Compound Information


Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz, Millipore : kenpaullone

Inchikey
Same : QQUXFYAWXPMDOE-N
RBC, Metz, Millipore : QQUXFYAWXPMDOE-UHFFFAOYSA-N

ChemSpider
RBC, Metz, Millipore : 3688

Pubchem CID
RBC, Metz, Millipore : 3820

ChEMBL
RBC, Metz, Millipore : CHEMBL296586




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
1111
3333
7535
7613
8847
5322
9958
232-
3211
3313
41--
AGC - PDK1

Bioactivity
KinaseRBCMetzMillipore
PDK1inactive (94.88%)inactive (1258.93nM)inactive (85%)
AGC - Akt

Bioactivity
KinaseRBCMetzMillipore
AKT1inactive (99.92%)inactive (>7943.28nM)inactive (107%)
AKT2inactive (103.58%)inactive (>7943.28nM)inactive (89%)
AKT3inactive (105.46%)inactive (>10000nM)inactive (101%)
AGC - DMPK

Bioactivity
KinaseRBCMetzMillipore
DMPK1inactive (109.51%)-inactive (97%)
MRCKainactive (98.98%)inactive (5011.87nM)inactive (103%)
MRCKbinactive (95.93%)-inactive (72%)
ROCK1inactive (96.09%)inactive (1995.26nM)inactive (117%)
ROCK2inactive (84.61%)inactive (2511.89nM)inactive (73%)
AGC - GRK

Bioactivity
KinaseRBCMetzMillipore
BARK1inactive (102.54%)--
BARK2inactive (108.68%)--
GPRK4inactive (97.88%)--
GPRK5inactive (96.96%)-inactive (95%)
GPRK6inactive (104.51%)-inactive (92%)
GPRK7inactive (100.16%)-inactive (89%)
AGC - RSK

Bioactivity
KinaseRBCMetzMillipore
MSK1inactive (99.63%)-inactive (99%)
MSK2inactive (108.12%)-inactive (82%)
p70S6Kinactive (102.94%)inactive (>6309.57nM)inactive (66%)
p70S6Kbinactive (99.4%)--
RSK2inactive (94.26%)inactive (>7943.28nM)active (33%)
RSK4inactive (95.89%)-inactive (85%)
RSK1inactive (90.79%)-active (12%)
RSK3inactive (94.87%)-inactive (78%)
AGC - PKA

Bioactivity
KinaseRBCMetzMillipore
PKACginactive (105.21%)--
PRKXinactive (100.2%)-inactive (85%)
PKACainactive (102.02%)inactive (>7943.28nM)inactive (89%)
AGC - PKC

Bioactivity
KinaseRBCMetzMillipore
PKCainactive (98.57%)-inactive (90%)
PKCdinactive (92.74%)inactive (>7943.28nM)inactive (99%)
PKCeinactive (96.89%)-inactive (103%)
PKChinactive (95.26%)-inactive (72%)
PKCginactive (93.79%)inactive (>7943.28nM)inactive (104%)
PKCiinactive (89.07%)-inactive (103%)
PKCtinactive (114.32%)-active (49%)
PKCzinactive (98.3%)inactive (>7943.28nM)inactive (107%)
PKCbinactive (102.33%)--
AGC - PKG

Bioactivity
KinaseRBCMetzMillipore
PKG2inactive (100.6%)--
PKG1inactive (95.88%)--
AGC - PKN

Bioactivity
KinaseRBCMetzMillipore
PKN1inactive (101.44%)--
PKN2inactive (96.77%)-inactive (60%)
AGC - SGK

Bioactivity
KinaseRBCMetzMillipore
SGK1inactive (106.58%)inactive (>10000nM)inactive (95%)
SGK2inactive (98.95%)-inactive (99%)
SGK3inactive (106.58%)-inactive (91%)
AGC - NDR

Bioactivity
KinaseRBCMetzMillipore
NDR1inactive (98.61%)--

TK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
2212
2111
2221
3323
1111910
5534
5555
2211
21-1
4332
1412111
2222
2222
4424
3333
3323
4432
11-1
1111
2222
1111
2212
21-1
3332
TK - Abl

Bioactivity
KinaseRBCMetzMillipore
ABL1inactive (82.59%)active (158.49nM)inactive (64%)
ABL2inactive (84.89%)-inactive (76%)
TK - Ack

Bioactivity
KinaseRBCMetzMillipore
ACKactive (38.76%)-active (24%)
TK - ALK

Bioactivity
KinaseRBCMetzMillipore
ALKinactive (90.82%)-inactive (88%)
LTKinactive (91.82%)--
TK - Axl

Bioactivity
KinaseRBCMetzMillipore
AXLinactive (101.42%)-inactive (85%)
MERinactive (89.46%)-inactive (78%)
TYRO3inactive (97.74%)-inactive (92%)
TK - Src

Bioactivity
KinaseRBCMetzMillipore
BLKinactive (92.74%)inactive (>1584.89nM)active (48%)
BRKinactive (87.72%)-inactive (95%)
SRCinactive (71.35%)active (1000nM)inactive (73%)
FGRinactive (74.42%)-active (48%)
FRKinactive (97.43%)-inactive (68%)
FYNinactive (73.44%)active (63.1nM)active (31%)
HCKinactive (85.46%)-active (48%)
LCKinactive (81.93%)inactive (1584.89nM)active (18%)
SRMinactive (105.02%)--
YESinactive (59.11%)-active (42%)
LYNinactive (67.18%)active (125.89nM)active (10%)
TK - Tec

Bioactivity
KinaseRBCMetzMillipore
BMXinactive (99.62%)-inactive (72%)
BTKinactive (97.95%)-inactive (85%)
ITKinactive (101.58%)inactive (>1584.89nM)inactive (83%)
TECinactive (96.37%)--
TXKinactive (82.63%)-inactive (73%)
TK - PDGFR

Bioactivity
KinaseRBCMetzMillipore
KITinactive (90.31%)inactive (>1258.93nM)inactive (116%)
FLT3active (47.73%)inactive (1584.89nM)inactive (65%)
FMSinactive (92.57%)inactive (1995.26nM)active (49%)
PDGFRbinactive (93.22%)-inactive (112%)
PDGFRainactive (102.61%)-inactive (117%)
TK - Csk

Bioactivity
KinaseRBCMetzMillipore
CSKinactive (88.04%)-inactive (104%)
CTKinactive (93.57%)--
TK - DDR

Bioactivity
KinaseRBCMetzMillipore
DDR2inactive (98.41%)-inactive (89%)
TK - EGFR

Bioactivity
KinaseRBCMetzMillipore
EGFRinactive (103.57%)inactive (>1995.26nM)inactive (113%)
ErbB2inactive (103.31%)inactive (>1584.89nM)-
ErbB4inactive (100.86%)inactive (>3981.07nM)inactive (111%)
TK - Eph

Bioactivity
KinaseRBCMetzMillipore
EphA1inactive (100.1%)-inactive (91%)
EphA2inactive (98.34%)inactive (>3162.28nM)inactive (91%)
EphA3inactive (95.98%)-inactive (83%)
EphA4inactive (96.12%)-inactive (103%)
EphA5inactive (96.61%)-inactive (114%)
EphA6inactive (93.66%)--
EphA7inactive (100.98%)-inactive (98%)
EphA8inactive (101.39%)-inactive (95%)
EphB1inactive (93.55%)-inactive (98%)
EphB2inactive (95.55%)-inactive (121%)
EphB3inactive (92.31%)-inactive (114%)
EphB4inactive (100.12%)-inactive (89%)
TK - FAK

Bioactivity
KinaseRBCMetzMillipore
FAKinactive (94.28%)-inactive (82%)
PYK2inactive (101.61%)-inactive (89%)
TK - Fer

Bioactivity
KinaseRBCMetzMillipore
FERinactive (89.75%)-inactive (86%)
FESinactive (87.83%)-inactive (63%)
TK - FGFR

Bioactivity
KinaseRBCMetzMillipore
FGFR1inactive (99.37%)inactive (>5011.87nM)inactive (87%)
FGFR2inactive (100.39%)-inactive (106%)
FGFR3inactive (100.55%)inactive (>1995.26nM)inactive (127%)
FGFR4inactive (112.73%)-inactive (118%)
TK - VEGFR

Bioactivity
KinaseRBCMetzMillipore
FLT1inactive (78.92%)active (398.11nM)inactive (77%)
FLT4inactive (78.7%)active (398.11nM)inactive (56%)
KDRinactive (98.1%)inactive (1995.26nM)inactive (74%)
TK - InsR

Bioactivity
KinaseRBCMetzMillipore
IGF1Rinactive (102.8%)inactive (>1995.26nM)inactive (113%)
IRRinactive (95.81%)-inactive (107%)
INSRinactive (101.03%)inactive (>5011.87nM)inactive (95%)
TK - JakA

Bioactivity
KinaseRBCMetzMillipore
JAK1inactive (102.5%)--
JAK2inactive (101.67%)inactive (>1584.89nM)inactive (100%)
JAK3inactive (102.8%)inactive (>1584.89nM)inactive (104%)
TYK2inactive (81.69%)inactive (>1995.26nM)-
TK - Musk

Bioactivity
KinaseRBCMetzMillipore
MUSKinactive (87.65%)-active (42%)
TK - Ret

Bioactivity
KinaseRBCMetzMillipore
RETinactive (102.32%)-inactive (93%)
TK - Met

Bioactivity
KinaseRBCMetzMillipore
RONinactive (93.59%)-inactive (72%)
METinactive (101.88%)inactive (>3162.28nM)inactive (123%)
TK - Sev

Bioactivity
KinaseRBCMetzMillipore
ROSinactive (83.59%)-inactive (100%)
TK - Syk

Bioactivity
KinaseRBCMetzMillipore
SYKinactive (81.51%)-inactive (72%)
ZAP70inactive (93.62%)-inactive (110%)
TK - Tie

Bioactivity
KinaseRBCMetzMillipore
TIE2inactive (105.64%)-inactive (98%)
TK - Trk

Bioactivity
KinaseRBCMetzMillipore
TRKAinactive (111.59%)inactive (>2511.89nM)inactive (59%)
TRKBinactive (95.04%)inactive (>5011.87nM)inactive (103%)
TRKCinactive (70.66%)--

TKL


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
12512
5311
4222
4111
211-
10522
51-1
TKL - STKR

Bioactivity
KinaseRBCMetzMillipore
ALK1inactive (99.04%)--
ALK2inactive (162.08%)--
ALK4inactive (99.77%)-inactive (105%)
TGFbR1inactive (97.67%)-inactive (85%)
TGFbR2inactive (74.25%)--
TKL - RAF

Bioactivity
KinaseRBCMetzMillipore
ARAFinactive (103.94%)--
BRAFinactive (97.66%)--
RAF1inactive (91.53%)-inactive (75%)
TKL - IRAK

Bioactivity
KinaseRBCMetzMillipore
IRAK1inactive (98.6%)-inactive (94%)
IRAK4inactive (88.25%)inactive (>10000nM)inactive (81%)
TKL - LISK

Bioactivity
KinaseRBCMetzMillipore
LIMK1inactive (99.18%)inactive (7943.28nM)inactive (89%)
TKL - LRRK

Bioactivity
KinaseRBCMetzMillipore
LRRK2inactive (78.66%)--
TKL - MLK

Bioactivity
KinaseRBCMetzMillipore
MLK1inactive (64.56%)-active (22%)
MLK2inactive (79.29%)--
MLK3active (49.38%)--
TAK1inactive (84.16%)-inactive (81%)
ZAKinactive (88.49%)--
TKL - RIPK

Bioactivity
KinaseRBCMetzMillipore
RIPK2inactive (75.94%)-active (49%)

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
2013912
5523
4443
1111
5424
3111
5544
52-1
2211
3333
3322
5222
1-1-
CAMK - CAMKL

Bioactivity
KinaseRBCMetzMillipore
NuaK1active (14.59%)-active (13%)
BRSK1inactive (60.51%)-inactive (64%)
BRSK2inactive (62.66%)-inactive (60%)
CHK1inactive (89.01%)inactive (3981.07nM)inactive (77%)
LKB1inactive (95.66%)-inactive (97%)
MARK1inactive (88.29%)-inactive (51%)
MARK3inactive (76.82%)active (630.96nM)-
MARK4inactive (60.19%)--
MELKinactive (74.77%)-inactive (89%)
PASKinactive (98.02%)-inactive (118%)
QIKinactive (63.46%)--
NuaK2inactive (71.06%)--
MARK2inactive (74.32%)active (1000nM)inactive (62%)
AMPKa1-inactive (>10000nM)inactive (75%)
AMPKa2--inactive (61%)
SIK--inactive (91%)
CAMK - CAMK1

Bioactivity
KinaseRBCMetzMillipore
CaMK1ainactive (105.73%)inactive (>7943.28nM)inactive (94%)
CaMK1binactive (99.65%)--
CaMK1dinactive (112.44%)-inactive (93%)
CaMK1ginactive (97.38%)--
CaMK4inactive (98.06%)-inactive (101%)
CAMK - CAMK2

Bioactivity
KinaseRBCMetzMillipore
CaMK2ainactive (105.22%)--
CaMK2binactive (97.81%)-inactive (81%)
CaMK2dinactive (91.07%)-inactive (58%)
CaMK2ginactive (116.13%)-active (50%)
CAMK - RAD53

Bioactivity
KinaseRBCMetzMillipore
CHK2inactive (59.03%)active (630.96nM)active (37%)
CAMK - DAPK

Bioactivity
KinaseRBCMetzMillipore
DAPK1inactive (101.06%)-inactive (84%)
DAPK2inactive (100.49%)-inactive (101%)
DRAK1inactive (101.65%)-inactive (76%)
DAPK3inactive (110.54%)inactive (>1258.93nM)inactive (94%)
CAMK - DCAMKL

Bioactivity
KinaseRBCMetzMillipore
DCLK2inactive (94.6%)-inactive (108%)
DCLK1---
CAMK - MAPKAPK

Bioactivity
KinaseRBCMetzMillipore
MAPKAPK2inactive (101.49%)inactive (>7943.28nM)inactive (73%)
MAPKAPK3inactive (100.29%)inactive (>10000nM)inactive (106%)
MAPKAPK5inactive (94.59%)-inactive (97%)
MNK1inactive (98.44%)--
MNK2inactive (101.83%)-inactive (90%)
CAMK - MLCK

Bioactivity
KinaseRBCMetzMillipore
smMLCKinactive (96.34%)-inactive (89%)
skMLCKinactive (96.82%)--
CAMK - PHK

Bioactivity
KinaseRBCMetzMillipore
PHKg1active (49.73%)--
PHKg2inactive (98.89%)-inactive (120%)
CAMK - PIM

Bioactivity
KinaseRBCMetzMillipore
PIM1inactive (96.8%)inactive (2511.89nM)inactive (75%)
PIM2inactive (104.2%)inactive (>1584.89nM)inactive (100%)
PIM3inactive (84.59%)-inactive (83%)
CAMK - PKD

Bioactivity
KinaseRBCMetzMillipore
PKD1inactive (100.82%)-inactive (99%)
PKD3inactive (95.53%)--
PKD2inactive (100.12%)inactive (>10000nM)inactive (104%)
CAMK - TSSK

Bioactivity
KinaseRBCMetzMillipore
TSSK1inactive (80.44%)-inactive (87%)
TSSK2inactive (99.3%)-inactive (96%)
CAMK - STK33

Bioactivity
KinaseRBCMetzMillipore
STK33inactive (102.61%)-inactive (97%)

STE


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
83-1
22--
3123914
7323
STE - STE11

Bioactivity
KinaseRBCMetzMillipore
MAP3K5inactive (99.19%)-inactive (84%)
MAP3K2inactive (94.2%)--
MAP3K3inactive (93.19%)--
STE - STE-Unique

Bioactivity
KinaseRBCMetzMillipore
COTinactive (98.63%)--
NIKinactive (106.07%)--
STE - STE20

Bioactivity
KinaseRBCMetzMillipore
GCKactive (20.06%)-active (6%)
HGKactive (6.61%)--
KHS1active (30.06%)--
LOKinactive (89.85%)-inactive (96%)
MINKactive (29.57%)-active (27%)
MST1inactive (81.79%)-active (44%)
MST2inactive (83.2%)active (630.96nM)inactive (87%)
MST3inactive (84.78%)-inactive (65%)
MST4inactive (107.77%)--
OSR1inactive (107.32%)--
PAK1inactive (85.04%)inactive (>10000nM)-
PAK2inactive (95.54%)-inactive (91%)
PAK3inactive (96.64%)-inactive (94%)
PAK4inactive (92.2%)inactive (>5011.87nM)active (25%)
PAK5inactive (85.12%)-active (35%)
PAK6inactive (97.84%)-inactive (73%)
SLKinactive (95.68%)--
YSK1inactive (98.8%)--
STLK3inactive (90.08%)--
TAO1inactive (99.36%)-inactive (76%)
TAO2inactive (93.97%)-inactive (84%)
TAO3inactive (82.77%)-inactive (78%)
MYO3Binactive (97.39%)--
STE - STE7

Bioactivity
KinaseRBCMetzMillipore
MAP2K1inactive (84.31%)-inactive (107%)
MAP2K2inactive (115.56%)--
MAP2K6inactive (95.29%)-inactive (100%)
MAP2K7--inactive (95%)

Other


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
3323
221-
11-1
4443
11825
111-
4333
11--
41--
11--
53-2
311-
42-2
21-1
1-1-
Other - Aur

Bioactivity
KinaseRBCMetzMillipore
AurAinactive (99.71%)inactive (1258.93nM)inactive (97%)
AurBinactive (84.25%)inactive (6309.57nM)inactive (69%)
AurCinactive (90.91%)-inactive (76%)
Other - CAMKK

Bioactivity
KinaseRBCMetzMillipore
CaMKK1inactive (99.85%)--
CaMKK2inactive (77.82%)--
Other - Haspin

Bioactivity
KinaseRBCMetzMillipore
Haspininactive (89.05%)-inactive (60%)
Other - IKK

Bioactivity
KinaseRBCMetzMillipore
IKKainactive (98.59%)inactive (>3981.07nM)inactive (124%)
IKKbinactive (100.96%)inactive (>3162.28nM)inactive (115%)
IKKeinactive (89.81%)--
TBK1inactive (92.95%)-inactive (53%)
Other - NEK

Bioactivity
KinaseRBCMetzMillipore
NEK1inactive (95.36%)--
NEK11inactive (106.71%)-active (38%)
NEK2inactive (87.11%)inactive (>10000nM)inactive (95%)
NEK4inactive (98.92%)--
NEK6inactive (100.22%)-inactive (113%)
NEK7inactive (94.29%)-inactive (100%)
NEK9inactive (94.03%)--
NEK3inactive (96.2%)-inactive (81%)
Other - TOPK

Bioactivity
KinaseRBCMetzMillipore
PBKinactive (99.28%)--
Other - PLK

Bioactivity
KinaseRBCMetzMillipore
PLK1inactive (94.86%)inactive (>7943.28nM)inactive (76%)
PLK2inactive (99.14%)-inactive (99%)
PLK3inactive (95.98%)inactive (>7943.28nM)inactive (95%)
PLK4-active (398.11nM)-
Other - SgK496

Bioactivity
KinaseRBCMetzMillipore
SgK496inactive (98.62%)--
Other - NAK

Bioactivity
KinaseRBCMetzMillipore
MPSK1inactive (98.87%)--
Other - TTK

Bioactivity
KinaseRBCMetzMillipore
TTKinactive (80.87%)--
Other - ULK

Bioactivity
KinaseRBCMetzMillipore
ULK1inactive (93.83%)--
ULK2inactive (90.06%)-inactive (79%)
ULK3inactive (83.18%)-inactive (74%)
Other - WEE

Bioactivity
KinaseRBCMetzMillipore
Wee1inactive (87.69%)--
Other - WNK

Bioactivity
KinaseRBCMetzMillipore
Wnk2inactive (112.21%)-inactive (93%)
Wnk3inactive (95.51%)-inactive (88%)
Other - TLK

Bioactivity
KinaseRBCMetzMillipore
TLK2inactive (99.39%)-inactive (89%)
Other - CDC7

Bioactivity
KinaseRBCMetzMillipore
CDC7-active (100nM)-

CK1


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
7654
31-1
CK1 - CK1

Bioactivity
KinaseRBCMetzMillipore
CK1dinactive (103.59%)inactive (>7943.28nM)inactive (80%)
CK1g1inactive (101.78%)-inactive (106%)
CK1g2inactive (101.59%)-inactive (114%)
CK1g3inactive (102.99%)-inactive (101%)
CK1ainactive (95.15%)--
CK1einactive (103.27%)--
CK1 - VRK

Bioactivity
KinaseRBCMetzMillipore
VRK1inactive (87.27%)--
VRK2--inactive (99%)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
3212
4422
10964
1410810
2222
3313
20-7-
CMGC - CK2

Bioactivity
KinaseRBCMetzMillipore
CK2a1inactive (79.07%)active (398.11nM)inactive (79%)
CK2a2inactive (74.58%)-inactive (112%)
CMGC - CLK

Bioactivity
KinaseRBCMetzMillipore
CLK1inactive (96.72%)--
CLK2inactive (95.69%)-inactive (80%)
CLK3inactive (99.27%)-inactive (78%)
CLK4inactive (91.13%)--
CMGC - DYRK

Bioactivity
KinaseRBCMetzMillipore
DYRK1Ainactive (98.84%)inactive (5011.87nM)-
DYRK1Binactive (101.93%)--
DYRK2inactive (106.83%)-inactive (92%)
DYRK3inactive (112.62%)--
DYRK4inactive (97.16%)--
HIPK1inactive (102.91%)-inactive (103%)
HIPK2inactive (106.86%)-inactive (98%)
HIPK3inactive (109.29%)-inactive (102%)
HIPK4inactive (104.94%)--
CMGC - MAPK

Bioactivity
KinaseRBCMetzMillipore
Erk1inactive (100.3%)-inactive (85%)
Erk2inactive (90.48%)inactive (>7943.28nM)inactive (114%)
JNK3inactive (89.57%)-inactive (67%)
NLKinactive (98.7%)-inactive (83%)
p38ainactive (92.98%)-inactive (90%)
p38binactive (103.63%)-inactive (98%)
p38dinactive (102.75%)inactive (>7943.28nM)inactive (98%)
p38ginactive (101.45%)inactive (>6309.57nM)inactive (101%)
JNK1inactive (87.45%)inactive (>3162.28nM)inactive (95%)
JNK2inactive (93.85%)inactive (>3981.07nM)inactive (87%)
CMGC - GSK

Bioactivity
KinaseRBCMetzMillipore
GSK3Aactive (5.87%)active (7.94nM)active (5%)
GSK3Bactive (19.67%)active (19.95nM)active (8%)
CMGC - SRPK

Bioactivity
KinaseRBCMetzMillipore
MSSK1inactive (100.45%)-inactive (98%)
SRPK1inactive (99.57%)-inactive (105%)
SRPK2inactive (98.94%)-inactive (105%)
CMGC - CDK

Bioactivity
KinaseRBCMetzMillipore
CDC2---
CDK2-active (100nM)-
CDK5-inactive (1584.89nM)-
CDK8---
CDK7---
CDK9---
CDK11---

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
51--
6-11
6--1
Atypical - PDHK

Bioactivity
KinaseRBCMetzMillipore
PDHK1inactive (94.88%)--
Atypical - Alpha

Bioactivity
KinaseRBCMetzMillipore
eEF2K--inactive (106%)
Atypical - PIKK

Bioactivity
KinaseRBCMetzMillipore
FRAP--inactive (114%)