Compound in Profiling

Compound Information

Test on : RBC, Millipore

Compound Name
RBC : 608512-97-6
Millipore : PKR Inhibitor

Inchikey
Same : VFBGXTUGODTSPK-N
RBC : VFBGXTUGODTSPK-UHFFFAOYSA-N
Millipore : VFBGXTUGODTSPK-BAQGIRSFSA-N

ChemSpider
RBC : 28467728
Millipore : 4990932

Pubchem CID
RBC : 57351456
Millipore : 6490494

ChEMBL
RBC : -
Millipore : CHEMBL235641

RBC	Millipore

	DRx	RBC	Metz	Millipore	GPCR
bioactivity	Kd (nM)	Remain Activity (%)	Ki (nM)	Remain Activity (%)	Inhibition (%)
active criteria	<3000nM	<50%	<1000nM	<50%	>50%

AGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDK1	1	1	1
Akt	3	3	3
DMPK	7	5	5
GRK	7	6	3
RSK	8	8	7
PKA	5	3	2
PKC	9	9	8
PKG	2	3	-
PKN	3	2	1
SGK	3	3	3
NDR	4	1	-

AGC - PDK1

Bioactivity
Kinase	RBC	Millipore
PDK1	inactive (76.73%)	active (31%)

AGC - Akt

Bioactivity
Kinase	RBC	Millipore
AKT1	inactive (79.23%)	inactive (99%)
AKT2	inactive (89.71%)	inactive (128%)
AKT3	inactive (90.23%)	inactive (78%)

AGC - DMPK

Bioactivity
Kinase	RBC	Millipore
DMPK1	inactive (95.79%)	inactive (120%)
MRCKa	inactive (94.16%)	inactive (104%)
MRCKb	inactive (87.81%)	inactive (75%)
ROCK1	active (26.01%)	inactive (59%)
ROCK2	active (11.68%)	active (5%)

AGC - GRK

Bioactivity
Kinase	RBC	Millipore
BARK1	inactive (107.27%)	-
BARK2	inactive (97.31%)	-
GPRK4	inactive (86.89%)	-
GPRK5	inactive (81.33%)	inactive (71%)
GPRK6	inactive (67.72%)	inactive (78%)
GPRK7	inactive (81.27%)	inactive (63%)

AGC - RSK

Bioactivity
Kinase	RBC	Millipore
MSK1	active (34.66%)	active (43%)
MSK2	active (28%)	active (20%)
p70S6K	inactive (57.11%)	active (46%)
p70S6Kb	inactive (95.14%)	-
RSK2	active (28.02%)	active (18%)
RSK4	active (8.68%)	active (14%)
RSK1	active (20.44%)	active (5%)
RSK3	active (7.84%)	active (28%)

AGC - PKA

Bioactivity
Kinase	RBC	Millipore
PKACg	inactive (87.58%)	-
PRKX	active (28.21%)	active (24%)
PKACa	active (40.08%)	active (25%)

AGC - PKC

Bioactivity
Kinase	RBC	Millipore
PKCa	inactive (91.36%)	inactive (67%)
PKCd	active (29.15%)	active (15%)
PKCe	active (19.45%)	active (27%)
PKCh	active (41.16%)	active (23%)
PKCg	inactive (98.68%)	inactive (69%)
PKCi	inactive (80.28%)	inactive (85%)
PKCt	inactive (112.33%)	active (49%)
PKCz	inactive (83.18%)	inactive (86%)
PKCb	inactive (87.58%)	-

AGC - PKG

Bioactivity
Kinase	RBC	Millipore
PKG2	active (3%)	-
PKG1	active (17.46%)	-

AGC - PKN

Bioactivity
Kinase	RBC	Millipore
PKN1	active (22.02%)	-
PKN2	active (44.05%)	active (4%)

AGC - SGK

Bioactivity
Kinase	RBC	Millipore
SGK1	active (24.67%)	active (31%)
SGK2	active (24.96%)	active (12%)
SGK3	inactive (81.25%)	inactive (73%)

AGC - NDR

Bioactivity
Kinase	RBC	Millipore
NDR1	inactive (51.03%)	-

TK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Abl	2	2	2
Ack	2	1	1
ALK	2	2	1
Axl	3	3	3
Src	11	11	10
Tec	5	5	4
PDGFR	5	5	5
Csk	2	2	1
DDR	2	1	1
EGFR	4	3	2
Eph	14	12	11
FAK	2	2	2
Fer	2	2	2
FGFR	4	4	4
VEGFR	3	3	3
InsR	3	3	3
JakA	4	4	2
Musk	1	1	1
Ret	1	1	1
Met	2	2	2
Sev	1	1	1
Syk	2	2	2
Tie	2	1	1
Trk	3	3	2

TK - Abl

Bioactivity
Kinase	RBC	Millipore
ABL1	inactive (71.63%)	inactive (66%)
ABL2	inactive (69.82%)	inactive (82%)

TK - Ack

Bioactivity
Kinase	RBC	Millipore
ACK	inactive (71.24%)	inactive (64%)

TK - ALK

Bioactivity
Kinase	RBC	Millipore
ALK	inactive (72.44%)	inactive (72%)
LTK	inactive (82.99%)	-

TK - Axl

Bioactivity
Kinase	RBC	Millipore
AXL	inactive (100.7%)	active (26%)
MER	inactive (75.09%)	active (6%)
TYRO3	inactive (84.13%)	inactive (56%)

TK - Src

Bioactivity
Kinase	RBC	Millipore
BLK	inactive (81.27%)	active (44%)
BRK	inactive (64.47%)	inactive (66%)
SRC	inactive (78.1%)	inactive (70%)
FGR	inactive (62.81%)	active (47%)
FRK	inactive (84.96%)	inactive (83%)
FYN	inactive (75.13%)	active (46%)
HCK	inactive (73.89%)	inactive (58%)
LCK	inactive (84.84%)	inactive (55%)
SRM	inactive (96.93%)	-
YES	inactive (54.31%)	inactive (52%)
LYN	inactive (73.22%)	active (46%)

TK - Tec

Bioactivity
Kinase	RBC	Millipore
BMX	inactive (81.9%)	inactive (52%)
BTK	inactive (85.18%)	inactive (88%)
ITK	inactive (80.89%)	inactive (67%)
TEC	inactive (115.53%)	-
TXK	inactive (70.14%)	inactive (82%)

TK - PDGFR

Bioactivity
Kinase	RBC	Millipore
KIT	active (46.79%)	active (25%)
FLT3	active (2.82%)	active (1%)
FMS	inactive (58.51%)	active (22%)
PDGFRb	active (40.97%)	inactive (79%)
PDGFRa	inactive (57.73%)	inactive (68%)

TK - Csk

Bioactivity
Kinase	RBC	Millipore
CSK	inactive (87.2%)	inactive (104%)
CTK	inactive (101.94%)	-

TK - DDR

Bioactivity
Kinase	RBC	Millipore
DDR2	inactive (100.69%)	inactive (113%)

TK - EGFR

Bioactivity
Kinase	RBC	Millipore
EGFR	inactive (74.42%)	inactive (116%)
ErbB2	inactive (99.76%)	-
ErbB4	inactive (94.77%)	inactive (88%)

TK - Eph

Bioactivity
Kinase	RBC	Millipore
EphA1	inactive (83.94%)	inactive (58%)
EphA2	inactive (78.83%)	inactive (77%)
EphA3	inactive (77.13%)	inactive (82%)
EphA4	inactive (85.57%)	inactive (102%)
EphA5	inactive (92.35%)	inactive (89%)
EphA6	active (48.65%)	-
EphA7	inactive (71.27%)	inactive (77%)
EphA8	inactive (93.43%)	inactive (95%)
EphB1	inactive (62.23%)	inactive (60%)
EphB2	inactive (94.25%)	inactive (87%)
EphB3	inactive (86.05%)	inactive (120%)
EphB4	inactive (90.56%)	inactive (79%)

TK - FAK

Bioactivity
Kinase	RBC	Millipore
FAK	inactive (71.39%)	inactive (73%)
PYK2	inactive (88.01%)	inactive (79%)

TK - Fer

Bioactivity
Kinase	RBC	Millipore
FER	inactive (77.87%)	inactive (97%)
FES	inactive (73.5%)	inactive (62%)

TK - FGFR

Bioactivity
Kinase	RBC	Millipore
FGFR1	active (41.31%)	active (9%)
FGFR2	active (37.6%)	active (18%)
FGFR3	active (34.75%)	active (19%)
FGFR4	inactive (90.67%)	inactive (112%)

TK - VEGFR

Bioactivity
Kinase	RBC	Millipore
FLT1	active (40.09%)	active (1%)
FLT4	active (12.11%)	active (0%)
KDR	active (34.51%)	active (2%)

TK - InsR

Bioactivity
Kinase	RBC	Millipore
IGF1R	inactive (97.5%)	inactive (132%)
IRR	inactive (100.36%)	inactive (119%)
INSR	inactive (93.27%)	inactive (85%)

TK - JakA

Bioactivity
Kinase	RBC	Millipore
JAK1	inactive (53.95%)	-
JAK2	inactive (69.9%)	inactive (59%)
JAK3	active (20.63%)	active (16%)
TYK2	active (12.35%)	-

TK - Musk

Bioactivity
Kinase	RBC	Millipore
MUSK	active (21.61%)	inactive (53%)

TK - Ret

Bioactivity
Kinase	RBC	Millipore
RET	active (10.56%)	active (9%)

TK - Met

Bioactivity
Kinase	RBC	Millipore
RON	inactive (70.18%)	inactive (60%)
MET	inactive (74.42%)	active (18%)

TK - Sev

Bioactivity
Kinase	RBC	Millipore
ROS	inactive (73.65%)	inactive (88%)

TK - Syk

Bioactivity
Kinase	RBC	Millipore
SYK	inactive (74.41%)	inactive (101%)
ZAP70	inactive (99.03%)	inactive (102%)

TK - Tie

Bioactivity
Kinase	RBC	Millipore
TIE2	inactive (90.57%)	inactive (67%)

TK - Trk

Bioactivity
Kinase	RBC	Millipore
TRKA	inactive (53.74%)	active (3%)
TRKB	active (17.37%)	active (19%)
TRKC	active (6.55%)	-

TKL

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STKR	12	5	2
RAF	5	3	1
IRAK	4	2	2
LISK	4	1	1
LRRK	2	1	-
MLK	10	5	2
RIPK	5	1	1

TKL - STKR

Bioactivity
Kinase	RBC	Millipore
ALK1	inactive (112.76%)	-
ALK2	inactive (143.53%)	-
ALK4	inactive (130.99%)	inactive (85%)
TGFbR1	inactive (103.11%)	inactive (68%)
TGFbR2	inactive (75.11%)	-

TKL - RAF

Bioactivity
Kinase	RBC	Millipore
ARAF	inactive (115.03%)	-
BRAF	inactive (100.23%)	-
RAF1	inactive (104.3%)	active (48%)

TKL - IRAK

Bioactivity
Kinase	RBC	Millipore
IRAK1	inactive (52.51%)	active (28%)
IRAK4	inactive (59.48%)	active (41%)

TKL - LISK

Bioactivity
Kinase	RBC	Millipore
LIMK1	inactive (61.27%)	inactive (55%)

TKL - LRRK

Bioactivity
Kinase	RBC	Millipore
LRRK2	active (8.5%)	-

TKL - MLK

Bioactivity
Kinase	RBC	Millipore
MLK1	active (46.08%)	active (9%)
MLK2	inactive (65.36%)	-
MLK3	active (28.86%)	-
TAK1	active (11.97%)	active (16%)
ZAK	inactive (52.84%)	-

TKL - RIPK

Bioactivity
Kinase	RBC	Millipore
RIPK2	inactive (84.96%)	inactive (59%)

CAMK

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CAMKL	20	13	12
CAMK1	5	5	3
CAMK2	4	4	3
RAD53	1	1	1
DAPK	5	4	4
DCAMKL	3	1	1
MAPKAPK	5	5	4
MLCK	5	2	1
PHK	2	2	1
PIM	3	3	3
PKD	3	3	2
TSSK	5	2	2
STK33	1	-	-

CAMK - CAMKL

Bioactivity
Kinase	RBC	Millipore
NuaK1	active (0.75%)	active (6%)
BRSK1	active (10.03%)	active (2%)
BRSK2	active (10.25%)	active (11%)
CHK1	active (27.09%)	active (35%)
LKB1	active (13.52%)	active (21%)
MARK1	active (19.96%)	active (9%)
MARK3	active (21.26%)	-
MARK4	active (12.85%)	-
MELK	active (4.74%)	active (6%)
PASK	active (40.85%)	active (46%)
QIK	inactive (74.01%)	-
NuaK2	active (41.21%)	-
MARK2	active (16.72%)	active (10%)
AMPKa1	-	active (10%)
AMPKa2	-	active (3%)
SIK	-	active (49%)

CAMK - CAMK1

Bioactivity
Kinase	RBC	Millipore
CaMK1a	inactive (81.91%)	inactive (72%)
CaMK1b	inactive (99.56%)	-
CaMK1d	inactive (117.32%)	inactive (72%)
CaMK1g	inactive (102.26%)	-
CaMK4	inactive (101.15%)	inactive (80%)

CAMK - CAMK2

Bioactivity
Kinase	RBC	Millipore
CaMK2a	active (42.26%)	-
CaMK2b	active (40.76%)	active (13%)
CaMK2d	inactive (53.06%)	active (18%)
CaMK2g	inactive (101.04%)	active (21%)

CAMK - RAD53

Bioactivity
Kinase	RBC	Millipore
CHK2	active (49.84%)	active (50%)

CAMK - DAPK

Bioactivity
Kinase	RBC	Millipore
DAPK1	inactive (94.35%)	inactive (85%)
DAPK2	inactive (125.24%)	inactive (71%)
DRAK1	active (6.82%)	active (1%)
DAPK3	inactive (89.1%)	inactive (68%)

CAMK - DCAMKL

Bioactivity
Kinase	RBC	Millipore
DCLK2	inactive (69.76%)	inactive (55%)

CAMK - MAPKAPK

Bioactivity
Kinase	RBC	Millipore
MAPKAPK2	inactive (97.59%)	inactive (82%)
MAPKAPK3	inactive (91.02%)	inactive (103%)
MAPKAPK5	inactive (74.45%)	active (49%)
MNK1	active (9.89%)	-
MNK2	active (17.64%)	active (9%)

CAMK - MLCK

Bioactivity
Kinase	RBC	Millipore
smMLCK	active (40.07%)	active (25%)
skMLCK	active (12.04%)	-

CAMK - PHK

Bioactivity
Kinase	RBC	Millipore
PHKg1	active (37.18%)	-
PHKg2	inactive (68.08%)	active (47%)

CAMK - PIM

Bioactivity
Kinase	RBC	Millipore
PIM1	active (28.24%)	active (26%)
PIM2	inactive (83.05%)	active (13%)
PIM3	active (34.87%)	inactive (53%)

CAMK - PKD

Bioactivity
Kinase	RBC	Millipore
PKD1	active (4.14%)	active (5%)
PKD3	active (3.58%)	-
PKD2	active (4.17%)	active (30%)

CAMK - TSSK

Bioactivity
Kinase	RBC	Millipore
TSSK1	inactive (60.09%)	inactive (68%)
TSSK2	inactive (94.88%)	inactive (89%)

CAMK - STK33

Bioactivity
Kinase	RBC	Millipore
STK33	active (35.7%)	inactive (62%)

STE

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
STE11	8	3	1
STE-Unique	2	2	-
STE20	31	23	14
STE7	7	3	3

STE - STE11

Bioactivity
Kinase	RBC	Millipore
MAP3K5	inactive (61.55%)	active (26%)
MAP3K2	inactive (77.32%)	-
MAP3K3	inactive (82.51%)	-

STE - STE-Unique

Bioactivity
Kinase	RBC	Millipore
COT	inactive (103.18%)	-
NIK	inactive (141.92%)	-

STE - STE20

Bioactivity
Kinase	RBC	Millipore
GCK	active (10%)	active (7%)
HGK	active (5.36%)	-
KHS1	active (6.41%)	-
LOK	active (37.96%)	active (29%)
MINK	active (24.43%)	active (27%)
MST1	active (5.51%)	active (1%)
MST2	active (3.37%)	active (2%)
MST3	active (11.61%)	active (3%)
MST4	active (10.77%)	-
OSR1	inactive (79.76%)	-
PAK1	inactive (81.12%)	-
PAK2	inactive (82.83%)	inactive (96%)
PAK3	inactive (85.45%)	inactive (71%)
PAK4	inactive (76.46%)	inactive (67%)
PAK5	inactive (87.83%)	inactive (70%)
PAK6	inactive (92.76%)	inactive (83%)
SLK	inactive (62.9%)	-
YSK1	active (30.66%)	-
STLK3	inactive (93.67%)	-
TAO1	active (37.52%)	active (11%)
TAO2	inactive (56.91%)	active (33%)
TAO3	active (18.56%)	active (17%)
MYO3B	active (30.95%)	-

STE - STE7

Bioactivity
Kinase	RBC	Millipore
MAP2K1	inactive (87.17%)	active (15%)
MAP2K2	inactive (95.03%)	-
MAP2K6	inactive (56.81%)	active (-1%)
MAP2K7	-	active (43%)

Other

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
Aur	3	3	3
CAMKK	2	2	-
Haspin	1	1	1
IKK	4	4	3
NEK	11	8	5
TOPK	1	1	-
PLK	4	3	3
SgK496	1	1	-
NAK	4	1	-
TTK	1	1	-
ULK	5	3	2
WEE	3	1	-
WNK	4	2	2
TLK	2	1	1

Other - Aur

Bioactivity
Kinase	RBC	Millipore
AurA	active (20.01%)	active (0%)
AurB	active (11.08%)	active (2%)
AurC	active (31.39%)	active (18%)

Other - CAMKK

Bioactivity
Kinase	RBC	Millipore
CaMKK1	inactive (58.14%)	-
CaMKK2	inactive (54.44%)	-

Other - Haspin

Bioactivity
Kinase	RBC	Millipore
Haspin	active (5.68%)	active (3%)

Other - IKK

Bioactivity
Kinase	RBC	Millipore
IKKa	inactive (53.2%)	active (8%)
IKKb	inactive (70.24%)	inactive (68%)
IKKe	active (27.64%)	-
TBK1	active (18.79%)	active (7%)

Other - NEK

Bioactivity
Kinase	RBC	Millipore
NEK1	active (34.31%)	-
NEK11	inactive (111.62%)	active (50%)
NEK2	inactive (77.22%)	inactive (64%)
NEK4	active (39.49%)	-
NEK6	inactive (93.16%)	inactive (80%)
NEK7	inactive (79.56%)	inactive (84%)
NEK9	active (31.96%)	-
NEK3	inactive (80.2%)	inactive (102%)

Other - TOPK

Bioactivity
Kinase	RBC	Millipore
PBK	inactive (67.36%)	-

Other - PLK

Bioactivity
Kinase	RBC	Millipore
PLK1	inactive (88.99%)	inactive (84%)
PLK2	inactive (78.73%)	active (49%)
PLK3	inactive (86.68%)	inactive (70%)

Other - SgK496

Bioactivity
Kinase	RBC	Millipore
SgK496	inactive (97.03%)	-

Other - NAK

Bioactivity
Kinase	RBC	Millipore
MPSK1	active (27.95%)	-

Other - TTK

Bioactivity
Kinase	RBC	Millipore
TTK	active (31.15%)	-

Other - ULK

Bioactivity
Kinase	RBC	Millipore
ULK1	active (20.96%)	-
ULK2	inactive (51.52%)	active (37%)
ULK3	inactive (57.87%)	active (42%)

Other - WEE

Bioactivity
Kinase	RBC	Millipore
Wee1	inactive (75.43%)	-

Other - WNK

Bioactivity
Kinase	RBC	Millipore
Wnk2	inactive (120.26%)	inactive (89%)
Wnk3	inactive (84.94%)	inactive (84%)

Other - TLK

Bioactivity
Kinase	RBC	Millipore
TLK2	active (16.37%)	active (19%)

CK1

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK1	7	6	4
VRK	3	1	1

CK1 - CK1

Bioactivity
Kinase	RBC	Millipore
CK1d	active (42.84%)	active (23%)
CK1g1	inactive (86.93%)	inactive (70%)
CK1g2	inactive (79.15%)	inactive (63%)
CK1g3	inactive (65.78%)	inactive (61%)
CK1a	inactive (67.65%)	-
CK1e	active (35.67%)	-

CK1 - VRK

Bioactivity
Kinase	RBC	Millipore
VRK1	inactive (69.07%)	-
VRK2	-	inactive (75%)

CMGC

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
CK2	3	2	2
CLK	4	4	2
DYRK	10	9	4
MAPK	14	10	10
GSK	2	2	2
SRPK	3	3	3

CMGC - CK2

Bioactivity
Kinase	RBC	Millipore
CK2a1	active (48.2%)	active (30%)
CK2a2	active (21.97%)	active (12%)

CMGC - CLK

Bioactivity
Kinase	RBC	Millipore
CLK1	active (19.92%)	-
CLK2	active (9.96%)	active (8%)
CLK3	inactive (65.54%)	active (38%)
CLK4	active (9.93%)	-

CMGC - DYRK

Bioactivity
Kinase	RBC	Millipore
DYRK1A	active (15.36%)	-
DYRK1B	active (11.34%)	-
DYRK2	active (12.09%)	active (1%)
DYRK3	active (39.21%)	-
DYRK4	inactive (93.56%)	-
HIPK1	inactive (102.93%)	inactive (64%)
HIPK2	inactive (81.24%)	active (32%)
HIPK3	inactive (78.68%)	active (31%)
HIPK4	inactive (87.8%)	-

CMGC - MAPK

Bioactivity
Kinase	RBC	Millipore
Erk1	active (11.56%)	active (5%)
Erk2	active (28.79%)	active (4%)
JNK3	inactive (116.96%)	active (20%)
NLK	active (35.53%)	active (29%)
p38a	inactive (93.9%)	inactive (80%)
p38b	inactive (96.12%)	inactive (71%)
p38d	inactive (90.43%)	inactive (62%)
p38g	inactive (92.23%)	active (50%)
JNK1	inactive (86.59%)	inactive (63%)
JNK2	active (45.84%)	inactive (71%)

CMGC - GSK

Bioactivity
Kinase	RBC	Millipore
GSK3A	active (2.04%)	active (4%)
GSK3B	active (6.34%)	active (4%)

CMGC - SRPK

Bioactivity
Kinase	RBC	Millipore
MSSK1	inactive (90.2%)	inactive (98%)
SRPK1	inactive (108.28%)	inactive (102%)
SRPK2	inactive (97.77%)	inactive (104%)

Atypical

Test Member No. in Family
Family	no. Member on 518kinase	RBC	Millipore
PDHK	5	1	-
Alpha	6	-	1
PIKK	6	-	1

Atypical - PDHK

Bioactivity
Kinase	RBC	Millipore
PDHK1	inactive (76.73%)	-

Atypical - Alpha

Bioactivity
Kinase	RBC	Millipore
eEF2K	-	inactive (79%)

Atypical - PIKK

Bioactivity
Kinase	RBC	Millipore
FRAP	-	inactive (73%)