Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : CTK5I7912
Millipore : VEGF Receptor 2 Kinase Inhibitor II

Inchikey
Same : RFHPWPWVGFSLOP-N
RBC : RFHPWPWVGFSLOP-UHFFFAOYSA-N
Millipore : RFHPWPWVGFSLOP-ZROIWOOFSA-N

ChemSpider
RBC : 5453
Millipore : 4486317

Pubchem CID
RBC : 5655
Millipore : 5329155

ChEMBL
RBC : -
Millipore : CHEMBL88606

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (95.27%)	inactive (109%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (99.82%)	inactive (95%)
AKT2	inactive (90.3%)	inactive (112%)
AKT3	inactive (96.61%)	inactive (105%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (101.07%)	inactive (115%)
MRCKa	inactive (81.85%)	inactive (108%)
MRCKb	inactive (113.52%)	inactive (98%)
ROCK1	inactive (98.77%)	inactive (119%)
ROCK2	inactive (92.79%)	inactive (101%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (105.14%)	-
BARK2	inactive (89.86%)	-
GPRK4	inactive (100.86%)	-
GPRK5	inactive (105.93%)	inactive (104%)
GPRK6	inactive (95.79%)	inactive (102%)
GPRK7	inactive (85.17%)	inactive (98%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (90.35%)	inactive (111%)
MSK2	inactive (94.21%)	inactive (88%)
p70S6K	inactive (91.92%)	inactive (84%)
p70S6Kb	inactive (102.37%)	-
RSK2	inactive (80.87%)	active (45%)
RSK4	inactive (78.64%)	inactive (79%)
RSK1	inactive (70.43%)	inactive (79%)
RSK3	inactive (71.96%)	inactive (84%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (98.09%)	-
PRKX	inactive (97.21%)	inactive (113%)
PKACa	inactive (96.53%)	inactive (108%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (101.97%)	inactive (104%)
PKCd	inactive (95.62%)	inactive (100%)
PKCe	inactive (99.08%)	inactive (84%)
PKCh	inactive (97.43%)	inactive (102%)
PKCg	inactive (100.1%)	inactive (109%)
PKCi	inactive (91.95%)	inactive (84%)
PKCt	inactive (98.4%)	inactive (100%)
PKCz	inactive (104.03%)	inactive (103%)
PKCb	inactive (85.48%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (92.38%)	-
PKG1	inactive (77.01%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (91.66%)	-
PKN2	inactive (91.33%)	inactive (95%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (93.4%)	inactive (104%)
SGK2	inactive (101.18%)	inactive (111%)
SGK3	inactive (97.57%)	inactive (96%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (80.12%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (91.77%)	inactive (105%)
ABL2	inactive (82.57%)	inactive (94%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (92.85%)	inactive (54%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (88.48%)	inactive (76%)
LTK	inactive (70.57%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (90.01%)	inactive (72%)
MER	inactive (81.2%)	inactive (68%)
TYRO3	inactive (103.62%)	inactive (93%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (74.42%)	inactive (82%)
BRK	inactive (82.28%)	inactive (107%)
SRC	inactive (88.76%)	inactive (73%)
FGR	inactive (67.67%)	inactive (81%)
FRK	inactive (91.03%)	inactive (102%)
FYN	inactive (87.54%)	inactive (74%)
HCK	inactive (88.49%)	inactive (59%)
LCK	inactive (84.5%)	inactive (123%)
SRM	inactive (104.07%)	-
YES	inactive (67.17%)	inactive (79%)
LYN	inactive (70.81%)	active (21%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (89.94%)	inactive (96%)
BTK	inactive (90.54%)	inactive (93%)
ITK	inactive (87.48%)	inactive (87%)
TEC	inactive (128.82%)	-
TXK	inactive (97.26%)	inactive (107%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (30.49%)	inactive (66%)
FLT3	active (3.86%)	active (3%)
FMS	active (49.69%)	active (11%)
PDGFRb	inactive (58.77%)	inactive (74%)
PDGFRa	inactive (76.16%)	active (34%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (98.5%)	inactive (118%)
CTK	inactive (94.21%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (101.47%)	inactive (110%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (87.38%)	inactive (103%)
ErbB2	inactive (115.1%)	-
ErbB4	inactive (84.61%)	inactive (109%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (93.12%)	inactive (91%)
EphA2	inactive (110.13%)	inactive (112%)
EphA3	inactive (94.62%)	inactive (108%)
EphA4	inactive (94.84%)	inactive (106%)
EphA5	inactive (91.31%)	inactive (110%)
EphA6	inactive (89.15%)	-
EphA7	inactive (85.29%)	inactive (94%)
EphA8	inactive (94.45%)	inactive (93%)
EphB1	inactive (85.48%)	inactive (101%)
EphB2	inactive (85.38%)	inactive (111%)
EphB3	inactive (99.69%)	inactive (114%)
EphB4	inactive (88.59%)	inactive (118%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (81.92%)	inactive (78%)
PYK2	inactive (82.4%)	inactive (75%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (74.67%)	inactive (119%)
FES	inactive (83.82%)	inactive (107%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (76.66%)	inactive (81%)
FGFR2	inactive (87.38%)	inactive (63%)
FGFR3	inactive (55.84%)	inactive (86%)
FGFR4	inactive (77.02%)	inactive (116%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (73.44%)	active (17%)
FLT4	inactive (56.12%)	active (1%)
KDR	inactive (70.92%)	active (12%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (74.28%)	inactive (120%)
IRR	inactive (94.78%)	inactive (114%)
INSR	inactive (85.84%)	inactive (96%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (99.35%)	-
JAK2	inactive (95.22%)	inactive (105%)
JAK3	inactive (89.34%)	inactive (108%)
TYK2	inactive (86.03%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (88.6%)	inactive (61%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (42.87%)	inactive (74%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (88.31%)	inactive (116%)
MET	inactive (81.57%)	inactive (104%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (98.61%)	inactive (94%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (90.49%)	inactive (123%)
ZAP70	inactive (93.86%)	inactive (112%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (98.18%)	inactive (110%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (51.76%)	active (19%)
TRKB	active (43.58%)	active (48%)
TRKC	active (11.87%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (102.88%)	-
ALK2	inactive (96.96%)	-
ALK4	inactive (99.01%)	inactive (112%)
TGFbR1	inactive (100.44%)	inactive (98%)
TGFbR2	inactive (101.18%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (106.31%)	-
BRAF	inactive (92.47%)	-
RAF1	inactive (88.25%)	inactive (99%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (97.02%)	inactive (92%)
IRAK4	inactive (67.23%)	inactive (82%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (82.95%)	inactive (99%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (7.03%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (53.42%)	inactive (63%)
MLK2	inactive (99.82%)	-
MLK3	active (16.75%)	-
TAK1	inactive (60.94%)	inactive (94%)
ZAK	inactive (87.69%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (87.15%)	inactive (100%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (27.73%)	inactive (70%)
BRSK1	inactive (80.78%)	inactive (90%)
BRSK2	inactive (93.84%)	inactive (107%)
CHK1	inactive (81.76%)	inactive (78%)
LKB1	inactive (88.74%)	inactive (97%)
MARK1	inactive (69.05%)	inactive (72%)
MARK3	inactive (84.87%)	-
MARK4	inactive (82.86%)	-
MELK	inactive (75.62%)	inactive (78%)
PASK	inactive (98.86%)	inactive (129%)
QIK	inactive (92.73%)	-
NuaK2	inactive (133.13%)	-
MARK2	inactive (77%)	inactive (81%)
AMPKa1	-	inactive (76%)
AMPKa2	-	inactive (87%)
SIK	-	inactive (97%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (98.41%)	inactive (105%)
CaMK1b	inactive (98.59%)	-
CaMK1d	inactive (96.76%)	inactive (114%)
CaMK1g	inactive (103.45%)	-
CaMK4	inactive (97.49%)	inactive (135%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (93.32%)	-
CaMK2b	inactive (85.78%)	inactive (72%)
CaMK2d	inactive (84.21%)	active (18%)
CaMK2g	inactive (92.38%)	active (20%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (68.23%)	active (44%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (110.94%)	inactive (98%)
DAPK2	inactive (102.44%)	inactive (95%)
DRAK1	inactive (72.86%)	active (48%)
DAPK3	inactive (92.79%)	inactive (96%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (98.16%)	inactive (94%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (97.45%)	inactive (108%)
MAPKAPK3	inactive (95.07%)	inactive (126%)
MAPKAPK5	inactive (90.64%)	inactive (82%)
MNK1	inactive (106.37%)	-
MNK2	inactive (87.13%)	inactive (108%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (95.68%)	inactive (83%)
skMLCK	inactive (78.2%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (60.17%)	-
PHKg2	inactive (90.5%)	inactive (77%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (100.64%)	inactive (96%)
PIM2	inactive (100.15%)	inactive (129%)
PIM3	inactive (87.52%)	inactive (105%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (93.82%)	inactive (91%)
PKD3	inactive (90.3%)	-
PKD2	inactive (95.84%)	inactive (96%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	active (36.09%)	inactive (98%)
TSSK2	inactive (89.85%)	inactive (90%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (77.26%)	inactive (89%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (100.88%)	inactive (83%)
MAP3K2	inactive (93.61%)	-
MAP3K3	inactive (88.55%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (105.06%)	-
NIK	inactive (111.64%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (58.08%)	active (24%)
HGK	active (6.84%)	-
KHS1	active (17.7%)	-
LOK	inactive (65.53%)	inactive (74%)
MINK	active (26.38%)	inactive (87%)
MST1	active (44.08%)	inactive (60%)
MST2	inactive (60.67%)	active (46%)
MST3	inactive (94.2%)	inactive (88%)
MST4	inactive (87.9%)	-
OSR1	inactive (96.74%)	-
PAK1	inactive (95.67%)	-
PAK2	inactive (90.02%)	inactive (113%)
PAK3	inactive (96.42%)	inactive (114%)
PAK4	inactive (76.76%)	inactive (84%)
PAK5	inactive (85.39%)	inactive (93%)
PAK6	inactive (89.82%)	inactive (85%)
SLK	inactive (73.45%)	-
YSK1	inactive (101.6%)	-
STLK3	inactive (85.98%)	-
TAO1	inactive (92.32%)	inactive (104%)
TAO2	inactive (89.4%)	inactive (111%)
TAO3	inactive (75.3%)	inactive (100%)
MYO3B	inactive (55.14%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (84.82%)	inactive (87%)
MAP2K2	inactive (92.1%)	-
MAP2K6	inactive (109.87%)	inactive (76%)
MAP2K7	-	inactive (87%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (87.45%)	inactive (85%)
AurB	inactive (56.68%)	active (18%)
AurC	inactive (86.27%)	inactive (82%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (69.65%)	-
CaMKK2	inactive (68.09%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (88.01%)	inactive (87%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (99.09%)	inactive (102%)
IKKb	inactive (102.15%)	inactive (101%)
IKKe	inactive (89.53%)	-
TBK1	inactive (66.88%)	inactive (59%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (94.64%)	-
NEK11	inactive (110.69%)	inactive (87%)
NEK2	inactive (87.89%)	inactive (91%)
NEK4	inactive (80.52%)	-
NEK6	inactive (102.57%)	inactive (104%)
NEK7	inactive (103.17%)	inactive (101%)
NEK9	inactive (85.62%)	-
NEK3	inactive (86.73%)	inactive (102%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (87.83%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (102.17%)	inactive (82%)
PLK2	inactive (101.79%)	inactive (105%)
PLK3	inactive (97.85%)	inactive (87%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (93.05%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (94.27%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (95.08%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (69.42%)	-
ULK2	inactive (113.58%)	inactive (100%)
ULK3	inactive (55.47%)	inactive (52%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (95.89%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (100.82%)	inactive (110%)
Wnk3	inactive (93.77%)	inactive (118%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	inactive (100.56%)	inactive (107%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (72.41%)	inactive (86%)
CK1g1	inactive (101.73%)	inactive (100%)
CK1g2	inactive (96.83%)	inactive (95%)
CK1g3	inactive (102.91%)	inactive (118%)
CK1a	inactive (100.49%)	-
CK1e	inactive (84.26%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (107.82%)	-
VRK2	-	inactive (98%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (96.05%)	inactive (77%)
CK2a2	-	inactive (120%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (97.21%)	-
CLK2	inactive (88.58%)	inactive (106%)
CLK3	inactive (101.23%)	inactive (91%)
CLK4	inactive (84.45%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (87.15%)	-
DYRK1B	inactive (93.86%)	-
DYRK2	inactive (90.83%)	inactive (97%)
DYRK3	inactive (94.03%)	-
DYRK4	inactive (101.72%)	-
HIPK1	inactive (97.21%)	inactive (98%)
HIPK2	inactive (90.96%)	inactive (82%)
HIPK3	inactive (96.73%)	inactive (97%)
HIPK4	inactive (103.93%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (95.02%)	inactive (89%)
Erk2	inactive (103.47%)	inactive (104%)
JNK3	inactive (98.68%)	inactive (115%)
NLK	-	inactive (97%)
p38a	-	inactive (86%)
p38b	inactive (96.78%)	inactive (98%)
p38d	inactive (100.2%)	inactive (111%)
p38g	inactive (93.04%)	inactive (115%)
JNK1	inactive (106.63%)	inactive (114%)
JNK2	inactive (99.43%)	inactive (101%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (88.47%)	inactive (113%)
GSK3B	inactive (94.12%)	inactive (86%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (77.82%)	inactive (101%)
SRPK1	inactive (98.32%)	inactive (111%)
SRPK2	inactive (90.59%)	inactive (88%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (95.27%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (91%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (116%)