Compound in Profiling

Compound Information

Test on : RBC

Compound Name : ZINC6974611

Inchikey : RODAAYVFYDKHGT-AUWJEWJLSA-N

ChemSpider : 4496294

Pubchem CID : 5339183

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDK1	1	1
Akt	3	3
DMPK	7	5
GRK	7	6
RSK	8	8
PKA	5	3
PKC	9	9
PKG	2	3
PKN	3	2
SGK	3	3
NDR	4	1

AGC - PDK1

Bioactivity
Kinase	RBC
PDK1	inactive (94.62%)

AGC - Akt

Bioactivity
Kinase	RBC
AKT1	inactive (99.71%)
AKT2	inactive (99.68%)
AKT3	inactive (94.34%)

AGC - DMPK

Bioactivity
Kinase	RBC
DMPK1	inactive (101.89%)
MRCKa	inactive (87.33%)
MRCKb	inactive (95.4%)
ROCK1	inactive (91.69%)
ROCK2	inactive (86.32%)

AGC - GRK

Bioactivity
Kinase	RBC
BARK1	inactive (98.88%)
BARK2	inactive (101.87%)
GPRK4	inactive (95.45%)
GPRK5	inactive (123.4%)
GPRK6	inactive (98.26%)
GPRK7	inactive (97%)

AGC - RSK

Bioactivity
Kinase	RBC
MSK1	inactive (100.84%)
MSK2	inactive (98.9%)
p70S6K	inactive (100.32%)
p70S6Kb	inactive (101.59%)
RSK2	inactive (100.86%)
RSK4	inactive (96.94%)
RSK1	inactive (86.33%)
RSK3	inactive (94.46%)

AGC - PKA

Bioactivity
Kinase	RBC
PKACg	-
PRKX	inactive (97.83%)
PKACa	inactive (93.27%)

AGC - PKC

Bioactivity
Kinase	RBC
PKCa	inactive (114.79%)
PKCd	inactive (94.21%)
PKCe	inactive (90.46%)
PKCh	inactive (98.05%)
PKCg	inactive (96.37%)
PKCi	inactive (92.32%)
PKCt	inactive (94.6%)
PKCz	inactive (90.13%)
PKCb	inactive (100.29%)

AGC - PKG

Bioactivity
Kinase	RBC
PKG2	inactive (98.71%)
PKG1	inactive (87.42%)

AGC - PKN

Bioactivity
Kinase	RBC
PKN1	inactive (93.91%)
PKN2	inactive (92.63%)

AGC - SGK

Bioactivity
Kinase	RBC
SGK1	inactive (92.45%)
SGK2	inactive (101.31%)
SGK3	inactive (107.42%)

AGC - NDR

Bioactivity
Kinase	RBC
NDR1	active (0%)

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Abl	2	2
Ack	2	1
ALK	2	2
Axl	3	3
Src	11	11
Tec	5	5
PDGFR	5	5
Csk	2	2
DDR	2	1
EGFR	4	3
Eph	14	12
FAK	2	2
Fer	2	2
FGFR	4	4
VEGFR	3	3
InsR	3	3
JakA	4	4
Musk	1	1
Ret	1	1
Met	2	2
Sev	1	1
Syk	2	2
Tie	2	1
Trk	3	3

TK - Abl

Bioactivity
Kinase	RBC
ABL1	inactive (101.43%)
ABL2	inactive (95.75%)

TK - Ack

Bioactivity
Kinase	RBC
ACK	inactive (99.88%)

TK - ALK

Bioactivity
Kinase	RBC
ALK	inactive (93.65%)
LTK	inactive (101.71%)

TK - Axl

Bioactivity
Kinase	RBC
AXL	inactive (100.02%)
MER	inactive (92.25%)
TYRO3	inactive (91.54%)

TK - Src

Bioactivity
Kinase	RBC
BLK	inactive (101.83%)
BRK	inactive (101.24%)
SRC	inactive (99.01%)
FGR	inactive (90.87%)
FRK	inactive (90.05%)
FYN	inactive (100.54%)
HCK	inactive (114.25%)
LCK	inactive (98.62%)
SRM	inactive (90.23%)
YES	inactive (95.62%)
LYN	inactive (96.35%)

TK - Tec

Bioactivity
Kinase	RBC
BMX	inactive (90.13%)
BTK	inactive (109.57%)
ITK	inactive (99.49%)
TEC	inactive (146.92%)
TXK	inactive (98.29%)

TK - PDGFR

Bioactivity
Kinase	RBC
KIT	inactive (96.4%)
FLT3	inactive (99.27%)
FMS	inactive (94.45%)
PDGFRb	inactive (128.77%)
PDGFRa	inactive (93.2%)

TK - Csk

Bioactivity
Kinase	RBC
CSK	inactive (98.53%)
CTK	inactive (94.26%)

TK - DDR

Bioactivity
Kinase	RBC
DDR2	inactive (101.37%)

TK - EGFR

Bioactivity
Kinase	RBC
EGFR	inactive (100.21%)
ErbB2	inactive (100.06%)
ErbB4	inactive (102.63%)

TK - Eph

Bioactivity
Kinase	RBC
EphA1	inactive (88.87%)
EphA2	inactive (106.82%)
EphA3	inactive (99.27%)
EphA4	inactive (103.82%)
EphA5	inactive (100.46%)
EphA6	-
EphA7	inactive (97.85%)
EphA8	inactive (101.91%)
EphB1	inactive (106.8%)
EphB2	inactive (84.58%)
EphB3	inactive (91.72%)
EphB4	inactive (91.6%)

TK - FAK

Bioactivity
Kinase	RBC
FAK	inactive (107.27%)
PYK2	inactive (91.45%)

TK - Fer

Bioactivity
Kinase	RBC
FER	inactive (94.67%)
FES	inactive (101.24%)

TK - FGFR

Bioactivity
Kinase	RBC
FGFR1	inactive (97.63%)
FGFR2	inactive (103.6%)
FGFR3	inactive (99.63%)
FGFR4	inactive (105.83%)

TK - VEGFR

Bioactivity
Kinase	RBC
FLT1	inactive (97.62%)
FLT4	inactive (86.33%)
KDR	inactive (96.73%)

TK - InsR

Bioactivity
Kinase	RBC
IGF1R	inactive (96.35%)
IRR	inactive (99.24%)
INSR	inactive (91.97%)

TK - JakA

Bioactivity
Kinase	RBC
JAK1	inactive (101.91%)
JAK2	inactive (98.82%)
JAK3	inactive (102.78%)
TYK2	inactive (109.89%)

TK - Musk

Bioactivity
Kinase	RBC
MUSK	inactive (94.41%)

TK - Ret

Bioactivity
Kinase	RBC
RET	inactive (99.86%)

TK - Met

Bioactivity
Kinase	RBC
RON	inactive (97.58%)
MET	inactive (96.28%)

TK - Sev

Bioactivity
Kinase	RBC
ROS	inactive (97.51%)

TK - Syk

Bioactivity
Kinase	RBC
SYK	inactive (91.84%)
ZAP70	inactive (93.11%)

TK - Tie

Bioactivity
Kinase	RBC
TIE2	inactive (99.56%)

TK - Trk

Bioactivity
Kinase	RBC
TRKA	inactive (95.96%)
TRKB	inactive (82.4%)
TRKC	inactive (104.02%)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STKR	12	5
RAF	5	3
IRAK	4	2
LISK	4	1
LRRK	2	1
MLK	10	5
RIPK	5	1

TKL - STKR

Bioactivity
Kinase	RBC
ALK1	inactive (105.81%)
ALK2	inactive (97.98%)
ALK4	inactive (100.9%)
TGFbR1	inactive (96.62%)
TGFbR2	inactive (123.09%)

TKL - RAF

Bioactivity
Kinase	RBC
ARAF	inactive (92.68%)
BRAF	inactive (98.35%)
RAF1	inactive (98.14%)

TKL - IRAK

Bioactivity
Kinase	RBC
IRAK1	inactive (105.92%)
IRAK4	inactive (87.27%)

TKL - LISK

Bioactivity
Kinase	RBC
LIMK1	inactive (99.67%)

TKL - LRRK

Bioactivity
Kinase	RBC
LRRK2	inactive (90.99%)

TKL - MLK

Bioactivity
Kinase	RBC
MLK1	inactive (100.77%)
MLK2	inactive (101.18%)
MLK3	inactive (99.4%)
TAK1	inactive (91.45%)
ZAK	inactive (98.04%)

TKL - RIPK

Bioactivity
Kinase	RBC
RIPK2	inactive (105.82%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CAMKL	20	13
CAMK1	5	5
CAMK2	4	4
RAD53	1	1
DAPK	5	4
DCAMKL	3	1
MAPKAPK	5	5
MLCK	5	2
PHK	2	2
PIM	3	3
PKD	3	3
TSSK	5	2
STK33	1	-

CAMK - CAMKL

Bioactivity
Kinase	RBC
NuaK1	inactive (96.39%)
BRSK1	inactive (97.25%)
BRSK2	inactive (105.59%)
CHK1	inactive (106.8%)
LKB1	inactive (98.71%)
MARK1	inactive (90.7%)
MARK3	inactive (107%)
MARK4	inactive (87.64%)
MELK	inactive (102.25%)
PASK	inactive (88.38%)
QIK	inactive (91.62%)
NuaK2	inactive (95.21%)
MARK2	inactive (108.48%)

CAMK - CAMK1

Bioactivity
Kinase	RBC
CaMK1a	inactive (106.01%)
CaMK1b	inactive (100.49%)
CaMK1d	inactive (96.43%)
CaMK1g	inactive (103.53%)
CaMK4	inactive (95.21%)

CAMK - CAMK2

Bioactivity
Kinase	RBC
CaMK2a	inactive (100.07%)
CaMK2b	inactive (100.12%)
CaMK2d	inactive (90.08%)
CaMK2g	inactive (82.15%)

CAMK - RAD53

Bioactivity
Kinase	RBC
CHK2	inactive (103.66%)

CAMK - DAPK

Bioactivity
Kinase	RBC
DAPK1	inactive (97.83%)
DAPK2	inactive (80.14%)
DRAK1	inactive (100.19%)
DAPK3	inactive (103.03%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC
DCLK2	inactive (100.93%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC
MAPKAPK2	inactive (96.28%)
MAPKAPK3	inactive (95.41%)
MAPKAPK5	inactive (94.59%)
MNK1	inactive (97.41%)
MNK2	inactive (89.29%)

CAMK - MLCK

Bioactivity
Kinase	RBC
smMLCK	inactive (92.53%)
skMLCK	inactive (100.15%)

CAMK - PHK

Bioactivity
Kinase	RBC
PHKg1	inactive (100.84%)
PHKg2	inactive (100.25%)

CAMK - PIM

Bioactivity
Kinase	RBC
PIM1	inactive (92.94%)
PIM2	inactive (106.05%)
PIM3	inactive (113.73%)

CAMK - PKD

Bioactivity
Kinase	RBC
PKD1	inactive (102.53%)
PKD3	inactive (93.87%)
PKD2	inactive (94.3%)

CAMK - TSSK

Bioactivity
Kinase	RBC
TSSK1	inactive (96.7%)
TSSK2	inactive (101.01%)

CAMK - STK33

Bioactivity
Kinase	RBC
STK33	inactive (102.15%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC
STE11	8	3
STE-Unique	2	2
STE20	31	23
STE7	7	3

STE - STE11

Bioactivity
Kinase	RBC
MAP3K5	inactive (92.46%)
MAP3K2	inactive (96.99%)
MAP3K3	inactive (93.82%)

STE - STE-Unique

Bioactivity
Kinase	RBC
COT	inactive (98.85%)
NIK	inactive (77.88%)

STE - STE20

Bioactivity
Kinase	RBC
GCK	inactive (114.64%)
HGK	inactive (95.56%)
KHS1	inactive (109.06%)
LOK	inactive (99.6%)
MINK	inactive (84.07%)
MST1	inactive (96.52%)
MST2	inactive (100.39%)
MST3	inactive (87.7%)
MST4	inactive (99.54%)
OSR1	inactive (102.17%)
PAK1	inactive (91.37%)
PAK2	inactive (102.52%)
PAK3	inactive (95.06%)
PAK4	inactive (95.34%)
PAK5	inactive (96.97%)
PAK6	inactive (99.02%)
SLK	inactive (101.02%)
YSK1	inactive (86.31%)
STLK3	inactive (91.81%)
TAO1	inactive (89.56%)
TAO2	inactive (95.3%)
TAO3	inactive (99.52%)
MYO3B	active (0%)

STE - STE7

Bioactivity
Kinase	RBC
MAP2K1	inactive (105.45%)
MAP2K2	inactive (78.2%)
MAP2K6	inactive (111.18%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC
Aur	3	3
CAMKK	2	2
Haspin	1	1
IKK	4	4
NEK	11	8
TOPK	1	1
PLK	4	3
SgK496	1	1
NAK	4	1
TTK	1	1
ULK	5	3
WEE	3	1
WNK	4	2
TLK	2	1

Other - Aur

Bioactivity
Kinase	RBC
AurA	inactive (105.16%)
AurB	inactive (99.07%)
AurC	inactive (90.54%)

Other - CAMKK

Bioactivity
Kinase	RBC
CaMKK1	inactive (106.25%)
CaMKK2	inactive (113.56%)

Other - Haspin

Bioactivity
Kinase	RBC
Haspin	inactive (89.11%)

Other - IKK

Bioactivity
Kinase	RBC
IKKa	inactive (88.05%)
IKKb	inactive (86.01%)
IKKe	inactive (100.96%)
TBK1	inactive (104.01%)

Other - NEK

Bioactivity
Kinase	RBC
NEK1	inactive (97.72%)
NEK11	inactive (109.54%)
NEK2	inactive (88.86%)
NEK4	inactive (102.78%)
NEK6	inactive (93.4%)
NEK7	inactive (101.83%)
NEK9	inactive (91.79%)
NEK3	inactive (101.18%)

Other - TOPK

Bioactivity
Kinase	RBC
PBK	inactive (111.16%)

Other - PLK

Bioactivity
Kinase	RBC
PLK1	inactive (98.56%)
PLK2	inactive (107.2%)
PLK3	inactive (96.77%)

Other - SgK496

Bioactivity
Kinase	RBC
SgK496	inactive (95.39%)

Other - NAK

Bioactivity
Kinase	RBC
MPSK1	inactive (104.9%)

Other - TTK

Bioactivity
Kinase	RBC
TTK	inactive (95.92%)

Other - ULK

Bioactivity
Kinase	RBC
ULK1	inactive (93.75%)
ULK2	inactive (87.32%)
ULK3	active (0%)

Other - WEE

Bioactivity
Kinase	RBC
Wee1	inactive (100.05%)

Other - WNK

Bioactivity
Kinase	RBC
Wnk2	inactive (105.83%)
Wnk3	inactive (96.6%)

Other - TLK

Bioactivity
Kinase	RBC
TLK2	active (0%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK1	7	6
VRK	3	1

CK1 - CK1

Bioactivity
Kinase	RBC
CK1d	inactive (99.85%)
CK1g1	inactive (96.41%)
CK1g2	inactive (101.02%)
CK1g3	inactive (86.18%)
CK1a	inactive (112.74%)
CK1e	inactive (91.03%)

CK1 - VRK

Bioactivity
Kinase	RBC
VRK1	inactive (95.14%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC
CK2	3	2
CLK	4	4
DYRK	10	9
MAPK	14	10
GSK	2	2
SRPK	3	3

CMGC - CK2

Bioactivity
Kinase	RBC
CK2a1	inactive (91.01%)
CK2a2	inactive (106.53%)

CMGC - CLK

Bioactivity
Kinase	RBC
CLK1	inactive (104.65%)
CLK2	inactive (88.31%)
CLK3	inactive (97.7%)
CLK4	inactive (102.63%)

CMGC - DYRK

Bioactivity
Kinase	RBC
DYRK1A	inactive (95.83%)
DYRK1B	inactive (103.61%)
DYRK2	inactive (93.08%)
DYRK3	inactive (101.52%)
DYRK4	inactive (92.69%)
HIPK1	inactive (81.06%)
HIPK2	inactive (102.72%)
HIPK3	inactive (103.3%)
HIPK4	inactive (101.88%)

CMGC - MAPK

Bioactivity
Kinase	RBC
Erk1	inactive (88.38%)
Erk2	inactive (99.73%)
JNK3	inactive (86.96%)
NLK	inactive (103.07%)
p38a	inactive (90.16%)
p38b	inactive (96.59%)
p38d	inactive (101.05%)
p38g	inactive (93.38%)
JNK1	inactive (91.15%)
JNK2	inactive (110.53%)

CMGC - GSK

Bioactivity
Kinase	RBC
GSK3A	inactive (108.11%)
GSK3B	inactive (116.93%)

CMGC - SRPK

Bioactivity
Kinase	RBC
MSSK1	inactive (100.14%)
SRPK1	inactive (94.92%)
SRPK2	inactive (100.92%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC
PDHK	5	1

Atypical - PDHK

Bioactivity
Kinase	RBC
PDHK1	inactive (94.62%)