Compound Information


Test on : RBC, Metz, Millipore

Compound Name
RBC, Metz, Millipore : Pyridone 6

Inchikey
Same : VNDWQCSOSCCWIP-N
RBC, Metz, Millipore : VNDWQCSOSCCWIP-UHFFFAOYSA-N

ChemSpider
RBC, Metz, Millipore : 4591874

Pubchem CID
RBC, Metz, Millipore : 5494425

ChEMBL
RBC, Metz, Millipore : CHEMBL21156




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
1111
3333
7535
7613
8847
5322
9958
232-
3211
3313
41--
AGC - PDK1

Bioactivity
KinaseRBCMetzMillipore
PDK1active (26.99%)-active (3%)
AGC - Akt

Bioactivity
KinaseRBCMetzMillipore
AKT1inactive (86.83%)-inactive (98%)
AKT2inactive (89.83%)-inactive (146%)
AKT3inactive (76.4%)-inactive (60%)
AGC - DMPK

Bioactivity
KinaseRBCMetzMillipore
DMPK1inactive (104.64%)-inactive (116%)
MRCKainactive (95.71%)-inactive (86%)
MRCKbinactive (96.82%)-inactive (78%)
ROCK1inactive (74.94%)active (501.19nM)inactive (91%)
ROCK2inactive (70.72%)-inactive (57%)
AGC - GRK

Bioactivity
KinaseRBCMetzMillipore
BARK1inactive (98.48%)--
BARK2inactive (104.22%)--
GPRK4inactive (74.16%)--
GPRK5inactive (72.94%)active (398.11nM)inactive (72%)
GPRK6active (48.16%)-inactive (59%)
GPRK7inactive (60.47%)-active (42%)
AGC - RSK

Bioactivity
KinaseRBCMetzMillipore
MSK1inactive (57.97%)-inactive (80%)
MSK2active (44.71%)-active (36%)
p70S6Kinactive (74.09%)-active (47%)
p70S6Kbinactive (101.62%)--
RSK2active (44.83%)active (398.11nM)active (43%)
RSK4active (33.89%)-active (42%)
RSK1active (38.57%)-active (25%)
RSK3active (34.6%)-inactive (65%)
AGC - PKA

Bioactivity
KinaseRBCMetzMillipore
PKACg---
PRKXinactive (79.18%)inactive (>3162.28nM)inactive (86%)
PKACainactive (97.95%)active (501.19nM)inactive (89%)
AGC - PKC

Bioactivity
KinaseRBCMetzMillipore
PKCainactive (65.62%)-inactive (65%)
PKCdactive (43.64%)-inactive (54%)
PKCeinactive (51.38%)-inactive (70%)
PKChinactive (81.46%)-inactive (82%)
PKCginactive (79.93%)-active (40%)
PKCiinactive (95.98%)-inactive (90%)
PKCtinactive (66.8%)active (794.33nM)active (45%)
PKCzinactive (93.16%)-inactive (103%)
PKCbinactive (90.57%)--
AGC - PKG

Bioactivity
KinaseRBCMetzMillipore
PKG2active (14.27%)--
PKG1active (40.16%)--
AGC - PKN

Bioactivity
KinaseRBCMetzMillipore
PKN1active (28.26%)--
PKN2inactive (67.14%)-active (29%)
AGC - SGK

Bioactivity
KinaseRBCMetzMillipore
SGK1inactive (50.91%)-inactive (63%)
SGK2inactive (84.44%)-inactive (63%)
SGK3inactive (96.64%)-inactive (80%)
AGC - NDR

Bioactivity
KinaseRBCMetzMillipore
NDR1active (0%)--

TK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
2212
2111
2221
3323
1111910
5534
5555
2211
21-1
4332
1412111
2222
2222
4424
3333
3323
4432
11-1
1111
2222
1111
2212
21-1
3332
TK - Abl

Bioactivity
KinaseRBCMetzMillipore
ABL1inactive (98.37%)inactive (>2511.89nM)inactive (86%)
ABL2inactive (90.28%)-inactive (128%)
TK - Ack

Bioactivity
KinaseRBCMetzMillipore
ACKactive (4.36%)active (125.89nM)active (10%)
TK - ALK

Bioactivity
KinaseRBCMetzMillipore
ALKactive (19.98%)active (158.49nM)active (30%)
LTKactive (20.64%)active (25.12nM)-
TK - Axl

Bioactivity
KinaseRBCMetzMillipore
AXLinactive (81.87%)-active (40%)
MERinactive (79.39%)-active (29%)
TYRO3inactive (90.28%)inactive (>3162.28nM)inactive (75%)
TK - Src

Bioactivity
KinaseRBCMetzMillipore
BLKinactive (93.53%)-inactive (76%)
BRKinactive (88.05%)-inactive (93%)
SRCinactive (93.45%)-inactive (72%)
FGRinactive (76.85%)-inactive (69%)
FRKinactive (103.98%)-inactive (74%)
FYNinactive (52.34%)inactive (>6309.57nM)inactive (77%)
HCKinactive (84.79%)-active (49%)
LCKinactive (93.01%)inactive (>6309.57nM)inactive (115%)
SRMinactive (98.68%)--
YESinactive (76.12%)-inactive (87%)
LYNinactive (101.37%)-inactive (65%)
TK - Tec

Bioactivity
KinaseRBCMetzMillipore
BMXinactive (71.87%)-active (28%)
BTKinactive (80.46%)inactive (>6309.57nM)inactive (71%)
ITKinactive (86.03%)-inactive (84%)
TECinactive (106.35%)--
TXKinactive (77.14%)-inactive (63%)
TK - PDGFR

Bioactivity
KinaseRBCMetzMillipore
KITinactive (96.11%)-inactive (119%)
FLT3active (13.58%)inactive (>3162.28nM)active (45%)
FMSinactive (93%)inactive (>2511.89nM)inactive (54%)
PDGFRbinactive (74.83%)inactive (>1995.26nM)inactive (107%)
PDGFRainactive (92.14%)inactive (>2511.89nM)inactive (102%)
TK - Csk

Bioactivity
KinaseRBCMetzMillipore
CSKinactive (114.02%)-inactive (93%)
CTKinactive (101.51%)--
TK - DDR

Bioactivity
KinaseRBCMetzMillipore
DDR2inactive (107.06%)-inactive (110%)
TK - EGFR

Bioactivity
KinaseRBCMetzMillipore
EGFRinactive (94.84%)-inactive (121%)
ErbB2inactive (108.6%)--
ErbB4inactive (99.91%)-inactive (90%)
TK - Eph

Bioactivity
KinaseRBCMetzMillipore
EphA1inactive (80.5%)-inactive (74%)
EphA2inactive (98.48%)-inactive (103%)
EphA3inactive (89.2%)-inactive (99%)
EphA4inactive (100.92%)-inactive (105%)
EphA5inactive (99.99%)-inactive (95%)
EphA6---
EphA7inactive (96.05%)-inactive (89%)
EphA8inactive (104.94%)-inactive (103%)
EphB1inactive (94.91%)-inactive (84%)
EphB2inactive (92.84%)-inactive (115%)
EphB3inactive (87.06%)-inactive (105%)
EphB4inactive (88.23%)-inactive (90%)
TK - FAK

Bioactivity
KinaseRBCMetzMillipore
FAKactive (35.31%)active (794.33nM)inactive (51%)
PYK2active (48.38%)-active (17%)
TK - Fer

Bioactivity
KinaseRBCMetzMillipore
FERactive (34.04%)-inactive (67%)
FESinactive (78.01%)-inactive (76%)
TK - FGFR

Bioactivity
KinaseRBCMetzMillipore
FGFR1inactive (75.78%)inactive (>3981.07nM)active (43%)
FGFR2inactive (99.11%)-inactive (79%)
FGFR3inactive (93.02%)-inactive (94%)
FGFR4inactive (96.49%)-inactive (119%)
TK - VEGFR

Bioactivity
KinaseRBCMetzMillipore
FLT1inactive (92.28%)inactive (>3981.07nM)inactive (52%)
FLT4inactive (71.19%)-active (28%)
KDRinactive (102.99%)inactive (1584.89nM)inactive (65%)
TK - InsR

Bioactivity
KinaseRBCMetzMillipore
IGF1Rinactive (91.27%)inactive (>2511.89nM)inactive (119%)
IRRinactive (75.21%)-inactive (101%)
INSRinactive (80.6%)-inactive (101%)
TK - JakA

Bioactivity
KinaseRBCMetzMillipore
JAK1active (2.54%)--
JAK2active (1.37%)active (2.51nM)active (-1%)
JAK3active (0.44%)active (39.81nM)active (1%)
TYK2active (1.48%)--
TK - Musk

Bioactivity
KinaseRBCMetzMillipore
MUSKinactive (81.74%)-inactive (86%)
TK - Ret

Bioactivity
KinaseRBCMetzMillipore
RETactive (18.33%)active (199.53nM)active (18%)
TK - Met

Bioactivity
KinaseRBCMetzMillipore
RONinactive (102.83%)active (31.62nM)inactive (87%)
METinactive (91.03%)inactive (>2511.89nM)inactive (91%)
TK - Sev

Bioactivity
KinaseRBCMetzMillipore
ROSactive (31.17%)-inactive (90%)
TK - Syk

Bioactivity
KinaseRBCMetzMillipore
SYKinactive (79.04%)-inactive (110%)
ZAP70inactive (88.9%)-inactive (91%)
TK - Tie

Bioactivity
KinaseRBCMetzMillipore
TIE2inactive (101.01%)-inactive (78%)
TK - Trk

Bioactivity
KinaseRBCMetzMillipore
TRKAactive (48.68%)inactive (>3162.28nM)active (3%)
TRKBactive (16.09%)active (1000nM)inactive (71%)
TRKCactive (6.81%)inactive (3162.28nM)-

TKL


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
12512
5311
4222
4111
211-
10522
51-1
TKL - STKR

Bioactivity
KinaseRBCMetzMillipore
ALK1inactive (105.26%)--
ALK2inactive (134.71%)inactive (>3981.07nM)-
ALK4inactive (109.56%)-inactive (110%)
TGFbR1inactive (102.13%)-inactive (75%)
TGFbR2inactive (58.17%)--
TKL - RAF

Bioactivity
KinaseRBCMetzMillipore
ARAFinactive (122.34%)--
BRAFinactive (116.94%)--
RAF1inactive (134.07%)-inactive (82%)
TKL - IRAK

Bioactivity
KinaseRBCMetzMillipore
IRAK1inactive (76.31%)-inactive (55%)
IRAK4inactive (96.34%)-inactive (61%)
TKL - LISK

Bioactivity
KinaseRBCMetzMillipore
LIMK1inactive (73.73%)inactive (>3162.28nM)inactive (98%)
TKL - LRRK

Bioactivity
KinaseRBCMetzMillipore
LRRK2active (47.53%)active (25.12nM)-
TKL - MLK

Bioactivity
KinaseRBCMetzMillipore
MLK1active (20.38%)-active (9%)
MLK2inactive (89.75%)--
MLK3inactive (56.98%)--
TAK1active (46.58%)-active (44%)
ZAKinactive (78.1%)--
TKL - RIPK

Bioactivity
KinaseRBCMetzMillipore
RIPK2active (34.6%)-active (18%)

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
2013912
5523
4443
1111
5424
3111
5544
52-1
2211
3333
3322
5222
1-1-
CAMK - CAMKL

Bioactivity
KinaseRBCMetzMillipore
NuaK1active (3.04%)-active (8%)
BRSK1active (15.37%)-active (32%)
BRSK2active (21.35%)-active (13%)
CHK1active (22.86%)inactive (3162.28nM)active (37%)
LKB1inactive (58.44%)-inactive (99%)
MARK1active (40.15%)-active (29%)
MARK3inactive (55.86%)--
MARK4active (44.46%)--
MELKactive (5.23%)-active (2%)
PASKinactive (83.15%)-inactive (87%)
QIKinactive (60.19%)--
NuaK2inactive (66.02%)--
MARK2active (41.5%)-active (40%)
AMPKa1-active (158.49nM)active (33%)
AMPKa2--active (20%)
SIK--active (31%)
CAMK - CAMK1

Bioactivity
KinaseRBCMetzMillipore
CaMK1ainactive (79.28%)-inactive (60%)
CaMK1binactive (112.17%)--
CaMK1dinactive (81.58%)inactive (>2511.89nM)inactive (60%)
CaMK1ginactive (95.34%)--
CaMK4inactive (81.8%)-active (1%)
CAMK - CAMK2

Bioactivity
KinaseRBCMetzMillipore
CaMK2aactive (35.1%)inactive (>3981.07nM)-
CaMK2binactive (73.41%)-active (43%)
CaMK2dinactive (59.43%)-active (24%)
CaMK2ginactive (72.82%)-active (21%)
CAMK - RAD53

Bioactivity
KinaseRBCMetzMillipore
CHK2active (0.72%)-active (2%)
CAMK - DAPK

Bioactivity
KinaseRBCMetzMillipore
DAPK1active (3.03%)-active (8%)
DAPK2active (18.04%)-active (11%)
DRAK1active (6.42%)-active (0%)
DAPK3active (2.18%)active (1nM)active (0%)
CAMK - DCAMKL

Bioactivity
KinaseRBCMetzMillipore
DCLK2inactive (65.79%)-active (38%)
DCLK1---
CAMK - MAPKAPK

Bioactivity
KinaseRBCMetzMillipore
MAPKAPK2inactive (99.56%)-inactive (79%)
MAPKAPK3inactive (94.38%)-inactive (89%)
MAPKAPK5inactive (88.1%)-active (47%)
MNK1inactive (100.6%)--
MNK2inactive (61.97%)-inactive (66%)
CAMK - MLCK

Bioactivity
KinaseRBCMetzMillipore
smMLCKactive (9.03%)-active (2%)
skMLCKinactive (67.2%)--
CAMK - PHK

Bioactivity
KinaseRBCMetzMillipore
PHKg1active (34.53%)--
PHKg2inactive (57.34%)-active (41%)
CAMK - PIM

Bioactivity
KinaseRBCMetzMillipore
PIM1active (38.6%)active (630.96nM)active (43%)
PIM2inactive (90.83%)-active (43%)
PIM3active (33.91%)-inactive (88%)
CAMK - PKD

Bioactivity
KinaseRBCMetzMillipore
PKD1active (8.19%)-active (8%)
PKD3active (10.81%)active (79.43nM)-
PKD2active (6.13%)-active (40%)
CAMK - TSSK

Bioactivity
KinaseRBCMetzMillipore
TSSK1active (37.33%)-active (42%)
TSSK2inactive (92.52%)-inactive (81%)
CAMK - STK33

Bioactivity
KinaseRBCMetzMillipore
STK33inactive (53.81%)-active (34%)

STE


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
83-1
22--
3123914
7323
STE - STE11

Bioactivity
KinaseRBCMetzMillipore
MAP3K5inactive (84.35%)-inactive (81%)
MAP3K2active (33.88%)--
MAP3K3inactive (61.13%)--
STE - STE-Unique

Bioactivity
KinaseRBCMetzMillipore
COTinactive (128%)--
NIKinactive (71.26%)--
STE - STE20

Bioactivity
KinaseRBCMetzMillipore
GCKinactive (66.15%)inactive (2511.89nM)active (19%)
HGKactive (38.41%)inactive (>5011.87nM)-
KHS1inactive (65.77%)--
LOKinactive (72.55%)-inactive (72%)
MINKinactive (52%)-inactive (81%)
MST1active (6.84%)-active (8%)
MST2active (5.45%)-active (14%)
MST3inactive (82.38%)-active (41%)
MST4inactive (70.9%)--
OSR1inactive (100.27%)--
PAK1inactive (82.05%)--
PAK2inactive (88.81%)-inactive (93%)
PAK3inactive (90.07%)-inactive (59%)
PAK4inactive (105.06%)inactive (>5011.87nM)inactive (70%)
PAK5inactive (90.55%)-inactive (78%)
PAK6inactive (90.9%)-inactive (96%)
SLKinactive (91.38%)--
YSK1inactive (86.88%)--
STLK3inactive (93.85%)--
TAO1inactive (86.89%)inactive (>6309.57nM)inactive (56%)
TAO2inactive (87.76%)-inactive (88%)
TAO3inactive (50.29%)-inactive (68%)
MYO3Bactive (0%)--
STE - STE7

Bioactivity
KinaseRBCMetzMillipore
MAP2K1inactive (94.94%)active (100nM)inactive (66%)
MAP2K2inactive (82.13%)active (398.11nM)-
MAP2K6inactive (89%)-active (39%)
MAP2K7--inactive (69%)

Other


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
3323
221-
11-1
4443
11825
111-
4333
11--
41--
11--
53-2
311-
42-2
21-1
1-1-
Other - Aur

Bioactivity
KinaseRBCMetzMillipore
AurAactive (22.34%)inactive (>1584.89nM)active (13%)
AurBactive (11.19%)active (50.12nM)active (1%)
AurCactive (29.25%)-active (11%)
Other - CAMKK

Bioactivity
KinaseRBCMetzMillipore
CaMKK1inactive (81.35%)--
CaMKK2inactive (69.37%)--
Other - Haspin

Bioactivity
KinaseRBCMetzMillipore
Haspininactive (67.15%)-inactive (74%)
Other - IKK

Bioactivity
KinaseRBCMetzMillipore
IKKainactive (101.66%)-inactive (52%)
IKKbinactive (52.14%)-active (42%)
IKKeactive (25.4%)active (100nM)-
TBK1active (24.02%)active (199.53nM)active (15%)
Other - NEK

Bioactivity
KinaseRBCMetzMillipore
NEK1active (49%)--
NEK11inactive (92.41%)-inactive (98%)
NEK2inactive (101.95%)inactive (>3162.28nM)inactive (72%)
NEK4inactive (65.56%)--
NEK6inactive (82.52%)-inactive (85%)
NEK7inactive (76.51%)-inactive (87%)
NEK9inactive (71.68%)--
NEK3inactive (74.36%)-inactive (92%)
Other - TOPK

Bioactivity
KinaseRBCMetzMillipore
PBKactive (39.06%)--
Other - PLK

Bioactivity
KinaseRBCMetzMillipore
PLK1active (10.48%)-active (14%)
PLK2inactive (92.61%)-active (49%)
PLK3active (10.99%)-inactive (55%)
PLK4---
Other - SgK496

Bioactivity
KinaseRBCMetzMillipore
SgK496inactive (62.01%)--
Other - NAK

Bioactivity
KinaseRBCMetzMillipore
MPSK1inactive (90.08%)--
Other - TTK

Bioactivity
KinaseRBCMetzMillipore
TTKinactive (65.28%)--
Other - ULK

Bioactivity
KinaseRBCMetzMillipore
ULK1active (12.78%)--
ULK2active (41.5%)-active (26%)
ULK3active (0%)-inactive (56%)
Other - WEE

Bioactivity
KinaseRBCMetzMillipore
Wee1inactive (87.42%)--
Other - WNK

Bioactivity
KinaseRBCMetzMillipore
Wnk2inactive (104.5%)-inactive (96%)
Wnk3inactive (90.01%)-inactive (101%)
Other - TLK

Bioactivity
KinaseRBCMetzMillipore
TLK2active (0%)-inactive (54%)
Other - CDC7

Bioactivity
KinaseRBCMetzMillipore
CDC7---

CK1


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
7654
31-1
CK1 - CK1

Bioactivity
KinaseRBCMetzMillipore
CK1dinactive (89.13%)-inactive (82%)
CK1g1inactive (96.52%)-inactive (78%)
CK1g2inactive (100.31%)-inactive (86%)
CK1g3inactive (105.3%)-inactive (111%)
CK1ainactive (94.63%)inactive (>3981.07nM)-
CK1einactive (85.61%)--
CK1 - VRK

Bioactivity
KinaseRBCMetzMillipore
VRK1inactive (82.21%)--
VRK2--inactive (89%)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
3212
4422
10964
1410810
2222
3313
20-7-
CMGC - CK2

Bioactivity
KinaseRBCMetzMillipore
CK2a1inactive (82.91%)-inactive (56%)
CK2a2inactive (91.5%)-inactive (100%)
CMGC - CLK

Bioactivity
KinaseRBCMetzMillipore
CLK1inactive (81.58%)--
CLK2inactive (93.9%)inactive (>3981.07nM)active (34%)
CLK3inactive (50.48%)-inactive (68%)
CLK4inactive (70.71%)active (79.43nM)-
CMGC - DYRK

Bioactivity
KinaseRBCMetzMillipore
DYRK1Ainactive (101.7%)inactive (>1995.26nM)-
DYRK1Binactive (88.22%)inactive (>2511.89nM)-
DYRK2inactive (62.54%)-inactive (76%)
DYRK3inactive (104.65%)--
DYRK4inactive (104.11%)--
HIPK1inactive (88.72%)-inactive (84%)
HIPK2inactive (98.69%)-inactive (65%)
HIPK3inactive (78.56%)-inactive (79%)
HIPK4inactive (106.89%)--
CMGC - MAPK

Bioactivity
KinaseRBCMetzMillipore
Erk1inactive (85.7%)-active (47%)
Erk2inactive (96.11%)-inactive (92%)
JNK3inactive (107.42%)-active (-2%)
NLKactive (26.05%)-active (34%)
p38ainactive (93.48%)inactive (>3981.07nM)inactive (73%)
p38binactive (83.43%)-inactive (62%)
p38dinactive (103.86%)-inactive (83%)
p38ginactive (97.88%)-inactive (81%)
JNK1inactive (73.73%)active (15.85nM)active (32%)
JNK2active (31.11%)active (79.43nM)inactive (64%)
CMGC - GSK

Bioactivity
KinaseRBCMetzMillipore
GSK3Ainactive (121.43%)inactive (>3981.07nM)inactive (109%)
GSK3Binactive (95.12%)inactive (>3981.07nM)inactive (90%)
CMGC - SRPK

Bioactivity
KinaseRBCMetzMillipore
MSSK1inactive (58.64%)-inactive (79%)
SRPK1inactive (114.78%)-inactive (99%)
SRPK2inactive (70.53%)-inactive (84%)
CMGC - CDK

Bioactivity
KinaseRBCMetzMillipore
CDC2---
CDK2---
CDK5-inactive (>3162.28nM)-
CDK8-inactive (>3981.07nM)-
CDK7-inactive (>3981.07nM)-
CDK9-inactive (>1584.89nM)-
CDK11---

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseRBCMetzMillipore
51--
6-11
6--1
Atypical - PDHK

Bioactivity
KinaseRBCMetzMillipore
PDHK1active (26.99%)--
Atypical - Alpha

Bioactivity
KinaseRBCMetzMillipore
eEF2K--inactive (81%)
Atypical - PIKK

Bioactivity
KinaseRBCMetzMillipore
FRAP--inactive (91%)