Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC, Millipore : Aurora Kinase/Cdk Inhibitor

Inchikey
Same : RWSVQCBZVPWNFM-N
RBC, Millipore : RWSVQCBZVPWNFM-UHFFFAOYSA-N

ChemSpider
RBC, Millipore : 21396081

Pubchem CID
RBC, Millipore : 16760303

ChEMBL
RBC, Millipore : -

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (92.3%)	inactive (68%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (119.79%)	inactive (104%)
AKT2	inactive (106.94%)	inactive (116%)
AKT3	inactive (95.04%)	inactive (110%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (93.25%)	inactive (96%)
MRCKa	inactive (97.46%)	inactive (97%)
MRCKb	inactive (95.98%)	inactive (84%)
ROCK1	active (42.64%)	inactive (65%)
ROCK2	active (18.58%)	active (16%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (97.26%)	-
BARK2	inactive (87.24%)	-
GPRK4	inactive (94.65%)	-
GPRK5	inactive (85.87%)	inactive (78%)
GPRK6	inactive (77.16%)	inactive (98%)
GPRK7	inactive (65.92%)	inactive (55%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (97.24%)	inactive (97%)
MSK2	inactive (90.16%)	inactive (87%)
p70S6K	inactive (92.1%)	inactive (86%)
p70S6Kb	inactive (104.28%)	-
RSK2	active (38.56%)	active (32%)
RSK4	active (24.67%)	active (27%)
RSK1	active (42.12%)	active (19%)
RSK3	active (42.22%)	active (28%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (89%)	inactive (94%)
PKACa	inactive (98.84%)	inactive (107%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (55.7%)	inactive (63%)
PKCd	inactive (81.23%)	inactive (70%)
PKCe	inactive (97.23%)	inactive (86%)
PKCh	inactive (100.23%)	inactive (90%)
PKCg	inactive (81.33%)	inactive (61%)
PKCi	inactive (87.59%)	inactive (109%)
PKCt	inactive (113.72%)	active (30%)
PKCz	inactive (99.9%)	inactive (99%)
PKCb	inactive (90.5%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (92.22%)	-
PKG1	inactive (86.07%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (89.73%)	-
PKN2	inactive (85.64%)	inactive (81%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (92.97%)	inactive (124%)
SGK2	inactive (106.14%)	inactive (89%)
SGK3	inactive (113.73%)	inactive (106%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (50.12%)	active (44%)
ABL2	inactive (53.91%)	active (34%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (68.03%)	active (50%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (90.15%)	inactive (77%)
LTK	inactive (85.85%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (94.2%)	inactive (56%)
MER	inactive (70.15%)	active (36%)
TYRO3	inactive (98.62%)	inactive (81%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (90.15%)	inactive (74%)
BRK	inactive (83.89%)	inactive (106%)
SRC	inactive (76.31%)	inactive (88%)
FGR	inactive (63.5%)	inactive (63%)
FRK	inactive (90.89%)	inactive (90%)
FYN	inactive (78.6%)	inactive (51%)
HCK	inactive (86.24%)	inactive (71%)
LCK	inactive (87.87%)	inactive (58%)
SRM	inactive (96.48%)	-
YES	inactive (50.62%)	active (50%)
LYN	inactive (80.49%)	active (40%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (93.69%)	active (32%)
BTK	inactive (87.05%)	inactive (86%)
ITK	inactive (105.13%)	inactive (89%)
TEC	inactive (121.82%)	-
TXK	inactive (95.75%)	inactive (91%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (81.72%)	inactive (100%)
FLT3	active (44.28%)	inactive (56%)
FMS	active (49.17%)	active (30%)
PDGFRb	inactive (89.14%)	inactive (108%)
PDGFRa	inactive (82.03%)	inactive (106%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (88.9%)	inactive (99%)
CTK	inactive (104.06%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (113.27%)	inactive (99%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (96.96%)	inactive (105%)
ErbB2	inactive (91.11%)	-
ErbB4	inactive (110%)	inactive (93%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (73.73%)	inactive (58%)
EphA2	inactive (80.93%)	inactive (91%)
EphA3	inactive (106.83%)	inactive (94%)
EphA4	inactive (91.29%)	inactive (108%)
EphA5	inactive (92.23%)	inactive (103%)
EphA6	-	-
EphA7	inactive (68.7%)	inactive (52%)
EphA8	inactive (108.97%)	inactive (90%)
EphB1	inactive (84.12%)	inactive (78%)
EphB2	inactive (96.09%)	inactive (103%)
EphB3	inactive (98.51%)	inactive (115%)
EphB4	inactive (80.97%)	inactive (84%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (95.5%)	inactive (102%)
PYK2	inactive (79.65%)	inactive (55%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (81.97%)	inactive (101%)
FES	inactive (84.18%)	inactive (84%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	active (38.21%)	active (10%)
FGFR2	inactive (79.65%)	active (36%)
FGFR3	active (46.4%)	active (29%)
FGFR4	inactive (90.33%)	inactive (99%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (90.67%)	active (18%)
FLT4	active (38.05%)	active (1%)
KDR	inactive (64.64%)	active (33%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (86.89%)	inactive (92%)
IRR	inactive (93.76%)	inactive (112%)
INSR	inactive (94.89%)	inactive (93%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	active (5.19%)	-
JAK2	active (19.22%)	active (11%)
JAK3	active (8.5%)	active (7%)
TYK2	active (0.88%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (83.14%)	inactive (81%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (54.09%)	inactive (53%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (114.95%)	inactive (81%)
MET	inactive (75.27%)	active (45%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	active (39.45%)	inactive (101%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (61.63%)	active (47%)
ZAP70	inactive (94.81%)	inactive (98%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (84.2%)	active (36%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (98.8%)	active (41%)
TRKB	active (42.75%)	inactive (54%)
TRKC	active (37.56%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (88.51%)	-
ALK2	inactive (104.49%)	-
ALK4	inactive (117.87%)	inactive (100%)
TGFbR1	inactive (103.76%)	inactive (105%)
TGFbR2	inactive (98.54%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (93.07%)	-
BRAF	inactive (54.97%)	-
RAF1	inactive (95.69%)	inactive (79%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (89.76%)	inactive (90%)
IRAK4	inactive (151.14%)	inactive (96%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	active (16.58%)	active (12%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (48.3%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (25.56%)	active (16%)
MLK2	inactive (77.81%)	-
MLK3	active (47.19%)	-
TAK1	inactive (77.41%)	inactive (82%)
ZAK	inactive (100.04%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (77.76%)	inactive (62%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (3.29%)	active (4%)
BRSK1	active (49.19%)	inactive (55%)
BRSK2	active (48.96%)	active (40%)
CHK1	inactive (76.31%)	inactive (82%)
LKB1	inactive (85.79%)	inactive (99%)
MARK1	inactive (64.09%)	active (44%)
MARK3	inactive (67.56%)	-
MARK4	active (48.02%)	-
MELK	inactive (87.23%)	inactive (83%)
PASK	inactive (91.1%)	inactive (94%)
QIK	inactive (84.07%)	-
NuaK2	active (34.04%)	-
MARK2	inactive (63.49%)	active (46%)
AMPKa1	-	inactive (58%)
AMPKa2	-	active (47%)
SIK	-	active (50%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (90.43%)	inactive (90%)
CaMK1b	inactive (106.7%)	-
CaMK1d	inactive (97.67%)	inactive (110%)
CaMK1g	inactive (100.62%)	-
CaMK4	inactive (96.81%)	inactive (96%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (104.03%)	-
CaMK2b	inactive (99.73%)	inactive (90%)
CaMK2d	inactive (94.65%)	inactive (75%)
CaMK2g	inactive (104.42%)	inactive (73%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (63.62%)	inactive (52%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (93.79%)	inactive (97%)
DAPK2	inactive (106.97%)	inactive (97%)
DRAK1	inactive (83.94%)	inactive (77%)
DAPK3	inactive (99.35%)	inactive (96%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (85.27%)	inactive (68%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (95.83%)	inactive (94%)
MAPKAPK3	inactive (98.02%)	inactive (103%)
MAPKAPK5	inactive (80.26%)	inactive (101%)
MNK1	inactive (90.9%)	-
MNK2	inactive (95.88%)	inactive (95%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (79.98%)	inactive (78%)
skMLCK	inactive (96.11%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (101.67%)	-
PHKg2	inactive (101.63%)	inactive (100%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (97.62%)	inactive (71%)
PIM2	inactive (112.51%)	inactive (99%)
PIM3	inactive (101.65%)	inactive (99%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (66.45%)	inactive (75%)
PKD3	inactive (55.6%)	-
PKD2	inactive (86.03%)	inactive (113%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (85.48%)	inactive (87%)
TSSK2	inactive (102.59%)	inactive (103%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (74.39%)	inactive (92%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (103.3%)	inactive (102%)
MAP3K2	active (11.34%)	-
MAP3K3	active (27.53%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (94.44%)	-
NIK	inactive (105.7%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (58.38%)	active (33%)
HGK	inactive (83.81%)	-
KHS1	active (45.25%)	-
LOK	active (16.96%)	active (17%)
MINK	inactive (98.06%)	inactive (107%)
MST1	active (19.91%)	active (25%)
MST2	active (34.34%)	active (34%)
MST3	inactive (76.91%)	inactive (61%)
MST4	inactive (64.17%)	-
OSR1	inactive (88.8%)	-
PAK1	inactive (89.5%)	-
PAK2	inactive (98.95%)	inactive (118%)
PAK3	inactive (97.71%)	inactive (86%)
PAK4	inactive (89.98%)	inactive (65%)
PAK5	inactive (85.44%)	inactive (71%)
PAK6	inactive (100.96%)	inactive (79%)
SLK	active (19.1%)	-
YSK1	inactive (82.31%)	-
STLK3	inactive (89.48%)	-
TAO1	active (18.83%)	active (15%)
TAO2	active (8.92%)	active (6%)
TAO3	active (39.92%)	active (18%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (93.9%)	inactive (73%)
MAP2K2	inactive (85.59%)	-
MAP2K6	inactive (90.53%)	inactive (83%)
MAP2K7	-	inactive (104%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (13.01%)	active (0%)
AurB	active (11.7%)	active (-2%)
AurC	active (28.34%)	active (6%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (86.44%)	-
CaMKK2	inactive (61.53%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (106.75%)	inactive (96%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (98.96%)	inactive (88%)
IKKb	inactive (105.45%)	inactive (89%)
IKKe	inactive (95.89%)	-
TBK1	inactive (80.03%)	inactive (72%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (76.33%)	-
NEK11	inactive (95.78%)	inactive (56%)
NEK2	inactive (94.8%)	inactive (96%)
NEK4	inactive (79.24%)	-
NEK6	inactive (102.23%)	inactive (105%)
NEK7	inactive (98.96%)	inactive (111%)
NEK9	inactive (82.22%)	-
NEK3	inactive (92.59%)	inactive (92%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (92.1%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (97.52%)	inactive (97%)
PLK2	inactive (94.2%)	inactive (96%)
PLK3	inactive (91.3%)	inactive (98%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (86.23%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	active (48.53%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (77.45%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (62.52%)	-
ULK2	inactive (101.99%)	inactive (92%)
ULK3	active (0%)	active (46%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (83.59%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (116.13%)	inactive (96%)
Wnk3	inactive (98.25%)	inactive (100%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (68%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (94.54%)	inactive (100%)
CK1g1	inactive (71.29%)	inactive (53%)
CK1g2	inactive (50.88%)	active (26%)
CK1g3	inactive (62.61%)	inactive (102%)
CK1a	inactive (95.1%)	-
CK1e	inactive (96.89%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (90.38%)	-
VRK2	-	inactive (97%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (103.79%)	inactive (111%)
CK2a2	inactive (97.53%)	inactive (104%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (85.13%)	-
CLK2	inactive (71.54%)	active (40%)
CLK3	inactive (65.76%)	active (20%)
CLK4	active (41.57%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (100.8%)	-
DYRK1B	inactive (87.58%)	-
DYRK2	inactive (111.89%)	inactive (104%)
DYRK3	inactive (101.4%)	-
DYRK4	inactive (105.09%)	-
HIPK1	inactive (105.66%)	inactive (75%)
HIPK2	inactive (72.83%)	active (48%)
HIPK3	inactive (91.21%)	inactive (84%)
HIPK4	inactive (67.69%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (108.26%)	inactive (102%)
Erk2	inactive (98.44%)	inactive (108%)
JNK3	inactive (100.37%)	inactive (51%)
NLK	inactive (85.98%)	inactive (75%)
p38a	inactive (97.83%)	inactive (93%)
p38b	inactive (93.96%)	inactive (102%)
p38d	inactive (94.84%)	inactive (90%)
p38g	inactive (89.93%)	inactive (90%)
JNK1	inactive (85.9%)	inactive (99%)
JNK2	inactive (93.71%)	inactive (102%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (9.59%)	active (11%)
GSK3B	active (21.96%)	active (23%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (86.19%)	inactive (75%)
SRPK1	inactive (86.4%)	inactive (56%)
SRPK2	inactive (54.9%)	inactive (53%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (92.3%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (83%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (115%)