Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz, Millipore

Compound Name
DRx, RBC, Metz, Millipore : PI-103

Inchikey
Same : TUVCWJQQGGETHL-N
DRx, RBC, Metz, Millipore : TUVCWJQQGGETHL-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz, Millipore : 8060359

Pubchem CID
DRx, RBC, Metz, Millipore : 9884685

ChEMBL
DRx, RBC, Metz, Millipore : CHEMBL573339

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
NAK	4	4	1	-	-
Aur	3	3	3	2	3
CAMKK	2	2	2	1	-
PEK	4	2	-	-	-
IRE	2	1	-	-	-
IKK	4	4	4	4	3
NEK	11	9	8	2	5
WEE	3	3	1	1	-
PLK	4	4	3	3	3
SgK496	1	1	1	-	-
NKF1	3	2	-	-	-
NKF4	2	1	-	-	-
ULK	5	4	3	-	2
TLK	2	2	1	-	1
TTK	1	1	1	-	-
Haspin	1	-	1	-	1
TOPK	1	-	1	1	-
WNK	4	-	2	-	2
CDC7	1	-	-	1	-

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AAK1	inactive (10001nM)	-	-	-
BIKE	inactive (10001nM)	-	-	-
GAK	inactive (10001nM)	-	-	-
MPSK1	inactive (10001nM)	inactive (91.72%)	-	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AurA	inactive (10001nM)	inactive (91.94%)	-	inactive (104%)
AurB	inactive (10001nM)	inactive (99.38%)	-	inactive (98%)
AurC	inactive (10001nM)	inactive (98.13%)	-	inactive (102%)

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMKK1	inactive (10001nM)	inactive (84.63%)	-	-
CaMKK2	inactive (10001nM)	inactive (79.77%)	-	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HRI	inactive (10001nM)	-	-	-
PKR	inactive (10001nM)	-	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRE1	inactive (10001nM)	-	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IKKa	active (1700nM)	inactive (94.82%)	-	inactive (108%)
IKKb	inactive (10001nM)	inactive (98.34%)	-	inactive (113%)
IKKe	inactive (10001nM)	inactive (98.77%)	-	-
TBK1	inactive (10001nM)	inactive (93.03%)	-	inactive (82%)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
NEK1	inactive (10001nM)	inactive (77.83%)	-	-
NEK11	inactive (10001nM)	inactive (109.33%)	-	inactive (98%)
NEK2	inactive (10001nM)	inactive (88.58%)	-	inactive (83%)
NEK3	inactive (10001nM)	inactive (92.89%)	-	inactive (117%)
NEK4	inactive (10001nM)	inactive (90.43%)	-	-
NEK5	inactive (10001nM)	-	-	-
NEK6	inactive (10001nM)	inactive (105.59%)	-	inactive (102%)
NEK7	inactive (10001nM)	inactive (97.29%)	-	inactive (100%)
NEK9	inactive (10001nM)	inactive (99.3%)	-	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MYT1	inactive (10001nM)	-	-	-
Wee1	inactive (10001nM)	inactive (81.62%)	-	-
Wee1B	inactive (10001nM)	-	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PLK1	inactive (10001nM)	inactive (97.88%)	inactive (>7943.28nM)	inactive (102%)
PLK2	inactive (10001nM)	inactive (94.72%)	-	inactive (111%)
PLK3	inactive (10001nM)	inactive (94.62%)	inactive (>7943.28nM)	inactive (102%)
PLK4	inactive (10001nM)	-	-	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK496	inactive (10001nM)	inactive (96.14%)	-	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SBK	inactive (10001nM)	-	-	-
SgK110	inactive (10001nM)	-	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLIK1	inactive (10001nM)	-	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Fused	inactive (10001nM)	-	-	-
ULK1	inactive (10001nM)	inactive (113.44%)	-	-
ULK2	inactive (10001nM)	inactive (105.68%)	-	inactive (108%)
ULK3	inactive (10001nM)	inactive (99.68%)	-	inactive (111%)

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TLK1	inactive (10001nM)	-	-	-
TLK2	inactive (10001nM)	inactive (102.44%)	-	inactive (109%)

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TTK	inactive (10001nM)	inactive (93.29%)	-	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Haspin	-	inactive (90.28%)	-	inactive (76%)

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PBK	-	inactive (88.65%)	inactive (>10000nM)	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Wnk2	-	inactive (118.77%)	-	inactive (112%)
Wnk3	-	inactive (93.94%)	-	inactive (119%)

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDC7	-	-	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Abl	2	2	2	1	2
ALK	2	2	2	2	1
Axl	3	3	3	2	3
Src	11	11	11	9	10
Tec	5	5	5	3	4
PDGFR	5	5	5	5	5
Csk	2	2	2	1	1
DDR	2	2	1	-	1
EGFR	4	4	3	3	2
Eph	14	13	12	1	11
FAK	2	2	2	2	2
Fer	2	2	2	2	2
FGFR	4	4	4	2	4
VEGFR	3	3	3	3	3
InsR	3	3	3	2	3
JakA	4	4	4	3	2
Met	2	2	2	2	2
Musk	1	1	1	-	1
Ret	1	1	1	1	1
Sev	1	1	1	1	1
Syk	2	2	2	1	2
Tie	2	2	1	-	1
Ack	2	2	1	1	1
Trk	3	3	3	3	2

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ABL1	inactive (10001nM)	inactive (94.36%)	-	inactive (102%)
ABL2	inactive (10001nM)	inactive (94.91%)	-	inactive (99%)

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK	inactive (10001nM)	inactive (90.45%)	-	inactive (100%)
LTK	inactive (10001nM)	inactive (97.64%)	-	-

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AXL	inactive (10001nM)	inactive (105.4%)	-	inactive (111%)
MER	inactive (10001nM)	inactive (87.76%)	-	inactive (110%)
TYRO3	inactive (10001nM)	inactive (101.63%)	-	inactive (82%)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BLK	inactive (10001nM)	inactive (101%)	-	inactive (112%)
BRK	inactive (10001nM)	inactive (80.81%)	-	inactive (113%)
FGR	inactive (10001nM)	inactive (94.84%)	-	inactive (118%)
FRK	inactive (10001nM)	inactive (91.34%)	-	inactive (101%)
FYN	inactive (10001nM)	inactive (91.68%)	-	inactive (82%)
HCK	inactive (10001nM)	inactive (91.87%)	-	inactive (83%)
LCK	inactive (10001nM)	inactive (97.99%)	-	inactive (133%)
LYN	inactive (10001nM)	inactive (101.9%)	-	inactive (99%)
SRC	inactive (10001nM)	inactive (97.23%)	-	inactive (91%)
SRM	inactive (10001nM)	inactive (96.19%)	-	-
YES	inactive (10001nM)	inactive (94.32%)	-	inactive (110%)

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BMX	inactive (10001nM)	inactive (101.04%)	-	inactive (92%)
BTK	inactive (10001nM)	inactive (95.22%)	-	inactive (101%)
ITK	inactive (10001nM)	inactive (93.1%)	-	inactive (102%)
TEC	inactive (10001nM)	inactive (113.23%)	-	-
TXK	inactive (10001nM)	inactive (94.78%)	-	inactive (93%)

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FMS	inactive (10001nM)	inactive (108.04%)	-	inactive (78%)
FLT3	active (2500nM)	inactive (87.1%)	-	inactive (89%)
KIT	inactive (10001nM)	inactive (88.92%)	-	inactive (118%)
PDGFRa	inactive (10001nM)	inactive (99.39%)	-	inactive (127%)
PDGFRb	inactive (10001nM)	inactive (99.24%)	-	inactive (112%)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CSK	inactive (10001nM)	inactive (88.32%)	-	inactive (127%)
CTK	inactive (10001nM)	inactive (86.67%)	-	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DDR1	inactive (10001nM)	-	-	-
DDR2	inactive (10001nM)	inactive (94.64%)	-	inactive (107%)

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EGFR	inactive (10001nM)	inactive (83.82%)	-	inactive (119%)
ErbB2	inactive (10001nM)	inactive (105.36%)	-	-
ErbB3	inactive (10001nM)	-	-	-
ErbB4	inactive (10001nM)	inactive (97.65%)	-	inactive (104%)

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
EphA1	inactive (10001nM)	inactive (87.81%)	-	inactive (91%)
EphA2	inactive (10001nM)	inactive (99.91%)	-	inactive (113%)
EphA3	inactive (10001nM)	inactive (93.69%)	-	inactive (114%)
EphA4	inactive (10001nM)	inactive (96.36%)	-	inactive (119%)
EphA5	inactive (10001nM)	inactive (101.8%)	-	inactive (98%)
EphA6	inactive (10001nM)	inactive (78.99%)	-	-
EphA7	inactive (10001nM)	inactive (93.86%)	-	inactive (103%)
EphA8	inactive (10001nM)	inactive (93.88%)	-	inactive (107%)
EphB1	inactive (10001nM)	inactive (89.58%)	-	inactive (95%)
EphB2	inactive (10001nM)	inactive (88.61%)	-	inactive (130%)
EphB3	inactive (10001nM)	inactive (92.96%)	-	inactive (116%)
EphB4	inactive (10001nM)	inactive (104.49%)	-	inactive (106%)
EphB6	inactive (10001nM)	-	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FAK	inactive (10001nM)	inactive (93.47%)	-	inactive (144%)
PYK2	inactive (10001nM)	inactive (102.84%)	-	inactive (142%)

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FER	inactive (10001nM)	inactive (97.78%)	-	inactive (119%)
FES	inactive (10001nM)	inactive (98.82%)	-	inactive (137%)

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FGFR1	inactive (10001nM)	inactive (91.72%)	-	inactive (97%)
FGFR2	inactive (10001nM)	inactive (95.75%)	-	inactive (122%)
FGFR3	inactive (10001nM)	inactive (100.59%)	-	inactive (112%)
FGFR4	inactive (10001nM)	inactive (101.99%)	-	inactive (112%)

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FLT1	inactive (10001nM)	inactive (83.59%)	-	inactive (91%)
FLT4	inactive (10001nM)	inactive (104.05%)	-	inactive (79%)
KDR	inactive (10001nM)	inactive (85.89%)	-	inactive (109%)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IGF1R	inactive (10001nM)	inactive (97.13%)	-	inactive (131%)
INSR	inactive (10001nM)	inactive (98.59%)	-	inactive (98%)
IRR	inactive (10001nM)	inactive (113.55%)	-	inactive (128%)

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
JAK1	inactive (10001nM)	inactive (103.69%)	-	-
JAK2	inactive (10001nM)	inactive (92.6%)	-	inactive (107%)
JAK3	inactive (10001nM)	inactive (99%)	-	inactive (103%)
TYK2	inactive (10001nM)	inactive (73.63%)	-	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MET	inactive (10001nM)	inactive (97.79%)	-	inactive (121%)
RON	inactive (10001nM)	inactive (94.31%)	-	inactive (102%)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MUSK	inactive (10001nM)	inactive (87.81%)	-	inactive (114%)

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RET	inactive (10001nM)	inactive (99.79%)	-	inactive (101%)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ROS	inactive (10001nM)	inactive (93.13%)	-	inactive (96%)

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SYK	inactive (10001nM)	inactive (94.15%)	-	inactive (131%)
ZAP70	inactive (10001nM)	inactive (91.43%)	-	inactive (110%)

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TIE1	inactive (10001nM)	-	-	-
TIE2	inactive (10001nM)	inactive (87.7%)	-	inactive (80%)

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TNK1	inactive (10001nM)	-	-	-
ACK	inactive (10001nM)	inactive (89.56%)	-	inactive (78%)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TRKA	inactive (10001nM)	inactive (94.95%)	-	inactive (93%)
TRKB	inactive (10001nM)	inactive (90.16%)	-	inactive (113%)
TRKC	inactive (10001nM)	inactive (91.1%)	-	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STKR	12	10	5	1	2
RIPK	5	4	1	-	1
RAF	5	2	3	1	1
MLK	10	8	5	2	2
IRAK	4	3	2	2	2
LISK	4	3	1	1	1
LRRK	2	1	1	1	-

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ALK2	inactive (10001nM)	inactive (104.87%)	-	-
ALK4	inactive (10001nM)	inactive (98.03%)	-	inactive (148%)
ACTR2	inactive (10001nM)	-	-	-
ACTR2B	inactive (10001nM)	-	-	-
ALK1	inactive (10001nM)	inactive (105.37%)	-	-
BMPR1A	inactive (10001nM)	-	-	-
BMPR1B	inactive (10001nM)	-	-	-
BMPR2	inactive (10001nM)	-	-	-
TGFbR1	inactive (10001nM)	inactive (94.96%)	-	inactive (82%)
TGFbR2	inactive (10001nM)	inactive (101.62%)	-	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SgK288	inactive (10001nM)	-	-	-
RIPK1	inactive (10001nM)	-	-	-
RIPK2	inactive (10001nM)	inactive (87.41%)	-	inactive (89%)
ANKRD3	inactive (10001nM)	-	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
BRAF	active (2900nM)	inactive (94%)	-	-
RAF1	inactive (3700nM)	inactive (79.1%)	-	inactive (81%)
ARAF	-	inactive (92.04%)	-	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DLK	inactive (10001nM)	-	-	-
LZK	inactive (10001nM)	-	-	-
MLK1	inactive (10001nM)	inactive (103.36%)	-	inactive (90%)
MLK2	inactive (10001nM)	inactive (91.96%)	-	-
MLK3	inactive (10001nM)	inactive (96.53%)	-	-
TAK1	inactive (10001nM)	inactive (97.36%)	-	inactive (99%)
HH498	inactive (10001nM)	-	-	-
ZAK	inactive (10001nM)	inactive (96.18%)	inactive (>7943.28nM)	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
IRAK1	inactive (10001nM)	inactive (84.2%)	inactive (>7943.28nM)	inactive (101%)
IRAK3	inactive (10001nM)	-	-	-
IRAK4	inactive (10001nM)	inactive (104.48%)	inactive (>10000nM)	inactive (99%)

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LIMK1	inactive (10001nM)	inactive (93.7%)	-	inactive (113%)
LIMK2	inactive (3500nM)	-	-	-
TESK1	inactive (10001nM)	-	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LRRK2	inactive (10001nM)	inactive (100.52%)	-	-

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
ABC1	5	2	-	-	-
PIKK	6	1	-	-	1
RIO	3	3	-	-	-
Alpha	6	1	-	1	1
PDHK	5	-	1	-	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ADCK3	inactive (10001nM)	-	-	-
ADCK4	inactive (10001nM)	-	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
FRAP	active (12nM)	-	-	active (49%)

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RIOK1	inactive (10001nM)	-	-	-
RIOK2	active (770nM)	-	-	-
RIOK3	inactive (10001nM)	-	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ChaK2	inactive (10001nM)	-	-	-
eEF2K	-	-	-	inactive (102%)

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDHK1	-	inactive (102.92%)	-	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
Akt	3	3	3	3	3
DMPK	7	7	5	3	5
GRK	7	3	6	1	3
NDR	4	4	1	-	-
MAST	5	1	-	-	-
PDK1	1	1	1	1	1
PKA	5	3	3	2	2
PKN	3	2	2	1	1
PKC	9	5	9	5	8
PKG	2	2	3	2	-
RSK	8	1	8	4	7
SGK	3	1	3	1	3
YANK	3	3	-	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AKT1	inactive (10001nM)	inactive (95.26%)	inactive (>7943.28nM)	inactive (104%)
AKT2	inactive (10001nM)	inactive (99.13%)	inactive (>7943.28nM)	inactive (130%)
AKT3	inactive (10001nM)	inactive (99.03%)	inactive (>10000nM)	inactive (95%)

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CRIK	inactive (10001nM)	-	-	-
DMPK1	inactive (10001nM)	inactive (99.51%)	-	inactive (101%)
DMPK2	inactive (10001nM)	-	-	-
MRCKa	active (1800nM)	inactive (94.5%)	inactive (>10000nM)	inactive (97%)
MRCKb	inactive (10001nM)	inactive (99.36%)	-	inactive (91%)
ROCK1	inactive (10001nM)	inactive (94.9%)	-	inactive (123%)
ROCK2	inactive (10001nM)	inactive (94.5%)	-	inactive (103%)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
RHOK	inactive (10001nM)	-	-	-
GPRK4	inactive (10001nM)	inactive (101.95%)	-	-
GPRK7	inactive (10001nM)	inactive (99.98%)	-	inactive (93%)
BARK1	-	inactive (107.47%)	-	-
BARK2	-	inactive (109.79%)	-	-
GPRK5	-	inactive (103.5%)	-	inactive (104%)
GPRK6	-	inactive (98.15%)	-	inactive (103%)

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
LATS1	inactive (10001nM)	-	-	-
LATS2	inactive (10001nM)	-	-	-
NDR1	inactive (10001nM)	inactive (98.99%)	-	-
NDR2	inactive (10001nM)	-	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAST1	inactive (10001nM)	-	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PDK1	inactive (10001nM)	inactive (102.92%)	-	inactive (116%)

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKACa	inactive (10001nM)	inactive (99.53%)	-	inactive (95%)
PKACb	inactive (10001nM)	-	-	-
PRKX	inactive (10001nM)	inactive (96.15%)	-	inactive (96%)
PKACg	-	inactive (101.32%)	-	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKN1	inactive (10001nM)	inactive (101.14%)	-	-
PKN2	inactive (10001nM)	inactive (87.56%)	-	inactive (101%)

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKCd	inactive (10001nM)	inactive (95.95%)	inactive (>7943.28nM)	inactive (94%)
PKCe	inactive (10001nM)	inactive (100.44%)	-	inactive (91%)
PKCh	inactive (10001nM)	inactive (89.75%)	-	inactive (107%)
PKCi	inactive (10001nM)	inactive (94.9%)	-	inactive (89%)
PKCt	inactive (10001nM)	inactive (104.89%)	-	inactive (84%)
PKCa	-	inactive (102.91%)	-	inactive (106%)
PKCg	-	inactive (101.72%)	inactive (>7943.28nM)	inactive (114%)
PKCz	-	inactive (99.07%)	inactive (>7943.28nM)	inactive (104%)
PKCb	-	inactive (102.48%)	-	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKG1	inactive (10001nM)	inactive (96.3%)	-	-
PKG2	inactive (10001nM)	inactive (89.24%)	-	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
p70S6K	inactive (10001nM)	inactive (105.51%)	-	inactive (68%)
MSK1	-	inactive (86.47%)	-	inactive (130%)
MSK2	-	inactive (104.45%)	-	inactive (98%)
p70S6Kb	-	inactive (95.79%)	-	-
RSK2	-	inactive (101.09%)	-	inactive (70%)
RSK4	-	inactive (98.2%)	-	inactive (115%)
RSK1	-	inactive (79.48%)	-	inactive (108%)
RSK3	-	inactive (88.09%)	-	inactive (141%)

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SGK3	inactive (10001nM)	inactive (95.79%)	-	inactive (102%)
SGK1	-	inactive (100.35%)	inactive (>7943.28nM)	inactive (105%)
SGK2	-	inactive (96.68%)	-	inactive (112%)

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
YANK1	inactive (10001nM)	-	-	-
YANK2	inactive (10001nM)	-	-	-
YANK3	inactive (10001nM)	-	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CAMKL	20	19	13	9	12
CAMK1	5	4	5	2	3
CAMK2	4	4	4	4	3
CASK	1	1	-	-	-
RAD53	1	1	1	1	1
DAPK	5	5	4	2	4
DCAMKL	3	3	1	1	1
MAPKAPK	5	4	5	4	4
MLCK	5	4	2	-	1
PHK	2	2	2	1	1
PIM	3	3	3	3	3
PKD	3	3	3	2	2
STK33	1	1	-	1	-
TSSK	5	1	2	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
AMPKa1	inactive (10001nM)	-	-	inactive (114%)
AMPKa2	inactive (10001nM)	-	-	inactive (113%)
NuaK1	inactive (10001nM)	inactive (86.63%)	-	inactive (98%)
BRSK1	inactive (10001nM)	inactive (91.08%)	inactive (>10000nM)	inactive (95%)
BRSK2	inactive (10001nM)	inactive (97.12%)	-	inactive (96%)
CHK1	inactive (10001nM)	inactive (93.96%)	-	inactive (93%)
HUNK	inactive (10001nM)	-	-	-
LKB1	inactive (10001nM)	inactive (86.38%)	-	inactive (104%)
MARK1	inactive (10001nM)	inactive (97.63%)	-	inactive (104%)
MARK2	inactive (10001nM)	inactive (92.94%)	inactive (>7943.28nM)	inactive (91%)
MARK3	inactive (10001nM)	inactive (97.41%)	-	-
MARK4	inactive (10001nM)	inactive (93.36%)	-	-
MELK	inactive (10001nM)	inactive (75.49%)	-	inactive (74%)
NIM1	inactive (10001nM)	-	-	-
QSK	inactive (10001nM)	-	-	-
SIK	inactive (10001nM)	-	-	inactive (91%)
QIK	inactive (10001nM)	inactive (98.95%)	-	-
NuaK2	inactive (10001nM)	inactive (75.29%)	-	-
SNRK	inactive (10001nM)	-	-	-
PASK	-	inactive (83.82%)	-	inactive (107%)

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK1a	inactive (10001nM)	inactive (100.64%)	-	inactive (103%)
CaMK1d	inactive (10001nM)	inactive (120.58%)	-	inactive (102%)
CaMK1g	inactive (10001nM)	inactive (99.24%)	-	-
CaMK4	inactive (10001nM)	inactive (103.33%)	-	inactive (108%)
CaMK1b	-	inactive (96.67%)	-	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CaMK2a	inactive (10001nM)	inactive (93.74%)	-	-
CaMK2b	inactive (10001nM)	inactive (98.24%)	inactive (>7943.28nM)	inactive (98%)
CaMK2d	inactive (10001nM)	inactive (96.18%)	-	inactive (104%)
CaMK2g	inactive (10001nM)	inactive (100.02%)	-	inactive (98%)

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CASK	inactive (10001nM)	-	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CHK2	inactive (10001nM)	inactive (90.42%)	-	inactive (100%)

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DAPK1	active (2400nM)	inactive (77.96%)	-	inactive (99%)
DAPK2	active (2700nM)	inactive (116.67%)	-	inactive (93%)
DAPK3	active (840nM)	inactive (93.13%)	active (794.33nM)	inactive (85%)
DRAK1	inactive (10001nM)	inactive (93.79%)	-	inactive (116%)
DRAK2	inactive (10001nM)	-	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DCLK1	inactive (10001nM)	-	inactive (>10000nM)	-
DCLK2	inactive (10001nM)	inactive (101.53%)	-	inactive (94%)
DCLK3	inactive (10001nM)	-	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAPKAPK2	inactive (10001nM)	inactive (97.81%)	inactive (>7943.28nM)	inactive (81%)
MAPKAPK5	inactive (10001nM)	inactive (85.66%)	-	inactive (98%)
MNK1	inactive (10001nM)	inactive (102.44%)	-	-
MNK2	inactive (10001nM)	inactive (92.6%)	inactive (>10000nM)	inactive (109%)
MAPKAPK3	-	inactive (93.92%)	inactive (>10000nM)	inactive (92%)

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
caMLCK	inactive (10001nM)	-	-	-
smMLCK	active (1500nM)	inactive (77.15%)	-	inactive (71%)
skMLCK	inactive (10001nM)	inactive (98.98%)	-	-
SgK085	inactive (10001nM)	-	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PHKg1	inactive (10001nM)	inactive (93.34%)	-	-
PHKg2	inactive (10001nM)	inactive (99.1%)	-	inactive (105%)

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PIM1	inactive (10001nM)	inactive (91.23%)	-	inactive (88%)
PIM2	inactive (10001nM)	inactive (96.93%)	-	inactive (102%)
PIM3	inactive (10001nM)	inactive (104.04%)	inactive (5011.87nM)	inactive (98%)

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PKD1	inactive (10001nM)	inactive (98.33%)	-	inactive (97%)
PKD2	inactive (10001nM)	inactive (93.83%)	inactive (>10000nM)	inactive (99%)
PKD3	inactive (10001nM)	inactive (92.93%)	-	-

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
STK33	inactive (10001nM)	inactive (101.23%)	-	inactive (101%)

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
TSSK1	inactive (10001nM)	inactive (93.39%)	-	inactive (104%)
TSSK2	-	inactive (101.57%)	-	inactive (93%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
STE11	8	8	3	-	1
STE20	31	27	23	9	14
STE7	7	7	3	2	3
STE-Unique	2	-	2	-	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP3K5	inactive (10001nM)	inactive (101.41%)	-	inactive (109%)
MAP3K6	inactive (10001nM)	-	-	-
MAP3K1	inactive (10001nM)	-	-	-
MAP3K7	inactive (10001nM)	-	-	-
MAP3K2	inactive (10001nM)	inactive (103.2%)	-	-
MAP3K3	inactive (10001nM)	inactive (96.04%)	-	-
MAP3K4	inactive (10001nM)	-	-	-
MAP3K8	active (930nM)	-	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
HPK1	inactive (10001nM)	-	-	-
LOK	inactive (10001nM)	inactive (92.13%)	-	inactive (96%)
GCK	inactive (10001nM)	inactive (93.01%)	-	inactive (101%)
KHS2	inactive (10001nM)	-	-	-
HGK	inactive (10001nM)	inactive (91.37%)	-	-
KHS1	inactive (10001nM)	inactive (82.41%)	-	-
MINK	inactive (10001nM)	inactive (96%)	inactive (>7943.28nM)	inactive (110%)
MST1	inactive (10001nM)	inactive (93.34%)	-	inactive (97%)
MST2	inactive (10001nM)	inactive (105.2%)	-	inactive (120%)
MST3	inactive (10001nM)	inactive (100.02%)	-	inactive (75%)
MST4	inactive (10001nM)	inactive (98.65%)	-	-
MYO3A	inactive (10001nM)	-	-	-
MYO3B	inactive (10001nM)	inactive (81.27%)	-	-
OSR1	inactive (10001nM)	inactive (93.23%)	-	-
PAK1	inactive (10001nM)	inactive (97.59%)	inactive (>10000nM)	-
PAK2	inactive (10001nM)	inactive (97.49%)	-	inactive (105%)
PAK3	inactive (10001nM)	inactive (97.51%)	-	inactive (60%)
PAK4	inactive (10001nM)	inactive (90.69%)	-	inactive (100%)
PAK6	inactive (10001nM)	inactive (104.61%)	-	inactive (100%)
PAK5	inactive (10001nM)	inactive (92.83%)	-	inactive (84%)
SLK	inactive (10001nM)	inactive (101.43%)	inactive (>10000nM)	-
STLK3	inactive (10001nM)	inactive (104.72%)	-	-
TAO1	inactive (10001nM)	inactive (91.57%)	-	inactive (93%)
TAO2	inactive (10001nM)	inactive (92.21%)	-	inactive (104%)
TAO3	inactive (10001nM)	inactive (86.75%)	-	inactive (109%)
TNIK	inactive (10001nM)	-	-	-
YSK1	inactive (10001nM)	inactive (93.39%)	-	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
MAP2K1	inactive (10001nM)	inactive (97.66%)	-	inactive (102%)
MAP2K2	inactive (10001nM)	inactive (85.03%)	-	-
MAP2K3	inactive (10001nM)	-	-	-
MAP2K4	inactive (10001nM)	-	-	-
MAP2K5	inactive (10001nM)	-	-	-
MAP2K6	inactive (10001nM)	inactive (86.57%)	-	inactive (91%)
MAP2K7	inactive (10001nM)	-	-	inactive (101%)

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
COT	-	inactive (99.19%)	-	-
NIK	-	-	-	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CDK	20	8	-	7	-
CDKL	5	4	-	-	-
CLK	4	4	4	2	2
CK2	3	2	2	1	2
DYRK	10	8	9	6	4
MAPK	14	14	10	8	10
GSK	2	2	2	2	2
RCK	3	2	-	-	-
SRPK	3	3	3	1	3

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
PITSLRE	inactive (10001nM)	-	-	-
CHED	inactive (10001nM)	-	-	-
CDK11	inactive (10001nM)	-	-	-
PCTAIRE1	inactive (10001nM)	-	-	-
PCTAIRE2	inactive (10001nM)	-	-	-
PCTAIRE3	inactive (10001nM)	-	-	-
PFTAIRE2	inactive (10001nM)	-	-	-
PFTAIRE1	inactive (10001nM)	-	-	-
CDC2	-	-	inactive (>7943.28nM)	-
CDK2	-	-	inactive (>7943.28nM)	-
CDK5	-	-	-	-
CDK8	-	-	-	-
CDK7	-	-	-	-
CDK9	-	-	-	-

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CDKL1	inactive (10001nM)	-	-	-
CDKL2	inactive (10001nM)	-	-	-
CDKL3	inactive (10001nM)	-	-	-
CDKL5	inactive (10001nM)	-	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CLK1	inactive (3900nM)	inactive (85.18%)	-	-
CLK2	inactive (5500nM)	inactive (87.96%)	-	inactive (118%)
CLK3	inactive (5900nM)	inactive (93.1%)	-	inactive (79%)
CLK4	inactive (10001nM)	inactive (81.51%)	active (794.33nM)	-

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK2a1	inactive (5400nM)	inactive (94.66%)	-	inactive (89%)
CK2a2	active (2900nM)	inactive (56.22%)	-	inactive (140%)

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
DYRK1A	inactive (10001nM)	inactive (94.31%)	-	-
DYRK1B	inactive (5700nM)	inactive (98.91%)	-	-
DYRK2	inactive (4100nM)	inactive (97.64%)	-	inactive (94%)
HIPK1	inactive (3300nM)	inactive (101.2%)	-	inactive (85%)
HIPK2	active (290nM)	inactive (102.05%)	inactive (2511.89nM)	inactive (84%)
HIPK3	active (310nM)	inactive (93.82%)	-	inactive (93%)
HIPK4	inactive (10001nM)	inactive (106.74%)	inactive (>7943.28nM)	-
PRP4	inactive (10001nM)	-	-	-
DYRK3	-	inactive (94.86%)	-	-
DYRK4	-	inactive (96.63%)	-	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
Erk1	inactive (10001nM)	inactive (94.12%)	-	inactive (83%)
Erk2	inactive (10001nM)	inactive (88.98%)	-	inactive (122%)
Erk3	inactive (10001nM)	-	-	-
Erk4	inactive (10001nM)	-	-	-
Erk5	inactive (10001nM)	-	-	-
Erk7	inactive (10001nM)	-	-	-
JNK1	inactive (10001nM)	inactive (89.83%)	-	inactive (109%)
JNK2	inactive (10001nM)	inactive (89.43%)	-	inactive (107%)
JNK3	inactive (10001nM)	inactive (101.88%)	-	inactive (91%)
NLK	inactive (10001nM)	inactive (97.37%)	-	inactive (102%)
p38a	inactive (10001nM)	inactive (101.07%)	-	inactive (109%)
p38b	inactive (10001nM)	inactive (102.62%)	-	inactive (102%)
p38d	inactive (10001nM)	inactive (97.41%)	inactive (>7943.28nM)	inactive (106%)
p38g	inactive (10001nM)	inactive (93.4%)	-	inactive (112%)

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
GSK3A	inactive (10001nM)	inactive (90.21%)	-	inactive (111%)
GSK3B	inactive (10001nM)	inactive (94.8%)	-	inactive (101%)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
ICK	inactive (10001nM)	-	-	-
MAK	inactive (10001nM)	-	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
SRPK1	inactive (10001nM)	inactive (104.96%)	inactive (>7943.28nM)	inactive (97%)
SRPK2	inactive (10001nM)	inactive (97.31%)	-	inactive (103%)
MSSK1	inactive (10001nM)	inactive (95.04%)	-	inactive (110%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz	Millipore
CK1	7	7	6	5	4
VRK	3	1	1	-	1

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
CK1a	inactive (10001nM)	inactive (87.88%)	-	-
CK1a2	inactive (10001nM)	-	-	-
CK1d	inactive (10001nM)	inactive (91.33%)	inactive (>7943.28nM)	inactive (83%)
CK1e	inactive (10001nM)	inactive (87.09%)	-	-
CK1g1	inactive (10001nM)	inactive (89.41%)	-	inactive (90%)
CK1g2	inactive (10001nM)	inactive (88.13%)	-	inactive (108%)
CK1g3	inactive (10001nM)	inactive (99.94%)	-	inactive (115%)

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz	Millipore
VRK2	inactive (10001nM)	-	-	inactive (111%)
VRK1	-	inactive (98.35%)	-	-