Compound Information


Test on : DRx, RBC, Metz

Compound Name
DRx, RBC, Metz : Sorafenib

Inchikey
Same : MLDQJTXFUGDVEO-N
DRx, RBC, Metz : MLDQJTXFUGDVEO-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz : 187440

Pubchem CID
DRx, RBC, Metz : 216239

ChEMBL
DRx, RBC, Metz : CHEMBL1336




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

Other


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
441-
3332
2221
42--
21--
4444
11982
3311
4433
111-
32--
21--
543-
221-
111-
1-1-
1-11
4-2-
1--1
Other - NAK

Bioactivity
KinaseDRxRBCMetz
AAK1inactive (10001nM)--
BIKEinactive (10001nM)--
GAKinactive (10001nM)--
MPSK1inactive (10001nM)inactive (104.88%)-
Other - Aur

Bioactivity
KinaseDRxRBCMetz
AurAinactive (10001nM)inactive (102.56%)active (794.33nM)
AurBactive (440nM)inactive (63.13%)active (199.53nM)
AurCactive (210nM)inactive (105.76%)-
Other - CAMKK

Bioactivity
KinaseDRxRBCMetz
CaMKK1inactive (10001nM)inactive (103.45%)-
CaMKK2inactive (10001nM)inactive (103.4%)inactive (>2511.89nM)
Other - PEK

Bioactivity
KinaseDRxRBCMetz
HRIinactive (10001nM)--
PKRinactive (10001nM)--
Other - IRE

Bioactivity
KinaseDRxRBCMetz
IRE1inactive (10001nM)--
Other - IKK

Bioactivity
KinaseDRxRBCMetz
IKKainactive (10001nM)inactive (99.82%)inactive (>3981.07nM)
IKKbinactive (10001nM)inactive (88.35%)inactive (>3162.28nM)
IKKeinactive (10001nM)inactive (89.83%)inactive (>3162.28nM)
TBK1inactive (10001nM)inactive (98.6%)inactive (>3162.28nM)
Other - NEK

Bioactivity
KinaseDRxRBCMetz
NEK1inactive (10001nM)inactive (88.81%)-
NEK11inactive (10001nM)inactive (105.08%)-
NEK2inactive (10001nM)inactive (99.34%)inactive (>6309.57nM)
NEK3inactive (10001nM)inactive (97.18%)-
NEK4inactive (10001nM)inactive (99.47%)inactive (>6309.57nM)
NEK5inactive (10001nM)--
NEK6inactive (10001nM)inactive (104.55%)-
NEK7inactive (10001nM)inactive (98.22%)-
NEK9inactive (10001nM)inactive (95.44%)-
Other - WEE

Bioactivity
KinaseDRxRBCMetz
MYT1inactive (10001nM)--
Wee1inactive (10001nM)inactive (103.46%)-
Wee1Binactive (10001nM)--
Other - PLK

Bioactivity
KinaseDRxRBCMetz
PLK1inactive (10001nM)inactive (98.08%)inactive (>7943.28nM)
PLK2inactive (10001nM)inactive (100.73%)-
PLK3inactive (10001nM)inactive (99.3%)inactive (>7943.28nM)
PLK4inactive (4500nM)-active (398.11nM)
Other - SgK496

Bioactivity
KinaseDRxRBCMetz
SgK496inactive (10001nM)inactive (97.71%)-
Other - NKF1

Bioactivity
KinaseDRxRBCMetz
SBKinactive (10001nM)--
SgK110inactive (10001nM)--
Other - NKF4

Bioactivity
KinaseDRxRBCMetz
CLIK1inactive (10001nM)--
Other - ULK

Bioactivity
KinaseDRxRBCMetz
Fusedinactive (3800nM)--
ULK1inactive (10001nM)inactive (94.3%)-
ULK2inactive (10001nM)inactive (105.77%)-
ULK3inactive (10001nM)inactive (102.76%)-
Other - TLK

Bioactivity
KinaseDRxRBCMetz
TLK1inactive (10001nM)--
TLK2inactive (10001nM)inactive (84.83%)-
Other - TTK

Bioactivity
KinaseDRxRBCMetz
TTKinactive (3500nM)inactive (104.11%)-
Other - Haspin

Bioactivity
KinaseDRxRBCMetz
Haspin-inactive (99.28%)-
Other - TOPK

Bioactivity
KinaseDRxRBCMetz
PBK-inactive (97.47%)inactive (>10000nM)
Other - WNK

Bioactivity
KinaseDRxRBCMetz
Wnk2-inactive (101.14%)-
Wnk3-inactive (99.25%)-
Other - CDC7

Bioactivity
KinaseDRxRBCMetz
CDC7--inactive (>1258.93nM)

TK


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
2221
2222
3332
1111119
5553
5555
2221
221-
4433
1413121
2222
2222
4442
3333
3332
4443
2222
111-
1111
1111
2221
221-
2211
3333
TK - Abl

Bioactivity
KinaseDRxRBCMetz
ABL1active (130nM)inactive (90.43%)active (158.49nM)
ABL2active (2900nM)inactive (99.37%)-
TK - ALK

Bioactivity
KinaseDRxRBCMetz
ALKinactive (10001nM)inactive (97.27%)inactive (>6309.57nM)
LTKinactive (10001nM)inactive (99.91%)inactive (>2511.89nM)
TK - Axl

Bioactivity
KinaseDRxRBCMetz
AXLinactive (4500nM)inactive (105.41%)active (158.49nM)
MERinactive (3600nM)inactive (88.19%)-
TYRO3inactive (10001nM)inactive (91.73%)inactive (>3162.28nM)
TK - Src

Bioactivity
KinaseDRxRBCMetz
BLKinactive (10001nM)inactive (99.08%)active (794.33nM)
BRKinactive (10001nM)inactive (96.92%)-
FGRinactive (7800nM)inactive (88.73%)-
FRKactive (510nM)inactive (81.75%)-
FYNinactive (8400nM)inactive (91.64%)inactive (>3162.28nM)
HCKinactive (8500nM)inactive (90.33%)inactive (>3162.28nM)
LCKactive (2700nM)inactive (81.24%)inactive (>1995.26nM)
LYNactive (3000nM)inactive (88.13%)active (398.11nM)
SRCinactive (10001nM)inactive (95.61%)inactive (>1995.26nM)
SRMinactive (9800nM)inactive (107.34%)-
YESinactive (10001nM)inactive (82.79%)-
TK - Tec

Bioactivity
KinaseDRxRBCMetz
BMXinactive (10001nM)inactive (93.26%)-
BTKinactive (10001nM)inactive (101.6%)inactive (>6309.57nM)
ITKinactive (10001nM)inactive (105.66%)inactive (>1584.89nM)
TECinactive (10001nM)inactive (100.93%)-
TXKinactive (10001nM)inactive (105.72%)-
TK - PDGFR

Bioactivity
KinaseDRxRBCMetz
FMSactive (28nM)active (5.55%)active (158.49nM)
FLT3active (13nM)active (9.22%)inactive (>794.33nM)
KITactive (28nM)inactive (53.28%)inactive (>3981.07nM)
PDGFRaactive (62nM)active (7.77%)active (1000nM)
PDGFRbactive (37nM)active (12.03%)active (3.98nM)
TK - Csk

Bioactivity
KinaseDRxRBCMetz
CSKinactive (10001nM)inactive (90.32%)-
CTKinactive (10001nM)inactive (114.46%)-
TK - DDR

Bioactivity
KinaseDRxRBCMetz
DDR1active (1.5nM)--
DDR2active (6.6nM)active (3.41%)-
TK - EGFR

Bioactivity
KinaseDRxRBCMetz
EGFRinactive (10001nM)inactive (95.09%)inactive (>1995.26nM)
ErbB2inactive (10001nM)inactive (102.73%)inactive (>1584.89nM)
ErbB3inactive (10001nM)--
ErbB4inactive (10001nM)inactive (94.85%)inactive (>3981.07nM)
TK - Eph

Bioactivity
KinaseDRxRBCMetz
EphA1inactive (3100nM)inactive (87.67%)-
EphA2active (2000nM)inactive (83.85%)active (794.33nM)
EphA3active (1900nM)inactive (95.47%)-
EphA4active (3000nM)inactive (92.55%)-
EphA5inactive (3500nM)inactive (99.4%)-
EphA6active (370nM)active (41.99%)-
EphA7inactive (5300nM)inactive (80.7%)-
EphA8active (2400nM)inactive (94.49%)-
EphB1active (3000nM)inactive (102.09%)-
EphB2active (1900nM)inactive (93.15%)-
EphB3inactive (10001nM)inactive (95.51%)-
EphB4active (1800nM)inactive (86.81%)-
EphB6active (240nM)--
TK - FAK

Bioactivity
KinaseDRxRBCMetz
FAKinactive (10001nM)inactive (102.27%)inactive (>6309.57nM)
PYK2inactive (10001nM)inactive (101.14%)inactive (>1584.89nM)
TK - Fer

Bioactivity
KinaseDRxRBCMetz
FERinactive (10001nM)inactive (100.85%)-
FESinactive (10001nM)inactive (103.66%)-
TK - FGFR

Bioactivity
KinaseDRxRBCMetz
FGFR1active (2800nM)inactive (90.93%)inactive (>2511.89nM)
FGFR2active (2700nM)inactive (72.71%)-
FGFR3inactive (4200nM)inactive (89.46%)inactive (1258.93nM)
FGFR4inactive (10001nM)inactive (103.61%)-
TK - VEGFR

Bioactivity
KinaseDRxRBCMetz
FLT1active (31nM)inactive (50.49%)active (316.23nM)
FLT4active (95nM)active (42.96%)active (100nM)
KDRactive (59nM)active (36.93%)active (39.81nM)
TK - InsR

Bioactivity
KinaseDRxRBCMetz
IGF1Rinactive (10001nM)inactive (94.28%)inactive (>1995.26nM)
INSRinactive (10001nM)inactive (105.77%)inactive (>5011.87nM)
IRRinactive (10001nM)inactive (103.85%)-
TK - JakA

Bioactivity
KinaseDRxRBCMetz
JAK1inactive (10001nM)inactive (110.42%)-
JAK2inactive (10001nM)inactive (98.16%)inactive (>2511.89nM)
JAK3inactive (7300nM)inactive (99.36%)inactive (>5011.87nM)
TYK2inactive (10001nM)inactive (98.92%)inactive (>1995.26nM)
TK - Met

Bioactivity
KinaseDRxRBCMetz
METinactive (10001nM)inactive (105.49%)inactive (>2511.89nM)
RONinactive (10001nM)inactive (97.6%)inactive (>3981.07nM)
TK - Musk

Bioactivity
KinaseDRxRBCMetz
MUSKactive (130nM)inactive (100.77%)-
TK - Ret

Bioactivity
KinaseDRxRBCMetz
RETactive (13nM)active (1.78%)active (100nM)
TK - Sev

Bioactivity
KinaseDRxRBCMetz
ROSinactive (10001nM)inactive (95.67%)inactive (>3162.28nM)
TK - Syk

Bioactivity
KinaseDRxRBCMetz
SYKinactive (10001nM)inactive (101.11%)-
ZAP70inactive (10001nM)inactive (97.8%)-
TK - Tie

Bioactivity
KinaseDRxRBCMetz
TIE1active (68nM)--
TIE2active (2100nM)inactive (104.47%)-
TK - Ack

Bioactivity
KinaseDRxRBCMetz
TNK1active (2300nM)--
ACKinactive (10001nM)inactive (97.6%)inactive (>3981.07nM)
TK - Trk

Bioactivity
KinaseDRxRBCMetz
TRKAinactive (6300nM)inactive (76.09%)inactive (1584.89nM)
TRKBactive (2100nM)inactive (89.97%)active (630.96nM)
TRKCactive (600nM)inactive (65.54%)active (398.11nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
121051
541-
5231
10852
4322
4311
2111
TKL - STKR

Bioactivity
KinaseDRxRBCMetz
ALK2inactive (10001nM)inactive (98.73%)inactive (>3981.07nM)
ALK4inactive (10001nM)inactive (101.97%)-
ACTR2inactive (10001nM)--
ACTR2Binactive (10001nM)--
ALK1inactive (10001nM)inactive (103.84%)-
BMPR1Ainactive (10001nM)--
BMPR1Binactive (10001nM)--
BMPR2inactive (10001nM)--
TGFbR1inactive (10001nM)inactive (94.13%)-
TGFbR2inactive (6900nM)inactive (99.87%)-
TKL - RIPK

Bioactivity
KinaseDRxRBCMetz
SgK288inactive (10001nM)--
RIPK1inactive (10001nM)--
RIPK2active (1300nM)inactive (86.17%)-
ANKRD3inactive (10001nM)--
TKL - RAF

Bioactivity
KinaseDRxRBCMetz
BRAFactive (540nM)active (19.41%)-
RAF1active (230nM)active (1.35%)-
ARAF-active (7.04%)-
TKL - MLK

Bioactivity
KinaseDRxRBCMetz
DLKinactive (10001nM)--
LZKinactive (10001nM)--
MLK1inactive (10001nM)inactive (102.53%)-
MLK2inactive (10001nM)inactive (104.42%)inactive (>3162.28nM)
MLK3inactive (10001nM)inactive (98.26%)-
TAK1active (690nM)inactive (101.28%)-
HH498active (280nM)--
ZAKactive (6.3nM)active (16.69%)active (15.85nM)
TKL - IRAK

Bioactivity
KinaseDRxRBCMetz
IRAK1inactive (10001nM)inactive (100.95%)inactive (7943.28nM)
IRAK3inactive (10001nM)--
IRAK4inactive (10001nM)inactive (99.58%)inactive (>10000nM)
TKL - LISK

Bioactivity
KinaseDRxRBCMetz
LIMK1active (1600nM)inactive (76.75%)active (630.96nM)
LIMK2inactive (9600nM)--
TESK1inactive (10001nM)--
TKL - LRRK

Bioactivity
KinaseDRxRBCMetz
LRRK2inactive (10001nM)inactive (106.39%)inactive (>2511.89nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
52--
61--
33--
61-1
5-1-
Atypical - ABC1

Bioactivity
KinaseDRxRBCMetz
ADCK3inactive (10001nM)--
ADCK4inactive (10001nM)--
Atypical - PIKK

Bioactivity
KinaseDRxRBCMetz
FRAPinactive (10001nM)--
Atypical - RIO

Bioactivity
KinaseDRxRBCMetz
RIOK1inactive (10001nM)--
RIOK2inactive (10001nM)--
RIOK3inactive (10001nM)--
Atypical - Alpha

Bioactivity
KinaseDRxRBCMetz
ChaK2inactive (10001nM)--
eEF2K--inactive (>3981.07nM)
Atypical - PDHK

Bioactivity
KinaseDRxRBCMetz
PDHK1-inactive (95.77%)-

AGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
3333
7753
7361
441-
51--
1111
5332
3221
9595
2232
8184
3131
33--
AGC - Akt

Bioactivity
KinaseDRxRBCMetz
AKT1inactive (10001nM)inactive (96.17%)inactive (>7943.28nM)
AKT2inactive (10001nM)inactive (102.65%)inactive (>7943.28nM)
AKT3inactive (10001nM)inactive (94.22%)inactive (>10000nM)
AGC - DMPK

Bioactivity
KinaseDRxRBCMetz
CRIKinactive (6200nM)--
DMPK1inactive (10001nM)inactive (93.16%)-
DMPK2inactive (10001nM)--
MRCKainactive (10001nM)inactive (85.25%)inactive (>10000nM)
MRCKbinactive (10001nM)inactive (102.32%)-
ROCK1inactive (10001nM)inactive (101.93%)inactive (>3162.28nM)
ROCK2inactive (10001nM)inactive (100.81%)inactive (>5011.87nM)
AGC - GRK

Bioactivity
KinaseDRxRBCMetz
RHOKinactive (10001nM)--
GPRK4inactive (10001nM)inactive (102.67%)-
GPRK7inactive (10001nM)inactive (97.3%)-
BARK1-inactive (111.83%)-
BARK2-inactive (98.38%)-
GPRK5-inactive (97.83%)inactive (>3981.07nM)
GPRK6-inactive (106.88%)-
AGC - NDR

Bioactivity
KinaseDRxRBCMetz
LATS1inactive (10001nM)--
LATS2inactive (10001nM)--
NDR1inactive (10001nM)inactive (99.82%)-
NDR2inactive (10001nM)--
AGC - MAST

Bioactivity
KinaseDRxRBCMetz
MAST1inactive (10001nM)--
AGC - PDK1

Bioactivity
KinaseDRxRBCMetz
PDK1inactive (10001nM)inactive (95.77%)inactive (>3981.07nM)
AGC - PKA

Bioactivity
KinaseDRxRBCMetz
PKACainactive (10001nM)inactive (92.6%)inactive (>2511.89nM)
PKACbinactive (10001nM)--
PRKXinactive (10001nM)inactive (97.68%)inactive (>3162.28nM)
PKACg-inactive (100.09%)-
AGC - PKN

Bioactivity
KinaseDRxRBCMetz
PKN1inactive (10001nM)inactive (105.83%)-
PKN2inactive (10001nM)inactive (94.19%)inactive (>7943.28nM)
AGC - PKC

Bioactivity
KinaseDRxRBCMetz
PKCdinactive (10001nM)inactive (104.04%)inactive (>7943.28nM)
PKCeinactive (10001nM)inactive (96.41%)-
PKChinactive (10001nM)inactive (107.22%)-
PKCiinactive (10001nM)inactive (89.9%)-
PKCtinactive (10001nM)inactive (100.47%)inactive (>2511.89nM)
PKCa-inactive (96.84%)-
PKCg-inactive (94.7%)inactive (>7943.28nM)
PKCz-inactive (94.51%)inactive (>7943.28nM)
PKCb-inactive (97.54%)-
AGC - PKG

Bioactivity
KinaseDRxRBCMetz
PKG1inactive (10001nM)inactive (88.58%)inactive (>1995.26nM)
PKG2inactive (10001nM)inactive (90.87%)inactive (>1584.89nM)
AGC - RSK

Bioactivity
KinaseDRxRBCMetz
p70S6Kinactive (10001nM)inactive (91.41%)active (398.11nM)
MSK1-inactive (102.46%)inactive (>1995.26nM)
MSK2-inactive (97.69%)-
p70S6Kb-inactive (102.62%)-
RSK2-inactive (100.19%)inactive (>3981.07nM)
RSK4-inactive (97.26%)-
RSK1-inactive (100.76%)-
RSK3-inactive (93.26%)-
AGC - SGK

Bioactivity
KinaseDRxRBCMetz
SGK3inactive (10001nM)inactive (100.56%)-
SGK1-inactive (95.18%)inactive (>7943.28nM)
SGK2-inactive (102.51%)-
AGC - YANK

Bioactivity
KinaseDRxRBCMetz
YANK1inactive (10001nM)--
YANK2inactive (10001nM)--
YANK3inactive (10001nM)--

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
2019139
5452
4444
11--
1111
5542
3311
5454
542-
2221
3333
3332
11-1
5122
CAMK - CAMKL

Bioactivity
KinaseDRxRBCMetz
AMPKa1inactive (10001nM)-inactive (>3162.28nM)
AMPKa2inactive (10001nM)--
NuaK1inactive (10001nM)inactive (102.54%)-
BRSK1inactive (10001nM)inactive (95.82%)inactive (>10000nM)
BRSK2inactive (10001nM)inactive (102.93%)-
CHK1inactive (10001nM)inactive (173.04%)inactive (>6309.57nM)
HUNKinactive (10001nM)--
LKB1inactive (10001nM)inactive (103.91%)-
MARK1inactive (10001nM)inactive (80.27%)-
MARK2inactive (10001nM)inactive (94.86%)inactive (>7943.28nM)
MARK3inactive (10001nM)inactive (102.96%)inactive (>5011.87nM)
MARK4inactive (10001nM)inactive (98.06%)inactive (>5011.87nM)
MELKinactive (10001nM)inactive (93.6%)inactive (>1995.26nM)
NIM1inactive (10001nM)--
QSKinactive (10001nM)--
SIKinactive (10001nM)--
QIKinactive (10001nM)inactive (101.65%)inactive (>3981.07nM)
NuaK2inactive (10001nM)inactive (100.58%)-
SNRKinactive (10001nM)--
PASK-inactive (99.52%)inactive (>1584.89nM)
CAMK - CAMK1

Bioactivity
KinaseDRxRBCMetz
CaMK1ainactive (10001nM)inactive (105.73%)inactive (>7943.28nM)
CaMK1dinactive (10001nM)inactive (103.09%)inactive (>2511.89nM)
CaMK1ginactive (10001nM)inactive (107.23%)-
CaMK4inactive (10001nM)inactive (106.69%)-
CaMK1b-inactive (94.67%)-
CAMK - CAMK2

Bioactivity
KinaseDRxRBCMetz
CaMK2ainactive (10001nM)inactive (95.33%)inactive (>3981.07nM)
CaMK2binactive (10001nM)inactive (96.66%)inactive (3981.07nM)
CaMK2dinactive (10001nM)inactive (102.22%)inactive (>6309.57nM)
CaMK2ginactive (10001nM)inactive (107.82%)inactive (>6309.57nM)
CAMK - CASK

Bioactivity
KinaseDRxRBCMetz
CASKinactive (10001nM)--
CAMK - RAD53

Bioactivity
KinaseDRxRBCMetz
CHK2inactive (10001nM)inactive (101.75%)inactive (>5011.87nM)
CAMK - DAPK

Bioactivity
KinaseDRxRBCMetz
DAPK1inactive (10001nM)inactive (101.32%)-
DAPK2inactive (10001nM)inactive (110.51%)-
DAPK3inactive (10001nM)inactive (92.87%)inactive (>3162.28nM)
DRAK1inactive (10001nM)inactive (96.02%)-
DRAK2inactive (10001nM)--
CAMK - DCAMKL

Bioactivity
KinaseDRxRBCMetz
DCLK1inactive (10001nM)-inactive (>10000nM)
DCLK2inactive (10001nM)inactive (102.14%)-
DCLK3inactive (10001nM)--
CAMK - MAPKAPK

Bioactivity
KinaseDRxRBCMetz
MAPKAPK2inactive (10001nM)inactive (100.36%)inactive (>7943.28nM)
MAPKAPK5inactive (10001nM)inactive (95.77%)inactive (>1584.89nM)
MNK1active (230nM)inactive (75.15%)-
MNK2active (130nM)inactive (70.27%)active (316.23nM)
MAPKAPK3-inactive (100.22%)inactive (>10000nM)
CAMK - MLCK

Bioactivity
KinaseDRxRBCMetz
caMLCKinactive (9600nM)--
smMLCKinactive (10001nM)inactive (93.66%)-
skMLCKinactive (5400nM)inactive (96.11%)-
SgK085inactive (10001nM)--
CAMK - PHK

Bioactivity
KinaseDRxRBCMetz
PHKg1inactive (10001nM)inactive (94.28%)-
PHKg2inactive (10001nM)inactive (91.26%)inactive (>5011.87nM)
CAMK - PIM

Bioactivity
KinaseDRxRBCMetz
PIM1inactive (10001nM)inactive (97.05%)inactive (>6309.57nM)
PIM2inactive (10001nM)inactive (102.62%)inactive (>1584.89nM)
PIM3inactive (10001nM)inactive (100.04%)-
CAMK - PKD

Bioactivity
KinaseDRxRBCMetz
PKD1inactive (10001nM)inactive (99.74%)-
PKD2inactive (10001nM)inactive (96.15%)inactive (>10000nM)
PKD3inactive (10001nM)inactive (94.03%)inactive (>6309.57nM)
CAMK - STK33

Bioactivity
KinaseDRxRBCMetz
STK33active (2400nM)inactive (83.94%)-
CAMK - TSSK

Bioactivity
KinaseDRxRBCMetz
TSSK1inactive (10001nM)inactive (98.73%)inactive (>1584.89nM)
TSSK2-inactive (101.9%)inactive (>1584.89nM)

STE


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
883-
3127239
7732
2-2-
STE - STE11

Bioactivity
KinaseDRxRBCMetz
MAP3K5inactive (10001nM)inactive (103.42%)-
MAP3K6inactive (10001nM)--
MAP3K1inactive (10001nM)--
MAP3K7inactive (10001nM)--
MAP3K2inactive (10001nM)inactive (108.94%)-
MAP3K3inactive (10001nM)inactive (106.6%)-
MAP3K4inactive (10001nM)--
MAP3K8active (99nM)--
STE - STE20

Bioactivity
KinaseDRxRBCMetz
HPK1inactive (4800nM)--
LOKactive (150nM)inactive (72.38%)-
GCKinactive (10001nM)inactive (107.52%)inactive (>5011.87nM)
KHS2inactive (10001nM)--
HGKinactive (4800nM)inactive (96.12%)inactive (>3162.28nM)
KHS1active (1600nM)inactive (56.98%)active (316.23nM)
MINKinactive (10001nM)inactive (108.46%)inactive (1584.89nM)
MST1inactive (10001nM)inactive (100.65%)-
MST2inactive (10001nM)inactive (96.85%)inactive (>6309.57nM)
MST3inactive (10001nM)inactive (110.04%)-
MST4inactive (10001nM)inactive (101.22%)-
MYO3Ainactive (10001nM)--
MYO3Binactive (7100nM)inactive (85.62%)-
OSR1inactive (10001nM)inactive (102.85%)-
PAK1inactive (10001nM)inactive (107.84%)inactive (>10000nM)
PAK2inactive (10001nM)inactive (101.31%)-
PAK3inactive (10001nM)inactive (103.37%)-
PAK4inactive (10001nM)inactive (91.85%)inactive (>5011.87nM)
PAK6inactive (10001nM)inactive (103.98%)-
PAK5inactive (10001nM)inactive (95.86%)-
SLKactive (1000nM)inactive (96.84%)inactive (1584.89nM)
STLK3inactive (10001nM)inactive (95.73%)-
TAO1inactive (3100nM)inactive (82.04%)active (398.11nM)
TAO2active (540nM)active (36.88%)-
TAO3active (2700nM)inactive (63.48%)-
TNIKinactive (7900nM)--
YSK1inactive (10001nM)inactive (103.8%)-
STE - STE7

Bioactivity
KinaseDRxRBCMetz
MAP2K1inactive (10001nM)inactive (102.46%)inactive (>3162.28nM)
MAP2K2inactive (10001nM)inactive (89.68%)inactive (>3981.07nM)
MAP2K3inactive (10001nM)--
MAP2K4inactive (10001nM)--
MAP2K5active (190nM)--
MAP2K6inactive (10001nM)inactive (96.86%)-
MAP2K7inactive (10001nM)--
STE - STE-Unique

Bioactivity
KinaseDRxRBCMetz
COT-inactive (93.55%)-
NIK-inactive (96.37%)-

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
208-7
54--
4442
3221
10896
1414108
2222
32--
3331
CMGC - CDK

Bioactivity
KinaseDRxRBCMetz
PITSLREinactive (10001nM)--
CHEDinactive (10001nM)--
CDK11active (250nM)--
PCTAIRE1inactive (10001nM)--
PCTAIRE2active (1600nM)--
PCTAIRE3inactive (10001nM)--
PFTAIRE2active (2900nM)--
PFTAIRE1active (2900nM)--
CDC2--inactive (>7943.28nM)
CDK2--inactive (>7943.28nM)
CDK5--inactive (>3981.07nM)
CDK8--active (79.43nM)
CDK7--inactive (>3981.07nM)
CDK9--inactive (>1584.89nM)
CMGC - CDKL

Bioactivity
KinaseDRxRBCMetz
CDKL1inactive (10001nM)--
CDKL2active (130nM)--
CDKL3active (490nM)--
CDKL5inactive (10001nM)--
CMGC - CLK

Bioactivity
KinaseDRxRBCMetz
CLK1inactive (7500nM)inactive (97.73%)-
CLK2inactive (10001nM)inactive (92.75%)inactive (>3981.07nM)
CLK3inactive (10001nM)inactive (99.31%)-
CLK4inactive (10001nM)inactive (95.24%)inactive (>3162.28nM)
CMGC - CK2

Bioactivity
KinaseDRxRBCMetz
CK2a1inactive (10001nM)inactive (108.15%)inactive (>6309.57nM)
CK2a2inactive (10001nM)inactive (94.43%)-
CMGC - DYRK

Bioactivity
KinaseDRxRBCMetz
DYRK1Ainactive (10001nM)inactive (102.72%)inactive (>1995.26nM)
DYRK1Binactive (10001nM)inactive (93.17%)inactive (>2511.89nM)
DYRK2inactive (10001nM)inactive (98.88%)-
HIPK1inactive (3300nM)inactive (99.69%)-
HIPK2active (1700nM)inactive (87.83%)active (501.19nM)
HIPK3active (440nM)inactive (85.72%)-
HIPK4active (3.3nM)active (4.85%)active (10nM)
PRP4inactive (10001nM)--
DYRK3-inactive (92.68%)inactive (1995.26nM)
DYRK4-inactive (104.84%)-
CMGC - MAPK

Bioactivity
KinaseDRxRBCMetz
Erk1inactive (10001nM)inactive (104.66%)-
Erk2inactive (10001nM)inactive (101.02%)inactive (>7943.28nM)
Erk3inactive (10001nM)--
Erk4inactive (10001nM)--
Erk5inactive (10001nM)--
Erk7active (46nM)--
JNK1inactive (10001nM)inactive (92.8%)inactive (>3981.07nM)
JNK2inactive (7400nM)inactive (94.85%)inactive (>3981.07nM)
JNK3inactive (10001nM)inactive (94.18%)inactive (>3162.28nM)
NLKactive (640nM)inactive (99.09%)-
p38aactive (370nM)active (40.18%)active (15.85nM)
p38bactive (230nM)active (46.88%)-
p38dinactive (6600nM)inactive (97.48%)inactive (>7943.28nM)
p38ginactive (7600nM)inactive (94.21%)inactive (>6309.57nM)
CMGC - GSK

Bioactivity
KinaseDRxRBCMetz
GSK3Ainactive (10001nM)inactive (102.54%)inactive (>5011.87nM)
GSK3Binactive (10001nM)inactive (100.75%)inactive (>3162.28nM)
CMGC - RCK

Bioactivity
KinaseDRxRBCMetz
ICKinactive (10001nM)--
MAKinactive (10001nM)--
CMGC - SRPK

Bioactivity
KinaseDRxRBCMetz
SRPK1inactive (10001nM)inactive (98.63%)inactive (5011.87nM)
SRPK2inactive (10001nM)inactive (101.67%)-
MSSK1inactive (10001nM)inactive (88.44%)-

CK1


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
7765
311-
CK1 - CK1

Bioactivity
KinaseDRxRBCMetz
CK1ainactive (10001nM)inactive (97.81%)inactive (>3981.07nM)
CK1a2inactive (10001nM)--
CK1dinactive (10001nM)inactive (103.19%)inactive (>7943.28nM)
CK1einactive (10001nM)inactive (95.92%)-
CK1g1inactive (10001nM)inactive (101.58%)inactive (>6309.57nM)
CK1g2inactive (10001nM)inactive (88.9%)inactive (>7943.28nM)
CK1g3inactive (10001nM)inactive (99.84%)-
CK1 - VRK

Bioactivity
KinaseDRxRBCMetz
VRK2inactive (10001nM)--
VRK1-inactive (99.28%)-