Compound in Profiling

Compound Information

Test on : RBC

Compound Name : CVT-313

Inchikey : NQVIIUBWMBHLOZ-UHFFFAOYSA-N

ChemSpider : 5293583

Pubchem CID : 6918386

ChEMBL : CHEMBL80713

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (96.72%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (103.48%)
AKT2	inactive (89.89%)
AKT3	inactive (100.09%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (101.28%)
MRCKa	inactive (95%)
MRCKb	inactive (82.61%)
ROCK1	inactive (94.54%)
ROCK2	inactive (92.63%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (97.69%)
BARK2	inactive (94.49%)
GPRK4	inactive (96.96%)
GPRK5	inactive (100.73%)
GPRK6	inactive (93.98%)
GPRK7	inactive (101.46%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (96.7%)
MSK2	inactive (96.51%)
p70S6K	inactive (92.71%)
p70S6Kb	inactive (96.11%)
RSK2	inactive (76.89%)
RSK4	inactive (97.3%)
RSK1	inactive (86.86%)
RSK3	inactive (79.42%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (97.34%)
PKACa	inactive (99.98%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (91.17%)
PKCd	inactive (103.04%)
PKCe	inactive (95.07%)
PKCh	inactive (94.32%)
PKCg	inactive (87.49%)
PKCi	inactive (97.65%)
PKCt	inactive (90.56%)
PKCz	inactive (92.82%)
PKCb	inactive (95.37%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (95.7%)
PKG1	inactive (92.34%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (97.64%)
PKN2	inactive (90.92%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (105.53%)
SGK2	inactive (99.81%)
SGK3	inactive (102.46%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (95.62%)
ABL2	inactive (103.8%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (101.13%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (98.98%)
LTK	inactive (91.67%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (97.79%)
MER	inactive (90.77%)
TYRO3	inactive (95.49%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (99.03%)
BRK	inactive (90.5%)
SRC	inactive (90.43%)
FGR	inactive (95.83%)
FRK	inactive (101.94%)
FYN	inactive (98.95%)
HCK	inactive (98.3%)
LCK	inactive (93.82%)
SRM	inactive (90.01%)
YES	inactive (99.58%)
LYN	inactive (100.23%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (97.98%)
BTK	inactive (98.8%)
ITK	inactive (100.13%)
TEC	inactive (114.81%)
TXK	inactive (100.73%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (76.34%)
FLT3	inactive (79.02%)
FMS	inactive (93.91%)
PDGFRb	inactive (99.4%)
PDGFRa	inactive (88.81%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (102.28%)
CTK	inactive (90.59%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (90.73%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (97.59%)
ErbB2	inactive (94.99%)
ErbB4	inactive (99.49%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (95.68%)
EphA2	inactive (99.71%)
EphA3	inactive (101.87%)
EphA4	inactive (94.47%)
EphA5	inactive (99.95%)
EphA6	-
EphA7	inactive (94.92%)
EphA8	inactive (89.65%)
EphB1	inactive (96.69%)
EphB2	inactive (104.72%)
EphB3	inactive (100.25%)
EphB4	inactive (89.61%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (95.65%)
PYK2	inactive (95.85%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (95.65%)
FES	inactive (73.71%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (90.34%)
FGFR2	inactive (96.53%)
FGFR3	inactive (99.51%)
FGFR4	inactive (93.27%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (90.67%)
FLT4	inactive (91.28%)
KDR	inactive (103.28%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (96.87%)
IRR	inactive (89.26%)
INSR	inactive (101.91%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (100.57%)
JAK2	inactive (96.44%)
JAK3	inactive (101.78%)
TYK2	inactive (108.77%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (72.17%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (99.11%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (102.05%)
MET	inactive (73.17%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (103.28%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (99.59%)
ZAP70	inactive (97.92%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (97.85%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (92.1%)
TRKB	inactive (102.78%)
TRKC	inactive (95.69%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (100.72%)
ALK2	inactive (85.92%)
ALK4	inactive (103.71%)
TGFbR1	inactive (96.59%)
TGFbR2	inactive (74.56%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (92.69%)
BRAF	inactive (98.37%)
RAF1	inactive (98.92%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (114.28%)
IRAK4	inactive (113.31%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (103.13%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (98.38%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (99.96%)
MLK2	inactive (92.36%)
MLK3	inactive (101.78%)
TAK1	inactive (102.49%)
ZAK	inactive (96.34%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (87.01%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (94.85%)
BRSK1	inactive (93.08%)
BRSK2	inactive (96.44%)
CHK1	inactive (109.64%)
LKB1	inactive (79.92%)
MARK1	inactive (92.17%)
MARK3	inactive (100.07%)
MARK4	inactive (99.82%)
MELK	inactive (72.27%)
PASK	inactive (96.86%)
QIK	inactive (118.36%)
NuaK2	inactive (95.92%)
MARK2	inactive (91.66%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (90.16%)
CaMK1b	inactive (108.59%)
CaMK1d	inactive (101.08%)
CaMK1g	inactive (99.04%)
CaMK4	inactive (95.3%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (103.97%)
CaMK2b	inactive (113.98%)
CaMK2d	inactive (90.26%)
CaMK2g	inactive (96.51%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (81.71%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (85.84%)
DAPK2	inactive (87.11%)
DRAK1	inactive (101.04%)
DAPK3	inactive (97.09%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (95.79%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (100.12%)
MAPKAPK3	inactive (91.45%)
MAPKAPK5	inactive (79.18%)
MNK1	inactive (102.68%)
MNK2	inactive (92.89%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (96.04%)
skMLCK	inactive (96.52%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (86.89%)
PHKg2	inactive (98.28%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (98.77%)
PIM2	inactive (103.76%)
PIM3	inactive (106.98%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (97.16%)
PKD3	inactive (92.6%)
PKD2	inactive (88.29%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (91.27%)
TSSK2	inactive (98.58%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (90.18%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (112.21%)
MAP3K2	inactive (96.59%)
MAP3K3	inactive (101.1%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (88.46%)
NIK	inactive (98.86%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (88.14%)
HGK	inactive (96.39%)
KHS1	inactive (92.98%)
LOK	inactive (95.01%)
MINK	inactive (95.6%)
MST1	inactive (97.78%)
MST2	inactive (98.49%)
MST3	inactive (97.47%)
MST4	inactive (86.7%)
OSR1	inactive (112.02%)
PAK1	inactive (98.78%)
PAK2	inactive (107.69%)
PAK3	inactive (98.61%)
PAK4	inactive (106.57%)
PAK5	inactive (75.28%)
PAK6	inactive (99.64%)
SLK	inactive (97.75%)
YSK1	inactive (87.33%)
STLK3	inactive (97.15%)
TAO1	inactive (100.1%)
TAO2	-
TAO3	inactive (100.27%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (96.64%)
MAP2K2	inactive (96.55%)
MAP2K6	inactive (93.9%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (100.74%)
AurB	inactive (101.44%)
AurC	inactive (89.87%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (86.78%)
CaMKK2	inactive (94.36%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (95.19%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (94.21%)
IKKb	inactive (101.21%)
IKKe	inactive (100.87%)
TBK1	inactive (90.54%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (100.5%)
NEK11	inactive (114.17%)
NEK2	inactive (100.32%)
NEK4	inactive (93.33%)
NEK6	inactive (103.46%)
NEK7	inactive (102.36%)
NEK9	inactive (83.19%)
NEK3	inactive (84.99%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (109.86%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (92.68%)
PLK2	inactive (98.22%)
PLK3	inactive (96.52%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (102%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (103.01%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (85.52%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (95.53%)
ULK2	inactive (92.91%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (102.21%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (92.76%)
Wnk3	inactive (94.55%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (74.94%)
CK1g1	inactive (93.48%)
CK1g2	inactive (76.33%)
CK1g3	inactive (81.84%)
CK1a	inactive (83.82%)
CK1e	inactive (66.01%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (97.91%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (88.75%)
CK2a2	inactive (93.18%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (95.53%)
CLK2	inactive (69.54%)
CLK3	inactive (78.6%)
CLK4	inactive (70%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (93.01%)
DYRK1B	inactive (79.6%)
DYRK2	inactive (92.79%)
DYRK3	inactive (98.32%)
DYRK4	inactive (114.22%)
HIPK1	inactive (107.01%)
HIPK2	inactive (93.8%)
HIPK3	inactive (99.44%)
HIPK4	inactive (90.02%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (109.63%)
Erk2	inactive (100.33%)
JNK3	inactive (103.26%)
NLK	inactive (101.03%)
p38a	inactive (95.88%)
p38b	inactive (98.32%)
p38d	inactive (98.19%)
p38g	inactive (93.91%)
JNK1	inactive (102.1%)
JNK2	inactive (95.74%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (104.89%)
GSK3B	inactive (97.65%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (89.62%)
SRPK1	inactive (98.52%)
SRPK2	inactive (92.12%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (96.72%)