Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : QDLHCMPXEPAAMD-BLNDMVMCSA-N

CANNOT FIND

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (96.53%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (95.43%)
AKT2	inactive (94.17%)
AKT3	inactive (94.59%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (98.68%)
MRCKa	inactive (89.2%)
MRCKb	inactive (111.86%)
ROCK1	inactive (90.74%)
ROCK2	inactive (88.17%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (98.29%)
BARK2	inactive (92.78%)
GPRK4	inactive (95.35%)
GPRK5	inactive (106.99%)
GPRK6	inactive (101.29%)
GPRK7	inactive (90.4%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (92.2%)
MSK2	inactive (96.74%)
p70S6K	inactive (89.02%)
p70S6Kb	inactive (100.44%)
RSK2	inactive (87.47%)
RSK4	inactive (96.73%)
RSK1	inactive (91.34%)
RSK3	inactive (94.8%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	inactive (96.11%)
PRKX	inactive (91.68%)
PKACa	inactive (93.02%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (96.3%)
PKCd	inactive (96.1%)
PKCe	inactive (86.47%)
PKCh	inactive (100.2%)
PKCg	inactive (113.77%)
PKCi	inactive (89.99%)
PKCt	inactive (94.69%)
PKCz	inactive (99.2%)
PKCb	inactive (117.13%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (100.94%)
PKG1	inactive (97.41%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (94.23%)
PKN2	inactive (98.53%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (100.56%)
SGK2	inactive (98.99%)
SGK3	inactive (101.94%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	inactive (110.69%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (101.37%)
ABL2	inactive (94.89%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (102.42%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (102.75%)
LTK	inactive (100.4%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (98.98%)
MER	inactive (88.72%)
TYRO3	inactive (106.65%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (87.76%)
BRK	inactive (81.73%)
SRC	inactive (99.48%)
FGR	inactive (87.89%)
FRK	inactive (94.26%)
FYN	inactive (92.28%)
HCK	inactive (91.33%)
LCK	inactive (92.73%)
SRM	inactive (103.2%)
YES	inactive (98.33%)
LYN	inactive (103.01%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (92.26%)
BTK	inactive (103.86%)
ITK	inactive (90.04%)
TEC	inactive (117.97%)
TXK	inactive (98.95%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (91.29%)
FLT3	inactive (93.38%)
FMS	inactive (93.6%)
PDGFRb	inactive (98.05%)
PDGFRa	inactive (97.39%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (101.03%)
CTK	inactive (98.75%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (95.7%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (97.02%)
ErbB2	inactive (94.5%)
ErbB4	inactive (83.88%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (98.34%)
EphA2	inactive (100.05%)
EphA3	inactive (98.05%)
EphA4	inactive (96.02%)
EphA5	inactive (86.53%)
EphA6	inactive (89.74%)
EphA7	inactive (89.38%)
EphA8	inactive (96.36%)
EphB1	inactive (89.93%)
EphB2	inactive (101.83%)
EphB3	inactive (96.85%)
EphB4	inactive (96.84%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (98.2%)
PYK2	inactive (86.26%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (81.68%)
FES	inactive (98.2%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (89.59%)
FGFR2	inactive (95.39%)
FGFR3	inactive (96.45%)
FGFR4	inactive (88.86%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (85.88%)
FLT4	inactive (112.89%)
KDR	inactive (88.4%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (81.89%)
IRR	inactive (100.01%)
INSR	inactive (87.68%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (90.91%)
JAK2	inactive (102.27%)
JAK3	inactive (95.47%)
TYK2	inactive (92.11%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (94.78%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (96.93%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (92.71%)
MET	inactive (100.36%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (100.32%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (106.68%)
ZAP70	inactive (91.64%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (90.87%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (97.9%)
TRKB	inactive (99.92%)
TRKC	inactive (87.78%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (98.79%)
ALK2	inactive (92.95%)
ALK4	inactive (97.71%)
TGFbR1	inactive (93.85%)
TGFbR2	inactive (103.52%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (82.47%)
BRAF	inactive (96.39%)
RAF1	inactive (95.97%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (118.88%)
IRAK4	inactive (86.27%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (86.69%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (97.57%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (91.56%)
MLK2	inactive (102.18%)
MLK3	inactive (97.06%)
TAK1	inactive (97.18%)
ZAK	inactive (94.32%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (99.7%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (94.95%)
BRSK1	inactive (91.24%)
BRSK2	inactive (95.26%)
CHK1	inactive (102.47%)
LKB1	inactive (83.49%)
MARK1	inactive (98.14%)
MARK3	inactive (112.09%)
MARK4	inactive (101.75%)
MELK	inactive (92.43%)
PASK	inactive (87.88%)
QIK	inactive (96.83%)
NuaK2	inactive (130.67%)
MARK2	inactive (92.96%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (104.18%)
CaMK1b	inactive (98.15%)
CaMK1d	inactive (95.91%)
CaMK1g	inactive (96.67%)
CaMK4	inactive (98.54%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (97.08%)
CaMK2b	inactive (95.73%)
CaMK2d	inactive (98.09%)
CaMK2g	inactive (86.4%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (95.58%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (105.53%)
DAPK2	inactive (87.07%)
DRAK1	inactive (96.17%)
DAPK3	inactive (87.55%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (96.66%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (96.86%)
MAPKAPK3	inactive (96.51%)
MAPKAPK5	inactive (88.35%)
MNK1	inactive (107.3%)
MNK2	inactive (80.23%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	active (29.52%)
skMLCK	inactive (95.86%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (92.55%)
PHKg2	inactive (88.2%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (72.42%)
PIM2	inactive (60.57%)
PIM3	inactive (92.99%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (97.31%)
PKD3	inactive (94.23%)
PKD2	inactive (96.59%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	-
TSSK2	inactive (96.95%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (88.25%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (104.51%)
MAP3K2	inactive (98.42%)
MAP3K3	inactive (107.54%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (108.32%)
NIK	inactive (106.02%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (97.67%)
HGK	inactive (93.04%)
KHS1	inactive (95.62%)
LOK	inactive (87.29%)
MINK	inactive (91.24%)
MST1	inactive (89.6%)
MST2	inactive (79.45%)
MST3	inactive (93.12%)
MST4	inactive (95.8%)
OSR1	inactive (99.56%)
PAK1	inactive (95.26%)
PAK2	inactive (86.5%)
PAK3	inactive (91.43%)
PAK4	inactive (91.04%)
PAK5	inactive (95.76%)
PAK6	inactive (95.42%)
SLK	inactive (94.06%)
YSK1	inactive (90.34%)
STLK3	inactive (96.48%)
TAO1	inactive (112.9%)
TAO2	inactive (97.61%)
TAO3	inactive (96.94%)
MYO3B	inactive (86.41%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (97.32%)
MAP2K2	inactive (93.78%)
MAP2K6	inactive (101.04%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (93.91%)
AurB	inactive (94.21%)
AurC	inactive (99.59%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (92.1%)
CaMKK2	inactive (79.3%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (88.29%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (106.14%)
IKKb	inactive (96.86%)
IKKe	inactive (97.96%)
TBK1	inactive (92.6%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (83.33%)
NEK11	inactive (95.1%)
NEK2	inactive (89.15%)
NEK4	inactive (74.74%)
NEK6	inactive (102.54%)
NEK7	inactive (108.33%)
NEK9	inactive (92.28%)
NEK3	inactive (97.93%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (103.52%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	active (2.36%)
PLK2	inactive (51.56%)
PLK3	active (14.41%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (95.41%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (88.77%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (98.2%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (87.49%)
ULK2	inactive (100.66%)
ULK3	inactive (84.42%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (96.92%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (93.04%)
Wnk3	inactive (99.49%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	inactive (99.5%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (96.62%)
CK1g1	inactive (94.63%)
CK1g2	inactive (85.83%)
CK1g3	inactive (96.2%)
CK1a	inactive (91.7%)
CK1e	inactive (95.53%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (101.49%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (94.85%)
CK2a2	inactive (98.32%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (90.74%)
CLK2	inactive (88.01%)
CLK3	inactive (97.51%)
CLK4	inactive (85.41%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (97.34%)
DYRK1B	inactive (99.97%)
DYRK2	inactive (110.84%)
DYRK3	inactive (92.58%)
DYRK4	inactive (101.55%)
HIPK1	inactive (108.19%)
HIPK2	inactive (99.63%)
HIPK3	inactive (103.48%)
HIPK4	inactive (99.27%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (94.66%)
Erk2	inactive (101.4%)
JNK3	inactive (96.78%)
NLK	inactive (93.79%)
p38a	inactive (119.92%)
p38b	inactive (91.6%)
p38d	inactive (105.45%)
p38g	inactive (97.74%)
JNK1	inactive (98.73%)
JNK2	inactive (100.13%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (92.84%)
GSK3B	inactive (80.53%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (95.26%)
SRPK1	inactive (94.4%)
SRPK2	inactive (85.4%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (96.53%)