Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : 203911-27-7

Inchikey
Same : NOXXIYDYFSNHDF-N
RBC, Millipore : NOXXIYDYFSNHDF-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 15893632

Pubchem CID
RBC, Millipore : 16219471

ChEMBL
RBC, Millipore : -

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (91.32%)	inactive (111%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (99.35%)	inactive (107%)
AKT2	inactive (115.19%)	inactive (109%)
AKT3	inactive (94.11%)	inactive (97%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (95.05%)	inactive (107%)
MRCKa	inactive (103.76%)	inactive (114%)
MRCKb	inactive (98.76%)	inactive (101%)
ROCK1	inactive (60.15%)	inactive (98%)
ROCK2	active (37.8%)	active (25%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (104.51%)	-
BARK2	inactive (100.23%)	-
GPRK4	inactive (103.81%)	-
GPRK5	inactive (109.07%)	inactive (105%)
GPRK6	inactive (95.45%)	inactive (100%)
GPRK7	inactive (113.98%)	inactive (108%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (62.08%)	inactive (81%)
MSK2	inactive (81.77%)	inactive (58%)
p70S6K	inactive (76.63%)	inactive (90%)
p70S6Kb	inactive (81.86%)	-
RSK2	inactive (91.2%)	inactive (82%)
RSK4	inactive (93.95%)	inactive (85%)
RSK1	inactive (89.23%)	inactive (76%)
RSK3	inactive (79.85%)	inactive (84%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	active (23.46%)	active (21%)
PKACa	inactive (80.08%)	inactive (53%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (94.83%)	inactive (106%)
PKCd	inactive (84.7%)	inactive (85%)
PKCe	inactive (76.47%)	inactive (110%)
PKCh	inactive (84.01%)	inactive (80%)
PKCg	inactive (109.99%)	inactive (97%)
PKCi	inactive (87.24%)	inactive (106%)
PKCt	inactive (89.94%)	inactive (97%)
PKCz	inactive (94.7%)	inactive (111%)
PKCb	inactive (101.26%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (98.85%)	-
PKG1	inactive (79.62%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	active (40.46%)	-
PKN2	inactive (102.54%)	inactive (56%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (96.58%)	inactive (84%)
SGK2	inactive (91.91%)	inactive (112%)
SGK3	inactive (91.58%)	inactive (116%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (96.84%)	inactive (110%)
ABL2	inactive (87.58%)	inactive (94%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (89.35%)	inactive (91%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (119.5%)	inactive (117%)
LTK	inactive (95.16%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (97.18%)	inactive (108%)
MER	inactive (88.34%)	inactive (110%)
TYRO3	inactive (87.9%)	inactive (96%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (85.29%)	inactive (120%)
BRK	inactive (96.1%)	inactive (105%)
SRC	inactive (85.32%)	inactive (114%)
FGR	inactive (90.54%)	inactive (98%)
FRK	inactive (78.09%)	inactive (115%)
FYN	inactive (106.32%)	inactive (84%)
HCK	inactive (95.93%)	inactive (99%)
LCK	inactive (101.13%)	inactive (98%)
SRM	inactive (97.46%)	-
YES	inactive (96.47%)	inactive (128%)
LYN	inactive (105.83%)	inactive (83%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (104.19%)	inactive (98%)
BTK	inactive (96.5%)	inactive (94%)
ITK	inactive (90.75%)	inactive (105%)
TEC	inactive (108.86%)	-
TXK	inactive (84.15%)	inactive (91%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (96.67%)	inactive (113%)
FLT3	inactive (103.08%)	inactive (87%)
FMS	inactive (97.92%)	inactive (120%)
PDGFRb	inactive (102.15%)	inactive (116%)
PDGFRa	inactive (105.91%)	inactive (106%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (87.88%)	inactive (106%)
CTK	inactive (99.57%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (92.18%)	inactive (99%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (99.11%)	inactive (102%)
ErbB2	inactive (107.61%)	-
ErbB4	inactive (101.5%)	inactive (118%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (79.95%)	inactive (100%)
EphA2	inactive (102.4%)	inactive (98%)
EphA3	inactive (104.71%)	inactive (99%)
EphA4	inactive (98.46%)	inactive (115%)
EphA5	inactive (90.5%)	inactive (109%)
EphA6	-	-
EphA7	inactive (97.25%)	inactive (107%)
EphA8	inactive (105.98%)	inactive (105%)
EphB1	inactive (105.76%)	inactive (114%)
EphB2	inactive (83.17%)	inactive (101%)
EphB3	inactive (95.43%)	inactive (107%)
EphB4	inactive (107.39%)	inactive (108%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (93.91%)	inactive (110%)
PYK2	inactive (90.62%)	inactive (104%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (102.97%)	inactive (92%)
FES	inactive (121.23%)	inactive (109%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (94.55%)	inactive (127%)
FGFR2	inactive (97.58%)	inactive (103%)
FGFR3	inactive (94.38%)	inactive (106%)
FGFR4	inactive (82.79%)	inactive (96%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (89.98%)	inactive (102%)
FLT4	inactive (93.99%)	inactive (94%)
KDR	inactive (86.89%)	inactive (113%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (111.86%)	inactive (96%)
IRR	inactive (99.74%)	inactive (94%)
INSR	inactive (95.01%)	inactive (131%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (111.18%)	-
JAK2	inactive (106.57%)	inactive (103%)
JAK3	inactive (119.65%)	inactive (98%)
TYK2	inactive (81.63%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (97.64%)	inactive (117%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (97.83%)	inactive (53%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (92.71%)	inactive (98%)
MET	inactive (93.75%)	inactive (143%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (100.94%)	inactive (110%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (84.33%)	inactive (109%)
ZAP70	inactive (108.27%)	inactive (128%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (98.41%)	inactive (107%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (89.65%)	inactive (110%)
TRKB	inactive (102.46%)	inactive (83%)
TRKC	inactive (85.46%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (111.18%)	-
ALK2	inactive (96.51%)	-
ALK4	inactive (100.17%)	inactive (104%)
TGFbR1	inactive (98.36%)	inactive (121%)
TGFbR2	inactive (96.96%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (95.19%)	-
BRAF	inactive (97.72%)	-
RAF1	inactive (98.34%)	inactive (81%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (86.24%)	inactive (114%)
IRAK4	inactive (108.2%)	inactive (110%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (100.24%)	inactive (108%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (94.17%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (94.43%)	inactive (110%)
MLK2	inactive (88.27%)	-
MLK3	inactive (99.74%)	-
TAK1	inactive (106.32%)	inactive (103%)
ZAK	inactive (100.71%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (86.42%)	inactive (105%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (73.16%)	inactive (97%)
BRSK1	inactive (97.5%)	inactive (108%)
BRSK2	inactive (91.69%)	inactive (117%)
CHK1	inactive (103.35%)	inactive (101%)
LKB1	inactive (97.63%)	inactive (100%)
MARK1	inactive (98.6%)	inactive (106%)
MARK3	inactive (96.05%)	-
MARK4	inactive (102.53%)	-
MELK	inactive (78.59%)	inactive (75%)
PASK	inactive (97.13%)	inactive (83%)
QIK	inactive (97.71%)	-
NuaK2	inactive (83.49%)	-
MARK2	inactive (107.53%)	inactive (99%)
AMPKa1	-	inactive (94%)
AMPKa2	-	inactive (116%)
SIK	-	inactive (126%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (99.39%)	inactive (103%)
CaMK1b	inactive (91.61%)	-
CaMK1d	inactive (91.46%)	inactive (123%)
CaMK1g	inactive (100.6%)	-
CaMK4	inactive (92.94%)	inactive (103%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (99.9%)	-
CaMK2b	inactive (93.24%)	inactive (103%)
CaMK2d	inactive (98.46%)	inactive (103%)
CaMK2g	inactive (93.09%)	inactive (100%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (98.93%)	inactive (90%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (78.99%)	inactive (89%)
DAPK2	inactive (83.56%)	inactive (99%)
DRAK1	inactive (98.19%)	inactive (111%)
DAPK3	inactive (93.01%)	inactive (94%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (83.94%)	inactive (120%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (100.54%)	inactive (107%)
MAPKAPK3	inactive (99.66%)	inactive (111%)
MAPKAPK5	inactive (72.6%)	inactive (105%)
MNK1	inactive (91.78%)	-
MNK2	inactive (72.05%)	inactive (99%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (97.42%)	inactive (127%)
skMLCK	inactive (99.56%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (90.8%)	-
PHKg2	inactive (95.37%)	inactive (105%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (76.98%)	inactive (92%)
PIM2	inactive (93.23%)	inactive (138%)
PIM3	inactive (91.41%)	inactive (96%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (65.12%)	inactive (84%)
PKD3	inactive (65.85%)	-
PKD2	inactive (84.99%)	inactive (100%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (93.47%)	inactive (105%)
TSSK2	inactive (80.23%)	inactive (99%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (90.28%)	inactive (107%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (88.67%)	inactive (104%)
MAP3K2	inactive (77.79%)	-
MAP3K3	inactive (89.34%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (91.81%)	-
NIK	inactive (97.68%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (45.74%)	inactive (104%)
HGK	active (44.11%)	-
KHS1	active (36.25%)	-
LOK	inactive (103.38%)	inactive (106%)
MINK	inactive (96.61%)	inactive (117%)
MST1	inactive (94.79%)	inactive (97%)
MST2	inactive (90%)	inactive (90%)
MST3	inactive (70.19%)	inactive (113%)
MST4	inactive (90.02%)	-
OSR1	inactive (94.88%)	-
PAK1	inactive (94.57%)	-
PAK2	inactive (109.18%)	inactive (109%)
PAK3	inactive (103.34%)	inactive (94%)
PAK4	inactive (110%)	inactive (106%)
PAK5	inactive (73.14%)	inactive (131%)
PAK6	inactive (86.98%)	inactive (95%)
SLK	inactive (95.77%)	-
YSK1	inactive (84.75%)	-
STLK3	inactive (103.36%)	-
TAO1	inactive (123.25%)	inactive (105%)
TAO2	inactive (87.26%)	inactive (121%)
TAO3	inactive (97.27%)	inactive (105%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (83%)	inactive (107%)
MAP2K2	inactive (117.15%)	-
MAP2K6	inactive (95.63%)	inactive (112%)
MAP2K7	-	inactive (85%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (101.39%)	inactive (116%)
AurB	inactive (98.79%)	inactive (115%)
AurC	inactive (97.42%)	inactive (96%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (107.84%)	-
CaMKK2	inactive (95.94%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (86.57%)	inactive (60%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (116.19%)	inactive (99%)
IKKb	inactive (90.4%)	inactive (134%)
IKKe	inactive (100.96%)	-
TBK1	inactive (97.32%)	inactive (115%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (90.29%)	-
NEK11	inactive (113.82%)	inactive (89%)
NEK2	inactive (92.33%)	inactive (113%)
NEK4	inactive (90.73%)	-
NEK6	inactive (97.59%)	inactive (104%)
NEK7	inactive (97.48%)	inactive (116%)
NEK9	inactive (95.91%)	-
NEK3	inactive (92.02%)	inactive (92%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (100.2%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (102.89%)	inactive (102%)
PLK2	inactive (100.42%)	inactive (108%)
PLK3	inactive (101.94%)	inactive (92%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (90.44%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (91.67%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (99.11%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (103.4%)	-
ULK2	inactive (101.41%)	inactive (111%)
ULK3	active (0%)	inactive (98%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (99.93%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (99.34%)	inactive (112%)
Wnk3	inactive (98.11%)	inactive (96%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (100%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (99.7%)	inactive (94%)
CK1g1	inactive (89.6%)	inactive (124%)
CK1g2	inactive (93.68%)	inactive (124%)
CK1g3	inactive (85%)	inactive (127%)
CK1a	inactive (64.3%)	-
CK1e	inactive (99.26%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (87.57%)	-
VRK2	-	inactive (101%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (94.89%)	inactive (103%)
CK2a2	inactive (91.91%)	inactive (95%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (96.26%)	-
CLK2	inactive (95.05%)	inactive (104%)
CLK3	inactive (83.67%)	inactive (94%)
CLK4	inactive (97.08%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (99.4%)	-
DYRK1B	inactive (96.32%)	-
DYRK2	inactive (97.89%)	inactive (104%)
DYRK3	inactive (89.15%)	-
DYRK4	inactive (97.92%)	-
HIPK1	inactive (96.8%)	inactive (112%)
HIPK2	inactive (101.23%)	inactive (104%)
HIPK3	inactive (106.65%)	inactive (98%)
HIPK4	inactive (103.35%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (96.08%)	inactive (136%)
Erk2	inactive (98.07%)	inactive (117%)
JNK3	inactive (85.35%)	inactive (114%)
NLK	inactive (97.35%)	inactive (105%)
p38a	inactive (104.37%)	inactive (90%)
p38b	inactive (91.89%)	inactive (118%)
p38d	inactive (98.78%)	inactive (111%)
p38g	inactive (99.28%)	inactive (102%)
JNK1	inactive (89.72%)	inactive (114%)
JNK2	inactive (86.97%)	inactive (93%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (102.1%)	inactive (97%)
GSK3B	inactive (101.96%)	inactive (136%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (96.36%)	inactive (101%)
SRPK1	inactive (92.64%)	inactive (105%)
SRPK2	inactive (83.95%)	inactive (107%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (91.32%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (106%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (89%)