Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : LY 303511

Inchikey
Same : NGAGMBNBKCDCDJ-N
RBC, Millipore : NGAGMBNBKCDCDJ-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 3833

Pubchem CID
RBC, Millipore : 3971

ChEMBL
RBC, Millipore : CHEMBL1363184

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (110.37%)	inactive (106%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (103%)	inactive (107%)
AKT2	inactive (100.06%)	inactive (98%)
AKT3	inactive (102.13%)	inactive (85%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (96.2%)	inactive (134%)
MRCKa	inactive (106.62%)	inactive (86%)
MRCKb	inactive (97.52%)	inactive (93%)
ROCK1	inactive (104.48%)	inactive (120%)
ROCK2	inactive (87.51%)	inactive (108%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (108.74%)	-
BARK2	inactive (97.39%)	-
GPRK4	inactive (106.47%)	-
GPRK5	inactive (103.44%)	inactive (81%)
GPRK6	inactive (89.59%)	inactive (102%)
GPRK7	inactive (113.87%)	inactive (95%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (99.15%)	inactive (123%)
MSK2	inactive (117.12%)	inactive (93%)
p70S6K	inactive (101.84%)	inactive (69%)
p70S6Kb	inactive (90.97%)	-
RSK2	inactive (101.32%)	inactive (51%)
RSK4	inactive (99.03%)	inactive (121%)
RSK1	inactive (104.09%)	inactive (115%)
RSK3	inactive (106.04%)	inactive (124%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (83.18%)	-
PRKX	inactive (99%)	inactive (93%)
PKACa	inactive (109.55%)	inactive (72%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (99.07%)	inactive (105%)
PKCd	inactive (99.6%)	inactive (101%)
PKCe	inactive (104.22%)	inactive (93%)
PKCh	inactive (97.02%)	inactive (99%)
PKCg	inactive (96.09%)	inactive (101%)
PKCi	inactive (105.41%)	inactive (93%)
PKCt	inactive (116.5%)	inactive (102%)
PKCz	inactive (116.39%)	inactive (102%)
PKCb	inactive (100.89%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (107.08%)	-
PKG1	inactive (102.17%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (99.6%)	-
PKN2	inactive (99.53%)	inactive (105%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (103.05%)	inactive (80%)
SGK2	inactive (101.59%)	inactive (113%)
SGK3	inactive (111.02%)	inactive (107%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (94.34%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (110.29%)	inactive (88%)
ABL2	inactive (99.5%)	inactive (97%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (90.71%)	inactive (88%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (83.83%)	inactive (69%)
LTK	inactive (96.92%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (117.04%)	inactive (80%)
MER	inactive (98.3%)	inactive (107%)
TYRO3	inactive (107.27%)	inactive (94%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (121.79%)	inactive (113%)
BRK	inactive (99.18%)	inactive (108%)
SRC	inactive (91.21%)	inactive (94%)
FGR	inactive (99.91%)	inactive (106%)
FRK	inactive (104.74%)	inactive (117%)
FYN	inactive (103.99%)	inactive (88%)
HCK	inactive (93.72%)	inactive (79%)
LCK	inactive (103.54%)	inactive (113%)
SRM	inactive (103.53%)	-
YES	inactive (96.44%)	inactive (106%)
LYN	inactive (95.83%)	inactive (107%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (97.98%)	inactive (88%)
BTK	inactive (85.65%)	inactive (114%)
ITK	inactive (88.08%)	inactive (83%)
TEC	inactive (99.82%)	-
TXK	inactive (95.39%)	inactive (113%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (100.67%)	inactive (97%)
FLT3	inactive (108.39%)	inactive (78%)
FMS	inactive (107.59%)	inactive (61%)
PDGFRb	inactive (100.92%)	inactive (99%)
PDGFRa	inactive (97.41%)	inactive (119%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (89.74%)	inactive (121%)
CTK	inactive (84.5%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (95.5%)	inactive (109%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (109.85%)	inactive (111%)
ErbB2	inactive (95.52%)	-
ErbB4	inactive (104.12%)	inactive (95%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (112.18%)	inactive (91%)
EphA2	inactive (108.5%)	inactive (99%)
EphA3	inactive (88.52%)	inactive (91%)
EphA4	inactive (100.04%)	inactive (110%)
EphA5	inactive (109.08%)	inactive (112%)
EphA6	inactive (88.17%)	-
EphA7	inactive (102.25%)	inactive (98%)
EphA8	inactive (98.12%)	inactive (102%)
EphB1	inactive (94.79%)	inactive (100%)
EphB2	inactive (97.33%)	inactive (103%)
EphB3	inactive (94.5%)	inactive (109%)
EphB4	inactive (101.35%)	inactive (97%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (99.01%)	inactive (105%)
PYK2	inactive (88.28%)	inactive (112%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (99.21%)	inactive (111%)
FES	inactive (95.44%)	inactive (106%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (110.29%)	inactive (105%)
FGFR2	inactive (98.86%)	inactive (106%)
FGFR3	inactive (96.3%)	inactive (122%)
FGFR4	inactive (105.57%)	inactive (111%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (86.56%)	inactive (88%)
FLT4	inactive (104.4%)	inactive (96%)
KDR	inactive (99.85%)	inactive (100%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (102.74%)	inactive (113%)
IRR	inactive (89.17%)	inactive (121%)
INSR	inactive (100.67%)	inactive (109%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (108.48%)	-
JAK2	inactive (104.36%)	inactive (112%)
JAK3	inactive (96.86%)	inactive (94%)
TYK2	inactive (98.47%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (103.21%)	inactive (92%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (105.9%)	inactive (108%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (96%)	inactive (76%)
MET	inactive (106.88%)	inactive (106%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (99.2%)	inactive (97%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (103.58%)	inactive (108%)
ZAP70	inactive (101.95%)	inactive (103%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (95.05%)	inactive (69%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (96.37%)	inactive (117%)
TRKB	inactive (102.32%)	inactive (109%)
TRKC	inactive (99.81%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (105.55%)	-
ALK2	inactive (90.29%)	-
ALK4	inactive (104.57%)	inactive (122%)
TGFbR1	inactive (97.25%)	inactive (91%)
TGFbR2	inactive (88.43%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (103.05%)	-
BRAF	inactive (95.42%)	-
RAF1	inactive (94.23%)	inactive (88%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (161.75%)	inactive (92%)
IRAK4	inactive (96.83%)	inactive (93%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (108.08%)	inactive (92%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (100.79%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (100.52%)	inactive (88%)
MLK2	inactive (87.88%)	-
MLK3	inactive (97.82%)	-
TAK1	inactive (94.18%)	inactive (95%)
ZAK	inactive (102.71%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (82.92%)	inactive (97%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (95.55%)	inactive (91%)
BRSK1	inactive (95.27%)	inactive (70%)
BRSK2	inactive (102.62%)	inactive (98%)
CHK1	inactive (103.69%)	inactive (83%)
LKB1	inactive (101.17%)	inactive (97%)
MARK1	inactive (99.32%)	inactive (82%)
MARK3	inactive (88.77%)	-
MARK4	inactive (92.76%)	-
MELK	inactive (94.53%)	inactive (80%)
PASK	inactive (92.97%)	inactive (148%)
QIK	inactive (109.83%)	-
NuaK2	inactive (89.17%)	-
MARK2	inactive (105.45%)	inactive (96%)
AMPKa1	-	inactive (95%)
AMPKa2	-	inactive (122%)
SIK	-	inactive (82%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (99.21%)	inactive (105%)
CaMK1b	inactive (99.78%)	-
CaMK1d	inactive (81.98%)	inactive (110%)
CaMK1g	inactive (94.74%)	-
CaMK4	inactive (104.35%)	inactive (113%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (104.29%)	-
CaMK2b	inactive (108.48%)	inactive (91%)
CaMK2d	inactive (93.64%)	inactive (101%)
CaMK2g	inactive (101.69%)	inactive (104%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (96.58%)	inactive (90%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (91.12%)	inactive (96%)
DAPK2	inactive (93.99%)	inactive (98%)
DRAK1	inactive (98.36%)	inactive (69%)
DAPK3	inactive (132.85%)	inactive (112%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (115.99%)	inactive (115%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (102.73%)	inactive (94%)
MAPKAPK3	inactive (107.72%)	inactive (108%)
MAPKAPK5	inactive (103.71%)	inactive (93%)
MNK1	inactive (106.54%)	-
MNK2	inactive (106.79%)	inactive (108%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (104.71%)	inactive (93%)
skMLCK	inactive (97.27%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (90.66%)	-
PHKg2	inactive (96.95%)	inactive (84%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (92.41%)	inactive (84%)
PIM2	inactive (120.74%)	inactive (100%)
PIM3	inactive (93.54%)	inactive (88%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (91.86%)	inactive (96%)
PKD3	inactive (88.64%)	-
PKD2	inactive (86.75%)	inactive (102%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (89.55%)	inactive (101%)
TSSK2	inactive (100.85%)	inactive (92%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (86.12%)	inactive (98%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (105.84%)	inactive (90%)
MAP3K2	inactive (105.03%)	-
MAP3K3	inactive (108.98%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (95.19%)	-
NIK	inactive (109.76%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (87.61%)	inactive (90%)
HGK	inactive (92.73%)	-
KHS1	-	-
LOK	inactive (94.26%)	inactive (95%)
MINK	inactive (96.96%)	inactive (104%)
MST1	inactive (88.71%)	inactive (98%)
MST2	inactive (102.28%)	inactive (95%)
MST3	inactive (89.59%)	inactive (59%)
MST4	inactive (96.34%)	-
OSR1	inactive (85.57%)	-
PAK1	inactive (99.05%)	-
PAK2	inactive (99.78%)	inactive (98%)
PAK3	inactive (99.79%)	inactive (66%)
PAK4	inactive (81.09%)	inactive (102%)
PAK5	inactive (104.39%)	inactive (104%)
PAK6	inactive (101.96%)	inactive (89%)
SLK	inactive (104.95%)	-
YSK1	inactive (115.66%)	-
STLK3	inactive (88.51%)	-
TAO1	inactive (90.84%)	inactive (107%)
TAO2	inactive (98.32%)	inactive (105%)
TAO3	inactive (92.79%)	inactive (98%)
MYO3B	inactive (97.54%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (102.79%)	inactive (99%)
MAP2K2	inactive (94.02%)	-
MAP2K6	inactive (96.21%)	inactive (92%)
MAP2K7	-	inactive (100%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (105.14%)	inactive (95%)
AurB	inactive (97.77%)	inactive (79%)
AurC	inactive (97.59%)	inactive (115%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (105.44%)	-
CaMKK2	inactive (83.65%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (94.27%)	inactive (83%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (103.13%)	inactive (106%)
IKKb	inactive (102.75%)	inactive (99%)
IKKe	inactive (88.05%)	-
TBK1	inactive (98.73%)	inactive (72%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (82.85%)	-
NEK11	inactive (97.95%)	inactive (104%)
NEK2	inactive (85.96%)	inactive (84%)
NEK4	inactive (86.36%)	-
NEK6	inactive (105.02%)	inactive (80%)
NEK7	inactive (95.75%)	inactive (104%)
NEK9	inactive (102.27%)	-
NEK3	inactive (105.92%)	inactive (101%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (123.75%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (96.58%)	inactive (82%)
PLK2	inactive (98.9%)	inactive (99%)
PLK3	inactive (103.94%)	inactive (100%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (92.8%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (97.41%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (91.36%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (107.19%)	-
ULK2	inactive (107.9%)	inactive (100%)
ULK3	inactive (101.35%)	inactive (101%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (83.37%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (111%)	inactive (108%)
Wnk3	inactive (93.36%)	inactive (133%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (94.84%)	inactive (97%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (99.49%)	inactive (88%)
CK1g1	inactive (103.17%)	inactive (97%)
CK1g2	inactive (100.8%)	inactive (81%)
CK1g3	inactive (101.65%)	inactive (88%)
CK1a	inactive (104.1%)	-
CK1e	inactive (101.11%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (92.14%)	-
VRK2	-	inactive (95%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (89.92%)	inactive (79%)
CK2a2	inactive (105.95%)	inactive (106%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (102.3%)	-
CLK2	inactive (100.39%)	inactive (90%)
CLK3	inactive (108.65%)	inactive (81%)
CLK4	inactive (88.9%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (96.85%)	-
DYRK1B	inactive (99.24%)	-
DYRK2	inactive (96.77%)	inactive (87%)
DYRK3	inactive (97.85%)	-
DYRK4	inactive (94.74%)	-
HIPK1	inactive (109.77%)	inactive (101%)
HIPK2	inactive (107.51%)	inactive (97%)
HIPK3	inactive (116.27%)	inactive (90%)
HIPK4	inactive (96.93%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (118.84%)	inactive (86%)
Erk2	inactive (65.4%)	inactive (101%)
JNK3	inactive (84.95%)	inactive (73%)
NLK	inactive (98.78%)	inactive (99%)
p38a	inactive (82.79%)	inactive (101%)
p38b	inactive (104.89%)	inactive (95%)
p38d	inactive (104.05%)	inactive (111%)
p38g	inactive (91.99%)	inactive (92%)
JNK1	inactive (89.34%)	inactive (106%)
JNK2	inactive (90.36%)	inactive (107%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (99.74%)	inactive (112%)
GSK3B	inactive (97.01%)	inactive (78%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (94.36%)	inactive (103%)
SRPK1	inactive (106.07%)	inactive (99%)
SRPK2	inactive (104.62%)	inactive (91%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (110.37%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (95%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (90%)