Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : 622387-85-3
Millipore : Syk Inhibitor

Inchikey
Same : MLKHXLFEYOOYEY-N
RBC : MLKHXLFEYOOYEY-UHFFFAOYSA-N
Millipore : MLKHXLFEYOOYEY-NVNXTCNLSA-N

ChemSpider
RBC : 21465194
Millipore : 4925379

Pubchem CID
RBC : 24906266
Millipore : 6419747

ChEMBL
RBC : -
Millipore : CHEMBL104279

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (94.97%)	inactive (76%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (104.79%)	inactive (96%)
AKT2	inactive (88.63%)	inactive (128%)
AKT3	inactive (97.4%)	inactive (88%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (106.1%)	inactive (80%)
MRCKa	inactive (70.73%)	inactive (103%)
MRCKb	inactive (113.85%)	inactive (83%)
ROCK1	inactive (63.85%)	inactive (92%)
ROCK2	active (40.98%)	active (37%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (100.49%)	-
BARK2	inactive (110.52%)	-
GPRK4	active (40.37%)	-
GPRK5	inactive (86.3%)	inactive (62%)
GPRK6	active (47.24%)	inactive (96%)
GPRK7	active (20.86%)	active (14%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (80.86%)	inactive (86%)
MSK2	inactive (71.18%)	inactive (56%)
p70S6K	active (44.3%)	active (29%)
p70S6Kb	inactive (94.57%)	-
RSK2	active (12.43%)	active (9%)
RSK4	active (6.55%)	active (21%)
RSK1	active (12.72%)	active (4%)
RSK3	active (9.26%)	active (9%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (100.59%)	-
PRKX	inactive (81.02%)	inactive (88%)
PKACa	inactive (103.58%)	inactive (93%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (122.79%)	inactive (108%)
PKCd	inactive (91.25%)	inactive (101%)
PKCe	inactive (77.28%)	inactive (90%)
PKCh	inactive (101.53%)	inactive (96%)
PKCg	inactive (105.95%)	inactive (95%)
PKCi	inactive (99.57%)	inactive (110%)
PKCt	inactive (102.85%)	inactive (84%)
PKCz	inactive (104.8%)	inactive (101%)
PKCb	inactive (86.7%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (85.02%)	-
PKG1	inactive (81.13%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (68.91%)	-
PKN2	inactive (81.83%)	inactive (58%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (71.82%)	inactive (85%)
SGK2	inactive (80.73%)	inactive (74%)
SGK3	inactive (94.72%)	inactive (112%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (53.15%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (52.48%)	inactive (57%)
ABL2	inactive (54.24%)	inactive (57%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (72.32%)	inactive (60%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (72.1%)	inactive (56%)
LTK	inactive (54.49%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	active (49.19%)	active (13%)
MER	active (45.93%)	active (22%)
TYRO3	inactive (90.45%)	inactive (67%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	active (42.85%)	active (9%)
BRK	inactive (80.16%)	inactive (97%)
SRC	active (45.06%)	active (49%)
FGR	active (28.37%)	active (9%)
FRK	inactive (97.07%)	inactive (74%)
FYN	active (45.66%)	active (10%)
HCK	active (49.98%)	active (26%)
LCK	inactive (57.6%)	active (20%)
SRM	inactive (99.76%)	-
YES	active (24.16%)	active (8%)
LYN	active (43.79%)	active (10%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (77.03%)	active (50%)
BTK	active (30.4%)	active (19%)
ITK	active (21.38%)	active (8%)
TEC	inactive (156.78%)	-
TXK	inactive (51.27%)	inactive (75%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (68.24%)	inactive (69%)
FLT3	active (1.56%)	active (1%)
FMS	inactive (82.53%)	inactive (52%)
PDGFRb	inactive (65.95%)	inactive (98%)
PDGFRa	inactive (81.05%)	inactive (77%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (89.29%)	inactive (114%)
CTK	inactive (103.08%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (100.33%)	inactive (94%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (77.54%)	inactive (103%)
ErbB2	inactive (120.19%)	-
ErbB4	inactive (81.29%)	inactive (94%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (100.61%)	inactive (89%)
EphA2	inactive (93.02%)	inactive (100%)
EphA3	inactive (80.89%)	active (50%)
EphA4	inactive (80.47%)	inactive (96%)
EphA5	inactive (69.28%)	inactive (54%)
EphA6	active (30.22%)	-
EphA7	active (41.29%)	active (32%)
EphA8	inactive (83.43%)	inactive (88%)
EphB1	inactive (68.72%)	inactive (66%)
EphB2	inactive (84.81%)	inactive (73%)
EphB3	inactive (93.24%)	inactive (100%)
EphB4	inactive (57.36%)	inactive (57%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (94.09%)	inactive (103%)
PYK2	active (43.14%)	active (22%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	active (20.01%)	active (35%)
FES	inactive (57.4%)	active (40%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (50.16%)	active (19%)
FGFR2	inactive (50.53%)	active (10%)
FGFR3	active (33.83%)	active (17%)
FGFR4	inactive (74.1%)	inactive (118%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (70.14%)	active (22%)
FLT4	inactive (65.13%)	active (11%)
KDR	inactive (74.29%)	active (28%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (87.95%)	inactive (118%)
IRR	inactive (86.91%)	inactive (124%)
INSR	inactive (87.44%)	inactive (91%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (83.87%)	-
JAK2	inactive (58.37%)	inactive (53%)
JAK3	active (43.7%)	active (45%)
TYK2	active (34.97%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (104.59%)	inactive (69%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (1.93%)	active (1%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (100.26%)	inactive (94%)
MET	inactive (84.18%)	inactive (84%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (82.21%)	inactive (98%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	active (16.45%)	active (38%)
ZAP70	inactive (102.3%)	inactive (107%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (95.83%)	inactive (86%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	active (6.15%)	active (1%)
TRKB	active (4.83%)	active (23%)
TRKC	active (1.18%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (99.11%)	-
ALK2	inactive (111.33%)	-
ALK4	inactive (98.38%)	inactive (118%)
TGFbR1	inactive (97.78%)	inactive (100%)
TGFbR2	inactive (100.83%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (112.89%)	-
BRAF	inactive (96.81%)	-
RAF1	inactive (102.02%)	inactive (91%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	active (14.17%)	active (1%)
IRAK4	active (2.98%)	active (0%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (74.07%)	inactive (101%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (9.76%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (28.12%)	active (6%)
MLK2	inactive (95.89%)	-
MLK3	active (9.89%)	-
TAK1	active (48.91%)	inactive (92%)
ZAK	inactive (94.96%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (74.25%)	inactive (52%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (5.88%)	active (18%)
BRSK1	active (47.82%)	active (23%)
BRSK2	inactive (65.52%)	active (36%)
CHK1	active (19.48%)	active (16%)
LKB1	inactive (68.18%)	inactive (103%)
MARK1	active (40.38%)	active (23%)
MARK3	inactive (57.23%)	-
MARK4	active (40.59%)	-
MELK	inactive (63.01%)	active (42%)
PASK	inactive (84.77%)	inactive (97%)
QIK	inactive (81.42%)	-
NuaK2	inactive (102.45%)	-
MARK2	active (45.49%)	active (29%)
AMPKa1	-	active (9%)
AMPKa2	-	active (9%)
SIK	-	active (24%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (75.73%)	inactive (54%)
CaMK1b	inactive (58.14%)	-
CaMK1d	inactive (69.56%)	inactive (65%)
CaMK1g	inactive (89.25%)	-
CaMK4	inactive (96.4%)	inactive (120%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (57.61%)	-
CaMK2b	inactive (86.45%)	inactive (65%)
CaMK2d	inactive (66.81%)	active (23%)
CaMK2g	inactive (91.93%)	active (23%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (1.3%)	active (4%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (98.85%)	inactive (94%)
DAPK2	inactive (94%)	inactive (92%)
DRAK1	inactive (57.49%)	active (22%)
DAPK3	inactive (94.13%)	inactive (106%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (93.19%)	inactive (97%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (101.27%)	inactive (83%)
MAPKAPK3	inactive (91.45%)	inactive (117%)
MAPKAPK5	inactive (88.33%)	inactive (62%)
MNK1	inactive (74.11%)	-
MNK2	inactive (71.11%)	inactive (80%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (95.01%)	inactive (63%)
skMLCK	inactive (53.56%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	active (20.6%)	-
PHKg2	inactive (51.96%)	active (24%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (96.53%)	inactive (76%)
PIM2	inactive (101.34%)	inactive (109%)
PIM3	inactive (91.55%)	inactive (102%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (79.98%)	inactive (84%)
PKD3	inactive (76.44%)	-
PKD2	inactive (87.22%)	inactive (103%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	active (17.04%)	active (19%)
TSSK2	inactive (83.98%)	inactive (72%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	active (46.27%)	active (22%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (53.23%)	active (29%)
MAP3K2	inactive (92.05%)	-
MAP3K3	inactive (80.67%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (96.81%)	-
NIK	inactive (122.87%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (17.39%)	active (7%)
HGK	active (22.51%)	-
KHS1	active (13.43%)	-
LOK	active (16.99%)	active (45%)
MINK	inactive (53.75%)	inactive (56%)
MST1	active (10.66%)	active (13%)
MST2	active (23.41%)	active (27%)
MST3	inactive (80.2%)	inactive (69%)
MST4	inactive (101.48%)	-
OSR1	inactive (93.75%)	-
PAK1	inactive (90.83%)	-
PAK2	inactive (79.19%)	inactive (124%)
PAK3	inactive (93.81%)	inactive (88%)
PAK4	inactive (86.19%)	active (28%)
PAK5	inactive (75.34%)	active (41%)
PAK6	inactive (90.12%)	active (46%)
SLK	active (28.63%)	-
YSK1	inactive (83.53%)	-
STLK3	inactive (79.26%)	-
TAO1	inactive (98.28%)	inactive (74%)
TAO2	inactive (86.45%)	inactive (100%)
TAO3	inactive (60.18%)	inactive (74%)
MYO3B	inactive (74.59%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (63.58%)	active (42%)
MAP2K2	inactive (94.67%)	-
MAP2K6	inactive (115.75%)	inactive (69%)
MAP2K7	-	inactive (89%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (20.01%)	active (-4%)
AurB	active (10.49%)	active (3%)
AurC	active (37.14%)	active (40%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	active (44.91%)	-
CaMKK2	active (34.37%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (93.08%)	inactive (101%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (109.38%)	inactive (100%)
IKKb	inactive (101.28%)	inactive (87%)
IKKe	active (21.9%)	-
TBK1	active (21.64%)	active (8%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (68.51%)	-
NEK11	inactive (96.06%)	inactive (83%)
NEK2	inactive (89.14%)	inactive (79%)
NEK4	inactive (81.05%)	-
NEK6	inactive (98.57%)	inactive (100%)
NEK7	inactive (101.09%)	inactive (103%)
NEK9	inactive (67.32%)	-
NEK3	inactive (66.21%)	inactive (72%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (99.56%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (92.06%)	inactive (109%)
PLK2	inactive (104.2%)	inactive (94%)
PLK3	inactive (99.01%)	inactive (100%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (92.49%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (78.71%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (97.26%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	active (27.48%)	-
ULK2	inactive (72.28%)	active (43%)
ULK3	active (15.83%)	active (19%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (82.29%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (97.71%)	inactive (111%)
Wnk3	inactive (99%)	inactive (97%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (63.17%)	inactive (87%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (102.34%)	inactive (93%)
CK1g1	inactive (88.32%)	inactive (88%)
CK1g2	inactive (100.25%)	inactive (98%)
CK1g3	inactive (109.35%)	inactive (97%)
CK1a	inactive (105.43%)	-
CK1e	inactive (89.02%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (102.9%)	-
VRK2	-	inactive (114%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (84.66%)	inactive (79%)
CK2a2	inactive (66.04%)	inactive (124%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (88.26%)	-
CLK2	active (38.13%)	active (35%)
CLK3	inactive (81.39%)	active (45%)
CLK4	active (42.57%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (92.17%)	-
DYRK1B	inactive (103.74%)	-
DYRK2	inactive (85.48%)	inactive (102%)
DYRK3	inactive (89.71%)	-
DYRK4	inactive (73.69%)	-
HIPK1	inactive (97.16%)	inactive (91%)
HIPK2	inactive (82.6%)	inactive (60%)
HIPK3	inactive (104.92%)	inactive (85%)
HIPK4	inactive (86.21%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (109.08%)	inactive (85%)
Erk2	inactive (98.19%)	inactive (106%)
JNK3	inactive (93.14%)	inactive (58%)
NLK	inactive (90.41%)	inactive (104%)
p38a	inactive (123.46%)	inactive (94%)
p38b	inactive (93.81%)	inactive (98%)
p38d	inactive (104.91%)	inactive (114%)
p38g	inactive (100.94%)	inactive (99%)
JNK1	inactive (108.33%)	inactive (109%)
JNK2	inactive (93.84%)	inactive (98%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (100.46%)	inactive (120%)
GSK3B	inactive (98.45%)	inactive (89%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (88.47%)	inactive (103%)
SRPK1	inactive (69.03%)	active (39%)
SRPK2	inactive (51.39%)	active (36%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (94.97%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (98%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (106%)