Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : SU4312
Millipore : dmbi

Inchikey
Same : UAKWLVYMKBWHMX-N
RBC : UAKWLVYMKBWHMX-UHFFFAOYSA-N
Millipore : UAKWLVYMKBWHMX-RVDMUPIBSA-N

ChemSpider
RBC : 3023
Millipore : 4510144

Pubchem CID
RBC : 3135
Millipore : 5353593

ChEMBL
RBC : -
Millipore : CHEMBL296455

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (82.31%)	inactive (114%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (101.28%)	inactive (112%)
AKT2	inactive (98.07%)	inactive (112%)
AKT3	inactive (102.88%)	inactive (96%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (104.98%)	inactive (111%)
MRCKa	inactive (100.87%)	inactive (113%)
MRCKb	inactive (89.46%)	inactive (106%)
ROCK1	inactive (98.32%)	inactive (132%)
ROCK2	inactive (95.17%)	inactive (112%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (101.08%)	-
BARK2	inactive (98.86%)	-
GPRK4	inactive (102.74%)	-
GPRK5	inactive (104.18%)	inactive (91%)
GPRK6	inactive (101.8%)	inactive (97%)
GPRK7	inactive (100.11%)	inactive (96%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (98.69%)	inactive (116%)
MSK2	inactive (95.18%)	inactive (87%)
p70S6K	inactive (97.05%)	inactive (69%)
p70S6Kb	inactive (101.41%)	-
RSK2	inactive (92.6%)	active (47%)
RSK4	inactive (93.94%)	inactive (91%)
RSK1	inactive (78.36%)	inactive (74%)
RSK3	inactive (89.12%)	inactive (66%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (103.61%)	inactive (92%)
PKACa	inactive (103.5%)	inactive (89%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (94.5%)	inactive (103%)
PKCd	inactive (95.58%)	inactive (88%)
PKCe	inactive (92.62%)	inactive (120%)
PKCh	inactive (92.31%)	inactive (102%)
PKCg	inactive (96.76%)	inactive (113%)
PKCi	inactive (100.97%)	inactive (92%)
PKCt	inactive (103.58%)	inactive (117%)
PKCz	inactive (112.3%)	inactive (118%)
PKCb	inactive (102.52%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (105.08%)	-
PKG1	inactive (99.7%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (98.4%)	-
PKN2	inactive (98.85%)	inactive (113%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (93.09%)	inactive (96%)
SGK2	inactive (98.57%)	inactive (83%)
SGK3	inactive (107.22%)	inactive (106%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (102.98%)	inactive (100%)
ABL2	inactive (100.36%)	inactive (103%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (101.32%)	inactive (89%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (99.72%)	inactive (80%)
LTK	inactive (96.81%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (93.8%)	inactive (78%)
MER	inactive (92.69%)	inactive (51%)
TYRO3	inactive (92.71%)	inactive (100%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (99.19%)	inactive (87%)
BRK	inactive (98.8%)	inactive (112%)
SRC	inactive (101.9%)	inactive (87%)
FGR	inactive (90.05%)	inactive (90%)
FRK	inactive (102.15%)	inactive (97%)
FYN	inactive (104.3%)	inactive (83%)
HCK	inactive (110.15%)	inactive (76%)
LCK	inactive (93.02%)	inactive (129%)
SRM	inactive (97.88%)	-
YES	inactive (89.3%)	inactive (98%)
LYN	inactive (108.42%)	inactive (86%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (92.22%)	inactive (80%)
BTK	inactive (103.64%)	inactive (113%)
ITK	inactive (99.02%)	inactive (98%)
TEC	inactive (103.27%)	-
TXK	inactive (96.1%)	inactive (108%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (45.6%)	active (24%)
FLT3	active (15.31%)	active (4%)
FMS	inactive (77.52%)	active (8%)
PDGFRb	inactive (85.8%)	inactive (101%)
PDGFRa	inactive (79.89%)	inactive (79%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (96.93%)	inactive (116%)
CTK	inactive (95.28%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (102.82%)	inactive (104%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (92.07%)	inactive (112%)
ErbB2	inactive (90.98%)	-
ErbB4	inactive (97.73%)	inactive (115%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (93.68%)	inactive (100%)
EphA2	inactive (106.98%)	inactive (123%)
EphA3	inactive (102.4%)	inactive (99%)
EphA4	inactive (95.21%)	inactive (115%)
EphA5	inactive (109.37%)	inactive (108%)
EphA6	-	-
EphA7	inactive (99.08%)	inactive (104%)
EphA8	inactive (102.61%)	inactive (102%)
EphB1	inactive (101.8%)	inactive (100%)
EphB2	inactive (86.47%)	inactive (112%)
EphB3	inactive (94.88%)	inactive (108%)
EphB4	inactive (97.36%)	inactive (97%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (103.76%)	inactive (82%)
PYK2	inactive (94.48%)	inactive (103%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (94.48%)	inactive (109%)
FES	inactive (97.78%)	inactive (113%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (92.01%)	inactive (61%)
FGFR2	inactive (98.23%)	inactive (94%)
FGFR3	inactive (96.31%)	inactive (89%)
FGFR4	inactive (97.43%)	inactive (122%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (92.01%)	active (14%)
FLT4	inactive (98.81%)	active (3%)
KDR	inactive (94.31%)	active (4%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (101.28%)	inactive (146%)
IRR	inactive (94.53%)	inactive (111%)
INSR	inactive (93.4%)	inactive (99%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (104.82%)	-
JAK2	inactive (94.84%)	inactive (115%)
JAK3	inactive (112.69%)	inactive (86%)
TYK2	inactive (103.26%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (96.41%)	inactive (94%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (78.04%)	inactive (66%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (106.2%)	inactive (91%)
MET	inactive (101.28%)	inactive (112%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (94.93%)	inactive (106%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (90.44%)	inactive (123%)
ZAP70	inactive (89.93%)	inactive (121%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (102.14%)	inactive (83%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (96.57%)	active (10%)
TRKB	inactive (54.82%)	active (46%)
TRKC	active (36.35%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (104.44%)	-
ALK2	inactive (103.71%)	-
ALK4	inactive (93.41%)	inactive (127%)
TGFbR1	inactive (96.66%)	inactive (93%)
TGFbR2	inactive (124.48%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (94.29%)	-
BRAF	inactive (100.53%)	-
RAF1	inactive (101.18%)	inactive (94%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (101.52%)	inactive (118%)
IRAK4	inactive (104.38%)	inactive (92%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (97.72%)	inactive (108%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (89.78%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (90.22%)	active (39%)
MLK2	inactive (96.55%)	-
MLK3	inactive (88.45%)	-
TAK1	inactive (100.43%)	inactive (100%)
ZAK	inactive (96.47%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (87.76%)	inactive (103%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (80.45%)	inactive (93%)
BRSK1	inactive (99.58%)	inactive (83%)
BRSK2	inactive (93.04%)	inactive (90%)
CHK1	inactive (98.17%)	inactive (90%)
LKB1	inactive (99.42%)	inactive (94%)
MARK1	inactive (97.25%)	inactive (83%)
MARK3	inactive (101.02%)	-
MARK4	inactive (97.03%)	-
MELK	inactive (89.32%)	active (49%)
PASK	inactive (94.97%)	inactive (86%)
QIK	inactive (101.04%)	-
NuaK2	inactive (94.25%)	-
MARK2	inactive (104.56%)	inactive (82%)
AMPKa1	-	inactive (92%)
AMPKa2	-	inactive (97%)
SIK	-	inactive (88%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (104.17%)	inactive (122%)
CaMK1b	inactive (101.67%)	-
CaMK1d	inactive (98.76%)	inactive (103%)
CaMK1g	inactive (99.89%)	-
CaMK4	inactive (97.78%)	inactive (87%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (106.47%)	-
CaMK2b	inactive (107.88%)	inactive (101%)
CaMK2d	inactive (96.43%)	inactive (89%)
CaMK2g	inactive (99.59%)	inactive (92%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (91.63%)	inactive (73%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (92.19%)	inactive (102%)
DAPK2	inactive (104.65%)	inactive (102%)
DRAK1	inactive (93.85%)	active (25%)
DAPK3	inactive (101.09%)	inactive (108%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (100.38%)	inactive (88%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (106.15%)	inactive (121%)
MAPKAPK3	inactive (100.27%)	inactive (101%)
MAPKAPK5	inactive (98.57%)	inactive (113%)
MNK1	inactive (97.31%)	-
MNK2	inactive (90.47%)	inactive (107%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (90.52%)	inactive (77%)
skMLCK	inactive (82.65%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (99.13%)	-
PHKg2	inactive (95.86%)	inactive (98%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (100.83%)	inactive (77%)
PIM2	inactive (82.35%)	inactive (92%)
PIM3	inactive (102.11%)	inactive (106%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (100.3%)	inactive (96%)
PKD3	inactive (99.21%)	-
PKD2	inactive (95.17%)	inactive (103%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (101.78%)	inactive (104%)
TSSK2	inactive (101.14%)	inactive (92%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (99.83%)	inactive (95%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (99.41%)	inactive (92%)
MAP3K2	inactive (99.78%)	-
MAP3K3	inactive (104.15%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (99.58%)	-
NIK	inactive (67.73%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (108.72%)	inactive (83%)
HGK	inactive (74.54%)	-
KHS1	inactive (84.54%)	-
LOK	inactive (95.35%)	inactive (100%)
MINK	inactive (79.02%)	inactive (82%)
MST1	inactive (93.24%)	inactive (95%)
MST2	inactive (99.99%)	inactive (108%)
MST3	inactive (96.68%)	inactive (66%)
MST4	inactive (90.9%)	-
OSR1	inactive (106.13%)	-
PAK1	inactive (95.73%)	-
PAK2	inactive (102.38%)	inactive (96%)
PAK3	inactive (99.04%)	inactive (91%)
PAK4	inactive (100.93%)	inactive (100%)
PAK5	inactive (101.2%)	inactive (95%)
PAK6	inactive (96.95%)	inactive (83%)
SLK	inactive (103.35%)	-
YSK1	inactive (90.23%)	-
STLK3	inactive (96.58%)	-
TAO1	inactive (94.66%)	inactive (113%)
TAO2	inactive (102.37%)	inactive (99%)
TAO3	inactive (95.15%)	inactive (100%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (97.81%)	inactive (114%)
MAP2K2	inactive (99.44%)	-
MAP2K6	inactive (94.75%)	inactive (97%)
MAP2K7	-	inactive (91%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (103.64%)	inactive (56%)
AurB	inactive (61.41%)	active (13%)
AurC	inactive (91.07%)	inactive (88%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (98.61%)	-
CaMKK2	inactive (99.97%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (88.46%)	inactive (83%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (93.35%)	inactive (102%)
IKKb	inactive (105.45%)	inactive (112%)
IKKe	inactive (98.18%)	-
TBK1	inactive (98.38%)	inactive (81%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (111.85%)	-
NEK11	inactive (96.4%)	inactive (90%)
NEK2	inactive (98.37%)	inactive (94%)
NEK4	inactive (101.5%)	-
NEK6	inactive (96.88%)	inactive (108%)
NEK7	inactive (101.62%)	inactive (118%)
NEK9	inactive (99.8%)	-
NEK3	inactive (95.23%)	inactive (111%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (101.17%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (102.53%)	inactive (88%)
PLK2	inactive (110.53%)	inactive (106%)
PLK3	inactive (96.97%)	inactive (94%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (103.36%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (87.87%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (99.74%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (91.93%)	-
ULK2	inactive (97.06%)	inactive (107%)
ULK3	active (0%)	inactive (100%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (88.61%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (104.45%)	inactive (110%)
Wnk3	inactive (98.11%)	inactive (117%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	inactive (98%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (69.03%)	inactive (56%)
CK1g1	inactive (92.98%)	inactive (91%)
CK1g2	inactive (96.69%)	inactive (85%)
CK1g3	inactive (101.34%)	inactive (85%)
CK1a	inactive (105.15%)	-
CK1e	inactive (57.21%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (89.05%)	-
VRK2	-	inactive (113%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (89.66%)	inactive (87%)
CK2a2	inactive (98.61%)	inactive (115%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (103%)	-
CLK2	inactive (99.66%)	inactive (86%)
CLK3	inactive (89.43%)	inactive (77%)
CLK4	inactive (94.13%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (102.89%)	-
DYRK1B	inactive (105.75%)	-
DYRK2	inactive (100.35%)	inactive (98%)
DYRK3	inactive (99.53%)	-
DYRK4	inactive (94.83%)	-
HIPK1	inactive (102.71%)	inactive (96%)
HIPK2	inactive (106.32%)	inactive (97%)
HIPK3	inactive (94.45%)	inactive (102%)
HIPK4	inactive (98.32%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (102.04%)	inactive (91%)
Erk2	inactive (96.37%)	inactive (107%)
JNK3	inactive (82.93%)	inactive (110%)
NLK	inactive (102.28%)	inactive (110%)
p38a	inactive (92.41%)	inactive (102%)
p38b	inactive (93.51%)	inactive (107%)
p38d	inactive (97.05%)	inactive (132%)
p38g	inactive (102.22%)	inactive (113%)
JNK1	inactive (103.23%)	inactive (106%)
JNK2	inactive (102.89%)	inactive (102%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (103.97%)	inactive (103%)
GSK3B	inactive (111.13%)	inactive (92%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (98.69%)	inactive (103%)
SRPK1	inactive (95.43%)	inactive (97%)
SRPK2	inactive (100.42%)	inactive (108%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (82.31%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (90%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (78%)