Compound Information


Test on : Metz, GPCR

Compound Name
Metz, GPCR : 504433-23-2

Inchikey
Same : NXNQLECPAXXYTR-N
Metz, GPCR : NXNQLECPAXXYTR-UHFFFAOYSA-N

ChemSpider
Metz, GPCR : 17346731

Pubchem CID
Metz, GPCR : 16219401

ChEMBL
Metz, GPCR : CHEMBL1516890




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
333
734
712
111
521
955
222
31-
847
313
AGC - Akt

Bioactivity
KinaseMetzGPCR
AKT1-inactive (0.22%)
AKT2inactive (>7943.28nM)inactive (1.6%)
AKT3inactive (>10000nM)inactive (0.99%)
AGC - DMPK

Bioactivity
KinaseMetzGPCR
MRCKainactive (>10000nM)inactive (0.55%)
ROCK1inactive (1258.93nM)inactive (5.28%)
ROCK2inactive (1584.89nM)inactive (8.3%)
MRCKb-inactive (0.99%)
AGC - GRK

Bioactivity
KinaseMetzGPCR
GPRK5--
GPRK7-inactive (10.62%)
GPRK6-inactive (6.18%)
AGC - PDK1

Bioactivity
KinaseMetzGPCR
PDK1inactive (>3981.07nM)inactive (2.99%)
AGC - PKA

Bioactivity
KinaseMetzGPCR
PKACainactive (>7943.28nM)-
PRKXinactive (>1584.89nM)inactive (0.1%)
AGC - PKC

Bioactivity
KinaseMetzGPCR
PKCdinactive (>7943.28nM)-
PKCginactive (>7943.28nM)inactive (-0.93%)
PKCzinactive (>7943.28nM)-
PKCiinactive (>5011.87nM)inactive (1.58%)
PKCt-inactive (0.22%)
PKCh-inactive (-0.57%)
PKCa-inactive (1.29%)
AGC - PKG

Bioactivity
KinaseMetzGPCR
PKG1inactive (>1995.26nM)inactive (3.04%)
PKG2inactive (>1584.89nM)inactive (3.03%)
AGC - PKN

Bioactivity
KinaseMetzGPCR
PKN2inactive (2511.89nM)-
AGC - RSK

Bioactivity
KinaseMetzGPCR
RSK2inactive (3162.28nM)inactive (6.08%)
p70S6Kinactive (2511.89nM)inactive (3.78%)
MSK1inactive (>1995.26nM)inactive (3.29%)
MSK2-inactive (10.11%)
RSK1-inactive (5.16%)
RSK4-inactive (10.19%)
RSK3-inactive (7.9%)
AGC - SGK

Bioactivity
KinaseMetzGPCR
SGK1inactive (2511.89nM)inactive (5.51%)
SGK3-inactive (0.63%)
SGK2-inactive (1.75%)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
61-
Atypical - Alpha

Bioactivity
KinaseMetzGPCR
eEF2K--

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
522
442
20913
521
311
545
212
333
323
111
11-
522
CAMK - CAMK1

Bioactivity
KinaseMetzGPCR
CaMK1ainactive (>3162.28nM)-
CaMK1d-inactive (2.41%)
CaMK4-inactive (-0.07%)
CAMK - CAMK2

Bioactivity
KinaseMetzGPCR
CaMK2binactive (>7943.28nM)-
CaMK2dinactive (3981.07nM)inactive (6.23%)
CaMK2ginactive (3981.07nM)-
CaMK2a-inactive (3.18%)
CAMK - CAMKL

Bioactivity
KinaseMetzGPCR
CHK1inactive (>7943.28nM)inactive (7.2%)
BRSK1inactive (5011.87nM)inactive (12.26%)
MARK2inactive (1584.89nM)-
MARK3inactive (1258.93nM)inactive (7.16%)
MELKinactive (>1584.89nM)inactive (23.5%)
AMPKa1inactive (1584.89nM)inactive (14.81%)
PASK-inactive (-2.27%)
MARK4-inactive (6.49%)
QIK-inactive (4.37%)
MARK1-inactive (9.52%)
SIK-inactive (9.48%)
NuaK1-inactive (44.53%)
BRSK2-inactive (12.35%)
AMPKa2-inactive (8.64%)
CAMK - DAPK

Bioactivity
KinaseMetzGPCR
DAPK3inactive (>1258.93nM)-
DRAK1active (125.89nM)-
DAPK1-inactive (7.28%)
CAMK - DCAMKL

Bioactivity
KinaseMetzGPCR
DCLK1inactive (>10000nM)-
DCLK2-inactive (3.71%)
CAMK - MAPKAPK

Bioactivity
KinaseMetzGPCR
MAPKAPK2inactive (>7943.28nM)inactive (1.83%)
MAPKAPK3inactive (>10000nM)inactive (5.11%)
MNK2-inactive (15.34%)
MAPKAPK5inactive (>1584.89nM)inactive (1.48%)
MNK1-inactive (15.49%)
CAMK - PHK

Bioactivity
KinaseMetzGPCR
PHKg2inactive (2511.89nM)inactive (2.8%)
PHKg1-inactive (20.78%)
CAMK - PIM

Bioactivity
KinaseMetzGPCR
PIM1active (630.96nM)inactive (10.37%)
PIM2inactive (>1584.89nM)inactive (3.47%)
PIM3inactive (2511.89nM)inactive (11.49%)
CAMK - PKD

Bioactivity
KinaseMetzGPCR
PKD3inactive (1584.89nM)inactive (10.27%)
PKD2inactive (5011.87nM)inactive (9.92%)
PKD1-inactive (10.61%)
CAMK - RAD53

Bioactivity
KinaseMetzGPCR
CHK2active (630.96nM)inactive (15.55%)
CAMK - STK33

Bioactivity
KinaseMetzGPCR
STK33--
CAMK - TSSK

Bioactivity
KinaseMetzGPCR
TSSK1inactive (>1584.89nM)inactive (1.12%)
TSSK2inactive (>1584.89nM)inactive (-0.52%)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
754
CK1 - CK1

Bioactivity
KinaseMetzGPCR
CK1ainactive (1584.89nM)inactive (14.31%)
CK1dactive (125.89nM)-
CK1g1inactive (>6309.57nM)inactive (4.56%)
CK1g2inactive (>7943.28nM)inactive (3.63%)
CK1g3inactive (>6309.57nM)inactive (5.3%)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
207-
311
422
1065
222
1486
312
CMGC - CDK

Bioactivity
KinaseMetzGPCR
CDC2inactive (6309.57nM)-
CDK2inactive (7943.28nM)-
CDK5inactive (10000nM)-
CDK8--
CDK7--
CDK9--
CDK11--
CMGC - CK2

Bioactivity
KinaseMetzGPCR
CK2a1inactive (1258.93nM)inactive (6.39%)
CMGC - CLK

Bioactivity
KinaseMetzGPCR
CLK2active (398.11nM)inactive (13.71%)
CLK4active (158.49nM)-
CLK3-inactive (-1.26%)
CMGC - DYRK

Bioactivity
KinaseMetzGPCR
DYRK1Ainactive (2511.89nM)inactive (10.61%)
DYRK3--
DYRK4inactive (>7943.28nM)-
HIPK2inactive (2511.89nM)-
HIPK4inactive (2511.89nM)inactive (15.19%)
DYRK1B-inactive (4.49%)
HIPK1-inactive (13.77%)
DYRK2-inactive (4.08%)
CMGC - GSK

Bioactivity
KinaseMetzGPCR
GSK3Ainactive (>7943.28nM)inactive (12.22%)
GSK3Binactive (1995.26nM)inactive (8.9%)
CMGC - MAPK

Bioactivity
KinaseMetzGPCR
Erk2inactive (>7943.28nM)inactive (2.73%)
p38ginactive (>6309.57nM)-
p38dinactive (>7943.28nM)inactive (2.23%)
JNK1inactive (>3162.28nM)-
JNK2inactive (1258.93nM)inactive (6.24%)
p38a-inactive (7.85%)
JNK3--
NLK--
p38b-inactive (5.58%)
Erk1-inactive (2.73%)
CMGC - SRPK

Bioactivity
KinaseMetzGPCR
SRPK1inactive (>7943.28nM)inactive (-4.48%)
MSSK1-inactive (-0.47%)

Other


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
323
21-
11-
444
1125
431
11-
31-
1-1
Other - Aur

Bioactivity
KinaseMetzGPCR
AurBactive (125.89nM)active (55.15%)
AurAactive (251.19nM)active (57%)
AurC-active (62.65%)
Other - CAMKK

Bioactivity
KinaseMetzGPCR
CaMKK2--
Other - CDC7

Bioactivity
KinaseMetzGPCR
CDC7inactive (>1258.93nM)-
Other - IKK

Bioactivity
KinaseMetzGPCR
IKKe-inactive (-10.6%)
TBK1-inactive (10.17%)
IKKa-inactive (-0.33%)
IKKb-inactive (1.05%)
Other - NEK

Bioactivity
KinaseMetzGPCR
NEK2inactive (5011.87nM)inactive (2.9%)
NEK4inactive (6309.57nM)-
NEK1-inactive (1.05%)
NEK9-inactive (4.67%)
NEK7-inactive (4.49%)
NEK6-inactive (-1.86%)
Other - PLK

Bioactivity
KinaseMetzGPCR
PLK1inactive (>7943.28nM)inactive (1.58%)
PLK3inactive (>7943.28nM)-
PLK4--
Other - TOPK

Bioactivity
KinaseMetzGPCR
PBKinactive (>10000nM)-
Other - WEE

Bioactivity
KinaseMetzGPCR
Wee1--
Other - TTK

Bioactivity
KinaseMetzGPCR
TTK-inactive (22.84%)

STE


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
31912
721
STE - STE20

Bioactivity
KinaseMetzGPCR
GCKactive (501.19nM)inactive (17.88%)
HGKactive (316.23nM)inactive (28.96%)
KHS1active (199.53nM)-
MINKactive (794.33nM)inactive (23.62%)
PAK1inactive (>10000nM)inactive (6%)
PAK4inactive (>5011.87nM)-
SLKactive (1000nM)-
MST2active (316.23nM)inactive (33.76%)
TAO1inactive (>10000nM)-
MST1-inactive (47.89%)
MST4-inactive (1.1%)
LOK-inactive (11.96%)
PAK3-inactive (3%)
PAK2-inactive (0.31%)
PAK5-inactive (-5.19%)
PAK6-inactive (0.69%)
STE - STE7

Bioactivity
KinaseMetzGPCR
MAP2K1-inactive (7.29%)
MAP2K2--

TK


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
212
212
222
323
211
433
1416
221
222
424
323
434
222
555
111
111
11910
212
535
333
333
2-1
1-1
2-1
TK - Abl

Bioactivity
KinaseMetzGPCR
ABL1-inactive (44.7%)
ABL2-inactive (20.93%)
TK - Ack

Bioactivity
KinaseMetzGPCR
ACK-inactive (1.72%)
TNK1-inactive (9.9%)
TK - ALK

Bioactivity
KinaseMetzGPCR
ALKactive (794.33nM)inactive (9.81%)
LTK-inactive (5.51%)
TK - Axl

Bioactivity
KinaseMetzGPCR
TYRO3inactive (>1995.26nM)inactive (13.2%)
AXL-inactive (19.15%)
MER-inactive (16.94%)
TK - Csk

Bioactivity
KinaseMetzGPCR
CTKinactive (>1995.26nM)-
CSK-inactive (-0.79%)
TK - EGFR

Bioactivity
KinaseMetzGPCR
EGFRinactive (>1995.26nM)inactive (7.13%)
ErbB2inactive (>1584.89nM)inactive (3.11%)
ErbB4inactive (>3981.07nM)inactive (9.14%)
TK - Eph

Bioactivity
KinaseMetzGPCR
EphA2inactive (>3162.28nM)inactive (0.79%)
EphA4-inactive (6.23%)
EphA3-inactive (4.83%)
EphB4-inactive (5.16%)
EphB3-inactive (-0.71%)
EphB2-inactive (12.04%)
TK - FAK

Bioactivity
KinaseMetzGPCR
FAK--
PYK2-inactive (25.21%)
TK - Fer

Bioactivity
KinaseMetzGPCR
FERinactive (1258.93nM)inactive (20.83%)
FESinactive (>1995.26nM)inactive (2.19%)
TK - FGFR

Bioactivity
KinaseMetzGPCR
FGFR1inactive (5011.87nM)inactive (17.32%)
FGFR3-inactive (47.75%)
FGFR2-inactive (42.19%)
FGFR4-inactive (14.05%)
TK - InsR

Bioactivity
KinaseMetzGPCR
IGF1Rinactive (1258.93nM)inactive (8.98%)
INSRinactive (2511.89nM)inactive (20.08%)
IRR-inactive (1.8%)
TK - JakA

Bioactivity
KinaseMetzGPCR
JAK2inactive (>1584.89nM)inactive (2.77%)
JAK3inactive (>1584.89nM)inactive (4.53%)
TYK2inactive (>1995.26nM)inactive (0.73%)
JAK1-inactive (-6.11%)
TK - Met

Bioactivity
KinaseMetzGPCR
MET-inactive (5.5%)
RON-inactive (0.13%)
TK - PDGFR

Bioactivity
KinaseMetzGPCR
FMSinactive (>2511.89nM)inactive (30.86%)
FLT3-active (66.23%)
KITinactive (>1258.93nM)active (52.66%)
PDGFRa-active (65.28%)
PDGFRb-inactive (42%)
TK - Ret

Bioactivity
KinaseMetzGPCR
RETactive (50.12nM)active (66.63%)
TK - Sev

Bioactivity
KinaseMetzGPCR
ROSinactive (>1995.26nM)inactive (10.13%)
TK - Src

Bioactivity
KinaseMetzGPCR
BLKactive (398.11nM)inactive (48.33%)
LCKactive (398.11nM)inactive (25.46%)
LYNactive (15.85nM)-
SRCactive (501.19nM)inactive (42.2%)
FRKactive (794.33nM)inactive (3.75%)
SRMinactive (>1584.89nM)inactive (0.18%)
FYNinactive (>794.33nM)inactive (15.37%)
BRK-inactive (2.28%)
HCK-inactive (42.08%)
FGR-inactive (43.99%)
YES-inactive (45.13%)
TK - Syk

Bioactivity
KinaseMetzGPCR
SYKactive (501.19nM)inactive (-2.64%)
ZAP70-inactive (11.51%)
TK - Tec

Bioactivity
KinaseMetzGPCR
BTK-inactive (3.46%)
ITKactive (199.53nM)inactive (15.72%)
BMX-inactive (4.89%)
TXK-inactive (6.47%)
TEC-inactive (8.75%)
TK - Trk

Bioactivity
KinaseMetzGPCR
TRKAactive (316.23nM)active (66%)
TRKBactive (794.33nM)active (75.45%)
TRKCactive (25.12nM)active (71.61%)
TK - VEGFR

Bioactivity
KinaseMetzGPCR
FLT4active (398.11nM)inactive (30.27%)
KDRactive (251.19nM)active (54.79%)
FLT1-inactive (13.11%)
TK - DDR

Bioactivity
KinaseMetzGPCR
DDR2-inactive (4.03%)
TK - Musk

Bioactivity
KinaseMetzGPCR
MUSK-inactive (12.78%)
TK - Tie

Bioactivity
KinaseMetzGPCR
TIE2-inactive (5.24%)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseMetzGPCR
421
41-
21-
102-
511
121-
TKL - IRAK

Bioactivity
KinaseMetzGPCR
IRAK1inactive (1584.89nM)-
IRAK4active (158.49nM)inactive (5.04%)
TKL - LISK

Bioactivity
KinaseMetzGPCR
LIMK1--
TKL - LRRK

Bioactivity
KinaseMetzGPCR
LRRK2--
TKL - MLK

Bioactivity
KinaseMetzGPCR
ZAKinactive (6309.57nM)-
MLK2--
TKL - RAF

Bioactivity
KinaseMetzGPCR
BRAF-inactive (6.52%)
TKL - STKR

Bioactivity
KinaseMetzGPCR
ALK2--