Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : Flt-3 Inhibitor II

Inchikey
Same : NIMIWWQLOGNYHD-N
RBC, Millipore : NIMIWWQLOGNYHD-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 9776500

Pubchem CID
RBC, Millipore : 11601743

ChEMBL
RBC, Millipore : CHEMBL377193

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (97.2%)	inactive (79%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (98.2%)	inactive (102%)
AKT2	inactive (104.38%)	inactive (92%)
AKT3	inactive (101.95%)	inactive (93%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (96.95%)	inactive (120%)
MRCKa	inactive (90.22%)	inactive (85%)
MRCKb	inactive (96.2%)	inactive (77%)
ROCK1	inactive (96.17%)	inactive (97%)
ROCK2	inactive (92.85%)	inactive (67%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (98.22%)	-
BARK2	inactive (101.72%)	-
GPRK4	inactive (103.19%)	-
GPRK5	inactive (104.2%)	inactive (79%)
GPRK6	inactive (101.88%)	inactive (88%)
GPRK7	inactive (99.8%)	inactive (75%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (96.1%)	inactive (99%)
MSK2	inactive (81.25%)	inactive (67%)
p70S6K	inactive (85.01%)	inactive (73%)
p70S6Kb	inactive (102.44%)	-
RSK2	active (37.75%)	active (30%)
RSK4	active (26.67%)	active (26%)
RSK1	active (30.07%)	active (13%)
RSK3	active (22.19%)	active (40%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (94.52%)	inactive (81%)
PKACa	inactive (107.36%)	inactive (74%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (84.09%)	inactive (104%)
PKCd	inactive (89.75%)	inactive (100%)
PKCe	inactive (119.31%)	inactive (93%)
PKCh	inactive (76.3%)	inactive (101%)
PKCg	inactive (85.05%)	inactive (101%)
PKCi	inactive (98.43%)	inactive (92%)
PKCt	inactive (92.09%)	inactive (83%)
PKCz	inactive (96.41%)	inactive (103%)
PKCb	inactive (98.86%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (80.64%)	-
PKG1	inactive (89.98%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (76.27%)	-
PKN2	inactive (97.11%)	inactive (72%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (74.16%)	inactive (68%)
SGK2	inactive (94.28%)	inactive (62%)
SGK3	inactive (112.7%)	inactive (81%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	active (27.81%)	active (11%)
ABL2	active (27.18%)	active (27%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (90.58%)	inactive (64%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (97.04%)	inactive (68%)
LTK	inactive (91.57%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (90.08%)	active (50%)
MER	inactive (81.79%)	active (47%)
TYRO3	inactive (76.35%)	active (39%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	active (49.73%)	active (6%)
BRK	inactive (91.87%)	inactive (90%)
SRC	active (36.45%)	active (28%)
FGR	active (12.73%)	active (5%)
FRK	inactive (86.07%)	active (37%)
FYN	active (28.82%)	active (7%)
HCK	inactive (51.23%)	active (23%)
LCK	inactive (51.98%)	active (16%)
SRM	inactive (93.74%)	-
YES	active (18.8%)	active (6%)
LYN	active (34.88%)	active (6%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (80.62%)	inactive (55%)
BTK	inactive (86.81%)	inactive (78%)
ITK	inactive (77.71%)	inactive (64%)
TEC	inactive (105.1%)	-
TXK	inactive (74.91%)	inactive (64%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (45.59%)	active (33%)
FLT3	active (3.53%)	active (0%)
FMS	inactive (97.75%)	inactive (54%)
PDGFRb	active (41.69%)	active (35%)
PDGFRa	inactive (65.29%)	active (46%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (106.33%)	inactive (100%)
CTK	inactive (93.28%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (95.71%)	inactive (95%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (97.63%)	inactive (103%)
ErbB2	inactive (112.93%)	-
ErbB4	inactive (101.57%)	inactive (73%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (81.15%)	inactive (83%)
EphA2	inactive (101.06%)	inactive (97%)
EphA3	inactive (100.56%)	inactive (90%)
EphA4	inactive (109.05%)	inactive (96%)
EphA5	inactive (100.32%)	inactive (78%)
EphA6	-	-
EphA7	inactive (100.82%)	inactive (83%)
EphA8	inactive (92.91%)	inactive (85%)
EphB1	inactive (96.95%)	inactive (84%)
EphB2	inactive (76.66%)	inactive (88%)
EphB3	inactive (92.31%)	inactive (105%)
EphB4	inactive (89.31%)	inactive (72%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (109.17%)	inactive (112%)
PYK2	inactive (85.55%)	inactive (68%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (86.55%)	inactive (107%)
FES	inactive (95.29%)	inactive (87%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (86.49%)	active (40%)
FGFR2	inactive (98.54%)	inactive (83%)
FGFR3	inactive (92.07%)	inactive (70%)
FGFR4	inactive (92.83%)	inactive (96%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (81.35%)	active (20%)
FLT4	inactive (67.1%)	active (4%)
KDR	inactive (69.9%)	active (18%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (103.1%)	inactive (65%)
IRR	inactive (97.09%)	inactive (101%)
INSR	inactive (93.77%)	inactive (94%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (98.65%)	-
JAK2	inactive (95.63%)	inactive (98%)
JAK3	inactive (94.51%)	inactive (64%)
TYK2	inactive (66.72%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (55.1%)	active (43%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (8.98%)	active (8%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (90.39%)	inactive (80%)
MET	inactive (89.15%)	inactive (74%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (105.21%)	inactive (93%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (72.03%)	inactive (82%)
ZAP70	inactive (100.53%)	inactive (127%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (103.96%)	inactive (67%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (57.22%)	active (13%)
TRKB	active (37%)	inactive (56%)
TRKC	active (13.37%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (98.44%)	-
ALK2	inactive (122.63%)	-
ALK4	inactive (98.85%)	inactive (111%)
TGFbR1	inactive (93.35%)	inactive (79%)
TGFbR2	inactive (122.91%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (98.58%)	-
BRAF	inactive (97.44%)	-
RAF1	inactive (104.26%)	inactive (76%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (98.12%)	inactive (65%)
IRAK4	inactive (85.92%)	active (50%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (87.89%)	inactive (74%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (87.24%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (42.58%)	active (16%)
MLK2	inactive (91.71%)	-
MLK3	active (24.47%)	-
TAK1	inactive (79.45%)	inactive (62%)
ZAK	active (34.27%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	active (37.8%)	active (18%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (69.16%)	inactive (65%)
BRSK1	inactive (53.55%)	active (5%)
BRSK2	active (44.27%)	active (37%)
CHK1	inactive (82.54%)	inactive (76%)
LKB1	inactive (100.59%)	inactive (100%)
MARK1	inactive (66.32%)	active (40%)
MARK3	inactive (84.43%)	-
MARK4	inactive (55.27%)	-
MELK	active (49.25%)	active (27%)
PASK	inactive (78.69%)	inactive (92%)
QIK	inactive (78.27%)	-
NuaK2	inactive (95.72%)	-
MARK2	inactive (59.85%)	active (40%)
AMPKa1	-	active (16%)
AMPKa2	-	active (13%)
SIK	-	active (39%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (97.36%)	inactive (88%)
CaMK1b	inactive (104.89%)	-
CaMK1d	inactive (91.46%)	inactive (87%)
CaMK1g	inactive (100.73%)	-
CaMK4	inactive (96.51%)	inactive (114%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (74.51%)	-
CaMK2b	inactive (93.37%)	inactive (53%)
CaMK2d	inactive (63.68%)	active (23%)
CaMK2g	inactive (89.51%)	active (30%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (80.15%)	inactive (60%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (100.96%)	inactive (90%)
DAPK2	inactive (100.6%)	inactive (88%)
DRAK1	inactive (51.7%)	active (13%)
DAPK3	inactive (104.22%)	inactive (85%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (88.44%)	inactive (70%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (102.92%)	inactive (64%)
MAPKAPK3	inactive (91.2%)	inactive (99%)
MAPKAPK5	inactive (89.63%)	inactive (71%)
MNK1	inactive (83.61%)	-
MNK2	active (46.75%)	active (33%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (91.38%)	inactive (70%)
skMLCK	active (21.08%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (72.08%)	-
PHKg2	inactive (105.13%)	inactive (91%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (76.1%)	inactive (60%)
PIM2	inactive (108.26%)	inactive (80%)
PIM3	inactive (98.88%)	inactive (84%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (58.51%)	inactive (80%)
PKD3	inactive (54.85%)	-
PKD2	inactive (71.65%)	inactive (103%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (96.41%)	inactive (88%)
TSSK2	inactive (93.63%)	inactive (77%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (77.52%)	inactive (83%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (89.6%)	inactive (101%)
MAP3K2	inactive (101.62%)	-
MAP3K3	inactive (96.01%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (93.01%)	-
NIK	inactive (77.08%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (67.07%)	active (24%)
HGK	active (6.63%)	-
KHS1	active (28.67%)	-
LOK	inactive (70.33%)	inactive (55%)
MINK	active (9.87%)	active (21%)
MST1	active (33.67%)	active (39%)
MST2	active (41.38%)	inactive (56%)
MST3	inactive (70.36%)	active (48%)
MST4	inactive (100.83%)	-
OSR1	inactive (104.53%)	-
PAK1	inactive (94.58%)	-
PAK2	inactive (97.02%)	inactive (100%)
PAK3	inactive (99.16%)	inactive (69%)
PAK4	inactive (110.94%)	inactive (71%)
PAK5	inactive (85.27%)	inactive (89%)
PAK6	inactive (74.44%)	inactive (83%)
SLK	inactive (78.61%)	-
YSK1	inactive (105.47%)	-
STLK3	inactive (97.6%)	-
TAO1	inactive (85.58%)	inactive (70%)
TAO2	inactive (99.02%)	inactive (80%)
TAO3	inactive (66.64%)	inactive (66%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (102.66%)	inactive (80%)
MAP2K2	inactive (98.82%)	-
MAP2K6	inactive (93.62%)	inactive (112%)
MAP2K7	-	inactive (113%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (71.63%)	active (23%)
AurB	active (24.2%)	active (9%)
AurC	inactive (83.23%)	inactive (61%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (63.33%)	-
CaMKK2	inactive (84.16%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	active (34.78%)	active (39%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (103.23%)	inactive (109%)
IKKb	inactive (91.34%)	inactive (70%)
IKKe	inactive (81.58%)	-
TBK1	active (34.97%)	active (16%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (93.36%)	-
NEK11	inactive (96.71%)	inactive (54%)
NEK2	inactive (100.51%)	inactive (77%)
NEK4	inactive (87.61%)	-
NEK6	inactive (99.61%)	inactive (92%)
NEK7	inactive (101.16%)	inactive (95%)
NEK9	inactive (93.56%)	-
NEK3	inactive (111.42%)	inactive (111%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (100.08%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (100.77%)	inactive (92%)
PLK2	inactive (101.69%)	inactive (87%)
PLK3	inactive (101.14%)	inactive (85%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (95.49%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (54.62%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (92.87%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (60.06%)	-
ULK2	inactive (94.55%)	inactive (82%)
ULK3	active (0%)	inactive (73%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (90.64%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (96.63%)	inactive (83%)
Wnk3	inactive (74.65%)	inactive (88%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (81%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (92.51%)	inactive (74%)
CK1g1	inactive (93.07%)	active (50%)
CK1g2	inactive (93.76%)	inactive (52%)
CK1g3	inactive (77.23%)	inactive (79%)
CK1a	inactive (96.32%)	-
CK1e	inactive (88.37%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (85.31%)	-
VRK2	-	inactive (72%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (88.68%)	inactive (93%)
CK2a2	inactive (78.83%)	inactive (104%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (82.07%)	-
CLK2	inactive (104.72%)	active (32%)
CLK3	active (24.8%)	inactive (69%)
CLK4	inactive (79.06%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (103.2%)	-
DYRK1B	inactive (91.96%)	-
DYRK2	inactive (89.01%)	inactive (81%)
DYRK3	inactive (114.67%)	-
DYRK4	inactive (99.75%)	-
HIPK1	inactive (94.29%)	inactive (99%)
HIPK2	inactive (102.06%)	inactive (83%)
HIPK3	inactive (97.34%)	inactive (76%)
HIPK4	inactive (99.82%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (107.11%)	inactive (82%)
Erk2	inactive (112.69%)	inactive (112%)
JNK3	inactive (91.64%)	inactive (51%)
NLK	inactive (83.19%)	inactive (61%)
p38a	inactive (102.51%)	inactive (75%)
p38b	inactive (95.68%)	inactive (98%)
p38d	inactive (108.5%)	inactive (94%)
p38g	inactive (97.87%)	inactive (94%)
JNK1	inactive (112.25%)	inactive (96%)
JNK2	inactive (116.44%)	inactive (99%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (75.68%)	inactive (85%)
GSK3B	inactive (78.75%)	inactive (59%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (99.35%)	inactive (92%)
SRPK1	inactive (92.17%)	inactive (81%)
SRPK2	inactive (97.13%)	inactive (85%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (97.2%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (95%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (99%)