Compound in Profiling

Compound Information

Test on : RBC, Metz

Compound Name
RBC, Metz : Dovitinib

Inchikey
Same : PIQCTGMSNWUMAF-N
RBC, Metz : PIQCTGMSNWUMAF-UHFFFAOYSA-N

ChemSpider
RBC, Metz : 11530944

Pubchem CID
RBC, Metz : 135398510

ChEMBL
RBC, Metz : CHEMBL522892

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	3
GRK	7	6	1
RSK	8	8	4
PKA	5	3	2
PKC	9	9	5
PKG	2	3	2
PKN	3	2	1
SGK	3	3	1
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Metz
PDK1	inactive (87.98%)	active (1000nM)

AGC - Akt

Bioactivity
Kinase	RBC	Metz
AKT1	inactive (98.49%)	inactive (>7943.28nM)
AKT2	inactive (108.64%)	inactive (>7943.28nM)
AKT3	inactive (88.04%)	-

AGC - DMPK

Bioactivity
Kinase	RBC	Metz
DMPK1	inactive (107.34%)	-
MRCKa	inactive (97.02%)	inactive (>10000nM)
MRCKb	inactive (99.16%)	-
ROCK1	inactive (100.36%)	inactive (>1584.89nM)
ROCK2	inactive (79.34%)	inactive (3981.07nM)

AGC - GRK

Bioactivity
Kinase	RBC	Metz
BARK1	inactive (98.13%)	-
BARK2	inactive (97.48%)	-
GPRK4	inactive (94.16%)	-
GPRK5	inactive (106.94%)	inactive (>3981.07nM)
GPRK6	inactive (103.22%)	-
GPRK7	inactive (95.24%)	-

AGC - RSK

Bioactivity
Kinase	RBC	Metz
MSK1	inactive (81.08%)	active (1000nM)
MSK2	inactive (72.07%)	-
p70S6K	inactive (77.32%)	active (100nM)
p70S6Kb	inactive (100.2%)	-
RSK2	active (34.34%)	active (316.23nM)
RSK4	active (16.12%)	-
RSK1	active (22.25%)	-
RSK3	active (13.05%)	-

AGC - PKA

Bioactivity
Kinase	RBC	Metz
PKACg	inactive (118.71%)	-
PRKX	inactive (103.97%)	inactive (1584.89nM)
PKACa	inactive (101.03%)	inactive (>3162.28nM)

AGC - PKC

Bioactivity
Kinase	RBC	Metz
PKCa	inactive (83.83%)	-
PKCd	inactive (90.91%)	inactive (1995.26nM)
PKCe	inactive (101.04%)	-
PKCh	inactive (103.06%)	-
PKCg	inactive (86.91%)	inactive (>7943.28nM)
PKCi	inactive (104.62%)	-
PKCt	inactive (97.57%)	inactive (>2511.89nM)
PKCz	inactive (80.99%)	inactive (>7943.28nM)
PKCb	inactive (92.02%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Metz
PKG2	inactive (99.03%)	inactive (>1584.89nM)
PKG1	inactive (81.18%)	inactive (>1995.26nM)

AGC - PKN

Bioactivity
Kinase	RBC	Metz
PKN1	active (15.54%)	-
PKN2	inactive (98.53%)	active (630.96nM)

AGC - SGK

Bioactivity
Kinase	RBC	Metz
SGK1	inactive (88.24%)	inactive (1258.93nM)
SGK2	inactive (89.84%)	-
SGK3	inactive (98.42%)	-

AGC - NDR

Bioactivity
Kinase	RBC	Metz
NDR1	inactive (97.05%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Abl	2	2	1
Ack	2	1	1
ALK	2	2	2
Axl	3	3	2
Src	11	11	9
Tec	5	5	3
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	-
EGFR	4	3	3
Eph	14	12	1
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	2
VEGFR	3	3	3
InsR	3	3	2
JakA	4	4	3
Musk	1	1	-
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	1
Tie	2	1	-
Trk	3	3	3

TK - Abl

Bioactivity
Kinase	RBC	Metz
ABL1	active (24.01%)	active (100nM)
ABL2	active (24.26%)	-

TK - Ack

Bioactivity
Kinase	RBC	Metz
ACK	inactive (83.12%)	inactive (>3981.07nM)

TK - ALK

Bioactivity
Kinase	RBC	Metz
ALK	inactive (80.51%)	active (630.96nM)
LTK	inactive (92.48%)	inactive (>1995.26nM)

TK - Axl

Bioactivity
Kinase	RBC	Metz
AXL	active (44.35%)	active (251.19nM)
MER	inactive (91.95%)	-
TYRO3	active (23.77%)	active (50.12nM)

TK - Src

Bioactivity
Kinase	RBC	Metz
BLK	active (12.26%)	active (12.59nM)
BRK	inactive (96.39%)	-
SRC	active (15.98%)	active (63.1nM)
FGR	active (6.34%)	-
FRK	inactive (56.05%)	-
FYN	active (22.51%)	active (63.1nM)
HCK	active (29.94%)	active (158.49nM)
LCK	active (4.75%)	active (19.95nM)
SRM	inactive (94.42%)	-
YES	active (6.3%)	-
LYN	active (9.15%)	active (63.1nM)

TK - Tec

Bioactivity
Kinase	RBC	Metz
BMX	inactive (70.11%)	-
BTK	active (37.34%)	inactive (1995.26nM)
ITK	inactive (70.9%)	active (50.12nM)
TEC	inactive (91.01%)	-
TXK	inactive (75.1%)	-

TK - PDGFR

Bioactivity
Kinase	RBC	Metz
KIT	active (9.89%)	active (19.95nM)
FLT3	active (2.97%)	active (3.16nM)
FMS	active (21.46%)	active (39.81nM)
PDGFRb	active (17.23%)	active (6.31nM)
PDGFRa	active (12.61%)	active (251.19nM)

TK - Csk

Bioactivity
Kinase	RBC	Metz
CSK	inactive (88.36%)	-
CTK	inactive (74.92%)	-

TK - DDR

Bioactivity
Kinase	RBC	Metz
DDR2	inactive (195.15%)	-

TK - EGFR

Bioactivity
Kinase	RBC	Metz
EGFR	inactive (97.24%)	inactive (>1995.26nM)
ErbB2	inactive (105.94%)	inactive (>1584.89nM)
ErbB4	inactive (95.22%)	inactive (>3981.07nM)

TK - Eph

Bioactivity
Kinase	RBC	Metz
EphA1	inactive (90.56%)	-
EphA2	inactive (76.87%)	inactive (>3162.28nM)
EphA3	inactive (88.05%)	-
EphA4	inactive (93.36%)	-
EphA5	inactive (99.11%)	-
EphA6	active (44.62%)	-
EphA7	inactive (76.54%)	-
EphA8	inactive (105.29%)	-
EphB1	inactive (58.15%)	-
EphB2	inactive (86.06%)	-
EphB3	inactive (51.93%)	-
EphB4	inactive (73.45%)	-

TK - FAK

Bioactivity
Kinase	RBC	Metz
FAK	inactive (95.3%)	inactive (>3981.07nM)
PYK2	inactive (84.31%)	inactive (>1584.89nM)

TK - Fer

Bioactivity
Kinase	RBC	Metz
FER	inactive (94.57%)	-
FES	inactive (91.86%)	-

TK - FGFR

Bioactivity
Kinase	RBC	Metz
FGFR1	active (18.21%)	active (25.12nM)
FGFR2	active (21.99%)	-
FGFR3	active (12.39%)	active (39.81nM)
FGFR4	inactive (59.62%)	-

TK - VEGFR

Bioactivity
Kinase	RBC	Metz
FLT1	active (26.24%)	active (39.81nM)
FLT4	active (11.3%)	active (100nM)
KDR	active (31.47%)	active (19.95nM)

TK - InsR

Bioactivity
Kinase	RBC	Metz
IGF1R	inactive (89.77%)	inactive (>1258.93nM)
IRR	inactive (67.12%)	-
INSR	inactive (84%)	inactive (1584.89nM)

TK - JakA

Bioactivity
Kinase	RBC	Metz
JAK1	inactive (92.06%)	-
JAK2	inactive (92.02%)	active (1000nM)
JAK3	inactive (83.88%)	inactive (>3162.28nM)
TYK2	inactive (59.4%)	active (199.53nM)

TK - Musk

Bioactivity
Kinase	RBC	Metz
MUSK	inactive (63.16%)	-

TK - Ret

Bioactivity
Kinase	RBC	Metz
RET	active (2.45%)	active (5.01nM)

TK - Met

Bioactivity
Kinase	RBC	Metz
RON	inactive (95.36%)	active (25.12nM)
MET	inactive (84.4%)	inactive (>2511.89nM)

TK - Sev

Bioactivity
Kinase	RBC	Metz
ROS	inactive (95.46%)	inactive (>3162.28nM)

TK - Syk

Bioactivity
Kinase	RBC	Metz
SYK	inactive (65.37%)	-
ZAP70	inactive (107.35%)	-

TK - Tie

Bioactivity
Kinase	RBC	Metz
TIE2	inactive (81.32%)	-

TK - Trk

Bioactivity
Kinase	RBC	Metz
TRKA	active (4.57%)	active (251.19nM)
TRKB	active (5.72%)	active (100nM)
TRKC	active (1.45%)	active (199.53nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STKR	12	5	1
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	1
MLK	10	5	2
RIPK	5	1	-

TKL - STKR

Bioactivity
Kinase	RBC	Metz
ALK1	inactive (125.16%)	-
ALK2	inactive (154.7%)	inactive (1258.93nM)
ALK4	inactive (98.78%)	-
TGFbR1	inactive (99.28%)	-
TGFbR2	inactive (108.68%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Metz
ARAF	inactive (122.99%)	-
BRAF	inactive (104.9%)	-
RAF1	inactive (114.76%)	-

TKL - IRAK

Bioactivity
Kinase	RBC	Metz
IRAK1	inactive (65.08%)	inactive (1258.93nM)
IRAK4	active (31.76%)	inactive (>10000nM)

TKL - LISK

Bioactivity
Kinase	RBC	Metz
LIMK1	inactive (88.28%)	inactive (1995.26nM)

TKL - LRRK

Bioactivity
Kinase	RBC	Metz
LRRK2	active (24.5%)	active (316.23nM)

TKL - MLK

Bioactivity
Kinase	RBC	Metz
MLK1	inactive (52.42%)	-
MLK2	inactive (91.44%)	inactive (1584.89nM)
MLK3	active (26.36%)	-
TAK1	active (19.34%)	-
ZAK	inactive (91.52%)	inactive (7943.28nM)

TKL - RIPK

Bioactivity
Kinase	RBC	Metz
RIPK2	inactive (92.98%)	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CAMKL	20	13	9
CAMK1	5	5	2
CAMK2	4	4	4
RAD53	1	1	1
DAPK	5	4	2
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	-
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	1

CAMK - CAMKL

Bioactivity
Kinase	RBC	Metz
NuaK1	active (3.13%)	-
BRSK1	inactive (59.8%)	active (398.11nM)
BRSK2	inactive (59.42%)	-
CHK1	active (30.81%)	active (158.49nM)
LKB1	inactive (103.58%)	-
MARK1	active (34.76%)	-
MARK3	active (36.5%)	active (125.89nM)
MARK4	active (25.51%)	active (100nM)
MELK	active (7.72%)	active (31.62nM)
PASK	inactive (104.74%)	inactive (>1584.89nM)
QIK	active (25.46%)	active (100nM)
NuaK2	inactive (60.22%)	-
MARK2	active (47.44%)	active (125.89nM)
AMPKa1	-	active (79.43nM)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Metz
CaMK1a	inactive (85.77%)	inactive (>6309.57nM)
CaMK1b	inactive (103.78%)	-
CaMK1d	inactive (103.26%)	inactive (>1995.26nM)
CaMK1g	inactive (100.36%)	-
CaMK4	inactive (91.72%)	-

CAMK - CAMK2

Bioactivity
Kinase	RBC	Metz
CaMK2a	inactive (53.95%)	inactive (>3162.28nM)
CaMK2b	inactive (85.6%)	inactive (>7943.28nM)
CaMK2d	inactive (56.88%)	active (316.23nM)
CaMK2g	inactive (97.57%)	active (794.33nM)

CAMK - RAD53

Bioactivity
Kinase	RBC	Metz
CHK2	inactive (84.45%)	inactive (1584.89nM)

CAMK - DAPK

Bioactivity
Kinase	RBC	Metz
DAPK1	inactive (107.67%)	-
DAPK2	inactive (82.29%)	-
DRAK1	inactive (67.98%)	-
DAPK3	inactive (108.71%)	inactive (>2511.89nM)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Metz
DCLK2	inactive (94.11%)	-
DCLK1	-	inactive (>10000nM)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Metz
MAPKAPK2	inactive (96.89%)	inactive (>7943.28nM)
MAPKAPK3	inactive (99.31%)	inactive (>10000nM)
MAPKAPK5	inactive (93.86%)	inactive (>1584.89nM)
MNK1	inactive (88.74%)	-
MNK2	inactive (89.62%)	inactive (>10000nM)

CAMK - MLCK

Bioactivity
Kinase	RBC	Metz
smMLCK	inactive (76.57%)	-
skMLCK	active (5.92%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Metz
PHKg1	active (30.38%)	-
PHKg2	inactive (87.64%)	active (1000nM)

CAMK - PIM

Bioactivity
Kinase	RBC	Metz
PIM1	inactive (99.19%)	inactive (>6309.57nM)
PIM2	inactive (114.1%)	inactive (1258.93nM)
PIM3	inactive (95.63%)	-

CAMK - PKD

Bioactivity
Kinase	RBC	Metz
PKD1	inactive (69%)	-
PKD3	inactive (60.22%)	inactive (1258.93nM)
PKD2	inactive (66.2%)	inactive (1995.26nM)

CAMK - TSSK

Bioactivity
Kinase	RBC	Metz
TSSK1	inactive (54.43%)	active (501.19nM)
TSSK2	inactive (80.57%)	inactive (>1584.89nM)

CAMK - STK33

Bioactivity
Kinase	RBC	Metz
STK33	inactive (60.75%)	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
STE11	8	3	-
STE-Unique	2	2	-
STE20	31	23	9
STE7	7	3	2

STE - STE11

Bioactivity
Kinase	RBC	Metz
MAP3K5	inactive (98.45%)	-
MAP3K2	inactive (66.17%)	-
MAP3K3	active (46.49%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Metz
COT	inactive (106.9%)	-
NIK	inactive (110.1%)	-

STE - STE20

Bioactivity
Kinase	RBC	Metz
GCK	active (49.39%)	active (630.96nM)
HGK	active (2.96%)	active (25.12nM)
KHS1	active (3.26%)	active (31.62nM)
LOK	active (41.57%)	-
MINK	active (1.65%)	active (10nM)
MST1	active (10.01%)	-
MST2	active (34.36%)	active (199.53nM)
MST3	active (44.46%)	-
MST4	inactive (105.06%)	-
OSR1	inactive (98.72%)	-
PAK1	inactive (111.43%)	inactive (>10000nM)
PAK2	inactive (96.94%)	-
PAK3	inactive (103.38%)	-
PAK4	inactive (92.96%)	inactive (1995.26nM)
PAK5	inactive (82.71%)	-
PAK6	inactive (102.88%)	-
SLK	inactive (68.06%)	active (199.53nM)
YSK1	inactive (86.03%)	-
STLK3	inactive (92.32%)	-
TAO1	inactive (98.35%)	inactive (>5011.87nM)
TAO2	inactive (97.4%)	-
TAO3	inactive (84.17%)	-
MYO3B	inactive (79.68%)	-

STE - STE7

Bioactivity
Kinase	RBC	Metz
MAP2K1	inactive (88.71%)	active (125.89nM)
MAP2K2	active (43.05%)	active (158.49nM)
MAP2K6	inactive (82.58%)	-

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
Aur	3	3	2
CAMKK	2	2	1
Haspin	1	1	-
IKK	4	4	4
NEK	11	8	2
TOPK	1	1	1
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	-
WEE	3	1	1
WNK	4	2	-
TLK	2	1	-
CDC7	1	-	1

Other - Aur

Bioactivity
Kinase	RBC	Metz
AurA	inactive (60.63%)	inactive (>1000nM)
AurB	active (26.95%)	active (79.43nM)
AurC	inactive (82.35%)	-

Other - CAMKK

Bioactivity
Kinase	RBC	Metz
CaMKK1	active (48.51%)	-
CaMKK2	inactive (85.92%)	active (158.49nM)

Other - Haspin

Bioactivity
Kinase	RBC	Metz
Haspin	inactive (75%)	-

Other - IKK

Bioactivity
Kinase	RBC	Metz
IKKa	inactive (88.1%)	inactive (>3981.07nM)
IKKb	inactive (87.77%)	inactive (>3162.28nM)
IKKe	active (42.88%)	active (794.33nM)
TBK1	active (38.5%)	inactive (>1000nM)

Other - NEK

Bioactivity
Kinase	RBC	Metz
NEK1	inactive (64.34%)	-
NEK11	inactive (93.59%)	-
NEK2	inactive (104.22%)	active (501.19nM)
NEK4	inactive (83.55%)	inactive (5011.87nM)
NEK6	inactive (84.47%)	-
NEK7	inactive (91.08%)	-
NEK9	inactive (58.87%)	-
NEK3	inactive (88.15%)	-

Other - TOPK

Bioactivity
Kinase	RBC	Metz
PBK	inactive (101.36%)	inactive (>10000nM)

Other - PLK

Bioactivity
Kinase	RBC	Metz
PLK1	inactive (96.87%)	inactive (>7943.28nM)
PLK2	inactive (101.84%)	-
PLK3	inactive (100.99%)	inactive (>7943.28nM)
PLK4	-	inactive (1258.93nM)

Other - SgK496

Bioactivity
Kinase	RBC	Metz
SgK496	inactive (98.38%)	-

Other - NAK

Bioactivity
Kinase	RBC	Metz
MPSK1	active (46.26%)	-

Other - TTK

Bioactivity
Kinase	RBC	Metz
TTK	inactive (101.89%)	-

Other - ULK

Bioactivity
Kinase	RBC	Metz
ULK1	active (20.43%)	-
ULK2	active (45.68%)	-
ULK3	inactive (65.97%)	-

Other - WEE

Bioactivity
Kinase	RBC	Metz
Wee1	inactive (92.02%)	-

Other - WNK

Bioactivity
Kinase	RBC	Metz
Wnk2	inactive (99.88%)	-
Wnk3	inactive (96.07%)	-

Other - TLK

Bioactivity
Kinase	RBC	Metz
TLK2	inactive (89.33%)	-

Other - CDC7

Bioactivity
Kinase	RBC	Metz
CDC7	-	inactive (>1258.93nM)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK1	7	6	5
VRK	3	1	-

CK1 - CK1

Bioactivity
Kinase	RBC	Metz
CK1d	inactive (79.3%)	inactive (1584.89nM)
CK1g1	inactive (96.43%)	inactive (>6309.57nM)
CK1g2	inactive (91.36%)	inactive (>7943.28nM)
CK1g3	inactive (94.63%)	-
CK1a	inactive (95.11%)	inactive (>5011.87nM)
CK1e	inactive (94.09%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Metz
VRK1	inactive (98.51%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
CK2	3	2	1
CLK	4	4	2
DYRK	10	9	6
MAPK	14	10	8
GSK	2	2	2
SRPK	3	3	1
CDK	20	-	7

CMGC - CK2

Bioactivity
Kinase	RBC	Metz
CK2a1	inactive (113.54%)	inactive (>6309.57nM)
CK2a2	inactive (85.55%)	-

CMGC - CLK

Bioactivity
Kinase	RBC	Metz
CLK1	inactive (67.82%)	-
CLK2	active (38.61%)	active (794.33nM)
CLK3	inactive (103.88%)	-
CLK4	inactive (52.16%)	active (100nM)

CMGC - DYRK

Bioactivity
Kinase	RBC	Metz
DYRK1A	inactive (96.52%)	inactive (>2511.89nM)
DYRK1B	inactive (87.95%)	inactive (>2511.89nM)
DYRK2	inactive (104.6%)	-
DYRK3	inactive (103.37%)	inactive (>6309.57nM)
DYRK4	inactive (98.15%)	-
HIPK1	inactive (95.71%)	-
HIPK2	inactive (81.48%)	inactive (>3162.28nM)
HIPK3	inactive (95.61%)	-
HIPK4	inactive (96.29%)	inactive (>7943.28nM)

CMGC - MAPK

Bioactivity
Kinase	RBC	Metz
Erk1	inactive (99.62%)	-
Erk2	inactive (82.39%)	inactive (>7943.28nM)
JNK3	inactive (107.94%)	active (630.96nM)
NLK	inactive (110.18%)	-
p38a	inactive (94%)	inactive (>3981.07nM)
p38b	inactive (103.75%)	-
p38d	inactive (90.42%)	inactive (>7943.28nM)
p38g	inactive (100.84%)	inactive (>6309.57nM)
JNK1	inactive (105.64%)	inactive (3162.28nM)
JNK2	inactive (108.97%)	inactive (>3981.07nM)

CMGC - GSK

Bioactivity
Kinase	RBC	Metz
GSK3A	inactive (100.04%)	inactive (>5011.87nM)
GSK3B	inactive (98.56%)	inactive (>3162.28nM)

CMGC - SRPK

Bioactivity
Kinase	RBC	Metz
MSSK1	inactive (103.81%)	-
SRPK1	inactive (97.54%)	inactive (5011.87nM)
SRPK2	inactive (99.93%)	-

CMGC - CDK

Bioactivity
Kinase	RBC	Metz
CDC2	-	inactive (>7943.28nM)
CDK2	-	inactive (>7943.28nM)
CDK5	-	inactive (>3981.07nM)
CDK8	-	inactive (>3981.07nM)
CDK7	-	active (251.19nM)
CDK9	-	inactive (>1584.89nM)
CDK11	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Metz
PDHK	5	1	-
Alpha	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Metz
PDHK1	inactive (87.98%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Metz
eEF2K	-	inactive (>3981.07nM)