Compound Information


Test on : RBC

Compound Name : TWS119

Inchikey : VPVLEBIVXZSOMQ-UHFFFAOYSA-N

ChemSpider : 7828205

Pubchem CID : 9549289

ChEMBL : CHEMBL405759




DRx RBC Metz Millipore GPCR
bioactivity Kd (nM) Remain Activity (%) Ki (nM) Remain Activity (%) Inhibition (%)
active criteria <3000nM <50% <1000nM <50% >50%

AGC


Test Member No. in Family
Familyno. Member on 518kinaseRBC
11
33
75
76
88
53
99
23
32
33
41
AGC - PDK1

Bioactivity
KinaseRBC
PDK1inactive (86.85%)
AGC - Akt

Bioactivity
KinaseRBC
AKT1inactive (92.51%)
AKT2inactive (109.41%)
AKT3inactive (96.21%)
AGC - DMPK

Bioactivity
KinaseRBC
DMPK1inactive (95.15%)
MRCKainactive (87.68%)
MRCKbinactive (93.46%)
ROCK1inactive (94.06%)
ROCK2inactive (94.55%)
AGC - GRK

Bioactivity
KinaseRBC
BARK1inactive (107.67%)
BARK2inactive (100.5%)
GPRK4inactive (94.7%)
GPRK5inactive (128.23%)
GPRK6inactive (98.01%)
GPRK7inactive (102.11%)
AGC - RSK

Bioactivity
KinaseRBC
MSK1inactive (83.59%)
MSK2inactive (102.82%)
p70S6Kinactive (95.26%)
p70S6Kbinactive (94.72%)
RSK2inactive (96.93%)
RSK4inactive (95.37%)
RSK1inactive (104.8%)
RSK3inactive (91.55%)
AGC - PKA

Bioactivity
KinaseRBC
PKACg-
PRKXinactive (113.94%)
PKACainactive (92.33%)
AGC - PKC

Bioactivity
KinaseRBC
PKCainactive (95.61%)
PKCdinactive (95.7%)
PKCeinactive (97.41%)
PKChinactive (90.02%)
PKCginactive (88.14%)
PKCiinactive (84.65%)
PKCtinactive (64.55%)
PKCzinactive (93.96%)
PKCbinactive (97.46%)
AGC - PKG

Bioactivity
KinaseRBC
PKG2inactive (108.18%)
PKG1inactive (103.33%)
AGC - PKN

Bioactivity
KinaseRBC
PKN1inactive (105.1%)
PKN2inactive (72.02%)
AGC - SGK

Bioactivity
KinaseRBC
SGK1inactive (101%)
SGK2inactive (96.23%)
SGK3inactive (116.54%)
AGC - NDR

Bioactivity
KinaseRBC
NDR1active (0%)

TK


Test Member No. in Family
Familyno. Member on 518kinaseRBC
22
21
22
33
1111
55
55
22
21
43
1412
22
22
44
33
33
44
11
11
22
11
22
21
33
TK - Abl

Bioactivity
KinaseRBC
ABL1active (5.5%)
ABL2active (1.4%)
TK - Ack

Bioactivity
KinaseRBC
ACKactive (19.61%)
TK - ALK

Bioactivity
KinaseRBC
ALKinactive (80.89%)
LTKactive (16.76%)
TK - Axl

Bioactivity
KinaseRBC
AXLinactive (75.92%)
MERinactive (63.77%)
TYRO3inactive (52.06%)
TK - Src

Bioactivity
KinaseRBC
BLKactive (38.12%)
BRKactive (11.11%)
SRCactive (2.07%)
FGRactive (5.28%)
FRKactive (6.95%)
FYNactive (7.92%)
HCKactive (6.65%)
LCKactive (24.25%)
SRMinactive (94.41%)
YESactive (6.05%)
LYNactive (11.06%)
TK - Tec

Bioactivity
KinaseRBC
BMXactive (24.28%)
BTKactive (33.62%)
ITKinactive (102.2%)
TECinactive (107.57%)
TXKactive (24.48%)
TK - PDGFR

Bioactivity
KinaseRBC
KITactive (35.09%)
FLT3active (30.74%)
FMSactive (13.58%)
PDGFRbactive (39.85%)
PDGFRainactive (73.62%)
TK - Csk

Bioactivity
KinaseRBC
CSKactive (43.63%)
CTKinactive (97.81%)
TK - DDR

Bioactivity
KinaseRBC
DDR2active (29.26%)
TK - EGFR

Bioactivity
KinaseRBC
EGFRactive (7.89%)
ErbB2inactive (76.57%)
ErbB4inactive (75.79%)
TK - Eph

Bioactivity
KinaseRBC
EphA1active (31.19%)
EphA2active (48.16%)
EphA3active (39.72%)
EphA4active (48.3%)
EphA5active (41.67%)
EphA6-
EphA7inactive (77.22%)
EphA8inactive (57.52%)
EphB1active (40%)
EphB2active (40.74%)
EphB3inactive (78.78%)
EphB4-
TK - FAK

Bioactivity
KinaseRBC
FAKinactive (88.43%)
PYK2inactive (65.56%)
TK - Fer

Bioactivity
KinaseRBC
FERactive (44.03%)
FESinactive (73.83%)
TK - FGFR

Bioactivity
KinaseRBC
FGFR1active (39.26%)
FGFR2active (46.12%)
FGFR3inactive (67.9%)
FGFR4active (45.09%)
TK - VEGFR

Bioactivity
KinaseRBC
FLT1active (8.56%)
FLT4active (15.83%)
KDRactive (6.7%)
TK - InsR

Bioactivity
KinaseRBC
IGF1Rinactive (99.51%)
IRRinactive (96.34%)
INSRinactive (93.71%)
TK - JakA

Bioactivity
KinaseRBC
JAK1inactive (106.31%)
JAK2inactive (85.43%)
JAK3inactive (122.54%)
TYK2active (36.89%)
TK - Musk

Bioactivity
KinaseRBC
MUSKinactive (62.8%)
TK - Ret

Bioactivity
KinaseRBC
RETactive (-0.23%)
TK - Met

Bioactivity
KinaseRBC
RONinactive (103.1%)
METinactive (109.88%)
TK - Sev

Bioactivity
KinaseRBC
ROSactive (39.7%)
TK - Syk

Bioactivity
KinaseRBC
SYKactive (36.14%)
ZAP70inactive (97.5%)
TK - Tie

Bioactivity
KinaseRBC
TIE2inactive (60.7%)
TK - Trk

Bioactivity
KinaseRBC
TRKAinactive (90.54%)
TRKBinactive (95.47%)
TRKCinactive (63.32%)

TKL


Test Member No. in Family
Familyno. Member on 518kinaseRBC
125
53
42
41
21
105
51
TKL - STKR

Bioactivity
KinaseRBC
ALK1inactive (70.29%)
ALK2inactive (182.6%)
ALK4inactive (122.17%)
TGFbR1inactive (100.63%)
TGFbR2active (42.56%)
TKL - RAF

Bioactivity
KinaseRBC
ARAFinactive (57.31%)
BRAFinactive (53.25%)
RAF1inactive (85.9%)
TKL - IRAK

Bioactivity
KinaseRBC
IRAK1inactive (91.42%)
IRAK4inactive (88.21%)
TKL - LISK

Bioactivity
KinaseRBC
LIMK1active (22.13%)
TKL - LRRK

Bioactivity
KinaseRBC
LRRK2inactive (93.37%)
TKL - MLK

Bioactivity
KinaseRBC
MLK1active (16.23%)
MLK2inactive (79.23%)
MLK3inactive (52.42%)
TAK1inactive (63.01%)
ZAKactive (13.89%)
TKL - RIPK

Bioactivity
KinaseRBC
RIPK2active (30.51%)

CAMK


Test Member No. in Family
Familyno. Member on 518kinaseRBC
2013
55
44
11
54
31
55
52
22
33
33
52
1-
CAMK - CAMKL

Bioactivity
KinaseRBC
NuaK1active (37%)
BRSK1inactive (83.08%)
BRSK2inactive (86.93%)
CHK1inactive (66.21%)
LKB1active (12.37%)
MARK1inactive (83.01%)
MARK3inactive (77.5%)
MARK4inactive (68.85%)
MELKinactive (93.4%)
PASKinactive (96.22%)
QIKinactive (69.44%)
NuaK2inactive (90.3%)
MARK2inactive (79.03%)
CAMK - CAMK1

Bioactivity
KinaseRBC
CaMK1ainactive (112.2%)
CaMK1binactive (98.24%)
CaMK1dinactive (97.71%)
CaMK1ginactive (99%)
CaMK4inactive (94.9%)
CAMK - CAMK2

Bioactivity
KinaseRBC
CaMK2ainactive (114.93%)
CaMK2binactive (100.7%)
CaMK2dinactive (99.83%)
CaMK2ginactive (105.41%)
CAMK - RAD53

Bioactivity
KinaseRBC
CHK2inactive (75.85%)
CAMK - DAPK

Bioactivity
KinaseRBC
DAPK1inactive (89.07%)
DAPK2inactive (106.04%)
DRAK1inactive (93.66%)
DAPK3inactive (93.96%)
CAMK - DCAMKL

Bioactivity
KinaseRBC
DCLK2inactive (89.04%)
CAMK - MAPKAPK

Bioactivity
KinaseRBC
MAPKAPK2inactive (108.07%)
MAPKAPK3inactive (97.59%)
MAPKAPK5inactive (124.69%)
MNK1inactive (87.63%)
MNK2inactive (67.46%)
CAMK - MLCK

Bioactivity
KinaseRBC
smMLCKinactive (81.73%)
skMLCKactive (29.94%)
CAMK - PHK

Bioactivity
KinaseRBC
PHKg1inactive (81.52%)
PHKg2inactive (108.97%)
CAMK - PIM

Bioactivity
KinaseRBC
PIM1inactive (85.89%)
PIM2inactive (107.83%)
PIM3inactive (128.81%)
CAMK - PKD

Bioactivity
KinaseRBC
PKD1inactive (94.44%)
PKD3inactive (91.02%)
PKD2inactive (81.68%)
CAMK - TSSK

Bioactivity
KinaseRBC
TSSK1inactive (91.12%)
TSSK2inactive (95.62%)
CAMK - STK33

Bioactivity
KinaseRBC
STK33inactive (80.28%)

STE


Test Member No. in Family
Familyno. Member on 518kinaseRBC
83
22
3123
73
STE - STE11

Bioactivity
KinaseRBC
MAP3K5inactive (94.87%)
MAP3K2inactive (86.94%)
MAP3K3inactive (96.43%)
STE - STE-Unique

Bioactivity
KinaseRBC
COTinactive (99.65%)
NIKinactive (69.64%)
STE - STE20

Bioactivity
KinaseRBC
GCKinactive (55.5%)
HGKactive (12.46%)
KHS1active (18.42%)
LOKactive (45.84%)
MINKactive (34.69%)
MST1inactive (94.43%)
MST2inactive (108.69%)
MST3inactive (64.19%)
MST4inactive (83.75%)
OSR1inactive (118.57%)
PAK1inactive (87.96%)
PAK2inactive (88.93%)
PAK3inactive (79.83%)
PAK4inactive (99.82%)
PAK5inactive (86.87%)
PAK6inactive (109.06%)
SLKinactive (64.09%)
YSK1inactive (91.58%)
STLK3inactive (119.13%)
TAO1inactive (142.19%)
TAO2inactive (81.43%)
TAO3inactive (93.51%)
MYO3Bactive (0%)
STE - STE7

Bioactivity
KinaseRBC
MAP2K1inactive (76.27%)
MAP2K2inactive (103.72%)
MAP2K6inactive (90.13%)

Other


Test Member No. in Family
Familyno. Member on 518kinaseRBC
33
22
11
44
118
11
43
11
41
11
53
31
42
21
Other - Aur

Bioactivity
KinaseRBC
AurAinactive (78.25%)
AurBinactive (71.86%)
AurCinactive (77.67%)
Other - CAMKK

Bioactivity
KinaseRBC
CaMKK1inactive (113.23%)
CaMKK2inactive (95.86%)
Other - Haspin

Bioactivity
KinaseRBC
Haspininactive (93.29%)
Other - IKK

Bioactivity
KinaseRBC
IKKainactive (101.9%)
IKKbinactive (90.79%)
IKKeinactive (88.12%)
TBK1inactive (92.89%)
Other - NEK

Bioactivity
KinaseRBC
NEK1inactive (92.34%)
NEK11inactive (89.58%)
NEK2inactive (98.05%)
NEK4inactive (91.39%)
NEK6inactive (90.18%)
NEK7inactive (99.44%)
NEK9inactive (103.43%)
NEK3inactive (57.48%)
Other - TOPK

Bioactivity
KinaseRBC
PBKinactive (93.86%)
Other - PLK

Bioactivity
KinaseRBC
PLK1inactive (103.96%)
PLK2inactive (106.23%)
PLK3inactive (95.67%)
Other - SgK496

Bioactivity
KinaseRBC
SgK496inactive (83.41%)
Other - NAK

Bioactivity
KinaseRBC
MPSK1inactive (70.36%)
Other - TTK

Bioactivity
KinaseRBC
TTKinactive (104.01%)
Other - ULK

Bioactivity
KinaseRBC
ULK1inactive (142.62%)
ULK2inactive (97.46%)
ULK3active (0%)
Other - WEE

Bioactivity
KinaseRBC
Wee1inactive (85.45%)
Other - WNK

Bioactivity
KinaseRBC
Wnk2inactive (103.43%)
Wnk3inactive (88.5%)
Other - TLK

Bioactivity
KinaseRBC
TLK2active (0%)

CK1


Test Member No. in Family
Familyno. Member on 518kinaseRBC
76
31
CK1 - CK1

Bioactivity
KinaseRBC
CK1dinactive (96.82%)
CK1g1inactive (101.8%)
CK1g2inactive (84.89%)
CK1g3inactive (92.57%)
CK1ainactive (61.78%)
CK1einactive (92.89%)
CK1 - VRK

Bioactivity
KinaseRBC
VRK1inactive (81.62%)

CMGC


Test Member No. in Family
Familyno. Member on 518kinaseRBC
32
44
109
1410
22
33
CMGC - CK2

Bioactivity
KinaseRBC
CK2a1inactive (96.77%)
CK2a2inactive (96.51%)
CMGC - CLK

Bioactivity
KinaseRBC
CLK1inactive (93.01%)
CLK2inactive (98.76%)
CLK3inactive (73.96%)
CLK4inactive (104.38%)
CMGC - DYRK

Bioactivity
KinaseRBC
DYRK1Ainactive (103.25%)
DYRK1Binactive (100.3%)
DYRK2inactive (76.93%)
DYRK3inactive (89.81%)
DYRK4inactive (100.86%)
HIPK1inactive (82.71%)
HIPK2inactive (99.99%)
HIPK3inactive (93.98%)
HIPK4inactive (102.98%)
CMGC - MAPK

Bioactivity
KinaseRBC
Erk1inactive (86.86%)
Erk2inactive (113.63%)
JNK3inactive (89.41%)
NLKinactive (87.69%)
p38ainactive (98.08%)
p38binactive (108.43%)
p38dinactive (104.18%)
p38ginactive (88.56%)
JNK1inactive (94.4%)
JNK2inactive (110.73%)
CMGC - GSK

Bioactivity
KinaseRBC
GSK3Aactive (41.59%)
GSK3Bactive (48.13%)
CMGC - SRPK

Bioactivity
KinaseRBC
MSSK1inactive (100.95%)
SRPK1inactive (107.37%)
SRPK2inactive (99.11%)

Atypical


Test Member No. in Family
Familyno. Member on 518kinaseRBC
51
Atypical - PDHK

Bioactivity
KinaseRBC
PDHK1inactive (86.85%)