Compound in Profiling

Compound Information

Test on : RBC

Compound Name : (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL

Inchikey : RAMROQQYRRQPDL-OAHLLOKOSA-N

ChemSpider : 5290490

Pubchem CID : 6914609

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (105.55%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (116.75%)
AKT2	inactive (100.45%)
AKT3	inactive (101.15%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (99.74%)
MRCKa	inactive (99.4%)
MRCKb	inactive (98.45%)
ROCK1	inactive (90.01%)
ROCK2	inactive (100.76%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (82.99%)
BARK2	inactive (97.09%)
GPRK4	inactive (103.27%)
GPRK5	inactive (100.57%)
GPRK6	inactive (72.14%)
GPRK7	inactive (79.32%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (103.01%)
MSK2	inactive (89.3%)
p70S6K	inactive (95.54%)
p70S6Kb	inactive (98.17%)
RSK2	inactive (54.06%)
RSK4	active (46.12%)
RSK1	active (37.21%)
RSK3	active (48.67%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (101.28%)
PKACa	inactive (101.33%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (66.15%)
PKCd	inactive (87.61%)
PKCe	inactive (105.16%)
PKCh	inactive (99.45%)
PKCg	inactive (106.83%)
PKCi	inactive (89.55%)
PKCt	inactive (119.19%)
PKCz	inactive (101.26%)
PKCb	inactive (97.34%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (88.77%)
PKG1	inactive (103.94%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (93.33%)
PKN2	inactive (97.96%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (93.09%)
SGK2	inactive (121.31%)
SGK3	inactive (99.91%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	active (45.51%)
ABL2	active (21.32%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	active (47.82%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (79.65%)
LTK	inactive (103.07%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (93.08%)
MER	inactive (79.7%)
TYRO3	inactive (103.12%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (79.65%)
BRK	inactive (85.6%)
SRC	active (3.75%)
FGR	active (15.02%)
FRK	inactive (70.29%)
FYN	active (18.92%)
HCK	active (27.31%)
LCK	inactive (70.17%)
SRM	inactive (96.83%)
YES	active (7.03%)
LYN	active (23.07%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (81.89%)
BTK	active (33.03%)
ITK	inactive (80.24%)
TEC	inactive (129.61%)
TXK	active (42.54%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (86.15%)
FLT3	active (8.35%)
FMS	inactive (71.09%)
PDGFRb	inactive (98.07%)
PDGFRa	inactive (89.42%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (79.28%)
CTK	inactive (111.14%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (127.93%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (93.9%)
ErbB2	inactive (92.91%)
ErbB4	inactive (131.04%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (76.89%)
EphA2	inactive (67.54%)
EphA3	inactive (86.64%)
EphA4	inactive (61.35%)
EphA5	inactive (63.98%)
EphA6	-
EphA7	inactive (80.2%)
EphA8	inactive (92.5%)
EphB1	inactive (59.19%)
EphB2	inactive (73.62%)
EphB3	inactive (95.33%)
EphB4	inactive (58.39%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (59.53%)
PYK2	inactive (63.57%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (54.9%)
FES	inactive (69.19%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (76.66%)
FGFR2	inactive (97.27%)
FGFR3	inactive (79.4%)
FGFR4	inactive (93.39%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (97.54%)
FLT4	inactive (80.7%)
KDR	inactive (101.5%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (72.99%)
IRR	inactive (70.76%)
INSR	inactive (85.03%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (100.94%)
JAK2	inactive (99.95%)
JAK3	inactive (107.5%)
TYK2	inactive (57.92%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	active (46.04%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (61.6%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (121.56%)
MET	inactive (109.4%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (96.55%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (81.1%)
ZAP70	inactive (101.55%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (92.45%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	active (45.35%)
TRKB	active (3.04%)
TRKC	active (4.42%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (108.78%)
ALK2	inactive (99.42%)
ALK4	inactive (106.52%)
TGFbR1	inactive (102.84%)
TGFbR2	inactive (93.49%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (82.39%)
BRAF	inactive (97.45%)
RAF1	inactive (113.1%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (97.08%)
IRAK4	inactive (86.76%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (106.54%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (100.84%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	active (7.81%)
MLK2	inactive (95.08%)
MLK3	active (17.71%)
TAK1	inactive (51.27%)
ZAK	inactive (92.26%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (87.72%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (61.55%)
BRSK1	inactive (93.13%)
BRSK2	inactive (88.25%)
CHK1	inactive (96.19%)
LKB1	inactive (60.25%)
MARK1	inactive (87.47%)
MARK3	inactive (85.2%)
MARK4	inactive (71.16%)
MELK	inactive (51.5%)
PASK	inactive (106.11%)
QIK	inactive (104%)
NuaK2	inactive (81.43%)
MARK2	inactive (74.12%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (95.31%)
CaMK1b	inactive (131.66%)
CaMK1d	inactive (103.16%)
CaMK1g	inactive (104.67%)
CaMK4	inactive (97.43%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (83.93%)
CaMK2b	inactive (98.18%)
CaMK2d	inactive (87.31%)
CaMK2g	inactive (104.49%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (96.28%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (95.33%)
DAPK2	inactive (100.74%)
DRAK1	inactive (96.3%)
DAPK3	inactive (96.72%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (104.59%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (92.77%)
MAPKAPK3	inactive (98.41%)
MAPKAPK5	inactive (95.81%)
MNK1	inactive (99.14%)
MNK2	inactive (113.18%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (81.3%)
skMLCK	inactive (99.49%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (81.1%)
PHKg2	inactive (104.51%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (98%)
PIM2	inactive (113.15%)
PIM3	inactive (93.01%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (94.21%)
PKD3	inactive (89.2%)
PKD2	inactive (103.12%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (91.25%)
TSSK2	inactive (101.9%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (56.22%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (95.58%)
MAP3K2	inactive (83.07%)
MAP3K3	inactive (100.01%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (109.19%)
NIK	inactive (100.3%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (90.71%)
HGK	inactive (86.05%)
KHS1	inactive (82.48%)
LOK	inactive (55.6%)
MINK	inactive (94.49%)
MST1	inactive (63.64%)
MST2	inactive (70.01%)
MST3	inactive (75.92%)
MST4	inactive (67.82%)
OSR1	inactive (100.4%)
PAK1	inactive (81.76%)
PAK2	inactive (95.47%)
PAK3	inactive (101.4%)
PAK4	inactive (101.52%)
PAK5	active (44.34%)
PAK6	inactive (57.26%)
SLK	active (39.77%)
YSK1	inactive (81.81%)
STLK3	inactive (83.66%)
TAO1	inactive (79.91%)
TAO2	inactive (82.15%)
TAO3	inactive (86.85%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (91.33%)
MAP2K2	inactive (87.5%)
MAP2K6	inactive (92.54%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (80.45%)
AurB	inactive (87.79%)
AurC	inactive (91.9%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (86.84%)
CaMKK2	active (33.25%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (99.88%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (97.26%)
IKKb	inactive (104.23%)
IKKe	inactive (88.44%)
TBK1	inactive (86.62%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (81.49%)
NEK11	inactive (84.23%)
NEK2	inactive (94.41%)
NEK4	inactive (80.18%)
NEK6	inactive (110.67%)
NEK7	inactive (89.01%)
NEK9	inactive (69.42%)
NEK3	inactive (100.4%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (75.63%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (54.95%)
PLK2	inactive (92.01%)
PLK3	inactive (62.84%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (93.12%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (73.98%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (84.52%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	active (41.52%)
ULK2	inactive (74.89%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (70.75%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (112.16%)
Wnk3	inactive (76.9%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (65.73%)
CK1g1	active (26.43%)
CK1g2	active (35.19%)
CK1g3	active (13.4%)
CK1a	inactive (75.51%)
CK1e	inactive (82.72%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (85.84%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (99.27%)
CK2a2	inactive (105.74%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (51.91%)
CLK2	active (17.65%)
CLK3	inactive (85.46%)
CLK4	active (16.49%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (57.1%)
DYRK1B	active (38.27%)
DYRK2	inactive (93.22%)
DYRK3	inactive (103.33%)
DYRK4	inactive (91.62%)
HIPK1	inactive (99.16%)
HIPK2	inactive (94.27%)
HIPK3	inactive (99.42%)
HIPK4	inactive (96.41%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (105.9%)
Erk2	inactive (95.41%)
JNK3	inactive (94.57%)
NLK	inactive (93.91%)
p38a	inactive (98.92%)
p38b	inactive (96.29%)
p38d	inactive (101.48%)
p38g	inactive (101.81%)
JNK1	inactive (93.42%)
JNK2	inactive (99.83%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (100.64%)
GSK3B	inactive (102.65%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	active (37.69%)
SRPK1	inactive (62.14%)
SRPK2	active (30.98%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (105.55%)