Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : CHEMBL4080283
Millipore : CGP74514A

Inchikey
Same : UTBSBSOBZHXMHI-N
RBC : UTBSBSOBZHXMHI-GJZGRUSLSA-N
Millipore : UTBSBSOBZHXMHI-LSDHHAIUSA-N

ChemSpider
RBC : 76792586
Millipore : 2073096

Pubchem CID
RBC : 60034150
Millipore : 2794188

ChEMBL
RBC : CHEMBL4080283
Millipore : CHEMBL367625

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (94.76%)	inactive (107%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (108.29%)	inactive (113%)
AKT2	inactive (107.73%)	inactive (99%)
AKT3	inactive (95.79%)	inactive (94%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (99.72%)	inactive (123%)
MRCKa	inactive (93.44%)	inactive (109%)
MRCKb	inactive (97.69%)	inactive (94%)
ROCK1	inactive (96.49%)	inactive (115%)
ROCK2	inactive (90.63%)	inactive (78%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (96.49%)	-
BARK2	inactive (89.17%)	-
GPRK4	inactive (96.2%)	-
GPRK5	inactive (105.65%)	inactive (96%)
GPRK6	inactive (99.64%)	inactive (91%)
GPRK7	inactive (97.89%)	inactive (74%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	inactive (87.75%)	inactive (112%)
MSK2	inactive (88.19%)	inactive (79%)
p70S6K	inactive (97.25%)	inactive (66%)
p70S6Kb	inactive (103.07%)	-
RSK2	inactive (64.06%)	active (28%)
RSK4	inactive (75.74%)	active (24%)
RSK1	active (0%)	active (30%)
RSK3	active (45.07%)	inactive (67%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	-	-
PRKX	inactive (101.66%)	inactive (95%)
PKACa	inactive (102.39%)	inactive (109%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (68.18%)	inactive (89%)
PKCd	inactive (91.23%)	inactive (86%)
PKCe	inactive (90.58%)	inactive (100%)
PKCh	inactive (77.57%)	inactive (93%)
PKCg	inactive (95.03%)	inactive (81%)
PKCi	inactive (99.74%)	inactive (101%)
PKCt	inactive (93.28%)	inactive (71%)
PKCz	inactive (106.45%)	inactive (110%)
PKCb	inactive (79.41%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	inactive (74.33%)	-
PKG1	inactive (91.42%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	inactive (69.93%)	-
PKN2	inactive (90.31%)	inactive (80%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	inactive (120.38%)	inactive (91%)
SGK2	inactive (98.2%)	inactive (97%)
SGK3	inactive (94.35%)	inactive (108%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	active (0%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (93.98%)	inactive (95%)
ABL2	inactive (65.66%)	inactive (62%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (92.42%)	active (34%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (92.35%)	inactive (82%)
LTK	inactive (93.85%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (98.68%)	inactive (78%)
MER	inactive (76.18%)	active (8%)
TYRO3	inactive (98.35%)	inactive (93%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (87.06%)	active (14%)
BRK	inactive (82.06%)	inactive (94%)
SRC	inactive (54.69%)	active (22%)
FGR	active (45.84%)	active (18%)
FRK	inactive (87.7%)	active (43%)
FYN	active (48.64%)	active (8%)
HCK	inactive (69.56%)	active (24%)
LCK	inactive (89.48%)	active (27%)
SRM	inactive (85.92%)	-
YES	active (35.4%)	active (7%)
LYN	inactive (67.28%)	active (6%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (90.68%)	active (19%)
BTK	inactive (82.51%)	inactive (71%)
ITK	inactive (104.75%)	inactive (89%)
TEC	inactive (122.89%)	-
TXK	inactive (69.12%)	inactive (52%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	inactive (100.76%)	inactive (107%)
FLT3	active (12.74%)	active (18%)
FMS	inactive (94.18%)	inactive (54%)
PDGFRb	inactive (99.6%)	inactive (106%)
PDGFRa	inactive (100.04%)	inactive (100%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (85.45%)	inactive (101%)
CTK	inactive (88.35%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (97.19%)	inactive (93%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (98.14%)	inactive (110%)
ErbB2	inactive (95.6%)	-
ErbB4	inactive (103.04%)	inactive (83%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (79.61%)	active (15%)
EphA2	inactive (86.7%)	inactive (66%)
EphA3	inactive (85.7%)	inactive (61%)
EphA4	inactive (78.49%)	inactive (98%)
EphA5	inactive (73.92%)	inactive (70%)
EphA6	-	-
EphA7	inactive (87.58%)	inactive (78%)
EphA8	inactive (93%)	inactive (89%)
EphB1	inactive (56.55%)	active (32%)
EphB2	inactive (82.93%)	inactive (56%)
EphB3	inactive (92.65%)	inactive (110%)
EphB4	inactive (70.82%)	inactive (51%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (83.14%)	inactive (53%)
PYK2	inactive (85.74%)	active (49%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (86.81%)	inactive (85%)
FES	inactive (83.54%)	inactive (55%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	inactive (85.73%)	inactive (76%)
FGFR2	inactive (102.75%)	inactive (103%)
FGFR3	inactive (90.38%)	inactive (113%)
FGFR4	inactive (97.54%)	inactive (118%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	inactive (92.77%)	inactive (63%)
FLT4	inactive (105.14%)	active (50%)
KDR	inactive (96.54%)	inactive (85%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (51.82%)	inactive (95%)
IRR	inactive (90.73%)	inactive (109%)
INSR	inactive (91.32%)	inactive (98%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (98.58%)	-
JAK2	inactive (104.48%)	inactive (116%)
JAK3	inactive (99.64%)	inactive (112%)
TYK2	inactive (110.07%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	inactive (79.81%)	inactive (61%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	inactive (69.26%)	inactive (61%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (99.6%)	inactive (85%)
MET	inactive (101.86%)	inactive (108%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (90.67%)	inactive (93%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (98.36%)	inactive (99%)
ZAP70	inactive (105.94%)	inactive (93%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (99.87%)	inactive (83%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (92.88%)	active (12%)
TRKB	inactive (55.32%)	active (15%)
TRKC	active (23.4%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (99.91%)	-
ALK2	inactive (92.71%)	-
ALK4	inactive (109.54%)	inactive (123%)
TGFbR1	inactive (95.57%)	inactive (101%)
TGFbR2	inactive (91.21%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (116.42%)	-
BRAF	inactive (93.01%)	-
RAF1	inactive (92.75%)	inactive (68%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (81.7%)	inactive (85%)
IRAK4	inactive (94.77%)	inactive (85%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (107.7%)	inactive (89%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	inactive (70.02%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	inactive (54.86%)	active (16%)
MLK2	inactive (92.92%)	-
MLK3	inactive (77.64%)	-
TAK1	inactive (98.92%)	inactive (89%)
ZAK	inactive (103.91%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (70.05%)	inactive (75%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	inactive (52.45%)	active (38%)
BRSK1	inactive (92.36%)	inactive (91%)
BRSK2	inactive (94%)	inactive (111%)
CHK1	inactive (85.8%)	inactive (83%)
LKB1	inactive (78%)	inactive (103%)
MARK1	inactive (93.13%)	inactive (77%)
MARK3	inactive (98.72%)	-
MARK4	inactive (95.47%)	-
MELK	inactive (76.97%)	inactive (59%)
PASK	inactive (88.04%)	inactive (113%)
QIK	inactive (89.1%)	-
NuaK2	inactive (93.69%)	-
MARK2	inactive (90.09%)	inactive (90%)
AMPKa1	-	inactive (77%)
AMPKa2	-	inactive (64%)
SIK	-	active (20%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (102.87%)	inactive (84%)
CaMK1b	inactive (98.5%)	-
CaMK1d	inactive (96.69%)	inactive (79%)
CaMK1g	inactive (94.11%)	-
CaMK4	inactive (103.24%)	inactive (77%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	inactive (96.53%)	-
CaMK2b	inactive (109.62%)	inactive (93%)
CaMK2d	inactive (89.02%)	active (44%)
CaMK2g	inactive (104.37%)	active (43%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	inactive (79.88%)	inactive (59%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (79.06%)	inactive (96%)
DAPK2	inactive (99.01%)	inactive (92%)
DRAK1	inactive (98.39%)	inactive (90%)
DAPK3	inactive (104.74%)	inactive (104%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (93.15%)	inactive (124%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (94.9%)	inactive (100%)
MAPKAPK3	inactive (91.28%)	inactive (115%)
MAPKAPK5	inactive (98.33%)	inactive (119%)
MNK1	inactive (101.11%)	-
MNK2	inactive (93.5%)	inactive (97%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	inactive (91.04%)	inactive (94%)
skMLCK	inactive (95.17%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	inactive (62.77%)	-
PHKg2	inactive (85.56%)	inactive (78%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	inactive (83.76%)	inactive (94%)
PIM2	inactive (111.43%)	inactive (97%)
PIM3	active (34.66%)	inactive (57%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	inactive (90.84%)	inactive (97%)
PKD3	inactive (90.64%)	-
PKD2	-	inactive (97%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (87.43%)	inactive (79%)
TSSK2	inactive (108.88%)	inactive (90%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	inactive (88.93%)	inactive (87%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (102.6%)	inactive (91%)
MAP3K2	inactive (91.66%)	-
MAP3K3	inactive (102.95%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (93.57%)	-
NIK	inactive (85.13%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	inactive (87.42%)	active (43%)
HGK	inactive (72.52%)	-
KHS1	inactive (91.15%)	-
LOK	inactive (75.07%)	inactive (60%)
MINK	inactive (95.22%)	inactive (99%)
MST1	inactive (91.29%)	inactive (64%)
MST2	inactive (83.91%)	inactive (108%)
MST3	inactive (78.96%)	inactive (78%)
MST4	inactive (104.15%)	-
OSR1	inactive (92.31%)	-
PAK1	inactive (88.79%)	-
PAK2	inactive (93.86%)	inactive (102%)
PAK3	inactive (91.95%)	inactive (106%)
PAK4	inactive (84.51%)	active (30%)
PAK5	inactive (64.74%)	active (38%)
PAK6	inactive (96.74%)	active (38%)
SLK	inactive (71.43%)	-
YSK1	inactive (100.81%)	-
STLK3	inactive (105.5%)	-
TAO1	inactive (90.16%)	inactive (68%)
TAO2	inactive (101.24%)	inactive (81%)
TAO3	inactive (104.28%)	inactive (82%)
MYO3B	active (0%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (92.16%)	inactive (87%)
MAP2K2	inactive (106.52%)	-
MAP2K6	inactive (100.33%)	inactive (99%)
MAP2K7	-	inactive (86%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	inactive (105.28%)	inactive (85%)
AurB	inactive (98.85%)	active (21%)
AurC	inactive (94.5%)	active (22%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (107.42%)	-
CaMKK2	inactive (86.14%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	inactive (90.39%)	active (48%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (91.72%)	inactive (99%)
IKKb	inactive (106.12%)	inactive (106%)
IKKe	inactive (99.47%)	-
TBK1	inactive (92.79%)	inactive (68%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	inactive (95.02%)	-
NEK11	inactive (100.65%)	inactive (68%)
NEK2	inactive (100.33%)	inactive (98%)
NEK4	inactive (96.85%)	-
NEK6	inactive (101.7%)	inactive (107%)
NEK7	inactive (86.03%)	inactive (101%)
NEK9	inactive (95.41%)	-
NEK3	inactive (100.26%)	inactive (75%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (105.01%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (85.97%)	inactive (71%)
PLK2	inactive (95.79%)	inactive (92%)
PLK3	inactive (90.09%)	inactive (94%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (97.8%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	inactive (101.21%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	inactive (99.66%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	inactive (74.54%)	-
ULK2	inactive (94.15%)	inactive (54%)
ULK3	active (0%)	active (40%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (110.16%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (94.09%)	inactive (88%)
Wnk3	inactive (91.98%)	inactive (87%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (0%)	active (31%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	inactive (97.78%)	inactive (89%)
CK1g1	inactive (56.84%)	active (30%)
CK1g2	inactive (69.52%)	inactive (52%)
CK1g3	active (45.92%)	inactive (88%)
CK1a	inactive (98.74%)	-
CK1e	inactive (92.14%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (102.63%)	-
VRK2	-	inactive (94%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	inactive (84.2%)	inactive (91%)
CK2a2	-	inactive (109%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	inactive (89.26%)	-
CLK2	active (26.57%)	active (10%)
CLK3	inactive (99.78%)	inactive (76%)
CLK4	active (49.93%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	inactive (100.15%)	-
DYRK1B	inactive (94.38%)	-
DYRK2	inactive (107.29%)	inactive (103%)
DYRK3	inactive (83.7%)	-
DYRK4	inactive (95.1%)	-
HIPK1	inactive (97.53%)	inactive (108%)
HIPK2	inactive (94%)	inactive (85%)
HIPK3	inactive (101.64%)	inactive (99%)
HIPK4	inactive (88.42%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	inactive (108.24%)	active (49%)
Erk2	inactive (91.68%)	inactive (62%)
JNK3	inactive (98.84%)	inactive (91%)
NLK	inactive (90.8%)	inactive (80%)
p38a	inactive (100.12%)	inactive (90%)
p38b	inactive (94.07%)	inactive (94%)
p38d	inactive (101.76%)	inactive (104%)
p38g	inactive (96.61%)	inactive (104%)
JNK1	inactive (97.62%)	inactive (102%)
JNK2	inactive (102.11%)	inactive (110%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	inactive (103.41%)	inactive (123%)
GSK3B	inactive (103.93%)	inactive (132%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (94.91%)	inactive (95%)
SRPK1	inactive (94.2%)	inactive (95%)
SRPK2	inactive (80.71%)	inactive (69%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (94.76%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (105%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (114%)