Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : 15966-93-5
Millipore : VEGF Receptor 2 Kinase Inhibitor I

Inchikey
Same : PMUJUSJUVIXDQC-N
RBC : PMUJUSJUVIXDQC-UHFFFAOYSA-N
Millipore : PMUJUSJUVIXDQC-LCYFTJDESA-N

ChemSpider
RBC : 5452
Millipore : 4925465

Pubchem CID
RBC : 5654
Millipore : 6419834

ChEMBL
RBC : -
Millipore : CHEMBL86943

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (92.53%)	inactive (107%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (96.09%)	inactive (87%)
AKT2	inactive (87.63%)	inactive (142%)
AKT3	inactive (102.75%)	inactive (111%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (101.3%)	inactive (94%)
MRCKa	inactive (85.73%)	inactive (104%)
MRCKb	inactive (110.23%)	inactive (91%)
ROCK1	inactive (99.14%)	inactive (100%)
ROCK2	inactive (94.33%)	inactive (103%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (98.15%)	-
BARK2	inactive (94.67%)	-
GPRK4	inactive (82.9%)	-
GPRK5	inactive (102%)	inactive (106%)
GPRK6	inactive (90.82%)	inactive (98%)
GPRK7	inactive (86.32%)	inactive (103%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (91.8%)	inactive (111%)
MSK2	inactive (87.02%)	inactive (87%)
p70S6K	inactive (85.67%)	inactive (108%)
p70S6Kb	inactive (102.62%)	-
RSK2	inactive (86.43%)	inactive (88%)
RSK4	inactive (87.63%)	inactive (88%)
RSK1	inactive (77.57%)	inactive (72%)
RSK3	inactive (71.45%)	inactive (117%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (88.36%)	-
PRKX	inactive (94.81%)	inactive (114%)
PKACa	inactive (97.25%)	inactive (101%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	-	inactive (108%)
PKCd	inactive (91.55%)	inactive (96%)
PKCe	inactive (98.19%)	inactive (83%)
PKCh	inactive (93.97%)	inactive (115%)
PKCg	inactive (91.93%)	inactive (110%)
PKCi	inactive (92.86%)	inactive (96%)
PKCt	inactive (115.88%)	inactive (103%)
PKCz	inactive (97.04%)	inactive (104%)
PKCb	inactive (91.55%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (78.94%)	-
PKG1	inactive (78.34%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (89.58%)	-
PKN2	inactive (91.98%)	inactive (104%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (92.04%)	inactive (102%)
SGK2	inactive (93.65%)	inactive (82%)
SGK3	inactive (88.15%)	inactive (93%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (101.49%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (95.36%)	inactive (90%)
ABL2	inactive (88.55%)	inactive (101%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (92.66%)	inactive (73%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (79.18%)	inactive (80%)
LTK	inactive (66.91%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (88.87%)	inactive (84%)
MER	inactive (69.34%)	active (16%)
TYRO3	inactive (96.86%)	inactive (97%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (80.22%)	inactive (89%)
BRK	inactive (82.81%)	inactive (99%)
SRC	inactive (93.82%)	inactive (86%)
FGR	inactive (79.3%)	inactive (87%)
FRK	inactive (95.29%)	inactive (103%)
FYN	inactive (97.27%)	inactive (87%)
HCK	inactive (92.58%)	inactive (77%)
LCK	inactive (88.22%)	inactive (105%)
SRM	inactive (103.81%)	-
YES	inactive (68.34%)	inactive (91%)
LYN	inactive (84.09%)	active (50%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (93.48%)	inactive (101%)
BTK	inactive (95.62%)	inactive (90%)
ITK	inactive (86.33%)	inactive (79%)
TEC	inactive (141.17%)	-
TXK	inactive (96.11%)	inactive (97%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (46.29%)	active (38%)
FLT3	active (13.31%)	active (6%)
FMS	inactive (52.54%)	active (20%)
PDGFRb	inactive (69.11%)	inactive (90%)
PDGFRa	inactive (82.79%)	active (43%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (104.05%)	inactive (107%)
CTK	inactive (101.37%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (98.02%)	inactive (104%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (92.18%)	inactive (113%)
ErbB2	inactive (101.08%)	-
ErbB4	inactive (71.23%)	inactive (97%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (90.82%)	inactive (83%)
EphA2	inactive (105.47%)	inactive (103%)
EphA3	inactive (96.29%)	inactive (111%)
EphA4	inactive (80.29%)	inactive (109%)
EphA5	inactive (91.85%)	inactive (101%)
EphA6	inactive (79.99%)	-
EphA7	inactive (85.29%)	inactive (97%)
EphA8	inactive (88.68%)	inactive (104%)
EphB1	inactive (97.49%)	inactive (97%)
EphB2	inactive (95.41%)	inactive (118%)
EphB3	inactive (94.38%)	inactive (111%)
EphB4	inactive (89.47%)	inactive (117%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (92.97%)	inactive (133%)
PYK2	inactive (80.63%)	inactive (80%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (72.52%)	inactive (124%)
FES	inactive (99.28%)	inactive (119%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (78.65%)	inactive (98%)
FGFR2	inactive (97.9%)	inactive (83%)
FGFR3	inactive (80.36%)	inactive (85%)
FGFR4	inactive (82.42%)	inactive (101%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (79.04%)	active (38%)
FLT4	inactive (79.17%)	active (1%)
KDR	inactive (93.18%)	active (16%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (79.54%)	inactive (119%)
IRR	inactive (93.78%)	inactive (93%)
INSR	inactive (90.61%)	inactive (93%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (97.06%)	-
JAK2	inactive (96.7%)	inactive (92%)
JAK3	inactive (69.08%)	inactive (100%)
TYK2	inactive (89.91%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (88.65%)	inactive (106%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (40.82%)	active (24%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (87.49%)	inactive (106%)
MET	inactive (87.4%)	inactive (104%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (99.14%)	inactive (95%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (89.33%)	inactive (123%)
ZAP70	inactive (98.81%)	inactive (112%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	-	inactive (108%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (69.9%)	active (13%)
TRKB	inactive (66.56%)	inactive (73%)
TRKC	active (27.9%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (94.77%)	-
ALK2	inactive (99.77%)	-
ALK4	inactive (96.56%)	inactive (120%)
TGFbR1	inactive (99.66%)	inactive (94%)
TGFbR2	inactive (101.47%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (94.67%)	-
BRAF	inactive (96.69%)	-
RAF1	inactive (89.55%)	inactive (100%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (110.52%)	inactive (94%)
IRAK4	inactive (96.76%)	inactive (97%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (81.32%)	inactive (117%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (28.59%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (61.62%)	active (43%)
MLK2	inactive (98.51%)	-
MLK3	active (47.02%)	-
TAK1	inactive (85.76%)	inactive (89%)
ZAK	inactive (92.71%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (88.27%)	inactive (96%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (62.26%)	inactive (88%)
BRSK1	inactive (92.6%)	inactive (89%)
BRSK2	inactive (98.73%)	inactive (97%)
CHK1	inactive (89.38%)	inactive (90%)
LKB1	inactive (85.15%)	inactive (97%)
MARK1	inactive (90.77%)	inactive (89%)
MARK3	inactive (99.77%)	-
MARK4	inactive (99.63%)	-
MELK	inactive (87.38%)	inactive (77%)
PASK	inactive (91.37%)	inactive (93%)
QIK	inactive (99.9%)	-
NuaK2	inactive (128.45%)	-
MARK2	inactive (87.56%)	inactive (92%)
AMPKa1	-	inactive (80%)
AMPKa2	-	inactive (85%)
SIK	-	inactive (95%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (98.11%)	inactive (91%)
CaMK1b	inactive (88.57%)	-
CaMK1d	inactive (93.11%)	inactive (125%)
CaMK1g	inactive (98.21%)	-
CaMK4	inactive (97.72%)	inactive (121%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (96.84%)	-
CaMK2b	inactive (95.98%)	inactive (98%)
CaMK2d	inactive (93.93%)	inactive (79%)
CaMK2g	inactive (97.55%)	inactive (77%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (70.5%)	active (45%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (100.22%)	inactive (83%)
DAPK2	inactive (96.33%)	inactive (95%)
DRAK1	inactive (81.41%)	inactive (86%)
DAPK3	inactive (85.09%)	inactive (94%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (94.65%)	inactive (106%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (98.64%)	inactive (80%)
MAPKAPK3	inactive (91.67%)	inactive (98%)
MAPKAPK5	inactive (93.91%)	inactive (88%)
MNK1	inactive (112.49%)	-
MNK2	inactive (87.39%)	inactive (109%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (94.78%)	inactive (90%)
skMLCK	inactive (74.65%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (73.29%)	-
PHKg2	inactive (96.16%)	inactive (87%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (95.77%)	inactive (72%)
PIM2	inactive (97.75%)	inactive (112%)
PIM3	inactive (75.11%)	inactive (108%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (91.26%)	inactive (88%)
PKD3	inactive (90.12%)	-
PKD2	inactive (97.12%)	inactive (92%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (91.16%)	inactive (93%)
TSSK2	inactive (95.85%)	inactive (90%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (83.73%)	inactive (89%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (105.2%)	inactive (105%)
MAP3K2	inactive (108.15%)	-
MAP3K3	inactive (92.82%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (108.36%)	-
NIK	inactive (118.47%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (95.53%)	inactive (89%)
HGK	inactive (64.49%)	-
KHS1	inactive (84.32%)	-
LOK	inactive (82.25%)	inactive (94%)
MINK	inactive (88.86%)	inactive (86%)
MST1	inactive (83.4%)	inactive (101%)
MST2	inactive (73.75%)	inactive (85%)
MST3	inactive (82.5%)	inactive (97%)
MST4	inactive (100.64%)	-
OSR1	inactive (87.88%)	-
PAK1	inactive (99.9%)	-
PAK2	inactive (92.52%)	inactive (114%)
PAK3	inactive (99.12%)	inactive (75%)
PAK4	inactive (71.78%)	inactive (90%)
PAK5	inactive (83.88%)	inactive (109%)
PAK6	inactive (81.43%)	inactive (91%)
SLK	inactive (89.78%)	-
YSK1	inactive (98.48%)	-
STLK3	inactive (85.12%)	-
TAO1	inactive (100.38%)	inactive (103%)
TAO2	inactive (104.95%)	inactive (115%)
TAO3	inactive (87.64%)	inactive (104%)
MYO3B	inactive (74.06%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (93.17%)	inactive (102%)
MAP2K2	inactive (101.81%)	-
MAP2K6	inactive (96.46%)	inactive (85%)
MAP2K7	-	inactive (84%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (90.38%)	inactive (105%)
AurB	inactive (67.25%)	inactive (74%)
AurC	inactive (89.11%)	inactive (103%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (95.26%)	-
CaMKK2	inactive (90.82%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (92.85%)	inactive (129%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (101.78%)	inactive (96%)
IKKb	inactive (101.27%)	inactive (103%)
IKKe	inactive (93.54%)	-
TBK1	inactive (70.51%)	inactive (92%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (92.48%)	-
NEK11	inactive (96.57%)	inactive (97%)
NEK2	inactive (91.4%)	inactive (82%)
NEK4	inactive (95.13%)	-
NEK6	inactive (98.09%)	inactive (103%)
NEK7	inactive (101.57%)	inactive (94%)
NEK9	inactive (80.78%)	-
NEK3	inactive (101.04%)	inactive (96%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (85.03%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (107.49%)	inactive (113%)
PLK2	inactive (101.83%)	inactive (103%)
PLK3	inactive (97.46%)	inactive (86%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (90.76%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (88.27%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (96.61%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (80.07%)	-
ULK2	inactive (105.07%)	inactive (103%)
ULK3	inactive (76.66%)	inactive (76%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (91.21%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (100.24%)	inactive (111%)
Wnk3	inactive (104.4%)	inactive (93%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (96.49%)	inactive (113%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (96.42%)	inactive (77%)
CK1g1	inactive (103.43%)	inactive (88%)
CK1g2	inactive (84.8%)	inactive (83%)
CK1g3	inactive (97.92%)	inactive (101%)
CK1a	inactive (98.62%)	-
CK1e	inactive (73.66%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (103.52%)	-
VRK2	-	inactive (108%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (114.42%)	inactive (77%)
CK2a2	inactive (94.69%)	inactive (131%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (98.18%)	-
CLK2	inactive (85.98%)	inactive (95%)
CLK3	inactive (100.05%)	inactive (82%)
CLK4	inactive (94.34%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (95.7%)	-
DYRK1B	inactive (104.89%)	-
DYRK2	inactive (92.36%)	inactive (104%)
DYRK3	inactive (102.46%)	-
DYRK4	inactive (99.6%)	-
HIPK1	inactive (97.29%)	inactive (90%)
HIPK2	inactive (95.45%)	inactive (95%)
HIPK3	inactive (94.47%)	inactive (102%)
HIPK4	inactive (90.25%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (101.41%)	inactive (81%)
Erk2	inactive (96.39%)	inactive (100%)
JNK3	inactive (86.83%)	inactive (95%)
NLK	inactive (94.75%)	inactive (101%)
p38a	inactive (133.71%)	inactive (89%)
p38b	inactive (97.54%)	inactive (98%)
p38d	inactive (98.25%)	inactive (115%)
p38g	inactive (100.65%)	inactive (99%)
JNK1	inactive (105.84%)	inactive (124%)
JNK2	inactive (93.9%)	inactive (108%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (93.46%)	inactive (112%)
GSK3B	inactive (104.79%)	inactive (99%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (88.79%)	inactive (95%)
SRPK1	inactive (95.43%)	inactive (92%)
SRPK2	inactive (92.33%)	inactive (93%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (92.53%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (99%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (98%)