Compound Information


Test on : DRx, RBC, Metz

Compound Name
DRx : (3S,4R)-Tofacitinib
RBC : (3R,4S)-Tofacitinib
Metz : racemic-Tasocitinib

Inchikey
Same : UJLAWZDWDVHWOW-N
DRx : UJLAWZDWDVHWOW-DGCLKSJQSA-N
RBC : UJLAWZDWDVHWOW-AAEUAGOBSA-N
Metz : UJLAWZDWDVHWOW-UHFFFAOYSA-N

ChemSpider
DRx : 8142130
RBC : 24691638
Metz : 7993981

Pubchem CID
DRx : 9966538
RBC : 25180101
Metz : 9818231

ChEMBL
DRx : CHEMBL459977
RBC : CHEMBL457871
Metz : CHEMBL234085



DRxRBCMetz

DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

Other


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
441-
3332
2221
42--
21--
4444
11982
3311
4433
111-
32--
21--
543-
221-
111-
1-1-
1-11
4-2-
1--1
Other - NAK

Bioactivity
KinaseDRxRBCMetz
AAK1inactive (10001nM)--
BIKEinactive (7100nM)--
GAKinactive (10001nM)--
MPSK1inactive (10001nM)inactive (94.69%)-
Other - Aur

Bioactivity
KinaseDRxRBCMetz
AurAinactive (10001nM)inactive (84.13%)inactive (>1584.89nM)
AurBinactive (10001nM)inactive (99.25%)inactive (>3981.07nM)
AurCinactive (10001nM)inactive (85.31%)-
Other - CAMKK

Bioactivity
KinaseDRxRBCMetz
CaMKK1inactive (10001nM)inactive (100.53%)-
CaMKK2inactive (10001nM)inactive (97.66%)inactive (>2511.89nM)
Other - PEK

Bioactivity
KinaseDRxRBCMetz
HRIinactive (10001nM)--
PKRinactive (10001nM)--
Other - IRE

Bioactivity
KinaseDRxRBCMetz
IRE1inactive (10001nM)--
Other - IKK

Bioactivity
KinaseDRxRBCMetz
IKKainactive (10001nM)inactive (94.96%)-
IKKbinactive (10001nM)inactive (88.18%)-
IKKeinactive (10001nM)inactive (94.77%)inactive (>3162.28nM)
TBK1inactive (10001nM)inactive (92.53%)inactive (>3162.28nM)
Other - NEK

Bioactivity
KinaseDRxRBCMetz
NEK1inactive (10001nM)inactive (84.64%)-
NEK11inactive (10001nM)inactive (91.69%)-
NEK2inactive (10001nM)inactive (103.32%)inactive (>3981.07nM)
NEK3inactive (10001nM)inactive (94.48%)-
NEK4inactive (10001nM)inactive (96.04%)inactive (>6309.57nM)
NEK5inactive (10001nM)--
NEK6inactive (10001nM)inactive (83.19%)-
NEK7inactive (10001nM)inactive (93.99%)-
NEK9inactive (10001nM)inactive (96.2%)-
Other - WEE

Bioactivity
KinaseDRxRBCMetz
MYT1inactive (10001nM)--
Wee1inactive (10001nM)inactive (97.72%)-
Wee1Binactive (10001nM)--
Other - PLK

Bioactivity
KinaseDRxRBCMetz
PLK1inactive (10001nM)inactive (100.93%)inactive (>7943.28nM)
PLK2inactive (10001nM)inactive (102.27%)-
PLK3inactive (10001nM)inactive (99.08%)inactive (>7943.28nM)
PLK4inactive (10001nM)-inactive (>3981.07nM)
Other - SgK496

Bioactivity
KinaseDRxRBCMetz
SgK496inactive (10001nM)inactive (98.41%)-
Other - NKF1

Bioactivity
KinaseDRxRBCMetz
SBKinactive (10001nM)--
SgK110inactive (10001nM)--
Other - NKF4

Bioactivity
KinaseDRxRBCMetz
CLIK1inactive (10001nM)--
Other - ULK

Bioactivity
KinaseDRxRBCMetz
Fusedinactive (10001nM)--
ULK1inactive (10001nM)inactive (83.05%)-
ULK2inactive (10001nM)inactive (92.04%)-
ULK3inactive (6400nM)inactive (101.31%)-
Other - TLK

Bioactivity
KinaseDRxRBCMetz
TLK1inactive (10001nM)--
TLK2inactive (10001nM)inactive (94.41%)-
Other - TTK

Bioactivity
KinaseDRxRBCMetz
TTKinactive (10001nM)inactive (107.75%)-
Other - Haspin

Bioactivity
KinaseDRxRBCMetz
Haspin-inactive (77.94%)-
Other - TOPK

Bioactivity
KinaseDRxRBCMetz
PBK-inactive (101.6%)inactive (>7943.28nM)
Other - WNK

Bioactivity
KinaseDRxRBCMetz
Wnk2-inactive (100.52%)-
Wnk3-inactive (103.88%)-
Other - CDC7

Bioactivity
KinaseDRxRBCMetz
CDC7--inactive (>1258.93nM)

TK


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
2221
2222
3332
1111119
5553
5555
2221
221-
4433
1413121
2222
2222
4442
3333
3332
4443
2222
111-
1111
1111
2221
221-
2211
3333
TK - Abl

Bioactivity
KinaseDRxRBCMetz
ABL1inactive (10001nM)inactive (100.92%)inactive (>3981.07nM)
ABL2inactive (10001nM)inactive (90.51%)-
TK - ALK

Bioactivity
KinaseDRxRBCMetz
ALKinactive (10001nM)inactive (106.54%)inactive (>6309.57nM)
LTKinactive (10001nM)inactive (96.02%)inactive (>1000nM)
TK - Axl

Bioactivity
KinaseDRxRBCMetz
AXLinactive (10001nM)inactive (97.7%)inactive (>1995.26nM)
MERinactive (10001nM)inactive (113.67%)-
TYRO3inactive (10001nM)inactive (102.8%)inactive (>3162.28nM)
TK - Src

Bioactivity
KinaseDRxRBCMetz
BLKinactive (10001nM)inactive (92.53%)inactive (>1584.89nM)
BRKinactive (10001nM)inactive (100.89%)inactive (>2511.89nM)
FGRinactive (10001nM)inactive (91.09%)-
FRKinactive (10001nM)inactive (105.98%)inactive (>2511.89nM)
FYNactive (1100nM)inactive (93.96%)inactive (>5011.87nM)
HCKinactive (10001nM)inactive (88.3%)inactive (>3162.28nM)
LCKactive (460nM)inactive (80.24%)inactive (>6309.57nM)
LYNinactive (10001nM)inactive (96.35%)inactive (>1584.89nM)
SRCinactive (10001nM)inactive (99.77%)inactive (>1995.26nM)
SRMinactive (10001nM)inactive (95.82%)inactive (>1584.89nM)
YESinactive (10001nM)inactive (87.06%)-
TK - Tec

Bioactivity
KinaseDRxRBCMetz
BMXinactive (10001nM)inactive (110.76%)-
BTKinactive (10001nM)inactive (98.72%)inactive (>6309.57nM)
ITKinactive (10001nM)inactive (99.14%)inactive (>5011.87nM)
TECinactive (10001nM)inactive (95.44%)-
TXKinactive (10001nM)inactive (98.42%)-
TK - PDGFR

Bioactivity
KinaseDRxRBCMetz
FMSinactive (10001nM)inactive (100.56%)inactive (>2511.89nM)
FLT3inactive (10001nM)inactive (77.86%)inactive (>1995.26nM)
KITinactive (10001nM)inactive (98.86%)inactive (>5011.87nM)
PDGFRainactive (10001nM)inactive (104.11%)inactive (>3162.28nM)
PDGFRbinactive (10001nM)inactive (95.1%)inactive (>1995.26nM)
TK - Csk

Bioactivity
KinaseDRxRBCMetz
CSKinactive (10001nM)inactive (100.63%)-
CTKinactive (10001nM)inactive (66.89%)inactive (>1995.26nM)
TK - DDR

Bioactivity
KinaseDRxRBCMetz
DDR1inactive (10001nM)--
DDR2inactive (10001nM)inactive (104.4%)-
TK - EGFR

Bioactivity
KinaseDRxRBCMetz
EGFRinactive (10001nM)inactive (95.96%)inactive (>1995.26nM)
ErbB2inactive (10001nM)inactive (108.75%)inactive (>1584.89nM)
ErbB3inactive (10001nM)--
ErbB4inactive (10001nM)inactive (100.25%)inactive (>3981.07nM)
TK - Eph

Bioactivity
KinaseDRxRBCMetz
EphA1inactive (10001nM)inactive (97.97%)-
EphA2inactive (10001nM)inactive (95.75%)inactive (>3162.28nM)
EphA3inactive (10001nM)inactive (94.09%)-
EphA4inactive (10001nM)inactive (99.06%)-
EphA5inactive (10001nM)inactive (99.94%)-
EphA6inactive (10001nM)inactive (98.98%)-
EphA7inactive (10001nM)inactive (89.04%)-
EphA8inactive (10001nM)inactive (108.81%)-
EphB1inactive (10001nM)inactive (105.59%)-
EphB2inactive (10001nM)inactive (100.21%)-
EphB3inactive (10001nM)inactive (54.86%)-
EphB4inactive (10001nM)inactive (89.83%)-
EphB6inactive (10001nM)--
TK - FAK

Bioactivity
KinaseDRxRBCMetz
FAKinactive (10001nM)inactive (103.35%)inactive (>6309.57nM)
PYK2inactive (10001nM)inactive (100.12%)inactive (>1584.89nM)
TK - Fer

Bioactivity
KinaseDRxRBCMetz
FERinactive (10001nM)inactive (104.16%)inactive (>1584.89nM)
FESinactive (10001nM)inactive (103.64%)inactive (>1995.26nM)
TK - FGFR

Bioactivity
KinaseDRxRBCMetz
FGFR1inactive (10001nM)inactive (101.08%)inactive (>3981.07nM)
FGFR2inactive (10001nM)inactive (91.68%)-
FGFR3inactive (10001nM)inactive (95.27%)inactive (>1995.26nM)
FGFR4inactive (10001nM)inactive (94.28%)-
TK - VEGFR

Bioactivity
KinaseDRxRBCMetz
FLT1inactive (10001nM)inactive (100.56%)inactive (>3981.07nM)
FLT4inactive (10001nM)inactive (97.52%)inactive (>6309.57nM)
KDRinactive (10001nM)inactive (105.92%)inactive (>1000nM)
TK - InsR

Bioactivity
KinaseDRxRBCMetz
IGF1Rinactive (10001nM)inactive (93.1%)inactive (>2511.89nM)
INSRinactive (10001nM)inactive (101.25%)inactive (>5011.87nM)
IRRinactive (10001nM)inactive (97.47%)-
TK - JakA

Bioactivity
KinaseDRxRBCMetz
JAK1active (1.6nM)active (2.3%)-
JAK2active (0.58nM)active (5.14%)active (3.98nM)
JAK3active (0.16nM)active (1.93%)active (5.01nM)
TYK2active (4.8nM)active (12.04%)active (50.12nM)
TK - Met

Bioactivity
KinaseDRxRBCMetz
METinactive (10001nM)inactive (86.66%)inactive (>2511.89nM)
RONinactive (10001nM)inactive (102%)inactive (>3981.07nM)
TK - Musk

Bioactivity
KinaseDRxRBCMetz
MUSKinactive (10001nM)inactive (103.43%)-
TK - Ret

Bioactivity
KinaseDRxRBCMetz
RETinactive (10001nM)inactive (92.43%)inactive (>3981.07nM)
TK - Sev

Bioactivity
KinaseDRxRBCMetz
ROSinactive (10001nM)inactive (94.09%)inactive (>3162.28nM)
TK - Syk

Bioactivity
KinaseDRxRBCMetz
SYKinactive (10001nM)inactive (107.39%)inactive (>1584.89nM)
ZAP70inactive (10001nM)inactive (104.83%)-
TK - Tie

Bioactivity
KinaseDRxRBCMetz
TIE1inactive (10001nM)--
TIE2inactive (10001nM)inactive (96.58%)-
TK - Ack

Bioactivity
KinaseDRxRBCMetz
TNK1active (120nM)--
ACKinactive (10001nM)inactive (87.07%)inactive (>3981.07nM)
TK - Trk

Bioactivity
KinaseDRxRBCMetz
TRKAinactive (10001nM)inactive (94.13%)inactive (>3162.28nM)
TRKBinactive (10001nM)inactive (97.08%)inactive (>3981.07nM)
TRKCinactive (10001nM)inactive (90.04%)inactive (>3162.28nM)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
121051
541-
5231
10852
4322
4311
2111
TKL - STKR

Bioactivity
KinaseDRxRBCMetz
ALK2inactive (10001nM)inactive (104.12%)inactive (>3981.07nM)
ALK4inactive (10001nM)inactive (99.76%)-
ACTR2inactive (10001nM)--
ACTR2Binactive (10001nM)--
ALK1inactive (10001nM)inactive (100.43%)-
BMPR1Ainactive (10001nM)--
BMPR1Binactive (10001nM)--
BMPR2inactive (10001nM)--
TGFbR1inactive (10001nM)inactive (98.83%)-
TGFbR2inactive (10001nM)inactive (98.76%)-
TKL - RIPK

Bioactivity
KinaseDRxRBCMetz
SgK288inactive (10001nM)--
RIPK1inactive (10001nM)--
RIPK2inactive (10001nM)inactive (112.68%)-
ANKRD3inactive (10001nM)--
TKL - RAF

Bioactivity
KinaseDRxRBCMetz
BRAFinactive (10001nM)inactive (93.69%)-
RAF1inactive (10001nM)inactive (95.46%)-
ARAF-inactive (102.24%)-
TKL - MLK

Bioactivity
KinaseDRxRBCMetz
DLKinactive (10001nM)--
LZKinactive (10001nM)--
MLK1inactive (10001nM)inactive (113.25%)-
MLK2inactive (10001nM)inactive (105.13%)inactive (>3162.28nM)
MLK3inactive (10001nM)inactive (104.31%)-
TAK1inactive (10001nM)inactive (87.46%)-
HH498inactive (10001nM)--
ZAKinactive (10001nM)inactive (98.18%)inactive (>7943.28nM)
TKL - IRAK

Bioactivity
KinaseDRxRBCMetz
IRAK1inactive (10001nM)inactive (93.93%)inactive (>7943.28nM)
IRAK3inactive (10001nM)--
IRAK4inactive (10001nM)inactive (88.48%)inactive (>10000nM)
TKL - LISK

Bioactivity
KinaseDRxRBCMetz
LIMK1inactive (10001nM)inactive (81.96%)inactive (>3162.28nM)
LIMK2inactive (10001nM)--
TESK1inactive (10001nM)--
TKL - LRRK

Bioactivity
KinaseDRxRBCMetz
LRRK2active (1300nM)inactive (51.35%)active (199.53nM)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
52--
61--
33--
61-1
5-1-
Atypical - ABC1

Bioactivity
KinaseDRxRBCMetz
ADCK3inactive (10001nM)--
ADCK4inactive (10001nM)--
Atypical - PIKK

Bioactivity
KinaseDRxRBCMetz
FRAPinactive (10001nM)--
Atypical - RIO

Bioactivity
KinaseDRxRBCMetz
RIOK1inactive (10001nM)--
RIOK2inactive (10001nM)--
RIOK3inactive (10001nM)--
Atypical - Alpha

Bioactivity
KinaseDRxRBCMetz
ChaK2inactive (10001nM)--
eEF2K--inactive (>3981.07nM)
Atypical - PDHK

Bioactivity
KinaseDRxRBCMetz
PDHK1-inactive (94.07%)-

AGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
3333
7753
7361
441-
51--
1111
5332
3221
9595
2232
8184
3131
33--
AGC - Akt

Bioactivity
KinaseDRxRBCMetz
AKT1inactive (10001nM)inactive (90.27%)inactive (>7943.28nM)
AKT2inactive (10001nM)inactive (98.03%)inactive (>7943.28nM)
AKT3inactive (10001nM)inactive (85.83%)inactive (>7943.28nM)
AGC - DMPK

Bioactivity
KinaseDRxRBCMetz
CRIKinactive (10001nM)--
DMPK1active (1200nM)inactive (108.48%)-
DMPK2inactive (10001nM)--
MRCKainactive (10001nM)inactive (110.03%)inactive (>10000nM)
MRCKbinactive (10001nM)inactive (95.41%)-
ROCK1active (470nM)inactive (90.13%)active (251.19nM)
ROCK2active (420nM)inactive (69.86%)active (398.11nM)
AGC - GRK

Bioactivity
KinaseDRxRBCMetz
RHOKinactive (10001nM)--
GPRK4inactive (10001nM)inactive (93.47%)-
GPRK7inactive (4300nM)inactive (101.65%)-
BARK1-inactive (95.26%)-
BARK2-inactive (99.23%)-
GPRK5-inactive (107.02%)inactive (>3981.07nM)
GPRK6-inactive (100.81%)-
AGC - NDR

Bioactivity
KinaseDRxRBCMetz
LATS1inactive (10001nM)--
LATS2inactive (10001nM)--
NDR1inactive (10001nM)inactive (95.68%)-
NDR2inactive (10001nM)--
AGC - MAST

Bioactivity
KinaseDRxRBCMetz
MAST1inactive (10001nM)--
AGC - PDK1

Bioactivity
KinaseDRxRBCMetz
PDK1inactive (10001nM)inactive (94.07%)inactive (>3981.07nM)
AGC - PKA

Bioactivity
KinaseDRxRBCMetz
PKACainactive (10001nM)inactive (96.54%)inactive (>3162.28nM)
PKACbinactive (10001nM)--
PRKXinactive (10001nM)inactive (109.77%)inactive (>3162.28nM)
PKACg-inactive (110.73%)-
AGC - PKN

Bioactivity
KinaseDRxRBCMetz
PKN1active (170nM)active (16.5%)-
PKN2active (1200nM)inactive (85.55%)active (251.19nM)
AGC - PKC

Bioactivity
KinaseDRxRBCMetz
PKCdactive (2000nM)inactive (75.29%)inactive (6309.57nM)
PKCeinactive (10001nM)inactive (98.51%)-
PKChinactive (10001nM)inactive (100.23%)-
PKCiinactive (10001nM)inactive (103.42%)inactive (>5011.87nM)
PKCtinactive (10001nM)inactive (89.03%)inactive (>1995.26nM)
PKCa-inactive (78.73%)-
PKCg-inactive (90.56%)inactive (3981.07nM)
PKCz-inactive (91.72%)inactive (>7943.28nM)
PKCb-inactive (88.11%)-
AGC - PKG

Bioactivity
KinaseDRxRBCMetz
PKG1inactive (10001nM)inactive (82.05%)inactive (>1995.26nM)
PKG2inactive (10001nM)inactive (106.03%)inactive (>1584.89nM)
AGC - RSK

Bioactivity
KinaseDRxRBCMetz
p70S6Kinactive (10001nM)inactive (102.86%)inactive (>3981.07nM)
MSK1-inactive (94.83%)inactive (>1995.26nM)
MSK2-inactive (104.64%)-
p70S6Kb-inactive (100.47%)-
RSK2-inactive (96.99%)inactive (>3981.07nM)
RSK4-inactive (98.15%)-
RSK1-inactive (90.91%)-
RSK3-inactive (89.66%)-
AGC - SGK

Bioactivity
KinaseDRxRBCMetz
SGK3inactive (10001nM)inactive (98.06%)-
SGK1-inactive (122.84%)inactive (>6309.57nM)
SGK2-inactive (103.65%)-
AGC - YANK

Bioactivity
KinaseDRxRBCMetz
YANK1inactive (10001nM)--
YANK2inactive (10001nM)--
YANK3inactive (10001nM)--

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
2019139
5452
4444
11--
1111
5542
3311
5454
542-
2221
3333
3332
11-1
5122
CAMK - CAMKL

Bioactivity
KinaseDRxRBCMetz
AMPKa1inactive (10001nM)-inactive (>3162.28nM)
AMPKa2inactive (10001nM)--
NuaK1inactive (10001nM)inactive (71.18%)-
BRSK1inactive (10001nM)inactive (101.71%)inactive (>10000nM)
BRSK2inactive (10001nM)inactive (86.94%)-
CHK1inactive (10001nM)inactive (94.12%)inactive (>3981.07nM)
HUNKinactive (10001nM)--
LKB1inactive (10001nM)inactive (103.67%)-
MARK1inactive (10001nM)inactive (118.55%)-
MARK2inactive (10001nM)inactive (91.83%)active (630.96nM)
MARK3inactive (10001nM)inactive (78.64%)active (630.96nM)
MARK4inactive (10001nM)inactive (81.68%)active (630.96nM)
MELKinactive (10001nM)inactive (79.44%)inactive (>630.96nM)
NIM1inactive (10001nM)--
QSKinactive (10001nM)--
SIKinactive (10001nM)--
QIKinactive (10001nM)inactive (89.23%)inactive (1258.93nM)
NuaK2active (240nM)inactive (80.25%)-
SNRKinactive (10001nM)--
PASK-inactive (105.23%)-
CAMK - CAMK1

Bioactivity
KinaseDRxRBCMetz
CaMK1aactive (1200nM)inactive (99.27%)inactive (>7943.28nM)
CaMK1dactive (1600nM)inactive (111.35%)inactive (>1584.89nM)
CaMK1ginactive (10001nM)inactive (97.81%)-
CaMK4inactive (10001nM)inactive (96.25%)-
CaMK1b-inactive (104.03%)-
CAMK - CAMK2

Bioactivity
KinaseDRxRBCMetz
CaMK2ainactive (3500nM)inactive (99.64%)inactive (>3981.07nM)
CaMK2binactive (10001nM)inactive (96.61%)inactive (>7943.28nM)
CaMK2dactive (2700nM)inactive (98.17%)inactive (1258.93nM)
CaMK2ginactive (10001nM)inactive (126.64%)inactive (>3981.07nM)
CAMK - CASK

Bioactivity
KinaseDRxRBCMetz
CASKinactive (10001nM)--
CAMK - RAD53

Bioactivity
KinaseDRxRBCMetz
CHK2inactive (10001nM)inactive (104%)inactive (>1584.89nM)
CAMK - DAPK

Bioactivity
KinaseDRxRBCMetz
DAPK1inactive (10001nM)inactive (108.52%)-
DAPK2inactive (10001nM)inactive (89.5%)-
DAPK3inactive (10001nM)inactive (105.7%)inactive (>5011.87nM)
DRAK1inactive (10001nM)inactive (105.93%)inactive (>3981.07nM)
DRAK2inactive (10001nM)--
CAMK - DCAMKL

Bioactivity
KinaseDRxRBCMetz
DCLK1inactive (6700nM)-inactive (>10000nM)
DCLK2inactive (10001nM)inactive (96.63%)-
DCLK3active (12nM)--
CAMK - MAPKAPK

Bioactivity
KinaseDRxRBCMetz
MAPKAPK2inactive (10001nM)inactive (96.63%)inactive (>7943.28nM)
MAPKAPK5inactive (10001nM)inactive (97.32%)inactive (>1584.89nM)
MNK1inactive (10001nM)inactive (89.94%)-
MNK2active (1600nM)inactive (97.38%)inactive (>10000nM)
MAPKAPK3-inactive (100.22%)inactive (>10000nM)
CAMK - MLCK

Bioactivity
KinaseDRxRBCMetz
caMLCKinactive (10001nM)--
smMLCKinactive (10001nM)inactive (89.95%)-
skMLCKinactive (10001nM)inactive (98.97%)-
SgK085inactive (10001nM)--
CAMK - PHK

Bioactivity
KinaseDRxRBCMetz
PHKg1inactive (10001nM)inactive (90%)-
PHKg2inactive (10001nM)inactive (98.64%)inactive (>5011.87nM)
CAMK - PIM

Bioactivity
KinaseDRxRBCMetz
PIM1inactive (10001nM)inactive (101.99%)inactive (>6309.57nM)
PIM2inactive (10001nM)inactive (115.85%)inactive (>1584.89nM)
PIM3inactive (10001nM)inactive (96.47%)inactive (>7943.28nM)
CAMK - PKD

Bioactivity
KinaseDRxRBCMetz
PKD1inactive (10001nM)inactive (97.32%)-
PKD2inactive (10001nM)inactive (92.61%)inactive (>10000nM)
PKD3inactive (10001nM)inactive (89.78%)inactive (>3981.07nM)
CAMK - STK33

Bioactivity
KinaseDRxRBCMetz
STK33inactive (10001nM)inactive (97.78%)-
CAMK - TSSK

Bioactivity
KinaseDRxRBCMetz
TSSK1inactive (10001nM)inactive (85.05%)inactive (>1584.89nM)
TSSK2-inactive (87.91%)inactive (>1584.89nM)

STE


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
883-
3127239
7732
2-2-
STE - STE11

Bioactivity
KinaseDRxRBCMetz
MAP3K5inactive (10001nM)inactive (97.83%)-
MAP3K6inactive (10001nM)--
MAP3K1inactive (10001nM)--
MAP3K7inactive (10001nM)--
MAP3K2inactive (10001nM)inactive (122.78%)-
MAP3K3inactive (10001nM)inactive (114.8%)-
MAP3K4inactive (10001nM)--
MAP3K8inactive (10001nM)--
STE - STE20

Bioactivity
KinaseDRxRBCMetz
HPK1inactive (10001nM)--
LOKinactive (10001nM)inactive (92.9%)-
GCKinactive (4800nM)inactive (101.97%)inactive (>3162.28nM)
KHS2inactive (10001nM)--
HGKinactive (10001nM)inactive (101.16%)inactive (>5011.87nM)
KHS1inactive (10001nM)inactive (112.09%)inactive (>7943.28nM)
MINKinactive (10001nM)inactive (100.25%)inactive (>7943.28nM)
MST1inactive (10001nM)inactive (95.49%)-
MST2inactive (10001nM)inactive (85.77%)inactive (>3162.28nM)
MST3inactive (10001nM)inactive (96.15%)-
MST4inactive (10001nM)inactive (104.52%)-
MYO3Ainactive (10001nM)--
MYO3Binactive (10001nM)inactive (89.31%)-
OSR1inactive (10001nM)inactive (98.25%)-
PAK1inactive (10001nM)inactive (108.21%)inactive (>10000nM)
PAK2inactive (10001nM)inactive (111.02%)-
PAK3inactive (10001nM)inactive (105.36%)-
PAK4inactive (10001nM)inactive (99.17%)inactive (>5011.87nM)
PAK6inactive (10001nM)inactive (102.39%)-
PAK5inactive (10001nM)inactive (93.64%)-
SLKinactive (10001nM)inactive (89.23%)inactive (5011.87nM)
STLK3inactive (10001nM)inactive (95.14%)-
TAO1inactive (10001nM)inactive (99.93%)inactive (>6309.57nM)
TAO2inactive (10001nM)inactive (100.09%)-
TAO3inactive (10001nM)inactive (94.87%)-
TNIKinactive (10001nM)--
YSK1inactive (10001nM)inactive (97.18%)-
STE - STE7

Bioactivity
KinaseDRxRBCMetz
MAP2K1inactive (10001nM)inactive (111.98%)inactive (>3162.28nM)
MAP2K2inactive (10001nM)inactive (117.38%)inactive (>3981.07nM)
MAP2K3inactive (10001nM)--
MAP2K4inactive (10001nM)--
MAP2K5inactive (10001nM)--
MAP2K6inactive (10001nM)inactive (99.42%)-
MAP2K7inactive (10001nM)--
STE - STE-Unique

Bioactivity
KinaseDRxRBCMetz
COT-inactive (93.5%)-
NIK-inactive (106.82%)-

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
208-7
54--
4442
3221
10896
1414108
2222
32--
3331
CMGC - CDK

Bioactivity
KinaseDRxRBCMetz
PITSLREinactive (10001nM)--
CHEDinactive (10001nM)--
CDK11inactive (10001nM)--
PCTAIRE1inactive (10001nM)--
PCTAIRE2inactive (10001nM)--
PCTAIRE3inactive (10001nM)--
PFTAIRE2inactive (10001nM)--
PFTAIRE1inactive (10001nM)--
CDC2--inactive (>7943.28nM)
CDK2--inactive (>7943.28nM)
CDK5--inactive (>3981.07nM)
CDK8--inactive (1584.89nM)
CDK7--inactive (>3981.07nM)
CDK9--inactive (>1584.89nM)
CMGC - CDKL

Bioactivity
KinaseDRxRBCMetz
CDKL1inactive (10001nM)--
CDKL2inactive (10001nM)--
CDKL3inactive (10001nM)--
CDKL5inactive (10001nM)--
CMGC - CLK

Bioactivity
KinaseDRxRBCMetz
CLK1inactive (10001nM)inactive (99.5%)-
CLK2inactive (10001nM)inactive (85.77%)inactive (>1995.26nM)
CLK3inactive (10001nM)inactive (105.54%)-
CLK4inactive (10001nM)inactive (111.22%)inactive (>3162.28nM)
CMGC - CK2

Bioactivity
KinaseDRxRBCMetz
CK2a1inactive (10001nM)inactive (103.65%)inactive (>6309.57nM)
CK2a2inactive (10001nM)inactive (96.58%)-
CMGC - DYRK

Bioactivity
KinaseDRxRBCMetz
DYRK1Ainactive (10001nM)inactive (101.97%)inactive (>1995.26nM)
DYRK1Binactive (10001nM)inactive (96.97%)inactive (>2511.89nM)
DYRK2inactive (10001nM)inactive (111.71%)-
HIPK1inactive (10001nM)inactive (98.07%)-
HIPK2inactive (10001nM)inactive (96.9%)inactive (>3162.28nM)
HIPK3inactive (10001nM)inactive (99.99%)-
HIPK4inactive (10001nM)inactive (96.24%)inactive (>7943.28nM)
PRP4inactive (10001nM)--
DYRK3-inactive (106.27%)inactive (>6309.57nM)
DYRK4-inactive (97.22%)inactive (>7943.28nM)
CMGC - MAPK

Bioactivity
KinaseDRxRBCMetz
Erk1inactive (10001nM)inactive (98.62%)-
Erk2inactive (10001nM)inactive (88.63%)-
Erk3inactive (10001nM)--
Erk4inactive (10001nM)--
Erk5inactive (10001nM)--
Erk7inactive (10001nM)--
JNK1inactive (10001nM)inactive (108.13%)inactive (>5011.87nM)
JNK2inactive (10001nM)inactive (112.1%)inactive (>3981.07nM)
JNK3inactive (10001nM)inactive (100.43%)inactive (>3162.28nM)
NLKinactive (10001nM)inactive (109.53%)-
p38ainactive (10001nM)inactive (93.36%)inactive (>3981.07nM)
p38binactive (10001nM)inactive (103.31%)-
p38dinactive (10001nM)inactive (93.77%)inactive (>7943.28nM)
p38ginactive (10001nM)inactive (96.73%)inactive (>6309.57nM)
CMGC - GSK

Bioactivity
KinaseDRxRBCMetz
GSK3Ainactive (10001nM)inactive (102.73%)inactive (>3981.07nM)
GSK3Binactive (10001nM)inactive (99.58%)inactive (>3981.07nM)
CMGC - RCK

Bioactivity
KinaseDRxRBCMetz
ICKinactive (10001nM)--
MAKinactive (10001nM)--
CMGC - SRPK

Bioactivity
KinaseDRxRBCMetz
SRPK1inactive (10001nM)inactive (99.77%)inactive (>7943.28nM)
SRPK2inactive (10001nM)inactive (90.66%)-
MSSK1inactive (10001nM)inactive (103.04%)-

CK1


Test Member No. in Family
Familyno. Member on 518kinaseDRxRBCMetz
7765
311-
CK1 - CK1

Bioactivity
KinaseDRxRBCMetz
CK1ainactive (10001nM)inactive (99.74%)inactive (>3981.07nM)
CK1a2inactive (10001nM)--
CK1dinactive (10001nM)inactive (86.02%)inactive (>7943.28nM)
CK1einactive (10001nM)inactive (101.07%)-
CK1g1inactive (10001nM)inactive (101%)-
CK1g2inactive (10001nM)inactive (95.4%)inactive (>7943.28nM)
CK1g3inactive (10001nM)inactive (100.67%)-
CK1 - VRK

Bioactivity
KinaseDRxRBCMetz
VRK2inactive (10001nM)--
VRK1-inactive (100.09%)-