Compound in Profiling

Compound Information

Test on : DRx, RBC, Metz

Compound Name
DRx, RBC, Metz : Vandetanib

Inchikey
Same : UHTHHESEBZOYNR-N
DRx, RBC, Metz : UHTHHESEBZOYNR-UHFFFAOYSA-N

ChemSpider
DRx, RBC, Metz : 2338979

Pubchem CID
DRx, RBC, Metz : 3081361

ChEMBL
DRx, RBC, Metz : CHEMBL24828

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

Other

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
NAK	4	4	1	-
Aur	3	3	3	2
CAMKK	2	2	2	1
PEK	4	2	-	-
IRE	2	1	-	-
IKK	4	4	4	4
NEK	11	9	8	2
WEE	3	3	1	1
PLK	4	4	3	3
SgK496	1	1	1	-
NKF1	3	2	-	-
NKF4	2	1	-	-
ULK	5	4	3	-
TLK	2	2	1	-
TTK	1	1	1	-
Haspin	1	-	1	-
TOPK	1	-	1	1
WNK	4	-	2	-
CDC7	1	-	-	1

Other - NAK

Bioactivity
Kinase	DRx	RBC	Metz
AAK1	inactive (10001nM)	-	-
BIKE	inactive (10001nM)	-	-
GAK	active (86nM)	-	-
MPSK1	inactive (10001nM)	inactive (101.43%)	-

Other - Aur

Bioactivity
Kinase	DRx	RBC	Metz
AurA	inactive (10001nM)	inactive (102.39%)	inactive (>1584.89nM)
AurB	inactive (10001nM)	inactive (95.49%)	inactive (2511.89nM)
AurC	active (1500nM)	inactive (101.94%)	-

Other - CAMKK

Bioactivity
Kinase	DRx	RBC	Metz
CaMKK1	inactive (10001nM)	inactive (90.36%)	-
CaMKK2	inactive (10001nM)	inactive (101.79%)	-

Other - PEK

Bioactivity
Kinase	DRx	RBC	Metz
HRI	inactive (10001nM)	-	-
PKR	inactive (10001nM)	-	-

Other - IRE

Bioactivity
Kinase	DRx	RBC	Metz
IRE1	inactive (10001nM)	-	-

Other - IKK

Bioactivity
Kinase	DRx	RBC	Metz
IKKa	inactive (10001nM)	inactive (96.57%)	-
IKKb	inactive (10001nM)	inactive (87.72%)	-
IKKe	inactive (10001nM)	inactive (85.83%)	inactive (>3162.28nM)
TBK1	inactive (10001nM)	inactive (99.91%)	inactive (>3162.28nM)

Other - NEK

Bioactivity
Kinase	DRx	RBC	Metz
NEK1	inactive (10001nM)	inactive (122.95%)	-
NEK11	inactive (10001nM)	inactive (103.41%)	-
NEK2	inactive (10001nM)	inactive (102.6%)	inactive (>3162.28nM)
NEK3	inactive (10001nM)	inactive (103.34%)	-
NEK4	inactive (10001nM)	inactive (101.73%)	-
NEK5	inactive (10001nM)	-	-
NEK6	inactive (10001nM)	inactive (96.87%)	-
NEK7	inactive (10001nM)	inactive (99.03%)	-
NEK9	inactive (10001nM)	inactive (100.71%)	-

Other - WEE

Bioactivity
Kinase	DRx	RBC	Metz
MYT1	inactive (10001nM)	-	-
Wee1	inactive (10001nM)	inactive (95.13%)	-
Wee1B	inactive (10001nM)	-	-

Other - PLK

Bioactivity
Kinase	DRx	RBC	Metz
PLK1	inactive (10001nM)	inactive (98.53%)	-
PLK2	inactive (10001nM)	inactive (102.99%)	-
PLK3	inactive (10001nM)	inactive (94.96%)	-
PLK4	active (620nM)	-	-

Other - SgK496

Bioactivity
Kinase	DRx	RBC	Metz
SgK496	inactive (10001nM)	inactive (96%)	-

Other - NKF1

Bioactivity
Kinase	DRx	RBC	Metz
SBK	inactive (10001nM)	-	-
SgK110	inactive (10001nM)	-	-

Other - NKF4

Bioactivity
Kinase	DRx	RBC	Metz
CLIK1	active (56nM)	-	-

Other - ULK

Bioactivity
Kinase	DRx	RBC	Metz
Fused	inactive (10001nM)	-	-
ULK1	inactive (10001nM)	inactive (95.67%)	-
ULK2	inactive (10001nM)	inactive (108.34%)	-
ULK3	inactive (6400nM)	inactive (105.28%)	-

Other - TLK

Bioactivity
Kinase	DRx	RBC	Metz
TLK1	inactive (10001nM)	-	-
TLK2	inactive (10001nM)	inactive (79.73%)	-

Other - TTK

Bioactivity
Kinase	DRx	RBC	Metz
TTK	inactive (10001nM)	inactive (95.12%)	-

Other - Haspin

Bioactivity
Kinase	DRx	RBC	Metz
Haspin	-	inactive (92.55%)	-

Other - TOPK

Bioactivity
Kinase	DRx	RBC	Metz
PBK	-	inactive (98.87%)	-

Other - WNK

Bioactivity
Kinase	DRx	RBC	Metz
Wnk2	-	inactive (100.07%)	-
Wnk3	-	inactive (97.98%)	-

Other - CDC7

Bioactivity
Kinase	DRx	RBC	Metz
CDC7	-	-	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Abl	2	2	2	1
ALK	2	2	2	2
Axl	3	3	3	2
Src	11	11	11	9
Tec	5	5	5	3
PDGFR	5	5	5	5
Csk	2	2	2	1
DDR	2	2	1	-
EGFR	4	4	3	3
Eph	14	13	12	1
FAK	2	2	2	2
Fer	2	2	2	2
FGFR	4	4	4	2
VEGFR	3	3	3	3
InsR	3	3	3	2
JakA	4	4	4	3
Met	2	2	2	2
Musk	1	1	1	-
Ret	1	1	1	1
Sev	1	1	1	1
Syk	2	2	2	1
Tie	2	2	1	-
Ack	2	2	1	1
Trk	3	3	3	3

TK - Abl

Bioactivity
Kinase	DRx	RBC	Metz
ABL1	active (48nM)	active (11.74%)	active (31.62nM)
ABL2	active (69nM)	active (14.01%)	-

TK - ALK

Bioactivity
Kinase	DRx	RBC	Metz
ALK	active (2100nM)	inactive (87.68%)	inactive (1584.89nM)
LTK	active (550nM)	inactive (64.58%)	active (398.11nM)

TK - Axl

Bioactivity
Kinase	DRx	RBC	Metz
AXL	active (250nM)	inactive (54.97%)	active (251.19nM)
MER	active (1400nM)	active (47.94%)	-
TYRO3	active (93nM)	active (33.01%)	active (63.1nM)

TK - Src

Bioactivity
Kinase	DRx	RBC	Metz
BLK	active (66nM)	active (33.83%)	-
BRK	active (160nM)	active (7.28%)	-
FGR	active (270nM)	active (30%)	-
FRK	active (170nM)	inactive (79.48%)	-
FYN	active (360nM)	active (48.24%)	active (630.96nM)
HCK	active (360nM)	active (29.18%)	-
LCK	active (17nM)	active (3.59%)	active (39.81nM)
LYN	active (110nM)	active (10.85%)	-
SRC	active (70nM)	active (11.03%)	-
SRM	active (1900nM)	inactive (98.78%)	-
YES	active (120nM)	active (11.34%)	-

TK - Tec

Bioactivity
Kinase	DRx	RBC	Metz
BMX	inactive (10001nM)	inactive (88.41%)	-
BTK	active (1700nM)	active (17.62%)	inactive (1258.93nM)
ITK	inactive (10001nM)	inactive (101.17%)	-
TEC	inactive (10001nM)	inactive (91.56%)	-
TXK	inactive (3700nM)	inactive (57.47%)	-

TK - PDGFR

Bioactivity
Kinase	DRx	RBC	Metz
FMS	active (1200nM)	inactive (93.43%)	inactive (>2511.89nM)
FLT3	active (850nM)	active (43.72%)	inactive (>3162.28nM)
KIT	active (260nM)	inactive (71.38%)	-
PDGFRa	active (230nM)	active (28.57%)	active (158.49nM)
PDGFRb	active (88nM)	inactive (84.38%)	active (1000nM)

TK - Csk

Bioactivity
Kinase	DRx	RBC	Metz
CSK	active (2500nM)	inactive (54.44%)	-
CTK	inactive (10001nM)	inactive (100.59%)	-

TK - DDR

Bioactivity
Kinase	DRx	RBC	Metz
DDR1	active (11nM)	-	-
DDR2	active (320nM)	inactive (68.04%)	-

TK - EGFR

Bioactivity
Kinase	DRx	RBC	Metz
EGFR	active (9.5nM)	active (6.65%)	-
ErbB2	active (2600nM)	inactive (72.23%)	-
ErbB3	active (160nM)	-	-
ErbB4	active (480nM)	active (45.57%)	-

TK - Eph

Bioactivity
Kinase	DRx	RBC	Metz
EphA1	active (230nM)	active (31.69%)	-
EphA2	active (1100nM)	active (21.54%)	-
EphA3	active (2000nM)	inactive (57.74%)	-
EphA4	active (1600nM)	active (33.66%)	-
EphA5	active (240nM)	inactive (54.37%)	-
EphA6	active (50nM)	active (3.27%)	-
EphA7	active (2400nM)	active (31.75%)	-
EphA8	active (91nM)	active (33.9%)	-
EphB1	active (290nM)	active (27.81%)	-
EphB2	active (440nM)	active (24.36%)	-
EphB3	inactive (10001nM)	inactive (77.39%)	-
EphB4	active (520nM)	active (13%)	-
EphB6	active (76nM)	-	-

TK - FAK

Bioactivity
Kinase	DRx	RBC	Metz
FAK	inactive (10001nM)	inactive (100.24%)	inactive (>6309.57nM)
PYK2	inactive (10001nM)	inactive (99.49%)	-

TK - Fer

Bioactivity
Kinase	DRx	RBC	Metz
FER	inactive (10001nM)	inactive (95.79%)	-
FES	inactive (10001nM)	inactive (104.48%)	-

TK - FGFR

Bioactivity
Kinase	DRx	RBC	Metz
FGFR1	active (560nM)	active (43.98%)	inactive (1995.26nM)
FGFR2	active (1100nM)	active (38.37%)	-
FGFR3	active (1600nM)	inactive (67.85%)	-
FGFR4	active (2300nM)	inactive (90.04%)	-

TK - VEGFR

Bioactivity
Kinase	DRx	RBC	Metz
FLT1	active (260nM)	active (29.5%)	active (63.1nM)
FLT4	active (1100nM)	active (16.08%)	-
KDR	active (820nM)	active (12.55%)	active (6.31nM)

TK - InsR

Bioactivity
Kinase	DRx	RBC	Metz
IGF1R	inactive (10001nM)	inactive (94.62%)	inactive (>2511.89nM)
INSR	inactive (10001nM)	inactive (102.15%)	-
IRR	inactive (10001nM)	inactive (105.46%)	-

TK - JakA

Bioactivity
Kinase	DRx	RBC	Metz
JAK1	inactive (10001nM)	inactive (99.14%)	-
JAK2	inactive (10001nM)	inactive (101.91%)	inactive (>2511.89nM)
JAK3	inactive (10001nM)	inactive (96.03%)	inactive (>5011.87nM)
TYK2	inactive (10001nM)	inactive (97.72%)	-

TK - Met

Bioactivity
Kinase	DRx	RBC	Metz
MET	inactive (5700nM)	inactive (86.25%)	inactive (>2511.89nM)
RON	inactive (10001nM)	inactive (93.58%)	inactive (>3981.07nM)

TK - Musk

Bioactivity
Kinase	DRx	RBC	Metz
MUSK	inactive (10001nM)	inactive (94.63%)	-

TK - Ret

Bioactivity
Kinase	DRx	RBC	Metz
RET	active (34nM)	active (3.93%)	active (19.95nM)

TK - Sev

Bioactivity
Kinase	DRx	RBC	Metz
ROS	inactive (10001nM)	inactive (76.46%)	-

TK - Syk

Bioactivity
Kinase	DRx	RBC	Metz
SYK	inactive (10001nM)	inactive (100.89%)	-
ZAP70	inactive (10001nM)	inactive (96.84%)	-

TK - Tie

Bioactivity
Kinase	DRx	RBC	Metz
TIE1	active (1500nM)	-	-
TIE2	active (1000nM)	inactive (50.81%)	-

TK - Ack

Bioactivity
Kinase	DRx	RBC	Metz
TNK1	inactive (10001nM)	-	-
ACK	inactive (10001nM)	inactive (85.37%)	inactive (>3981.07nM)

TK - Trk

Bioactivity
Kinase	DRx	RBC	Metz
TRKA	inactive (10001nM)	inactive (104.31%)	inactive (>3162.28nM)
TRKB	inactive (10001nM)	inactive (93.25%)	inactive (>3981.07nM)
TRKC	inactive (10001nM)	inactive (72.19%)	inactive (>3162.28nM)

TKL

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STKR	12	10	5	1
RIPK	5	4	1	-
RAF	5	2	3	1
MLK	10	8	5	2
IRAK	4	3	2	2
LISK	4	3	1	1
LRRK	2	1	1	1

TKL - STKR

Bioactivity
Kinase	DRx	RBC	Metz
ALK2	active (150nM)	inactive (208.31%)	active (199.53nM)
ALK4	inactive (10001nM)	inactive (107.3%)	-
ACTR2	inactive (10001nM)	-	-
ACTR2B	inactive (10001nM)	-	-
ALK1	active (470nM)	inactive (104.11%)	-
BMPR1A	inactive (10001nM)	-	-
BMPR1B	active (240nM)	-	-
BMPR2	inactive (10001nM)	-	-
TGFbR1	inactive (10001nM)	inactive (101.99%)	-
TGFbR2	inactive (10001nM)	inactive (101.94%)	-

TKL - RIPK

Bioactivity
Kinase	DRx	RBC	Metz
SgK288	inactive (10001nM)	-	-
RIPK1	inactive (10001nM)	-	-
RIPK2	active (4.6nM)	active (23.38%)	-
ANKRD3	active (620nM)	-	-

TKL - RAF

Bioactivity
Kinase	DRx	RBC	Metz
BRAF	inactive (10001nM)	inactive (94.79%)	-
RAF1	inactive (10001nM)	inactive (81.11%)	-
ARAF	-	inactive (83.98%)	-

TKL - MLK

Bioactivity
Kinase	DRx	RBC	Metz
DLK	inactive (10001nM)	-	-
LZK	inactive (10001nM)	-	-
MLK1	inactive (10001nM)	inactive (96.14%)	-
MLK2	inactive (10001nM)	inactive (101.87%)	-
MLK3	inactive (10001nM)	inactive (100.1%)	-
TAK1	inactive (10001nM)	inactive (93.89%)	-
HH498	active (2800nM)	-	-
ZAK	inactive (5100nM)	inactive (94.86%)	-

TKL - IRAK

Bioactivity
Kinase	DRx	RBC	Metz
IRAK1	active (1200nM)	inactive (87.69%)	-
IRAK3	inactive (10001nM)	-	-
IRAK4	active (75nM)	active (35.32%)	-

TKL - LISK

Bioactivity
Kinase	DRx	RBC	Metz
LIMK1	inactive (10001nM)	inactive (88.12%)	inactive (>3162.28nM)
LIMK2	inactive (10001nM)	-	-
TESK1	inactive (3700nM)	-	-

TKL - LRRK

Bioactivity
Kinase	DRx	RBC	Metz
LRRK2	inactive (10001nM)	inactive (113.04%)	inactive (1995.26nM)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
ABC1	5	2	-	-
PIKK	6	1	-	-
RIO	3	3	-	-
Alpha	6	1	-	1
PDHK	5	-	1	-

Atypical - ABC1

Bioactivity
Kinase	DRx	RBC	Metz
ADCK3	inactive (4500nM)	-	-
ADCK4	active (1700nM)	-	-

Atypical - PIKK

Bioactivity
Kinase	DRx	RBC	Metz
FRAP	inactive (10001nM)	-	-

Atypical - RIO

Bioactivity
Kinase	DRx	RBC	Metz
RIOK1	inactive (10001nM)	-	-
RIOK2	inactive (10001nM)	-	-
RIOK3	inactive (10001nM)	-	-

Atypical - Alpha

Bioactivity
Kinase	DRx	RBC	Metz
ChaK2	inactive (10001nM)	-	-
eEF2K	-	-	-

Atypical - PDHK

Bioactivity
Kinase	DRx	RBC	Metz
PDHK1	-	inactive (91.33%)	-

AGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
Akt	3	3	3	3
DMPK	7	7	5	3
GRK	7	3	6	1
NDR	4	4	1	-
MAST	5	1	-	-
PDK1	1	1	1	1
PKA	5	3	3	2
PKN	3	2	2	1
PKC	9	5	9	5
PKG	2	2	3	2
RSK	8	1	8	4
SGK	3	1	3	1
YANK	3	3	-	-

AGC - Akt

Bioactivity
Kinase	DRx	RBC	Metz
AKT1	inactive (10001nM)	inactive (94.7%)	-
AKT2	inactive (10001nM)	inactive (110.18%)	-
AKT3	inactive (10001nM)	inactive (100.37%)	-

AGC - DMPK

Bioactivity
Kinase	DRx	RBC	Metz
CRIK	active (1800nM)	-	-
DMPK1	inactive (10001nM)	inactive (94.57%)	-
DMPK2	active (2200nM)	-	-
MRCKa	active (2600nM)	inactive (83.73%)	-
MRCKb	active (2500nM)	inactive (98.03%)	-
ROCK1	inactive (10001nM)	inactive (99.36%)	inactive (>3981.07nM)
ROCK2	inactive (3600nM)	inactive (90.66%)	active (100nM)

AGC - GRK

Bioactivity
Kinase	DRx	RBC	Metz
RHOK	inactive (10001nM)	-	-
GPRK4	inactive (10001nM)	inactive (101.77%)	-
GPRK7	inactive (10001nM)	inactive (96.37%)	-
BARK1	-	inactive (92.2%)	-
BARK2	-	inactive (97.39%)	-
GPRK5	-	inactive (95.8%)	inactive (>3981.07nM)
GPRK6	-	inactive (104.15%)	-

AGC - NDR

Bioactivity
Kinase	DRx	RBC	Metz
LATS1	inactive (10001nM)	-	-
LATS2	inactive (10001nM)	-	-
NDR1	inactive (10001nM)	inactive (100.28%)	-
NDR2	inactive (10001nM)	-	-

AGC - MAST

Bioactivity
Kinase	DRx	RBC	Metz
MAST1	inactive (10001nM)	-	-

AGC - PDK1

Bioactivity
Kinase	DRx	RBC	Metz
PDK1	inactive (10001nM)	inactive (91.33%)	-

AGC - PKA

Bioactivity
Kinase	DRx	RBC	Metz
PKACa	inactive (10001nM)	inactive (92.81%)	inactive (>1258.93nM)
PKACb	inactive (10001nM)	-	-
PRKX	inactive (10001nM)	inactive (105.35%)	inactive (>3162.28nM)
PKACg	-	inactive (106.08%)	-

AGC - PKN

Bioactivity
Kinase	DRx	RBC	Metz
PKN1	inactive (10001nM)	inactive (103.2%)	-
PKN2	inactive (10001nM)	inactive (99.65%)	-

AGC - PKC

Bioactivity
Kinase	DRx	RBC	Metz
PKCd	inactive (10001nM)	inactive (102.51%)	-
PKCe	inactive (10001nM)	inactive (100.47%)	-
PKCh	inactive (10001nM)	inactive (116.79%)	-
PKCi	inactive (10001nM)	inactive (88.08%)	-
PKCt	inactive (10001nM)	inactive (100.48%)	inactive (>2511.89nM)
PKCa	-	inactive (97.06%)	-
PKCg	-	inactive (93.24%)	-
PKCz	-	inactive (97.77%)	-
PKCb	-	inactive (91.59%)	-

AGC - PKG

Bioactivity
Kinase	DRx	RBC	Metz
PKG1	inactive (10001nM)	inactive (96.57%)	-
PKG2	inactive (10001nM)	inactive (101.32%)	-

AGC - RSK

Bioactivity
Kinase	DRx	RBC	Metz
p70S6K	active (1600nM)	inactive (90.57%)	-
MSK1	-	inactive (100.65%)	-
MSK2	-	inactive (110.1%)	-
p70S6Kb	-	inactive (101.1%)	-
RSK2	-	inactive (97.81%)	inactive (>1995.26nM)
RSK4	-	inactive (99.31%)	-
RSK1	-	inactive (101.96%)	-
RSK3	-	inactive (85.89%)	-

AGC - SGK

Bioactivity
Kinase	DRx	RBC	Metz
SGK3	inactive (10001nM)	inactive (97.88%)	-
SGK1	-	inactive (115.43%)	-
SGK2	-	inactive (121.72%)	-

AGC - YANK

Bioactivity
Kinase	DRx	RBC	Metz
YANK1	inactive (5000nM)	-	-
YANK2	inactive (10001nM)	-	-
YANK3	inactive (10001nM)	-	-

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CAMKL	20	19	13	9
CAMK1	5	4	5	2
CAMK2	4	4	4	4
CASK	1	1	-	-
RAD53	1	1	1	1
DAPK	5	5	4	2
DCAMKL	3	3	1	1
MAPKAPK	5	4	5	4
MLCK	5	4	2	-
PHK	2	2	2	1
PIM	3	3	3	3
PKD	3	3	3	2
STK33	1	1	-	1
TSSK	5	1	2	2

CAMK - CAMKL

Bioactivity
Kinase	DRx	RBC	Metz
AMPKa1	active (3000nM)	-	inactive (>3162.28nM)
AMPKa2	inactive (10001nM)	-	-
NuaK1	inactive (10001nM)	inactive (92.7%)	-
BRSK1	inactive (10001nM)	inactive (97.14%)	-
BRSK2	inactive (10001nM)	inactive (103.5%)	-
CHK1	inactive (10001nM)	inactive (94.39%)	inactive (>3162.28nM)
HUNK	inactive (4100nM)	-	-
LKB1	inactive (10001nM)	inactive (104.74%)	-
MARK1	inactive (10001nM)	inactive (83.66%)	-
MARK2	inactive (10001nM)	inactive (107.42%)	-
MARK3	inactive (10001nM)	inactive (106.21%)	inactive (>5011.87nM)
MARK4	inactive (10001nM)	inactive (99.4%)	-
MELK	inactive (10001nM)	inactive (94.4%)	-
NIM1	inactive (10001nM)	-	-
QSK	inactive (3900nM)	-	-
SIK	active (1900nM)	-	-
QIK	active (430nM)	active (17.6%)	-
NuaK2	inactive (10001nM)	inactive (100.21%)	-
SNRK	inactive (10001nM)	-	-
PASK	-	inactive (102.49%)	-

CAMK - CAMK1

Bioactivity
Kinase	DRx	RBC	Metz
CaMK1a	inactive (10001nM)	inactive (81.63%)	-
CaMK1d	inactive (10001nM)	inactive (90.62%)	inactive (>2511.89nM)
CaMK1g	inactive (10001nM)	inactive (100.97%)	-
CaMK4	inactive (10001nM)	inactive (101.34%)	-
CaMK1b	-	inactive (99.51%)	-

CAMK - CAMK2

Bioactivity
Kinase	DRx	RBC	Metz
CaMK2a	inactive (10001nM)	inactive (99.83%)	inactive (>6309.57nM)
CaMK2b	inactive (10001nM)	inactive (98.17%)	-
CaMK2d	inactive (10001nM)	inactive (95.82%)	-
CaMK2g	inactive (10001nM)	inactive (112.31%)	-

CAMK - CASK

Bioactivity
Kinase	DRx	RBC	Metz
CASK	inactive (10001nM)	-	-

CAMK - RAD53

Bioactivity
Kinase	DRx	RBC	Metz
CHK2	inactive (10001nM)	inactive (62.07%)	-

CAMK - DAPK

Bioactivity
Kinase	DRx	RBC	Metz
DAPK1	inactive (10001nM)	inactive (104.58%)	-
DAPK2	inactive (10001nM)	inactive (93.3%)	-
DAPK3	inactive (10001nM)	inactive (90.33%)	inactive (>5011.87nM)
DRAK1	inactive (10001nM)	inactive (92.38%)	-
DRAK2	inactive (10001nM)	-	-

CAMK - DCAMKL

Bioactivity
Kinase	DRx	RBC	Metz
DCLK1	inactive (10001nM)	-	-
DCLK2	inactive (10001nM)	inactive (104.06%)	-
DCLK3	inactive (10001nM)	-	-

CAMK - MAPKAPK

Bioactivity
Kinase	DRx	RBC	Metz
MAPKAPK2	inactive (10001nM)	inactive (99.52%)	-
MAPKAPK5	inactive (10001nM)	inactive (94.75%)	-
MNK1	active (360nM)	active (49.32%)	-
MNK2	active (1700nM)	inactive (86.89%)	-
MAPKAPK3	-	inactive (98.48%)	-

CAMK - MLCK

Bioactivity
Kinase	DRx	RBC	Metz
caMLCK	inactive (10001nM)	-	-
smMLCK	inactive (10001nM)	inactive (94.24%)	-
skMLCK	inactive (10001nM)	inactive (97.14%)	-
SgK085	inactive (10001nM)	-	-

CAMK - PHK

Bioactivity
Kinase	DRx	RBC	Metz
PHKg1	active (1100nM)	inactive (55.47%)	-
PHKg2	inactive (7900nM)	inactive (99.08%)	-

CAMK - PIM

Bioactivity
Kinase	DRx	RBC	Metz
PIM1	inactive (10001nM)	inactive (94.97%)	inactive (>6309.57nM)
PIM2	inactive (10001nM)	inactive (99.4%)	-
PIM3	inactive (10001nM)	inactive (96.14%)	-

CAMK - PKD

Bioactivity
Kinase	DRx	RBC	Metz
PKD1	inactive (10001nM)	inactive (99.29%)	-
PKD2	inactive (10001nM)	inactive (92.03%)	-
PKD3	inactive (10001nM)	inactive (91.7%)	inactive (>3981.07nM)

CAMK - STK33

Bioactivity
Kinase	DRx	RBC	Metz
STK33	active (1400nM)	inactive (85.09%)	-

CAMK - TSSK

Bioactivity
Kinase	DRx	RBC	Metz
TSSK1	inactive (10001nM)	inactive (96.61%)	-
TSSK2	-	inactive (95.88%)	-

STE

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
STE11	8	8	3	-
STE20	31	27	23	9
STE7	7	7	3	2
STE-Unique	2	-	2	-

STE - STE11

Bioactivity
Kinase	DRx	RBC	Metz
MAP3K5	inactive (10001nM)	inactive (101.78%)	-
MAP3K6	inactive (10001nM)	-	-
MAP3K1	inactive (10001nM)	-	-
MAP3K7	inactive (10001nM)	-	-
MAP3K2	inactive (10001nM)	inactive (107.93%)	-
MAP3K3	inactive (10001nM)	inactive (102.02%)	-
MAP3K4	active (3000nM)	-	-
MAP3K8	active (980nM)	-	-

STE - STE20

Bioactivity
Kinase	DRx	RBC	Metz
HPK1	inactive (5500nM)	-	-
LOK	active (81nM)	active (21.32%)	-
GCK	active (1600nM)	inactive (103.37%)	inactive (>2511.89nM)
KHS2	active (1500nM)	-	-
HGK	active (1400nM)	inactive (79.77%)	active (158.49nM)
KHS1	active (450nM)	active (37.13%)	active (316.23nM)
MINK	inactive (3400nM)	inactive (81.47%)	-
MST1	inactive (10001nM)	inactive (102.63%)	-
MST2	inactive (10001nM)	inactive (97.51%)	-
MST3	inactive (10001nM)	inactive (103.74%)	-
MST4	inactive (10001nM)	inactive (102.34%)	-
MYO3A	inactive (10001nM)	-	-
MYO3B	inactive (10001nM)	inactive (84.19%)	-
OSR1	inactive (10001nM)	inactive (100.44%)	-
PAK1	inactive (10001nM)	inactive (107.9%)	-
PAK2	inactive (10001nM)	inactive (102.95%)	-
PAK3	inactive (10001nM)	inactive (102.81%)	-
PAK4	inactive (10001nM)	inactive (90.21%)	inactive (>5011.87nM)
PAK6	inactive (10001nM)	inactive (105.14%)	-
PAK5	inactive (10001nM)	inactive (93.52%)	-
SLK	active (95nM)	inactive (73.86%)	-
STLK3	inactive (10001nM)	inactive (97.35%)	-
TAO1	inactive (10001nM)	inactive (103.44%)	inactive (>6309.57nM)
TAO2	inactive (10001nM)	inactive (103.7%)	-
TAO3	inactive (10001nM)	inactive (98.39%)	-
TNIK	active (2300nM)	-	-
YSK1	inactive (10001nM)	inactive (99.01%)	-

STE - STE7

Bioactivity
Kinase	DRx	RBC	Metz
MAP2K1	active (1800nM)	inactive (104.81%)	active (1000nM)
MAP2K2	active (1100nM)	inactive (97.66%)	inactive (1584.89nM)
MAP2K3	inactive (10001nM)	-	-
MAP2K4	inactive (10001nM)	-	-
MAP2K5	active (49nM)	-	-
MAP2K6	inactive (10001nM)	inactive (96.21%)	-
MAP2K7	inactive (10001nM)	-	-

STE - STE-Unique

Bioactivity
Kinase	DRx	RBC	Metz
COT	-	inactive (97.26%)	-
NIK	-	inactive (155.4%)	-

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CDK	20	8	-	7
CDKL	5	4	-	-
CLK	4	4	4	2
CK2	3	2	2	1
DYRK	10	8	9	6
MAPK	14	14	10	8
GSK	2	2	2	2
RCK	3	2	-	-
SRPK	3	3	3	1

CMGC - CDK

Bioactivity
Kinase	DRx	RBC	Metz
PITSLRE	inactive (10001nM)	-	-
CHED	inactive (10001nM)	-	-
CDK11	inactive (10001nM)	-	-
PCTAIRE1	inactive (10001nM)	-	-
PCTAIRE2	inactive (10001nM)	-	-
PCTAIRE3	inactive (10001nM)	-	-
PFTAIRE2	inactive (10001nM)	-	-
PFTAIRE1	inactive (10001nM)	-	-
CDC2	-	-	-
CDK2	-	-	-
CDK5	-	-	inactive (>3162.28nM)
CDK8	-	-	inactive (>3981.07nM)
CDK7	-	-	inactive (>3981.07nM)
CDK9	-	-	inactive (>1584.89nM)

CMGC - CDKL

Bioactivity
Kinase	DRx	RBC	Metz
CDKL1	inactive (10001nM)	-	-
CDKL2	inactive (10001nM)	-	-
CDKL3	inactive (10001nM)	-	-
CDKL5	inactive (10001nM)	-	-

CMGC - CLK

Bioactivity
Kinase	DRx	RBC	Metz
CLK1	inactive (10001nM)	inactive (105.47%)	-
CLK2	inactive (10001nM)	inactive (89.66%)	inactive (>1995.26nM)
CLK3	inactive (10001nM)	inactive (100.42%)	-
CLK4	inactive (10001nM)	inactive (84.31%)	inactive (>1258.93nM)

CMGC - CK2

Bioactivity
Kinase	DRx	RBC	Metz
CK2a1	inactive (10001nM)	inactive (111.51%)	-
CK2a2	inactive (10001nM)	inactive (96.48%)	-

CMGC - DYRK

Bioactivity
Kinase	DRx	RBC	Metz
DYRK1A	inactive (10001nM)	inactive (105.79%)	inactive (>1000nM)
DYRK1B	inactive (10001nM)	inactive (92.95%)	inactive (>1258.93nM)
DYRK2	inactive (10001nM)	inactive (97.21%)	-
HIPK1	inactive (10001nM)	inactive (96.65%)	-
HIPK2	inactive (10001nM)	inactive (99.42%)	-
HIPK3	inactive (10001nM)	inactive (99.47%)	-
HIPK4	inactive (10001nM)	inactive (100.34%)	-
PRP4	inactive (10001nM)	-	-
DYRK3	-	inactive (96.03%)	-
DYRK4	-	inactive (101.52%)	-

CMGC - MAPK

Bioactivity
Kinase	DRx	RBC	Metz
Erk1	inactive (10001nM)	inactive (102.28%)	-
Erk2	inactive (10001nM)	inactive (99.14%)	-
Erk3	active (1500nM)	-	-
Erk4	inactive (10001nM)	-	-
Erk5	inactive (10001nM)	-	-
Erk7	inactive (10001nM)	-	-
JNK1	inactive (10001nM)	inactive (93.66%)	inactive (>5011.87nM)
JNK2	inactive (10001nM)	inactive (96.41%)	inactive (>3981.07nM)
JNK3	inactive (10001nM)	inactive (96.89%)	-
NLK	inactive (10001nM)	inactive (96.21%)	-
p38a	inactive (10001nM)	inactive (91.76%)	inactive (2511.89nM)
p38b	inactive (10001nM)	inactive (97.12%)	-
p38d	inactive (10001nM)	inactive (95.54%)	-
p38g	inactive (10001nM)	inactive (92.65%)	-

CMGC - GSK

Bioactivity
Kinase	DRx	RBC	Metz
GSK3A	inactive (10001nM)	inactive (102.83%)	inactive (>2511.89nM)
GSK3B	inactive (10001nM)	inactive (101.41%)	inactive (>1995.26nM)

CMGC - RCK

Bioactivity
Kinase	DRx	RBC	Metz
ICK	inactive (10001nM)	-	-
MAK	inactive (10001nM)	-	-

CMGC - SRPK

Bioactivity
Kinase	DRx	RBC	Metz
SRPK1	inactive (10001nM)	inactive (97.88%)	-
SRPK2	inactive (10001nM)	inactive (105.62%)	-
MSSK1	inactive (10001nM)	inactive (101.67%)	-

CK1

Test Member No. in Family
Family	no. Member on 518kinase	DRx	RBC	Metz
CK1	7	7	6	5
VRK	3	1	1	-

CK1 - CK1

Bioactivity
Kinase	DRx	RBC	Metz
CK1a	inactive (10001nM)	inactive (101.98%)	inactive (>3981.07nM)
CK1a2	inactive (10001nM)	-	-
CK1d	inactive (10001nM)	inactive (94.4%)	-
CK1e	active (3000nM)	inactive (91.47%)	-
CK1g1	inactive (10001nM)	inactive (100.49%)	-
CK1g2	inactive (10001nM)	inactive (98.45%)	-
CK1g3	inactive (10001nM)	inactive (98.11%)	-

CK1 - VRK

Bioactivity
Kinase	DRx	RBC	Metz
VRK2	inactive (10001nM)	-	-
VRK1	-	inactive (98.92%)	-