.62%)	inactive (98%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (99.66%)	inactive (92%)
CK1g1	inactive (101.16%)	inactive (110%)
CK1g2	inactive (93.76%)	inactive (107%)
CK1g3	inactive (101.17%)	inactive (93%)
CK1a	inactive (91.69%)	-
CK1e	inactive (104.14%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (104.03%)	-
VRK2	-	inactive (102%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (105.14%)	inactive (95%)
CK2a2	inactive (92.14%)	inactive (107%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (82.63%)	-
CLK2	active (32.09%)	inactive (69%)
CLK3	inactive (92.92%)	active (39%)
CLK4	inactive (50.71%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (81.07%)	-
DYRK1B	inactive (93.58%)	-
DYRK2	inactive (103.21%)	inactive (104%)
DYRK3	inactive (99.1%)	-
DYRK4	inactive (98.2%)	-
HIPK1	inactive (105.08%)	inactive (111%)
HIPK2	inactive (98.19%)	inactive (97%)
HIPK3	inactive (107.48%)	inactive (99%)
HIPK4	inactive (98.81%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (101.56%)	inactive (103%)
Erk2	inactive (100.56%)	inactive (105%)
JNK3	inactive (104.77%)	inactive (89%)
NLK	inactive (99.75%)	inactive (91%)
p38a	inactive (98.82%)	inactive (87%)
p38b	inactive (107.56%)	inactive (94%)
p38d	inactive (103.1%)	inactive (97%)
p38g	inactive (103.15%)	inactive (105%)
JNK1	inactive (91.1%)	inactive (99%)
JNK2	inactive (103.87%)	inactive (93%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (99.44%)	inactive (97%)
GSK3B	inactive (95.61%)	inactive (112%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (67.17%)	inactive (98%)
SRPK1	inactive (63.77%)	active (20%)
SRPK2	inactive (50.35%)	active (34%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (102.95%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (102%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (106%)