Compound in Profiling

Compound Information

Test on : RBC

Compound Name : -

Inchikey : RKUMZEVCWKZXFV-YOCZKUTFSA-N

ChemSpider : 25057868

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (83.33%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (95.55%)
AKT2	inactive (90.1%)
AKT3	inactive (92.95%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (99.47%)
MRCKa	inactive (88.59%)
MRCKb	inactive (96.58%)
ROCK1	inactive (100.82%)
ROCK2	inactive (90.96%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (100.55%)
BARK2	inactive (99.98%)
GPRK4	inactive (74.71%)
GPRK5	inactive (84.64%)
GPRK6	inactive (53.06%)
GPRK7	inactive (70.25%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	active (37.45%)
MSK2	active (21.7%)
p70S6K	active (47.82%)
p70S6Kb	inactive (105.58%)
RSK2	active (18.29%)
RSK4	active (16.4%)
RSK1	active (8.85%)
RSK3	active (12.14%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (84.17%)
PKACa	inactive (89.06%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (100.93%)
PKCd	inactive (80.59%)
PKCe	inactive (92.21%)
PKCh	inactive (82.16%)
PKCg	inactive (92.04%)
PKCi	inactive (100.22%)
PKCt	inactive (92.9%)
PKCz	inactive (98.49%)
PKCb	inactive (87.98%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	active (28.07%)
PKG1	active (45.15%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	active (49.9%)
PKN2	inactive (90.06%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (51.04%)
SGK2	inactive (75.85%)
SGK3	inactive (100.24%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (71.92%)
ABL2	active (38.52%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	active (4.93%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	active (38.1%)
LTK	active (34.75%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	active (42.68%)
MER	active (49.36%)
TYRO3	inactive (71.52%)

TK - Src

Bioactivity
Kinase	RBC
BLK	active (39.06%)
BRK	inactive (73.29%)
SRC	active (22.59%)
FGR	active (11.63%)
FRK	active (49.68%)
FYN	active (12.97%)
HCK	active (23.02%)
LCK	active (29.71%)
SRM	inactive (101.81%)
YES	active (13.38%)
LYN	active (25.41%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	active (40.23%)
BTK	active (24.08%)
ITK	active (34.8%)
TEC	inactive (101.13%)
TXK	active (25.57%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	active (44.84%)
FLT3	active (1.07%)
FMS	active (21.14%)
PDGFRb	active (42.84%)
PDGFRa	inactive (76.67%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (86.27%)
CTK	inactive (100.86%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (86.1%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (88.11%)
ErbB2	inactive (95.25%)
ErbB4	inactive (97.48%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (82.25%)
EphA2	inactive (65.31%)
EphA3	inactive (69.01%)
EphA4	inactive (77.94%)
EphA5	inactive (67.97%)
EphA6	-
EphA7	inactive (71.45%)
EphA8	inactive (91.92%)
EphB1	inactive (65.89%)
EphB2	inactive (74.98%)
EphB3	-
EphB4	inactive (72.17%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	active (34.96%)
PYK2	active (30.5%)

TK - Fer

Bioactivity
Kinase	RBC
FER	active (28.78%)
FES	inactive (81.66%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	active (27.88%)
FGFR2	inactive (75.97%)
FGFR3	active (45.83%)
FGFR4	inactive (65.67%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (51.03%)
FLT4	active (22.26%)
KDR	inactive (56.4%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	active (39.12%)
IRR	active (2.77%)
INSR	active (44.92%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	active (25.86%)
JAK2	active (43.1%)
JAK3	active (16.93%)
TYK2	active (9.42%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (58.02%)

TK - Ret

Bioactivity
Kinase	RBC
RET	active (1.22%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (100.7%)
MET	inactive (122.95%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	active (26.97%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	active (38.56%)
ZAP70	inactive (97.76%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (100.82%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	active (3.84%)
TRKB	active (1.62%)
TRKC	active (1.01%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (102.55%)
ALK2	inactive (199.37%)
ALK4	inactive (110.43%)
TGFbR1	inactive (102.36%)
TGFbR2	inactive (118.64%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (106.61%)
BRAF	inactive (102.98%)
RAF1	inactive (100.28%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	active (34.48%)
IRAK4	inactive (60.26%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	active (39.53%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (81.2%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	active (7.06%)
MLK2	inactive (86.88%)
MLK3	active (10.48%)
TAK1	inactive (50.49%)
ZAK	inactive (76.37%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (62.75%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	active (2.81%)
BRSK1	active (39.54%)
BRSK2	active (33.35%)
CHK1	inactive (67.03%)
LKB1	active (5.77%)
MARK1	inactive (60.54%)
MARK3	inactive (75.23%)
MARK4	active (43.52%)
MELK	active (13.12%)
PASK	inactive (89.79%)
QIK	inactive (75.06%)
NuaK2	inactive (55.11%)
MARK2	inactive (57.43%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (75.96%)
CaMK1b	inactive (101.37%)
CaMK1d	inactive (80.35%)
CaMK1g	inactive (101.8%)
CaMK4	inactive (93.58%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	active (12.24%)
CaMK2b	inactive (57.86%)
CaMK2d	active (29.13%)
CaMK2g	active (35.32%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	active (26.95%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (80.9%)
DAPK2	inactive (103.69%)
DRAK1	active (22.48%)
DAPK3	inactive (66.55%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (86.36%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (98.37%)
MAPKAPK3	inactive (98.86%)
MAPKAPK5	inactive (86.77%)
MNK1	inactive (95.32%)
MNK2	inactive (72.37%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	active (32.26%)
skMLCK	active (27.32%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	active (8.06%)
PHKg2	active (34.88%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (59.73%)
PIM2	inactive (99.48%)
PIM3	inactive (58.5%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (72.65%)
PKD3	inactive (68.14%)
PKD2	inactive (74.26%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (76.62%)
TSSK2	inactive (96.16%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	active (22.3%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (91.16%)
MAP3K2	inactive (60.65%)
MAP3K3	inactive (87.79%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (123.2%)
NIK	inactive (88.98%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (51.72%)
HGK	active (11.58%)
KHS1	active (15.46%)
LOK	inactive (52.09%)
MINK	active (20.99%)
MST1	active (8.29%)
MST2	active (4.81%)
MST3	inactive (51.86%)
MST4	inactive (73.1%)
OSR1	inactive (98.58%)
PAK1	inactive (71.31%)
PAK2	inactive (82.06%)
PAK3	inactive (73.84%)
PAK4	inactive (84.48%)
PAK5	inactive (81%)
PAK6	inactive (93.5%)
SLK	inactive (59.86%)
YSK1	inactive (73.98%)
STLK3	inactive (79.25%)
TAO1	inactive (98.17%)
TAO2	inactive (83.38%)
TAO3	inactive (55.38%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (99.66%)
MAP2K2	inactive (86.53%)
MAP2K6	inactive (79.66%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	active (9.78%)
AurB	active (27.36%)
AurC	active (43.19%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	active (26.18%)
CaMKK2	active (25.96%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	active (32.81%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (96.62%)
IKKb	inactive (90.54%)
IKKe	active (45.67%)
TBK1	active (29.85%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (92.85%)
NEK11	inactive (92.25%)
NEK2	inactive (113.62%)
NEK4	inactive (83.94%)
NEK6	inactive (96.26%)
NEK7	inactive (98.88%)
NEK9	inactive (73.61%)
NEK3	inactive (101.91%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (80.58%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (103.16%)
PLK2	inactive (104.75%)
PLK3	inactive (102.29%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (104.37%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	active (12.72%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	active (46.11%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (98.35%)
ULK2	inactive (102.32%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (82.04%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (85.35%)
Wnk3	inactive (79.7%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (52.93%)
CK1g1	inactive (89.22%)
CK1g2	inactive (85.19%)
CK1g3	inactive (90.69%)
CK1a	inactive (84.83%)
CK1e	active (43.16%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (88.35%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (57.6%)
CK2a2	active (28.25%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	active (36.65%)
CLK2	inactive (92.01%)
CLK3	active (16.08%)
CLK4	active (6.19%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (82.76%)
DYRK1B	inactive (65.12%)
DYRK2	inactive (61.4%)
DYRK3	inactive (105.04%)
DYRK4	inactive (100.35%)
HIPK1	inactive (95.98%)
HIPK2	inactive (97.61%)
HIPK3	inactive (66.22%)
HIPK4	inactive (108.1%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (98.66%)
Erk2	inactive (89.78%)
JNK3	inactive (103.04%)
NLK	inactive (100.57%)
p38a	inactive (101.04%)
p38b	inactive (95.22%)
p38d	inactive (94.8%)
p38g	inactive (89.87%)
JNK1	inactive (101.07%)
JNK2	active (44.34%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	active (7.31%)
GSK3B	active (12.58%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (59.51%)
SRPK1	inactive (71.33%)
SRPK2	inactive (86.55%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (83.33%)